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PATOFIZIOLOGIJA SEROTONERGIČNE NEUROTRANSMISIJE



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Oznaka: 0098081


PATOFIZIOLOGIJA SEROTONERGIČNE NEUROTRANSMISIJE

PATHOPHYSIOLOGY OF SEROTONERGIC NEUROTRANSMISSION
Voditelj projekta: dr. sc. Branimir Jernej

Tel. ++385 1 4561 150   e-mail: jernej@irb.hr



Suradnici
Zvonimir Bokulić, dipl. ing. kemije, znanstveni novak u suradničkom zvanju asistenta (do 31.10.2005.)
Tatjana Bordukalo Nikšić, magistrica biol. znanosti, znanstvena novakinja u suradničkom zvanju asistentice
Lipa Čičin-Šain, doktorica biol. znanosti, viša znanstvena suradnica
Dubravka Hranilović, doktorica biol. znanosti, znanstvena suradnica
Branimir Jernej, doktor med. znanosti, znanstveni savjetnik
Jasminka Štefulj, doktorica biol. znanosti, znanstvena novakinja u suradničkom zvanju više asistentice
Tehnički suradnici
Katarina Karlo
Vlado Vraneša

Vanjski suradnici
Melita Balija, doktorica med. znanosti, znanstvena suradnica, Hrvatski zavod za transfuzijsku medicinu, Zagreb
Milovan Kubat, doktor med. znanosti, viši znanstveni suradnik, Medicinski fakultet, Sveučilište u Zagrebu
Mirko Šarlija, doktor med. znanosti, Klinička bolnica Merkur, Zagreb

Program rada i rezultati na projektu:

Istraživanja su bila provođena na kliničkoj i eksperimentalnoj razini s fokusom na serotonergičnu transmisiju. Na kliničkoj razini, istražena je povezanost genskih varijanti monooksidaze A i B s etiopatogenezom migrene. Također je istražena povezanost suicidnog ponašanja sa varijantama gena za triptofan hidroksilazu. Na eksperimentalnoj razini, provedena je daljnja karakterizcija ponašanja štakora selektivno uzgojenih za ekstremne vrijednosti serotoninskog prijenosnika i posljedično promijenjene serotoninske homeostaze (Wistra-Zagreb 5HT štakor).



Research programme and results:

Investigations were conducted on the clinical and experimental levels focused on the serotonergic transimssion. At the clinical level, research was directed to the association of genes encoding monoaminoxidase A and B with etiopathogenesis of migraine, as well as on the association of the tryptophan hydroxylase gene with suicidal behaviour. At the experimental level, further behavioural characterisation of rats  selected for extreme values of serotonin transporter an consequent alternations of serotonergic homeostasis, was conducted (Wistra-Zagreb 5HT rat).




Oznaka: 0098082


ENDEMSKE I RELIKTNE FITOCENOZE HRVATSKE I NJIHOVA MIKOFLORA

ENDEMIC AND RELICT PHYTOCENOSES IN CROATIA AND THEIR MYCOFLORA
Voditelj projekta: dr. sc. Andrija-Željko Lovrić

Tel. ++385 1 4561 075   e-mail: azlovric@irb.hr



Suradnici
Oleg Antonić, doktor biol. znanosti, znanstveni suradnik
Andrija-Željko Lovrić, doktor biol. znanosti, znanstveni suradnik od 7.4.2005.
Armin Mešić, znanstveni novak u suradničkom zvanju asistenta

Mladen Rac, doktor biol. znanosti, znanstveni novak u suradničkom zvanju višeg asistenta


Zdenko Tkalčec, magistar biol. znanosti, znanstveni novak u suradničkom zvanju asistenta
Tehnički suradnici
Neven Matočec

Vanjski suradnici
Maja Kovačević, magistrica biol. znanosti, Arboretum HAZU, Trsteno

Program rada i rezultati na projektu:

Naše terensko uzorkovanje vegetacije i fitonima u god. 2005. obuhvaća: poluotok Pelješac (uključivo halofite i morske alge), gorski lanac Dinare (Troglav-Prolog-Kamešnica) i srednju Posavinu od Zagreba do Slavonskog Broda. Bioraznolikost gljiva je istraživana u cijeloj Hrvatskoj: registrirano je 3.465 vrsta gljiva i kartirano njih 587. Od toga su 55 vrsta gljiva i 8 rodova po prvi puta nadjeni u Hrvatskoj, iz čega su objavljena 3 mikološka rada. Poredbeno je proučena bioraznolikost i zdravstveno stanje šuma bukve i jele na hrvatskom krasu i završni rezultati toga će se objaviti 2006. Ove godine su neki pripadni rezultati iz 4-godišnjeg projekta “Kartiranje staništa Republike Hrvatske” (Ministarstvo zaštite prirode i prostornog planiranja) objavljeni u 3 rada. Ove godine je naš laboratorij objavio ukupno 11 znanstvenih i stručnih radova u časopisima i monografskim knjigama, od kojih je jedan registriran u CC i drugi u SCI.



