University of Cape Town
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- Module no: 18 (General Surgery)
Convenor: Paul GoldbergPaul.Goldberg@uct,ac,za Tel: 021 4043053 Title: Follow up of patients who have had restorative proctocolectomies No. of students: 2 Type: Telephonic survey Summary: About 260 patients have undergone restorative proctocolectomies at GSH for ulcerative colitis and familial adenomatous polyposis over the last 20 years. This telephonic survey will contact patients and establish stool frequency and continence. Module no: 18 (General Surgery)Contact: Professor Anwar Mall Tel: Ext 6168 (secretary, Ms Warda Brown) anwar.mall@uct.ac.za Title: Mucus and Mucous Glycoproteins (Mucins) in Respiratory Diseases No. of Students: 10 Type: Essay and observation Summary: Respiratory diseases are a major cause of death in South Africa and variations in mortality of the different ethnic groups have been reported. Hypersecretion and alterations in the type of mucus have been implicated in the morbidity and mortality of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. TB is a major cause of respiratory illness in adults and children.The physiochemical and biological properties of mucus are largely conferred by mucous glycoproteins (mucins), large O-glycosylated, sticky, viscoelastic glycoproteins responsible for the rheological properties of normal mucus gels. The airway mucus layer coats the epithelium, provides a protective barrier against infectious agents, and participates in the mucosal response to inflammation and infection. Two mucin gene products in particular i.e. MUC5AC and MUC5B gene products that originate in the goblet cells of the surface mucosa and submucosal glands respectively, have been identified as major contributors to the respiratory secretions. In addition MUC2 has been identified in the sputa of cystic fibrosis patients and tends to be up-regulated in inflammatory disease. A number of clinical studies have highlighted the differences between asthma and COPD. There is however a dearth in the literature on the biochemical properties of mucus secretions in asthma, COPD, cystic fibrosis and mainly TB. One review indicated that the mucus in COPD differed to that in asthma in that it was less viscous, had a reduced MUC5AC:MUC5B ratio and there was a full release of mucin into the airway lumen rather than ‘tethering’ of mucus as in asthma. The airways in asthma have been reported to be occluded by tenacious plugs of mucus which is often unusually solid and contributes to airway hyper-responsiveness. You are expected to: 1. Review the literature and write an essay (maximum 10 pages) on the “The role of mucus in the pathogenesis of respiratory diseases such as asthma, COPD, cystic fibrosis and tuberculosis (TB)”. An opening paragraph or two should focus on mucus and mucins in disease in general. Please use clear sub-headings for each of the sections 2. You will have to provide a comprehensive reference list with your essay. 3. You will visit the mucus research laboratory (J50-30, J Floor, Dept of Surgery- times will be arranged with Professor A Mall), and observe laboratory techniques employed in purifying mucins from crude mucus secretions. Module no: 19 (Ophthalmology) Contact: James Rice James.rice@uct.ac.za Tel: 021 4045063 No of students: 2 Title: Glucometer use among diabetics with severe diabetic retinopathy Type: Cross sectional survey Summary: To report the prevalence of home glucose monitoring among a sample of diabetics with advanced diabetic retinopathy. This data can be obtained by means of a patient questionnaire administered in the retinal clinic (Eye outpatient department). Students will be expected to design an appropriate questionnaire in which they should also examine the barriers to home glucose monitoring. Following their assessment of the problems they should propose possible strategies to improve glucose monitoring.
Summary: To report the time between diagnosis of diabetes and first retinal screening examination among a sample of diabetics with advanced diabetic retinopathy. To examine whether patients underwent any form of systematic screening for progressive retinopathy. To identify reasons for delayed ocular examination and barriers to screening. To suggest strategies to overcome these problems. Module no: 21 Convenor: Dr Delva Shamley; Contact: delva.shamley@uct.ac.uk No. of students: 2 Type: Survey Title: Prevalence of upper limb morbidity following treatment for breast cancer. Summary: In spite of less invasive surgery incidence of breast cancer patients in western countries presenting with decreased shoulder and/or arm mobility, tightness, oedema, weakness, pain and numbness after treatment varies from 17% to 79% and can occur as long as 6 years after treatment. Breast cancer survivors who experience shoulder and arm problems have significantly reduced functional use of their upper limb which limits their quality of life and their ability to return to work. These effects are believed to be partly due to the systemic effects of radiotherapy and chemotherapy. The prevalence and nature of morbidity in the South African populations is not known. This project will involve a survey of a large sample of patients treated in the last 5 years. The questionnaire will be sent by post or completed on annual check-up at GSH. The results will be correlated to clinical data.
or telephone: 021 406 6111 No. of students: 4 Title: Follow-up of Neurosurgical Patients Type: Record Review and Patient follow-up study Summary: This module will explore the experiences of neurosurgical patients after discharge. In our local context, patient follow-up rates after neurosurgery as low as 20% have been reported, and we do not know enough about what happens to them. The purpose of the module is to better understand the post-discharge experience of patients and to identify potential gaps in the discharge and follow-up process. The questions that such a project could answer are:
Students will be expected to review patient folders of discharged neuro-surgical patients and contact one patient for a follow-up home visit each. Home visits will be conducted in pairs. They will contribute to the development of an appropriate folder review tool. They will be offered the opportunity to observe the work of ComaCare® amongst patients with neurological conditions resulting from neurosurgical conditions. Students will write a report of their experience including a critical appraisal of the literature and submit this for assessment. HUMAN BIOLOGY: HUB2020S Module no: 23 (Sports Science) Yüklə 269,21 Kb. Dostları ilə paylaş:
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