Traditional Posters: Miscellaneous
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| Peter Sheffield1,2, Michael D. Noseworthy, 2,3
1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; 2Brain-Body Institute, St. Joseph's Healthcare, Hamilton, ON, Canada; 3Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada Herein we demonstrate the necessity for separating control subjects by gender when analyzing the metabolites of the GABA/glutamate/glutamine (Glx) spin system. Seven male and five female subjects were recruited to assess differences in these metabolites using a STEAM sequence optimized for Glx quantification. Results indicate that GABA concentrations in the anterior cingulate cortex of females are significantly lower than in males, in contrast to previous occipital GABA studies. Therefore, care must be taken when developing control groups for Glx metabolite analysis. Our results also illuminate a possible etiology for executive mood disorder obscured by previous reports. 941. Can You Really Use the Creatine Equilibrium to Calculate Free ADP Concentrations? Christine Nabuurs1, Cees Hilbers2, Arend Heerschap1 1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Laboratory of Physical Chemistry, Faculty of Science, Nijmegen, Netherlands 31P saturation transfer experiments in MAK=/= and WT muscle demonstrated a neglegible effect of CK and AK mediated enzymatic phosphoryl exchanges between â-ADP and â-ATP. These results are in conflict with the expected 65% reduction of â-ATP upon saturation of the (ãATP/)â-ADP resonance. Hence, the major ADP pool which is available to the CK reaction cannot be saturated. We propose a solid-state like ADP pool, which is in exchange with a transient ADP pool that associates with CK. The inability to saturate the âADP spin system challenges the validity of calculating the free ADP concentration from the CK equilibrium. 942. In Vivo GABA Measurement of Sensorimotor Cortex Pallab Bhattacharyya1, Micheal Phillips1, Lael Stone1, Mark Lowe1 1Cleveland Clinic, Cleveland, OH, United States Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. Abnormal GABA has been implicated in several neuropsychiatric disorders. Using a variant of MEGA point resolved spectroscopy (MEGA-PRESS) sequence with interleaved water scans to detect subject motion, GABA level of sensorimotor cortex in healthy volunteers was measured, where the spectroscopy voxel was identified from a functional MRI scan. In addition, using linear regression analysis, GABA concentration in gray matter and white matter in the sensorimotor region were obtained.
We compare the sensitivity of the two spectroscopic imaging sequences Echo Planar Spectroscopic Imaging (EPSI) and Linear Response Equilibrium (LRE), a steady state free precession sequence with intrinsic suppression of periodic bands. Simulations and phantom experiments were performed revealing a good SNR performance of LRE especially at low spectral bandwidth. 944. Accurate Brain Tumor Biopsy Using 3D 1H-MRS Neuronavigation Berkay Kanberoglu1, Josef P. Debbins2, Lina J. Karam1 1Electrical Engineering, Arizona State University, Tempe, AZ, United States; 2Keller Center for Imaging Innovation, Barrow Neurological Institute, Phoenix, AZ, United States To correlate the 3D H-MRS voxel spectra of tumors with genetic and ex-vivo NMR data, it is imperative that the biopsy of the tissue of interest be as accurate as possible. The goal of this work is to present a method to make biopsies more accurate by creating regions of intests (ROIs) from MRS data and overlaying them onto the structural datasets during the biopsy. The overlaid ROI masks illuminate the biopsy regions on the surgical navigation system and act as markers like the markers used in fMRI. 945. Open Coil Arrangement for Interventional Magnetic Particle Imaging Yüklə 355,76 Kb. Dostları ilə paylaş:
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