Research programme and results:

Our field sampling of the vegetation and phytonyms in 2005 included: Pelješac peninsula including halophytes and marine algae, Dinara mountain range of Troglav-Prolog-Kamešnica, and Sava valley from Zagreb to Slavonski Brod. Biodiversity of fungi on whole territory of Republic of Croatia has been studied: 3,465 records and 587 fungal species have been mapped. 55 species and 8 genera have been recorded as new for Croatian mycobiota, and 3 related scientific papers have been published. Comparative study of phytodiversity and health status of fir-beech forests on Croatian karst is finished and prepared for publishing in 2006. In 2005 selected results of the four-year project of Ministry of Nature Protection and Physical Planning (Mapping the habitats of the Republic of Croatia), were published in 3 references. During this year, our laboratory published 11 scientific and professional papers in the periodicals and monographs, including one quoted in Current Contents and another in Science Citation Index.





PRILOZI
Znanstveni i pregledni radovi objavljeni u časopisima koji su indeksirani u Current Contents-u


1.

Ahel, Ivan; Mikoč, Andreja; Gamulin, Vera. RecA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein. // FEMS microbiology letters. 248 (2005); 119-124.

2.

Brčić-Kostić, Krunoslav. Neutral mutation as the source of genetic variation in life history traits. // Genetical research. 86 (2005); 53-63.

3.

Breljak, Davorka; Ambriović-Ristov, Andreja; Kapitanović, Sanja; Čačev, Tamara; Gabrilovac, Jelka. Comparison of three RT-PCR-based methods for relative quantification of mRNA. // Food technology and biotechnology. 43 (2005), 4; 379-388.

4.

Čičin-Šain, Lipa; Froebe, Ana; Bordukalo-Nikšić, Tatjana; Jernej, Branimir. Serotonin transporter kinetics in rats selected for extreme values of platelet serotonin level. // Life sciences. 77 (2005); 452-461.

5.

Ferenac, Marina; Polančec, Denis; Huzak, Miljenko; Pereira-Smith, Olivia M.; Rubelj, Ivica. Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening. // Journals of gerontology series A-biological sciences and medical sciences. 60 (2005), 7; 820-829.

6.

Filić, Vedrana; Vladić, Anton; Štefulj, Jasminka; Čičin-Šain, Lipa; Balija, Melita; Sučić, Zvonimir; Jernej, Branimir. Monoamine oxidases A and B gene polymorphisms in migraine patients. // Journal of the neurological sciences. 228 (2005), 2; 149-153.

7.

Fulgosi, Hrvoje; Lepeduš, Hrvoje; Cesar, Vera; Ljubešić, Nikola. Differential accumulation of plastid preprotein translocon components during spruce (Picea abies L. Karst.) needle development. // Biological chemistry. 386 (2005), 8; 777-783.

8.

Gabrilovac, Jelka; Breljak, Davorka; Čupić, Barbara; Ambriović-Ristov, Andreja. Regulation of aminopeptidase N (EC 3.4.11.2 ; APN ; CD13) by interferon-gamma on the HL-60 cell line. // Life sciences. 76 (2005), 23; 2681-2697.

9.

Harcet, Matija; Lukić-Bilela, Lada; Ćetković, Helena; Müller, E.G. Werner; Gamulin, Vera. Identification and analysis of cDNAs encoding two nucleoside diphosphate kinases (NDPK/Nm23) from the marine sponge Suberites domuncula. // Croatica chemica acta. 78 (2005), 3; 343-348.

10.

Hranilović, Dubravka; Čičin-Šain, Lipa; Bordukalo-Nikšić, Tatjana; Jernej, Branimir. Rats with constitutionally upregulated/downregulated platelet 5HT transporter : differences in anxiety-related behavior. // Behavioural brain research. 165 (2005), 2; 271-277.

11.

Htun van der Horst, E.; Weber, Igor; Ulrich, A. Tyrosine phosphorylation of PYK2 mediates Heregulin-induced glioma invasion : novel heregulin/HER3-stimulated signaling pathway in glioma. // International journal of cancer. 113 (2005); 689-698.

12.

Ilić, Nebojša; Habuš, Ivan; Barkawi, Lana S.; Park, Seijin; Štefanić, Zoran; Kojić-Prodić, Biserka; Cohen, Jerry D.; Magnus, Volker. Aminoethyl-substituted indole-3-acetic acids for the preparation of tagged and carrier-linked auxin. // Bioorganic and medicinal chemistry. 13 (2005), 9; 3229-3240.

13.

Ivančić-Baće, Ivana; Salaj-Šmic, Erika; Brčić-Kostić, Krunoslav. Effects of recJ, recQ and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli. // Journal of bacteriology. 187 (2005), 4; 1350-1356.

14.

Jeličić, Branka; Traven, Ana; Filić, Vedrana; Sopta, Mary. Mitochondrial dysfunction enhances Gal4 dependent transcription. // FEMS microbiology letters. 253 (2005), 2; 207-213.

15.

Klarica, Marijan; Varda, Robert; Vukić, Miroslav; Orešković, Darko; Radoš, Milan; Bulat, Marin. Spinal contribution to CSF pressure lowering effect of mannitol in cats. // Acta neurochirurgica : supplement. 95 (2005); 407-410.

