Tttttgttttttccttcttacagaaggcactaccctggacgccgcttgcaaacgcctgaagagaaggcagggtgttcccactttttcagaatgggaccaggccctacggccccaatagcagaagcttctctaacccaggactgctcccctcaattcctcccaatatgctgaccgacagctcgacctcacctgggggcggttccgccaggggatggcttaggaaaacctcaggaagagcagcccagcgagtgacg



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tarix19.01.2018
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1   2   3   4
tatag agtat ggata gggat aaccg tcaca gaatc aaaat aaaaa ataat agaaa taaca
ggcag ccatt attcc tgtct ctatc tccag tctta catcc tcctt actgc cacaa gaatg atcat tctaa acatg

ccgtc ggtaa taagg acaga gatag aggtc agaat gtagg aggaa tgacg gtgtt cttac tagta agatt tgtac


IVS 26 (+ 3824 bp)
taggg acaca gccaa accat atcag tatgt atatg tatac aagta ttata tatat atgta tgtgt ttgta tgcat

atccc tgtgt cggtt tggta tagtc ataca tatac atatg ttcat aatat atata tacat acaca aacat acgta


acatg tatta tatat ggagg aaatt ctaat tttgt aaaaa actgg attgt gagtt ttaag gagat gttat ataaa

tgtac ataat atata cctcc tttaa gatta aaaca ttttt tgacc taaca ctcaa aattc ctcta caata tattt


gttaa gacaa tgtca ttttg tggta ttggt ctgaa ttaca atgta gtttc ttagt gatat ttttc cttta ttcag

caatt ctgtt acagt aaaac accat aacca gactt aatgt tacat caaag aatca ctata aaaag gaaat aagtc


2992 3000 3015 3030 3045

TGT GAA AAC ATC TCC TTA AAA GAA CAA GTG GAG TCT ATA AAT AAA GAA CTG GAG ATT ACC AAG GAA

ACA CTT TTG TAG AGG AAT TTT CTT GTT CAC CTC AGA TAT TTA TTT CTT GAC CTC TAA TGG TTC CTT

Cys Glu Asn Ile Ser Leu Lys Glu Gln Val Glu Ser Ile Asn Lys Glu Leu Glu Ile Thr Lys Glu

C E N I S L K E Q V E S I N K E L E I T K E

998 1000 1005 1010 1015


3060 3075 3090 3107

AAA CTT CAC ACT ATT GAA CAA GCC TGG GAA CAG GAA ACT AAA TTA GGT AA gtttt atgac tctga

TTT GAA GTG TGA TAA CTT GTT CGG ACC CTT GTC CTT TGA TTT AAT CCA TT caaaa tactg agact

Lys Leu His Thr Ile Glu Gln Ala Trp Glu Gln Glu Thr Lys Leu Gly Asn

K L H T I E Q A W E Q E T K L G N

1020 1025 1030 1036


taata taaaa tgatt aacat ctaat aatga atatt tctta tttaa agttc ctttt ttatg ctaga ttaaa aggaa

attat atttt actaa ttgta gatta ttact tataa agaat aaatt tcaag gaaaa aatac gatct aattt tcctt


gtatt ttgac taaaa aaaga aagaa ctttc tgcct aataa tttaa cttag gcaga tgaat aatcc tgtac ttaac

cataa aactg atttt tttct ttctt gaaag acgga ttatt aaatt gaatc cgtct actta ttagg acatg aattg


cccac caaag tttag ttttc agtcc ttaag ttaga tttgt ttcta atgaa atcat atatg ttaaa aattt atgac

gggtg gtttc aaatc aaaag tcagg aattc aatct aaaca aagat tactt tagta tatac aattt ttaaa tactg


IVS 27 (+ 2447 bp)
ttgat tgatg aagaa catta agttc cacag agatt aaatg gtaca ggcat cacac aggca ggaag taaca gagct

aacta actac ttctt gtaat tcaag gtgtc tctaa tttac catgt ccgta gtgtg tccgt ccttc attgt ctcga


aagat tagag tccag gtctg atgga attca gaaag ctaat gtgct ttcca tggaa ctata atgct ttcta atata

ttcta atctc aggtc cagac tacct taagt ctttc gatta cacga aaggt acctt gatat tacga aagat tatat


cagca tctaa aatat ctgag gtaat tttaa tataa acagc atgag attga cttaa atatt attgc atgta ggtaa

gtcgt agatt ttata gactc catta aaatt atatt tgtcg tactc taact gaatt tataa taacg tacat ccatt


3108 3120 3135 3150 3165

T GAA TCT AGC ATG GAT AAG GCA AAG AAA TCA ATA ACC AAC AGT GAC ATT GTT TCC ATT TCA AAA AAA

A CTT AGA TCG TAC CTA TTC CGT TTC TTT AGT TAT TGG TTG TCA CTG TAA CAA AGG TAA AGT TTT TTT

Asn Glu Ser Ser Met Asp Lys Ala Lys Lys Ser Ile Thr Asn Ser Asp Ile Val Ser Ile Ser Lys Lys

N E S S M D K A K K S I T N S D I V S I S K K

1036 1040 1045 1050 1055


insA (2)

|del (3)


|| 3180 3195 3210 3225 3240

ATA ACT ATG CTG GAA ATG AAG GAA TTA AAT GAA AGG CAG CGG GCT GAA CAT TGT CAA AAA ATG TAT

TAT TGA TAC GAC CTT TAC TTC CTT AAT TTA CTT TCC GTC GCC CGA CTT GTA ACA GTT TTT TAC ATA

Ile Thr Met Leu Glu Met Lys Glu Leu Asn Glu Arg Gln Arg Ala Glu His Cys Gln Lys Met Tyr

