Tttttgttttttccttcttacagaaggcactaccctggacgccgcttgcaaacgcctgaagagaaggcagggtgttcccactttttcagaatgggaccaggccctacggccccaatagcagaagcttctctaacccaggactgctcccctcaattcctcccaatatgctgaccgacagctcgacctcacctgggggcggttccgccaggggatggcttaggaaaacctcaggaagagcagcccagcgagtgacg
Yüklə 378,14 Kb.
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| tatag agtat ggata gggat aaccg tcaca gaatc aaaat aaaaa ataat agaaa taaca
ggcag ccatt attcc tgtct ctatc tccag tctta catcc tcctt actgc cacaa gaatg atcat tctaa acatg ccgtc ggtaa taagg acaga gatag aggtc agaat gtagg aggaa tgacg gtgtt cttac tagta agatt tgtac IVS 26 (+ 3824 bp) taggg acaca gccaa accat atcag tatgt atatg tatac aagta ttata tatat atgta tgtgt ttgta tgcat atccc tgtgt cggtt tggta tagtc ataca tatac atatg ttcat aatat atata tacat acaca aacat acgta acatg tatta tatat ggagg aaatt ctaat tttgt aaaaa actgg attgt gagtt ttaag gagat gttat ataaa tgtac ataat atata cctcc tttaa gatta aaaca ttttt tgacc taaca ctcaa aattc ctcta caata tattt gttaa gacaa tgtca ttttg tggta ttggt ctgaa ttaca atgta gtttc ttagt gatat ttttc cttta ttcag caatt ctgtt acagt aaaac accat aacca gactt aatgt tacat caaag aatca ctata aaaag gaaat aagtc 2992 3000 3015 3030 3045 TGT GAA AAC ATC TCC TTA AAA GAA CAA GTG GAG TCT ATA AAT AAA GAA CTG GAG ATT ACC AAG GAA ACA CTT TTG TAG AGG AAT TTT CTT GTT CAC CTC AGA TAT TTA TTT CTT GAC CTC TAA TGG TTC CTT Cys Glu Asn Ile Ser Leu Lys Glu Gln Val Glu Ser Ile Asn Lys Glu Leu Glu Ile Thr Lys Glu C E N I S L K E Q V E S I N K E L E I T K E 998 1000 1005 1010 1015 3060 3075 3090 3107 AAA CTT CAC ACT ATT GAA CAA GCC TGG GAA CAG GAA ACT AAA TTA GGT AA gtttt atgac tctga TTT GAA GTG TGA TAA CTT GTT CGG ACC CTT GTC CTT TGA TTT AAT CCA TT caaaa tactg agact Lys Leu His Thr Ile Glu Gln Ala Trp Glu Gln Glu Thr Lys Leu Gly Asn K L H T I E Q A W E Q E T K L G N 1020 1025 1030 1036 taata taaaa tgatt aacat ctaat aatga atatt tctta tttaa agttc ctttt ttatg ctaga ttaaa aggaa attat atttt actaa ttgta gatta ttact tataa agaat aaatt tcaag gaaaa aatac gatct aattt tcctt gtatt ttgac taaaa aaaga aagaa ctttc tgcct aataa tttaa cttag gcaga tgaat aatcc tgtac ttaac cataa aactg atttt tttct ttctt gaaag acgga ttatt aaatt gaatc cgtct actta ttagg acatg aattg cccac caaag tttag ttttc agtcc ttaag ttaga tttgt ttcta atgaa atcat atatg ttaaa aattt atgac gggtg gtttc aaatc aaaag tcagg aattc aatct aaaca aagat tactt tagta tatac aattt ttaaa tactg IVS 27 (+ 2447 bp) ttgat tgatg aagaa catta agttc cacag agatt aaatg gtaca ggcat cacac aggca ggaag taaca gagct aacta actac ttctt gtaat tcaag gtgtc tctaa tttac catgt ccgta gtgtg tccgt ccttc attgt ctcga aagat tagag tccag gtctg atgga attca gaaag ctaat gtgct ttcca tggaa ctata atgct ttcta atata ttcta atctc aggtc cagac tacct taagt ctttc gatta cacga aaggt acctt gatat tacga aagat