Chromatographic purification of compounds was achieved with Silica gel 60 (40-63 µm). Thin layer chromatographies were carried out on silica gel 60 F254 (1.1 mm) with spot detection under UV light or phosphomolybdic acid or ninhydrin or KMnO4 oxidation. 1H NMR spectra were recorded at 300 MHz on a Bruker AVANCE 300 using CDCl3, CD3CN or DMSO-d6 as solvents and with the residual solvent signals as internal standards unless otherwise indicated. Data appear in the following order: chemical shifts in ppm, multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet; br, broaded), coupling constant J in Hz and number of protons. 13C NMR spectra were acquired at 75 MHz operating with broad band 1H decoupling. IR spectra were obtained with Perkin Elmer Spectrum 100 FT-IR spectrometer or Perkin Elmer FT-IR 1650 spectrometer.The melting points of powder compounds were measured on a STUART-Advanced apparatus. Microanalyses were carried out at the analytical laboratory of our Department (IRCOF) on a Thermo Fisher FLASH 2000 series analyser found within ±0.4% of the theoretical values. High resolution mass spectra were performed by the Mass Spectrometry Laboratory of the University of Rouen on a Waters LCT Premiere ESI-TOF spectrometer. All solid phase chemistry was carried out on a Quest 210 Parallel Synthesizer from Argonaut. In vitro AChE inhibitory activities were measured by the Centre d’Etudes et de Recherche sur le Médicament de Normandie (CERMN).