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Plasmodium falciparum and Mycoplasma pneumoniae co-infection presenting with cerebral malaria manifesting orofacial dyskinesia and haemophagocytic lymphohistiocytosis



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Plasmodium falciparum and Mycoplasma pneumoniae co-infection presenting with cerebral malaria manifesting orofacial dyskinesia and haemophagocytic lymphohistiocytosis


Malaria is a mosquito-borne infectious disease with diverse clinical manifestations caused by a parasitic protozoan of the genus Plasmodium. Complex inter-relationships between Mycoplasma species and Plasmodium p...

Praveen Weeratunga, Gowri Rathnayake, Ahalya Sivashangar, Panduka Karunanayake, Ariaranee Gnanathasan and Thashi Chang

Malaria Journal 2016 15:461

Multi-method assessment of patients with febrile illness reveals over-diagnosis of malaria in rural Uganda


Health clinics in rural Africa are typically resource-limited. As a result, many patients presenting with fever are treated with anti-malarial drugs based only on clinical presentation. This is a considerable ...

Ria R. Ghai, Mary I. Thurber, Azza El Bakry, Colin A. Chapman and Tony L. Goldberg

Malaria Journal 2016 15:460

A malariometric survey of under-fives residing in indoor residual spraying-implementing and non-implementing communities of Lagos, Nigeria


Indoor residual spraying (IRS) is used as part of the integrated vector management strategy for the control of malaria in Lagos, Nigeria. The purpose of this study was to compare the malariometric indices of c...

Babatunde A. Odugbemi, Kikelomo O. Wright, Adebayo T. Onajole, Yetunde A. Kuyinu, Olayinka O. Goodman, Tinuola O. Odugbemi and Olumuyiwa O. Odusanya

Malaria Journal 2016 15:458

Characterization of fine specificity of the immune response to a Plasmodium falciparum rhoptry neck protein, PfAARP


Immunological characterization of potential blood-stage malaria antigens would be a valuable strategy in the development of an effective vaccine. Identifying B and CD4+ T cell epitopes will be important in unders...

Aakanksha Kalra, Paushali Mukherjee and Virander S. Chauhan

Malaria Journal 2016 15:457

The increasing importance of Plasmodium ovale and Plasmodium malariae in a malaria elimination setting: an observational study of imported cases in Jiangsu Province, China, 2011–2014


Following initiation of China’s National Malaria Elimination Action Plan in 2010, indigenous malaria infections in Jiangsu Province decreased significantly. Meanwhile imported Plasmodium infections have increased...

Yuanyuan Cao, Weiming Wang, Yaobao Liu, Chris Cotter, Huayun Zhou, Guoding Zhu, Jianxia Tang, Feng Tang, Feng Lu, Sui Xu, Yaping Gu, Chao Zhang, Julin Li and Jun Cao

Malaria Journal 2016 15:459

Field evaluation of diagnostic performance of malaria rapid diagnostic tests in western Kenya


Malaria continues to be a major burden in the endemic regions of Kenya. Health outcomes associated with case management are dependent on the use of appropriate diagnostic methods. Rapid diagnostic tests (RDTs)...

Elizabeth W. Wanja, Nickline Kuya, Collins Moranga, Mark Hickman, Jacob D. Johnson, Carolyne Moseti, Lalaine Anova, Bernhards Ogutu and Colin Ohrt

Malaria Journal 2016 15:456

Economic burden of malaria on businesses in Ghana: a case for private sector investment in malaria control


Despite the significant gains made globally in reducing the burden of malaria, the disease remains a major public health challenge, especially in sub-Saharan Africa (SSA) including Ghana. There is a significan...

Justice Nonvignon, Genevieve Cecilia Aryeetey, Keziah L. Malm, Samuel Agyei Agyemang, Vivian N. A. Aubyn, Nana Yaw Peprah, Constance N. Bart-Plange and Moses Aikins

Malaria Journal 2016 15:454

Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model


The US Army designed artelinate/lysine salt (AL) to overcome the instability of sodium artesunate in aqueous solution (AS). To select the most efficacious artemisinin treatment, direct comparison was performed...

Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoraj, Amporn Limsalakpeth, Nitima Chanarat, Natthasorn Komcharoen, Peter J. Weina, David L. Saunders, Montip Gettayacamin and R. Scott Miller

Malaria Journal 2016 15:453

In vivo efficacy of artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria: an open-randomized, non-inferiority clinical trial in South Kivu, Democratic Republic of Congo


Between 2009 and 2012, malaria cases diagnosed in a Médecins sans Frontières programme have increased fivefold in Baraka, South Kivu, Democratic Republic of the Congo (DRC). The cause of this increase is not k...

Marit de Wit, Anna L. Funk, Krystel Moussally, David Aksanti Nkuba, Ruby Siddiqui, Karla Bil, Erwan Piriou, Aldert Bart, Patrick Bahizi Bizoza and Teun Bousema

Malaria Journal 2016 15:455

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia


Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compou...

Sabina Dahlström Otienoburu, Oumou Maïga-Ascofaré, Birgit Schramm, Vincent Jullien, Joel J. Jones, Yah M. Zolia, Pascal Houzé, Elizabeth A. Ashley, Jean-René Kiechel, Philippe J. Guérin, Jacques Le Bras and Sandrine Houzé

Malaria Journal 2016 15:452

Malaria and large dams in sub-Saharan Africa: future impacts in a changing climate


Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understo...

Solomon Kibret, Jonathan Lautze, Matthew McCartney, Luxon Nhamo and G. Glenn Wilson

Malaria Journal 2016 15:448


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