tatat cagca tctaa aatat ctgag gtaat tttaa tataa acagc atgag attga cttaa atatt attgc atgta ggtaa gtcgt agatt ttata gactc catta aaatt atatt tgtcg tactc taact gaatt tataa taacg tacat ccatt 3108 3120 3135 3150 3165 T GAA TCT AGC ATG GAT AAG GCA AAG AAA TCA ATA ACC AAC AGT GAC ATT GTT TCC ATT TCA AAA AAA A CTT AGA TCG TAC CTA TTC CGT TTC TTT AGT TAT TGG TTG TCA CTG TAA CAA AGG TAA AGT TTT TTT Asn Glu Ser Ser Met Asp Lys Ala Lys Lys Ser Ile Thr Asn Ser Asp Ile Val Ser Ile Ser Lys Lys N E S S M D K A K K S I T N S D I V S I S K K 1036 1040 1045 1050 1055 insA (2) |del (3)
|| 3180 3195 3210 3225 3240 ATA ACT ATG CTG GAA ATG AAG GAA TTA AAT GAA AGG CAG CGG GCT GAA CAT TGT CAA AAA ATG TAT TAT TGA TAC GAC CTT TAC TTC CTT AAT TTA CTT TCC GTC GCC CGA CTT GTA ACA GTT TTT TAC ATA Ile Thr Met Leu Glu Met Lys Glu Leu Asn Glu Arg Gln Arg Ala Glu His Cys Gln Lys Met Tyr I T M L E M K E L N E R Q R A E H C Q K M Y 1060 1065 1070 1075 1080 3255 3270 3285 3300 GAA CAC TTA CGG ACT TCG TTA AAG CAA ATG GAG GAA CGT AAT TTT GAA TTG GAA ACC AAA TTT GCT CTT GTG AAT GCC TGA AGC AAT TTC GTT TAC CTC CTT GCA TTA AAA CTT AAC CTT TGG TTT AAA CGA Glu His Leu Arg Thr Ser Leu Lys Gln Met Glu Glu Arg Asn Phe Glu Leu Glu Thr Lys Phe Ala E H L R T S L K Q M E E R N F E L E T K F A 1085 1090 1095 1100 3309 GAG gtttg atatt ataag tttta tcata caatt ataga ataaa gaatt agttt tggta gacat tgtat tattg CTC caaac tataa tattc aaaat agtat gttaa tatct tattt cttaa tcaaa accat ctgta acata ataac Glu
E 1103
aattc accaa acaga cctag agact ttata gaata attat atcac ggata caaaa cacat tattt attta ttttc
taaat ttaga cttaa caaat tttcc tttcg tctat aaaga cattc aaaaa gagtg gttac aatat aataa tctaa taatt tatga aatgt tattt actaa acaat ggaat tgcct ttcac cacca tccct tcatt taaca aatat ttatt attaa atact ttaca ataaa tgatt tgtta cctta acgga aagtg gtggt aggga agtaa attgt ttata aataa IVS 28 (+ 417 bp) aaaaa tgact tttgg tggat tggaa tataa ccaga gtttc catag tttgt ttctg attct ttcat atttt ttacc ttttt actga aaacc accta acctt atatt ggtct caaag gtatc aaaca aagac taaga aagta taaaa aatgg ctcct tcagt ctgtt cttaa cactt cacac ttaat ataat atgtg aacta aggcc aagta aagag gattg cagta gagga agtca gacaa gaatt gtgaa gtgtg aatta tatta tacac ttgat tccgg ttcat ttctc ctaac gtcat cttta aaagc taaat tacaa agaaa acctc accaa aaatt gatgt atctg aacat ttttt gttac atttc cttag gaaat tttcg attta atgtt tcttt tggag tggtt tttaa ctaca tagac ttgta aaaaa caatg taaag gaatc 3310 3315 3330 3345 3360 3375 CTT ACC AAA ATC AAT TTG GAT GCA CAG AAG GTG GAA CAG ATG TTA AGA GAT GAA TTA GCT GAT AGT GAA TGG TTT TAG TTA AAC CTA CGT GTC TTC CAC CTT GTC TAC AAT TCT CTA CTT AAT CGA CTA TCA Leu Thr Lys Ile Asn Leu Asp Ala Gln Lys Val Glu Gln Met Leu Arg Asp Glu Leu Ala Asp Ser L T K I N L D A Q K V E Q M L R D