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Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas



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Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas


Plasmodium vivax is the most widely distributed species causing the highest number of malaria cases in the world. In Brazil, P. vivax is responsible for approximately 84 % of reported ...

Larissa Rodrigues Gomes, Natália Ketrin Almeida-de-Oliveira, Aline Rosa de Lavigne, Suelen Rezende Félix de Lima, Anielle de Pina-Costa, Patrícia Brasil, Cláudio Tadeu Daniel-Ribeiro, Didier Ménard and Maria de Fatima Ferreira-da-Cruz

Malaria Journal 2016 15:96

Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana


Malaria rapid diagnostic tests (RDTs) play a key role in malaria management and control. The PfHRP-2 based RDT is the most widely used RDT for malaria diagnosis in Ghana. Deletion of pfhrp2 in Plasmodium falcipar...

Linda Eva Amoah, Joana Abankwa and Akua Oppong

Malaria Journal 2016 15:101

Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial


Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for preventing relapsing Plasmodium vivax infection and ...

Pamela L. St Jean, Zhengyu Xue, Nick Carter, Gavin C. K. W. Koh, Stephan Duparc, Maxine Taylor, Claire Beaumont, Alejandro Llanos-Cuentas, Ronnatrai Rueangweerayut, Srivicha Krudsood, Justin A. Green and Justin P. Rubio

Malaria Journal 2016 15:97

Incremental impact upon malaria transmission of supplementing pyrethroid-impregnated long-lasting insecticidal nets with indoor residual spraying using pyrethroids or the organophosphate, pirimiphos methyl


Long-lasting, insecticidal nets (LLINs) and indoor residual spraying (IRS) are the most widely accepted and applied malaria vector control methods. However, evidence that incremental impact is achieved when th...

Busiku Hamainza, Chadwick H. Sikaala, Hawela B. Moonga, Javan Chanda, Dingani Chinula, Mulenga Mwenda, Mulakwa Kamuliwo, Adam Bennett, Aklilu Seyoum and Gerry F. Killeen

Malaria Journal 2016 15:100

Status of insecticide resistance in high-risk malaria provinces in Afghanistan


Insecticide resistance seriously threatens the efficacy of vector control interventions in malaria endemic countries. In Afghanistan, the status of insecticide resistance is largely unknown while distribution ...

Mushtaq Ahmad, Cyril Buhler, Patricia Pignatelli, Hilary Ranson, Sami Mohammad Nahzat, Mohammad Naseem, Muhammad Farooq Sabawoon, Abdul Majeed Siddiqi and Martijn Vink

Malaria Journal 2016 15:98

The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT): a systematic review


Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based combination therapy (ACT). However, small sample sizes make i...

Renée J. Burger, Benjamin J. Visser, Martin P. Grobusch and Michèle van Vugt

Malaria Journal 2016 15:99

Transmission-blocking strategies: the roadmap from laboratory bench to the community


Malaria remains one of the most prevalent tropical and infectious diseases in the world, with an estimated more than 200 million clinical cases every year. In recent years, the mosquito stages of the parasite ...

Daniel Gonçalves and Patrick Hunziker

Malaria Journal 2016 15:95

Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity


Artemisinin-based combination therapy is recommended to treat Plasmodium falciparum worldwide, but observations of longer artemisinin (ART) parasite clearance times (PCTs) in Southeast Asia are widely interpreted...

Whitney A. Kite, Viviana A. Melendez-Muniz, Roberto R. Moraes Barros, Thomas E. Wellems and Juliana M. Sá

Malaria Journal 2016 15:94

Survey of Plasmodium in the golden-headed lion tamarin (Leontopithecus chrysomelas) living in urban Atlantic forest in Rio de Janeiro, Brazil


Communicating the presence of potential zoonotic pathogens such as Plasmodium spp. in wild animals is important for developing both animal and human health policies.

Elizabeth Helen Aitken, Marina Galvão Bueno, Luana dos Santos Ortolan, José M. Alvaréz, Alcides Pissinatti, Maria Cecília Martins Kierulff, José Luiz Catão-Dias and Sabrina Epiphanio

Malaria Journal 2016 15:93

Novel molecular diagnostic tools for malaria elimination: a review of options from the point of view of high-throughput and applicability in resource limited settings


As malaria transmission continues to decrease, an increasing number of countries will enter pre-elimination and elimination. To interrupt transmission, changes in control strategies are likely to require more ...

Sumudu Britton, Qin Cheng and James S. McCarthy

Malaria Journal 2016 15:88

Positive deviance as a novel tool in malaria control and elimination: methodology, qualitative assessment and future potential


Positive deviance (PD) is an asset-based, community-driven approach to behaviour change that has successfully been applied to address many health and social problems. It is yet to have been assessed for malari...

Muhammad Shafique, Hannah M. Edwards, Celine Zegers De Beyl, Bou Kheng Thavrin, Myo Min and Arantxa Roca-Feltrer

Malaria Journal 2016 15:91


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