16.

Kovačević, Goran; Kalafatić, Mirjana; Ljubešić, Nikola. Endosymbiotic alga from green hydra under the influence of cinoxacin. // Folia microbiologica. 50 (2005), 3; 205-208.

17.

Lepeduš, Hrvoje; Viljevac, Marija; Cesar, Vera; Ljubešić, Nikola. Functioning of the photosynthetic apparatus under low and high light conditions in chlorotic spruce needles as evaluated by in vivo chlorophyll fluorescence. // Russian journal of plant physiology. 52 (2005), 2; 165-170.

18.

Mancuso, Stefano; Marras, Anna Maria; Magnus, Volker; Baluška, František. Non-invasive and continuous recording of auxin fluxes in intact root apex with a carbon-nanotube-modified and self-referencing microelectrode. // Analytical biochemistry. 341 (2005); 344-351.

19.

Matulić, Maja; Jevtov, Irena; Ferenac, Marina; Škrobot, Nikolina; Tominaga, Kaoru; Rubelj, Ivica. Human chromosome 1 in mouse immortal cell background. // Croatica chemica acta. 78 (2005), 3; 413-418.

20.

Meštrović, Nevenka; Randig, Onivaldo; Abad, Pierre; Plohl, Miroslav; Castagnone-Sereno, Philippe. Conserved and variable domains in satellite DNAs of mitotic parthenogenetic root-knot nematode species. // Gene. 362 (2005); 44-50.

21.

Miletić, Ivana; Devčić, Nevena; Anić, Ivica; Borčić, Josipa; Karlović, Zoran; Osmak, Maja. The cytotoxicity of RoekoSeal and AH plus compared during different setting periods. // Journal of endodontics. 31 (2005), 4; 307-309.

22.

Mravinac, Brankica; Plohl, Miroslav; Ugarković, Đurđica. Preservation and high sequence conservation of satellite DNAs suggest functional constraints. // Journal of molecular evolution. 61 (2005); 542-550.

23.

Mravinac, Brankica; Ugarković, Đurđica; Franjević, Damjan; Plohl, Miroslav. Long inversely oriented subunits form a complex monomer of Tribolium brevicornis satellite DNA. // Journal of molecular evolution. 60 (2005), 4; 513-525.

24.

Orešković, Darko; Vukić, Miroslav; Klarica, Marijan; Bulat, Marin. The investigation of CSF formation by ventriculo-aqueductal perfusion method in cats. // Acta neurochirurgica : supplement. 95 (2005); 433-436.

25.

Petrović, Vlatka; Plohl, Miroslav. Sequence divergence and conservation in organizationally distinct subfamilies of Donax trunculus satellite DNA. // Gene. 362 (2005); 37-43.

26.

Piljac, Jasenka; Martinez, Sanja; Valek, Lidija; Stipčević, Tamara; Kovačević Ganić, Karin. A comparison of methods used to define the phenolic content and antioxidant activity of Croatian wines. // Food technology and biotechnology. 43 (2005), 3; 271-276.

27.

Randić, Milan; Lerš, Nella; Plavšić, Dejan; Basak, Subhash C.; Balaban, Alexandru T. Four-color map representation of DNA or RNA sequences and their numerical characterization. // Chemical physics letters. 407 (2005), 1-3; 205-208.

28.

Randić, Milan; Lerš, Nella; Vukičević, Damir; Plavšić, Dejan; Basak, Subhash; Gute, Brian. Canonical labeling of proteome maps. // Journal of proteome research. 4 (2005), 4; 1347-1352.

29.

Sondi, Ivan; Salopek-Sondi, Branka. The influence of the primary structure of enzymes on the formation of CaCO3 polymorphs : a comparison of plant (Canavalia ensiformis) and bacterial (Bacillus pasteurii) ureases. // Langmuir. 21 (2005); 8876-8882.

30.

Šimaga, Šumski; Osmak, Maja; Babić, Damir; Šprem, Marina; Vukelić, Bojana; Abramić, Marija. Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues : correlation with tumor grade. // International journal of gynecological cancer. 15 (2005); 438-444.

31.

Štefulj, Jasminka; Kubat, Milovan; Balija, Melita; Škavić, Josip; Jernej, Branimir. Variability of the tryptophan hydroxylase gene : study in victims of violent suicide. // Psychiatry research. 134 (2005); 67-73.

32.

Ugarković, Đurđica. Functional elements residing within satellite DNAs. // EMBO reports. 6 (2005), 11; 1035-1039.

33.

Weber, Igor. Cryoelectron tomography : implications for actin cytoskeleton research. // Croatica chemica acta. 78 (2005); 325-331.

34.

Weber, Igor. Receptor occupancy on an ellipsoidal cell in the presence of a point source of a chemoattractant. // Journal of chemical information and modeling. 45 (2005), 6; 1647-1651.

35.

Đermić, Damir; Halupecki, Edyta; Zahradka, Davor; Petranović, Mirjana. RecBCD enzyme overproduction impairs DNA repair and homologous recombination in Escherichia coli. // Research in microbiology. 156 (2005), 3; 304-311.



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