E L A D S 1104 1105 1110 1115 1120 1125 3390 3405 3420 3435 GTG AGC AAG GCA GTA AGT GAT GCT GAT AGG CAA CGG ATT CTA GAA TTA GAG AAG AAT GAA ATG GAA CAC TCG TTC CGT CAT TCA CTA CGA CTA TCC GTT GCC TAA GAT CTT AAT CTC TTC TTA CTT TAC CTT Val Ser Lys Ala Val Ser Asp Ala Asp Arg Gln Arg Ile Leu Glu Leu Glu Lys Asn Glu Met Glu V S K A V S D A D R Q R I L E L E K N E M E 1130 1135 1140 1145 3450 3461 CTA AAA GTT GAA GTG TCA AA gtaag tgcat ataag cattt tagcc atttg actag atgta tcttc tttaa GAT TTT CAA CTT CAC AGT TT cattc acgta tattc gtaaa atcgg taaac tgatc tacat agaag aaatt Leu Lys Val Glu Val Ser Lys L K V E V S K 1150 1154 tttgt cttta agaaa cccaa ttaca ggtat acaat tctta gtagt aattg atact gattt ctttt tataa gaaca aaaca gaaat tcttt gggtt aatgt ccata tgtta agaat catca ttaac tatga ctaaa gaaaa atatt cttgt ggatt aagta atatt aagat cggtt ttaac agggt taaat aataa tattg acgag aataa tattg ttaaa gagga cctaa ttcat tataa ttcta gccaa aattg tccca attta ttatt ataac tgctc ttatt ataac aattt ctcct agtga cctct caaga tttgc atttt ttaga gttca ggaat attat tgcag aaagg tccag ttcct ccaca tattg tcact ggaga gttct aaacg taaaa aatct caagt cctta taata acgtc tttcc aggtc aagga ggtgt ataac IVS 29 (+ 1341 bp) aggga tgttg agaat gaagt ttttt ttata tagca aacat gataa cctct gatgg aatta tgttt catga aacag tccct acaac tctta cttca aaaaa aatat atcgt ttgta ctatt ggaga ctacc ttaat acaaa gtact ttgtc tttag gaaat cctgt tttaa tattt catac aaaga agaga tagat gctga aaacg aatgg ctttt tgaaa aaggg aaatc cttta ggaca aaatt ataaa gtatg tttct tctct atcta cgact tttgc ttacc gaaaa acttt ttccc tctag aaatt ttgaa ttttg gcatt tactt agaaa gtgta cttaa ttgtt cctga aatac cttat cattt cctag agatc tttaa aactt aaaac cgtaa atgaa tcttt cacat gaatt aacaa ggact ttatg gaata gtaaa ggatc 3462 3465 3480 3495 3510 3525 A CTG AGA GAG ATT TCT GAT ATT GCC AGA AGA CAA GTT GAA ATT TTG AAT GCA CAA CAA CAA TCT AGG T GAC TCT CTC TAA AGA CTA TAA CGG TCT TCT GTT CAA CTT TAA AAC TTA CGT GTT GTT GTT AGA TCC Lys Leu Arg Glu Ile Ser Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn Ala Gln Gln Gln Ser Arg K L R E I S D I A R R Q V E I L N A Q Q Q S R 1154 1155 1160 1165 1170 1175 3540 3555 3570 3573 GAC AAG GAA GTA GAG TCC CTC AGA ATG CAA CTG CTA GAC TAT CAG gtatg tgcag tattg gctct tctac CTG TTC CTT CAT CTC AGG GAG TCT TAC GTT GAC GAT CTG ATA GTC catac acgtc ataac cgaga agatg Asp Lys Glu Val Glu Ser Leu Arg Met Gln Leu Leu Asp Tyr Gln D K E V E S L R M Q L L D Y Q 1180 1185 1190 1191 ataga atcca ctttt ttccc taaat ttaca ttaga tgttg ggagt gggat atgtt atact ttttg tttgt ttcga tatct taggt gaaaa aaggg attta aatgt aatct acaac cctca cccta tacaa tatga aaaac aaaca aagct gatag ggtct cattc tgttg cccag ggtgg agtgc agtgg tacat tcaag gctca ttgca gcctt cacca cctgg ctatc ccaga gtaag acaac gggtc