Anti-malarial drug resistance to chloroquine and sulfadoxine–pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (AC...
Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet and Bruno Pradines
Malaria Journal 2017 16:148
Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening
Blocking malaria transmission is an important step in eradicating malaria. In the field, transmission requires the production of sexual stage Plasmodium parasites, called gametocytes, which are not effectively ki...
Wei Sun, Xiuli Huang, Hao Li, Gregory Tawa, Ethan Fisher, Takeshi Q. Tanaka, Paul Shinn, Wenwei Huang, Kim C. Williamson and Wei Zheng
Malaria Journal 2017 16:147
Spatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea
The transmission of malaria is intense in the majority of the countries of sub-Saharan Africa, particularly in those that are located along the Equatorial strip. The present study aimed to describe the current...
Diana Gómez-Barroso, Emely García-Carrasco, Zaida Herrador, Policarpo Ncogo, María Romay-Barja, Martín Eka Ondo Mangue, Gloria Nseng, Matilde Riloha, Maria Angeles Santana, Basilio Valladares, Pilar Aparicio and Agustín Benito
Malaria Journal 2017 16:146
Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear...
Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi and Gordon A. Awandare
Malaria Journal 2017 16:145
Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study
Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, decrease mortality particularly among children under 5 years of age. This study ...
Israel Mitiku and Adane Assefa
Malaria Journal 2017 16:144
Therapeutic efficacy and artemisinin resistance in northern Myanmar: evidence from in vivo and molecular marker studies
In Myanmar, three types of artemisinin-based combination therapy (ACT) are recommended as first-line treatment of uncomplicated falciparum malaria: artemether–lumefantrine (AL), artesunate–mefloquine (AS + MQ)...
Moe Kyaw Myint, Charlotte Rasmussen, Aung Thi, Dorina Bustos, Pascal Ringwald and Khin Lin
The protective effect of insecticide-treated bed nets against individual-level malaria transmission is well known, however community-level effects are less understood. Protective effects from community-level b...
Veronica Escamilla, Alisa Alker, Leonard Dandalo, Jonathan J. Juliano, William C. Miller, Portia Kamthuza, Tapiwa Tembo, Gerald Tegha, Francis Martinson, Michael Emch and Irving F. Hoffman
Malaria Journal 2017 16:142
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacifi...
Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P. Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J. Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M. Aktaruzzaman, Nayeem Sohel, Rinzin Namgay…
Malaria Journal 2017 16:141
Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border
A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated wit...
Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco and Hervé Bogreau
Malaria Journal 2017 16:140
Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar
Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must b...
Myo Thiha Zaw, Myo Thant, Tin Maung Hlaing, Naing Zin Aung, Min Thu, Kanit Phumchuea, Kanokwan Phusri, Teerawat Saeseu, Ritthideach Yorsaeng, Wang Nguitragool, Ingrid Felger, Jaranit Kaewkungwal, Liwang Cui and Jetsumon Sattabongkot
Malaria Journal 2017 16:138
A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions
Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission-blocking drugs and vaccines ...
Ellie Sherrard-Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough and Michael Betancourt