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Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast



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Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast


Targeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of malaria transmission have been used to detect malaria transmission hotspots, but f...

David Tiga Kangoye, Abdisalan Noor, Janet Midega, Joyce Mwongeli, Dora Mkabili, Polycarp Mogeni, Christine Kerubo, Pauline Akoo, Joseph Mwangangi, Chris Drakeley, Kevin Marsh, Philip Bejon and Patricia Njuguna

Malaria Journal 2016 15:213

A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein


Plasmodium circumsporozoite protein (CSP) is a major surface antigen present in the sporozoite (Spz) stage of a malaria parasite. RTS, S vaccine, the most clinically advanced malaria v...

Min Zhang, Izumi Kaneko, Tiffany Tsao, Robert Mitchell, Elizabeth H. Nardin, Shiroh Iwanaga, Masao Yuda and Moriya Tsuji

Malaria Journal 2016 15:201

Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes


In eukaryotic genomes, deletion or amplification rates have been estimated to be a thousand more frequent than single nucleotide variation. In Plasmodium falciparum, relatively few transcription factors have been...

Johann Beghain, Anne-Claire Langlois, Eric Legrand, Laura Grange, Nimol Khim, Benoit Witkowski, Valentine Duru, Laurence Ma, Christiane Bouchier, Didier Ménard, Richard E. Paul and Frédéric Ariey

Malaria Journal 2016 15:206

Large contractors in Africa: conundrums with malaria chemoprophylaxis


Despite high levels of naturally-acquired immunity (NAI) within local communities in malaria high transmission settings in Africa, such people often experience clinical disease during peak transmission months ...

Leo Braack

Malaria Journal 2016 15:207

Early prediction of cerebral malaria by 1H NMR based metabolomics


Cerebral malaria (CM) is a life-threatening disease, caused mainly by Plasmodium falciparum in humans. In adults only 1–2 % of P. falciparum-infected hosts transit to the cerebral form of the disease while most ...

Soumita Ghosh, Arjun Sengupta, Shobhona Sharma and Haripalsingh M. Sonawat

Malaria Journal 2016 15:198

Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases


Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of novel drug targets and inhibitor molecules. The multi-component protein translation machinery is a rich source of su...

Sameena Khan

Malaria Journal 2016 15:203

Key traveller groups of relevance to spatial malaria transmission: a survey of movement patterns in four sub-Saharan African countries


As malaria prevalence declines in many parts of the world due to widescale control efforts and as drug-resistant parasites begin to emerge, a quantitative understanding of human movement is becoming increasing...

John M. Marshall, Mahamoudou Touré, André Lin Ouédraogo, Micky Ndhlovu, Samson S. Kiware, Ashley Rezai, Emmy Nkhama, Jamie T. Griffin, T. Deirdre Hollingsworth, Seydou Doumbia, Nicodem J. Govella, Neil M. Ferguson and Azra C. Ghani

Malaria Journal 2016 15:200

Evidence of new species for malaria vector Anopheles nuneztovari sensu lato in the Brazilian Amazon region


Anopheles nuneztovari sensu lato comprises cryptic species in northern South America, and the Brazilian populations encompass distinct genetic lineages within the Brazilian Amazon regi...

Vera Margarete Scarpassa, Antonio Saulo Cunha-Machado and José Ferreira Saraiva

Malaria Journal 2016 15:205

Correlations between household occupancy and malaria vector biting risk in rural Tanzanian villages: implications for high-resolution spatial targeting of control interventions


Fine-scale targeting of interventions is increasingly important where epidemiological disease profiles depict high geographical stratifications. This study verified correlations between household biomass and m...

Emmanuel W. Kaindoa, Gustav Mkandawile, Godfrey Ligamba, Louise A. Kelly-Hope and Fredros O. Okumu

Malaria Journal 2016 15:199

Malaria in three epidemiological strata in Mauritania


Malaria epidemiology in Mauritania has been characterized on the basis of epidemiological strata, defined by climatic and geographic features, which divide the country into three zones: Sahelian zone, Sahelo-S...

Mohamed Ouldabdallahi Moukah, Ousmane Ba, Hampaté Ba, Mohamed Lemine Ould Khairy, Ousmane Faye, Hervé Bogreau, Frédéric Simard and Leonardo K. Basco

Malaria Journal 2016 15:204

Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45


Plasmodium vivax 48/45 protein is expressed on the surface of gametocytes/gametes and plays a key role in gamete fusion during fertilization. This protein was recently expressed in Esc...

Andres F. Vallejo, Nora L. Martinez, Alejandra Tobon, Jackeline Alger, Marcus V. Lacerda, Andrey V. Kajava, Myriam Arévalo-Herrera and Sócrates Herrera

Malaria Journal 2016 15:202

Some anti-malarials are too strong for your body, they will harm you.’ Socio-cultural factors influencing pregnant women’s adherence to anti-malarial treatment in rural Gambia


Despite declining prevalence of malaria in The Gambia, non-adherence to anti-malarial treatment still remains a challenge to control efforts. There is limited evidence on the socio-cultural factors that influe...

Fatou Jaiteh, Susan Dierickx, Charlotte Gryseels, Sarah O’Neill, Umberto D’Alessandro, Susana Scott, Julie Balen and Koen Peeters Grietens

Malaria Journal 2016 15:195


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