ccacc tcacg tcacc atgta agttc cgagt aacgt cggaa gtggt ggacc gttca ggtga tcctc ccacc tcagc ctctt agaca gctgg gacta caggc acgtg ccacc acacc taatt ttttt caagt ccact aggag ggtgg agtcg gagaa tctgt cgacc ctgat gtccg tgcac ggtgg tgtgg attaa aaaaa IVS 30 (+ 765 bp) ccact gttat tcagt tacat ttgga tttta agttt gtttg attct aggtt ttttc tttta cagtt ctttg gtaat ggtga caata agtca atgta aacct aaaat tcaaa caaac taaga tccaa aaaag aaaat gtcaa gaaac catta tattt gtatt aaagc aaagt tacat ttttg tagat ctcat gtgcc actgt gttaa aactt tgctt agtaa attgt ataaa cataa tttcg tttca atgta aaaac atcta gagta cacgg tgaca caatt ttgaa acgaa tcatt taaca gaatt ttaaa tctgt gataa ctttc actgg aaaaa tttga aactt actac aaata tatat ttttt ttaat atcag cttaa aattt agaca ctatt gaaag tgacc ttttt aaact ttgaa tgatg tttat atata aaaaa aatta tagtc 3574 3585 3600 3615 3630 GCA CAG TCT GAT GAA AAG TCG CTC ATT GCC AAG TTG CAC CAA CAT AAT GTC TCT CTT CAA CTG AGT CGT GTC AGA CTA CTT TTC AGC GAG TAA CGG TTC AAC GTG GTT GTA TTA CAG AGA GAA GTT GAC TCA Ala Gln Ser Asp Glu Lys Ser Leu Ile Ala Lys Leu His Gln His Asn Val Ser Leu Gln Leu Ser A Q S D E K S L I A K L H Q H N V S L Q L S 1192 1195 1200 1205 1210 3645 3660 3675 3690 3705 GAG GCT ACT GCT CTT GGT AAG TTG GAG TCA ATT ACA TCT AAA CTG CAG AAG ATG GAG GCC TAC AAC CTC CGA TGA CGA GAA CCA TTC AAC CTC AGT TAA TGT AGA TTT GAC GTC TTC TAC CTC CGG ATG TTG Glu Ala Thr Ala Leu Gly Lys Leu Glu Ser Ile Thr Ser Lys Leu Gln Lys Met Glu Ala Tyr Asn E A T A L G K L E S I T S K L Q K M E A Y N 1215 1220 1225 1230 1235 3720 3735 3750 3765 TTG CGC TTA GAG CAG AAA CTT GAT GAA AAA GAA CAG GCT CTC TAT TAT GCT CGT TTG GAG GGA AGA AAC GCG AAT CTC GTC TTT GAA CTA CTT TTT CTT GTC CGA GAG ATA ATA CGA GCA AAC CTC CCT TCT Leu Arg Leu Glu Gln Lys Leu Asp Glu Lys Glu Gln Ala Leu Tyr Tyr Ala Arg Leu Glu Gly Arg L R L E Q K L D E K E Q A L Y Y A R L E G R 1240 1245 1250 1255 T=ter (1) 3780 3795 3810 | 3825 AAC AGA GCA AAA CAT CTG CGC CAA ACA ATT CAG TCT CTA CGA CGA CAG TTT AGT GGA GCT TTA CCC TTG TCT CGT TTT GTA GAC GCG GTT TGT TAA GTC AGA GAT GCT GCT GTC AAA TCA CCT CGA AAT GGG Asn Arg Ala Lys His Leu Arg Gln Thr Ile Gln Ser Leu Arg Arg Gln Phe Ser Gly Ala Leu Pro N R A K H L R Q T I Q S L R R Q F S G A L P 1260 1265 1270 1275
TTG GCA CAA CAG GAA AAG TTC TCC AAA ACA ATG ATT CAA CTA CAA AAT GAC AAA CTT AAG ATA ATG AAC CGT GTT GTC CTT TTC AAG AGG TTT TGT TAC TAA GTT GAT GTT TTA CTG TTT GAA TTC TAT TAC Leu Ala Gln Gln Glu Lys Phe Ser Lys Thr Met Ile Gln Leu Gln Asn Asp Lys Leu Lys Ile Met L A Q Q E K F S K T M I Q L Q N D K L K I M 1280 1285 1290 1295 1300 3915 3930 3945 3960 CAA GAA ATG AAA AAT TCT CAA CAA GAA CAT AGA AAT ATG GAG AAC AAA ACA TTG GAG ATG GAA TTA GTT CTT TAC TTT TTA AGA GTT GTT CTT GTA TCT TTA TAC CTC TTG TTT TGT AAC CTC TAC CTT AAT Gln Glu Met Lys Asn Ser Gln Gln Glu His Arg Asn Met Glu Asn Lys Thr Leu Glu Met Glu Leu Q E M K N S Q Q E H R N M E N K T L E M E L 1305 1310 1315 1320 3975 3990 4005 4020 4029 AAA TTA AAG GGC CTG GAA GAG TTA ATA AGC ACT TTA AAG GAT ACC AAA GGA GCC CAA AAG gtaaa TTT AAT TTC CCG GAC CTT CTC AAT TAT TCG TGA AAT TTC CTA TGG TTT CCT CGG GTT TTC cattt Lys Leu Lys Gly Leu Glu Glu Leu Ile Ser Thr Leu Lys Asp Thr Lys Gly Ala Gln Lys K L K G L E E L I S T L K D T K G A Q K 1325 1330 1335 1340 1343 cattt aaact tgatt ttttt tttta agaga cagta tcttg atctg tttcc caggc tggag ttcag tggtg caaac gtaaa tttga actaa aaaaa aaaat tctct gtcat agaac tagac aaagg gtccg acctc aagtc accac gtttg atagc tggaa ctcct gggct caagg gactc tctag cctca gcctc ctgag tagtt gtagc tggca gtaca ggtgc tatcg acctt gagga cccga gttcc ctgag agatc ggagt cggag gactc atcaa catcg accgt catgt ccacg acacc accat accta cctaa ttttt taaaa ttttt aaatt ttttt gtaga gacaa ggtct cactt tgtca cccag tgtgg tggta tggat ggatt aaaaa atttt aaaaa tttaa aaaaa catct ctgtt ccaga gtgaa acagt gggtc IVS 31 (+ 632 bp) ttcca acata atttg aagat tttta ttgta aaatc ccaca tattt gtaga aaagt ctatg gaaat cctaa ataag aaggt tgtat taaac ttcta aaaat aacat tttag ggtgt ataaa catct tttca gatac cttta ggatt tattc atttt gtcat gtagt ttgac aaaag ataac attgt gtctt atttt atttt agaat ggcca ttact ttcaa ttaaa taaaa cagta catca aactg ttttc tattg taaca cagaa taaaa taaaa tctta ccggt aatga aagtt aattt atcat tatca tcaat ggagg aatgt tattt gttaa tatag cattt atatt tgtgt atata aattg taaat cttag tagta atagt agtta cctcc ttaca ataaa caatt atatc gtaaa tataa acaca tatat ttaac attta gaatc 4030 4035 4050 4065 4080 4095 GTA ATC AAC TGG CAT ATG AAA ATA GAA GAA CTT CGT CTT CAA GAA CTT AAA CTA AAT CGG GAA TTA CAT TAG TTG ACC GTA TAC TTT TAT CTT CTT GAA GCA GAA GTT CTT GAA TTT GAT TTA GCC CTT AAT Val Ile Asn Trp His Met Lys Ile Glu Glu Leu Arg Leu Gln Glu Leu Lys Leu Asn Arg Glu Leu V I N W H M K I E E L R L Q E L K L N R E L 1344 1345 1350 1355 1360 1365 del (1) 4110 || 4125 4140 4155 GTC AAG GAT AAA GAA GAA ATA AAA TAT TTG AAT AAC ATA ATT TCT GAA TAT GAA CGT ACA ATC AGC CAG TTC CTA TTT CTT CTT TAT TTT ATA AAC TTA TTG TAT TAA AGA CTT ATA CTT GCA TGT TAG TCG Val Lys Asp Lys Glu Glu Ile Lys Tyr Leu Asn Asn Ile Ile Ser Glu Tyr Glu Arg Thr Ile Ser V K D K E E I K Y L N N I I S E Y E R T I S 1370 1375 1380 1395
AGT CTT GAA GAA GAA ATT GTG CAA CAG AAC AAG gtttt atttt atatt tattt cattt ttttc cctaa TCA GAA CTT CTT CTT TAA CAC GTT GTC TTG TTC caaaa taaaa tataa ataaa gtaaa aaaag ggatt Ser Leu Glu Glu Glu Ile Val Gln Gln Asn Lys S L E E E I V Q Q N K 1390 1395 1398 gtttt ttttt ttttt ttttt ttttt gagat ggagt ctcac tctgt cgccc agact ggagt gcagt ggcgt gatct caaaa aaaaa aaaaa aaaaa aaaaa ctcta cctca gagtg agaca gcggg tctga cctca cgtca ccgca ctaga cggct cactg caagc tctgc ctccc gggtt catgc cattc tcctg cctca gcctc ccaag tagct gggac tacag gccga gtgac gttcg agacg gaggg cccaa gtacg gtaag aggac ggagt cggag ggttc atcga ccctg atgtc gcacc cgcca ccgtg cctgg ctaat ttttt gtatt tttag tagag acggg gtttc accat attag ccagg atggt cgtgg gcggt ggcac ggacc gatta aaaaa cataa aaatc atctc tgccc caaag tggta taatc ggtcc tacca IVS 32 (+ 796 bp) gatgg atgga tggat ggata gactg aaatc cttac ttcac atctg ccttt gtgat cttac acaag ttact tcacc ctacc tacct accta cctat ctgac tttag gaatg aagtg tagac ggaaa cacta gaatg tgttc aatga agtgg tctct gagtt tgtat ttttt tccat aaaag gaaaa taatt acagt ttctt caatg tgttg tgagg attag ataag agaga ctcaa acata aaaaa aggta ttttc ctttt attaa tgtca aagaa gttac acaac actcc taatc tattc aaaat atata taaaa tgcct gttat gtgcc tgatg tcttc gtgta tgtgt ctgac acaaa ttgtc ctttt tttag tttta tatat atttt acgga caata cacgg actac agaag cacat acaca gactg tgttt aacag gaaaa aaatc 4195 4200 4215 4230 4245 4260 TTT CAT GAA GAA AGA CAA ATG GCC TGG GAT CAA AGA GAA GTT GAC CTG GAA CGC CAA CTA GAC ATT AAA GTA CTT CTT TCT GTT TAC CGG ACC CTA GTT TCT CTT CAA CTG GAC CTT GCG GTT GAT CTG TAA Phe His Glu Glu Arg Gln Met Ala Trp Asp Gln Arg Glu Val Asp Leu Glu Arg Gln Leu Asp Ile F H E E R Q M A W D Q R E V D L E R Q L D I 1399 1400 1405 1410 1415 1420 4275 4290 4302 TTT GAC CGT CAG CAA AAT GAA ATA CTA AAT GCG GCA CAA AAG gtatg aatga ttaat cttgt ttgtt AAA CTG GCA GTC GTT TTA CTT TAT GAT TTA CGC CGT GTT TTC catac ttact aatta gaaca aacaa Phe Asp Arg Gln Gln Asn Glu Ile Leu Asn Ala Ala Gln Lys F D R Q Q N E I L N A A Q K 1425 1430 1434 actct gtagc atagt ctaga gtgtt aactc acaga aatat ttcct gtatc agatg taatt ttaat tgatg ttata tgaga catcg tatca gatct cacaa ttgag tgtct ttata aagga catag tctac attaa aatta actac aatat IVS 33 tt gtata tttaa aatat aagag gggtt taatc tatgt tttat catac agctg taaaa attaa tagtt actct aa catat aaatt ttata ttctc cccaa attag ataca aaata gtatg tcgac atttt taatt atcaa tgaga 4303 4320 caatg ctgca actgc ttttt taaaa aacat actat ttctt aatag TTT GAA GAA GCT ACA GGA TCA ATC CCT gttac gacgt tgacg aaaaa atttt ttgta tgata aagaa ttatc AAA CTT CTT CGA TGT CCT AGT TAG GGA Phe Glu Glu Ala Thr Gly Ser Ile Pro F E E A T G S I P 1435 1440 4335 4350 4365 4380 4395 GAC CCT AGT TTG CCC CTT CCA AAT CAA CTT GAG ATC GCT CTA AGG AAA ATT AAG GAG AAC ATT CGA CTG GGA TCA AAC GGG GAA GGT TTA GTT GAA CTC TAG CGA GAT TCC TTT TAA TTC CTC TTG TAA GCT Asp Pro Ser Leu Pro Leu Pro Asn Gln Leu Glu Ile Ala Leu Arg Lys Ile Lys Glu Asn Ile Arg D P S L P L P N Q L E I A L R K I K E N I R 1445 1450 1455 1460 1465 4410 4425 4437 ATA ATT CTA GAA ACA CGG GCA ACT TGC AAA TCA CTA GAA GAG gtaat tagaa gaatt tgcat tttga TAT TAA GAT CTT TGT GCC CGT TGA ACG TTT AGT GAT CTT CTC catta atctt cttaa acgta aaact Ile Ile Leu Glu Thr Arg Ala Thr Cys Lys Ser Leu Glu Glu I I L E T R A T C K S L E E 1470 1475 1479 ttagt gtatt atttg gtatg tttgg ggggc tttct aaata atatt tcttt atgag ggcaa tgcat agaat gatga aatca cataa taaac catac aaacc ccccg aaaga tttat tataa agaaa tactc ccgtt acgta tctta ctact atcta ttgct aattt cacta ttttt ctatt ctcct ataat gtttc taata gccaa taatg aacag cagat atagt tagat aacga ttaaa gtgat aaaaa gataa gagga tatta caaag attat cggtt attac ttgtc gtcta tatca taatt tgaat tcact attta attat tagtt ggtac ctttc ggtac actga atatg aaagg aaata aaaag cattt attaa actta agtga taaat taata atcaa ccatg gaaag ccatg tgact tatac tttcc tttat ttttc gtaaa IVS 34 (+ 711 bp) aatga agttt ctagc atatg taata gtctt ataaa taagc atgca aataa ctgct gtcaa ttaga attag tcagt ttact tcaaa gatcg tatac attat cagaa tattt attcg tacgt ttatt gacga cagtt aatct taatc agtca ttaac cttat taagt atcaa atggc tattg tacat atgat gtgaa aaata aagtg aattt ttttt ggcta ataac aattg gaata attca tagtt taccg ataac atgta tacta cactt tttat ttcac ttaaa aaaaa ccgat tattg taatc taaaa ttcag atgaa gcatt ttaaa gggaa aaaga tactt taatg attta ttata attta atcat tgcag attag atttt aagtc tactt cgtaa aattt ccctt tttct atgaa attac taaat aatat taaat tagta acgtc 4438 4455 4470 4485 4500 AAA CTA AAA GAG AAA GAA TCT GCT TTA AGG TTA GCA GAA CAA AAT ATA CTG TCA AGA GAC AAA GTA TTT GAT TTT CTC TTT CTT AGA CGA AAT TCC AAT CGT CTT GTT TTA TAT GAC AGT TCT CTG TTT CAT Lys Leu Lys Glu Lys Glu Ser Ala Leu Arg Leu Ala Glu Gln Asn Ile Leu Ser Arg Asp Lys Val K L K E K E S A L R L A E Q N I L S R D K V 1480 1485 1490 1495 1500 4515 4530 4545 4560 ATC AAT GAA CTG AGG CTT CGA TTG CCT GCC ACT GCA GAA AGA GAA AAG CTC ATA GCT GAG CTA GGC TAG TTA CTT GAC TCC GAA GCT AAC GGA CGG TGA CGT CTT TCT CTT TTC GAG TAT CGA CTC GAT CCG Ile Asn Glu Leu Arg Leu Arg Leu Pro Ala Thr Ala Glu Arg Glu Lys Leu Ile Ala Glu Leu Gly I N E L R L R L P A T A E R E K L I A E L G 1505 1510 1515 1520 4575 4590 4605 4620 4635 AGA AAA GAG ATG GAA CCA AAA TCT CAC CAC ACA TTG AAA ATT GCT CAT CAA ACC ATT GCA AAC ATG TCT TTT CTC TAC CTT GGT TTT AGA GTG GTG TGT AAC TTT TAA CGA GTA GTT TGG TAA CGT TTG TAC Arg Lys Glu Met Glu Pro Lys Ser His His Thr Leu Lys Ile Ala His Gln Thr Ile Ala Asn Met R K E M E P K S H H T L K I A H Q T I A N M 1525 1530 1535 1540 1545 del (2) 4650 | 4665 4680 4695 CAA GCA AGG TTA AAT CAA AAA GAA GAA GTA TTA AAG AAG TAT CAA CGT CTT CTA GAA AAA GCC AGA GTT CGT TCC AAT TTA GTT TTT CTT CTT CAT AAT TTC TTC ATA GTT GCA GAA GAT CTT TTT CGG TCT Gln Ala Arg Leu Asn Gln Lys Glu Glu Val Leu Lys Lys Tyr Gln Arg Leu Leu Glu Lys Ala Arg Q A R L N Q K E E V L K K Y Q R L L E K A R 1550 1555 1560 1565
GAG gtatt ttatt atatt atgag ttatg ctgtt atcca ttagt ttttt taagc aaatg ctaaa tatta tttta CTC cataa aataa tataa tactc aatac gacaa taggt aatca aaaaa attcg tttac gattt ataat aaaat Glu
E 1568
gggat ttcac cataa agaaa agaac gaaag tttac taaga taaat tctta acaat gaacg tacac taacc taatg
tggag acagt cattt tgacc ttcaa acaca tgtac ataga aagat aatat gtgac tgatt tggtg ctcat cgata catgg tgaaa tcata tgatt ttgaa aaata tttta attga gttta taggt gagga ttgag gcaat agggt ggaat gtacc acttt agtat actaa aactt tttat aaaat taact caaat atcca ctcct aactc cgtta tccca cctta IVS 35 g aaata tatca caccg gtaat cagta gaaat cagat ttgtt agaac ttcgt ggggg aaagc taaca tttaa c tttat atagt gtggc catta gtcat cttta gtcta aacaa tcttg aagca ccccc tttcg attgt aaatt ttttt tctag aagta agtta aaaga tgata gatac atgtc attct aatgt taaga ataaa ttatg aactg aggct aaaaa agatc ttcat tcaat tttct actat ctatg tacag taaga ttaca attct tattt aatac ttgac tccga gggct tgtca acttg aacat tgtct gaggg gacat gcata ccagt ctaga tacat acata tatgg agata ctgtt cccga acagt tgaac ttgta acaga ctccc ctgta cgtat ggtca gatct atgta tgtat atacc tctat gacaa tcttc ctcat ctcaa aggaa tttta gaaga ttgaa gagaa aatat ataag gtctt caaaa tgtga atttg tttta agaag gagta gagtt tcctt aaaat cttct aactt ctctt ttata tattc cagaa gtttt acact taaac aaaat (3) T=ter 4705 4710 4725 | atcac aattt aagat atagt ttcga ttttc tgtaa aacag GAG CAA AGA GAA ATT GTG AAG AAA CAT GAG tagtg ttaaa ttcta tatca aagct aaaag acatt ttgtc CTC GTT TCT CTT TAA CAC TTC TTT GTA CTC Glu Gln Arg Glu Ile Val Lys Lys His Glu E Q R E I V K K H E 1569 1570 1575
4740 4755 4770 | 4785 4800 GAA GAC CTT CAT ATT CTT CAT CAC AGA TTA GAA CTA CAG GCT GAT AGT TCA CTA AAT AAA TTC AAA CTT CTG GAA GTA TAA GAA GTA GTG TCT AAT CTT GAT GTC CGA CTA TCA AGT GAT TTA TTT AAG TTT Glu Asp Leu His Ile Leu His His Arg Leu Glu Leu Gln Ala Asp Ser Ser Leu Asn Lys Phe Lys E D L H I L H H R L E L Q A D S S L N K F K 1580 1585 1590 1595 1600
CAA ACG GCT TGG gtaag attct aagaa ctttg ttcca ttctt tattg atttt tgtga ccatg taaat taaaa GTT TGC CGA ACC cattc taaga ttctt gaaac aaggt aagaa ataac taaaa acact ggtac attta atttt Gln Thr Ala Trp Q T A W 1604
aagtc gagag aagaa aaaac cttac cttca atggg aaaaa caacg gtttt attag aagac ttttg tatcg agact
agtaa gaagg aggac atcga gtggc gacaa gtgtt ttaat ataaa tatta agaat cggta catga gttag acgat tgaac ctacc tgcct ttctt ttcaa attct actca ctgtg agttt agcta tatct aactt ccaga attca gctca acttg gatgg acgga aagaa aagtt taaga tgagt gacac tcaaa tcgat ataga ttgaa ggtct taagt cgagt IVS 36 t atttg cctct tttga ccatt ctgtt ccata tgtat gaaat gacat gtctt tcatc tttta atgtg taacc a taaac ggaga aaact ggtaa gacaa ggtat acata cttta ctgta cagaa agtag aaaat tacac attgg Yüklə 378,14 Kb. Dostları ilə paylaş:
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