I T M L E M K E L N E R Q R A E H C Q K M Y

1060 1065 1070 1075 1080


3255 3270 3285 3300

GAA CAC TTA CGG ACT TCG TTA AAG CAA ATG GAG GAA CGT AAT TTT GAA TTG GAA ACC AAA TTT GCT

CTT GTG AAT GCC TGA AGC AAT TTC GTT TAC CTC CTT GCA TTA AAA CTT AAC CTT TGG TTT AAA CGA

Glu His Leu Arg Thr Ser Leu Lys Gln Met Glu Glu Arg Asn Phe Glu Leu Glu Thr Lys Phe Ala

E H L R T S L K Q M E E R N F E L E T K F A

1085 1090 1095 1100


3309

GAG gtttg atatt ataag tttta tcata caatt ataga ataaa gaatt agttt tggta gacat tgtat tattg

CTC caaac tataa tattc aaaat agtat gttaa tatct tattt cttaa tcaaa accat ctgta acata ataac

Glu


E

1103
ttaag tggtt tgtct ggatc tctga aatat cttat taata tagtg cctat gtttt gtgta ataaa taaat aaaag

aattc accaa acaga cctag agact ttata gaata attat atcac ggata caaaa cacat tattt attta ttttc
attta aatct gaatt gttta aaagg aaagc agata tttct gtaag ttttt ctcac caatg ttata ttatt agatt

taaat ttaga cttaa caaat tttcc tttcg tctat aaaga cattc aaaaa gagtg gttac aatat aataa tctaa


taatt tatga aatgt tattt actaa acaat ggaat tgcct ttcac cacca tccct tcatt taaca aatat ttatt

attaa atact ttaca ataaa tgatt tgtta cctta acgga aagtg gtggt aggga agtaa attgt ttata aataa


IVS 28 (+ 417 bp)
aaaaa tgact tttgg tggat tggaa tataa ccaga gtttc catag tttgt ttctg attct ttcat atttt ttacc

ttttt actga aaacc accta acctt atatt ggtct caaag gtatc aaaca aagac taaga aagta taaaa aatgg


ctcct tcagt ctgtt cttaa cactt cacac ttaat ataat atgtg aacta aggcc aagta aagag gattg cagta

gagga agtca gacaa gaatt gtgaa gtgtg aatta tatta tacac ttgat tccgg ttcat ttctc ctaac gtcat


cttta aaagc taaat tacaa agaaa acctc accaa aaatt gatgt atctg aacat ttttt gttac atttc cttag

gaaat tttcg attta atgtt tcttt tggag tggtt tttaa ctaca tagac ttgta aaaaa caatg taaag gaatc


3310 3315 3330 3345 3360 3375

CTT ACC AAA ATC AAT TTG GAT GCA CAG AAG GTG GAA CAG ATG TTA AGA GAT GAA TTA GCT GAT AGT

GAA TGG TTT TAG TTA AAC CTA CGT GTC TTC CAC CTT GTC TAC AAT TCT CTA CTT AAT CGA CTA TCA

Leu Thr Lys Ile Asn Leu Asp Ala Gln Lys Val Glu Gln Met Leu Arg Asp Glu Leu Ala Asp Ser

L T K I N L D A Q K V E Q M L R D E L A D S

1104 1105 1110 1115 1120 1125


3390 3405 3420 3435

GTG AGC AAG GCA GTA AGT GAT GCT GAT AGG CAA CGG ATT CTA GAA TTA GAG AAG AAT GAA ATG GAA

CAC TCG TTC CGT CAT TCA CTA CGA CTA TCC GTT GCC TAA GAT CTT AAT CTC TTC TTA CTT TAC CTT

Val Ser Lys Ala Val Ser Asp Ala Asp Arg Gln Arg Ile Leu Glu Leu Glu Lys Asn Glu Met Glu

V S K A V S D A D R Q R I L E L E K N E M E

1130 1135 1140 1145


3450 3461

CTA AAA GTT GAA GTG TCA AA gtaag tgcat ataag cattt tagcc atttg actag atgta tcttc tttaa

GAT TTT CAA CTT CAC AGT TT cattc acgta tattc gtaaa atcgg taaac tgatc tacat agaag aaatt

Leu Lys Val Glu Val Ser Lys

L K V E V S K

1150 1154


tttgt cttta agaaa cccaa ttaca ggtat acaat tctta gtagt aattg atact gattt ctttt tataa gaaca

aaaca gaaat tcttt gggtt aatgt ccata tgtta agaat catca ttaac tatga ctaaa gaaaa atatt cttgt


ggatt aagta atatt aagat cggtt ttaac agggt taaat aataa tattg acgag aataa tattg ttaaa gagga

cctaa ttcat tataa ttcta gccaa aattg tccca attta ttatt ataac tgctc ttatt ataac aattt ctcct


agtga cctct caaga tttgc atttt ttaga gttca ggaat attat tgcag aaagg tccag ttcct ccaca tattg

tcact ggaga gttct aaacg taaaa aatct caagt cctta taata acgtc tttcc aggtc aagga ggtgt ataac


IVS 29 (+ 1341 bp)
aggga tgttg agaat gaagt ttttt ttata tagca aacat gataa cctct gatgg aatta tgttt catga aacag

tccct acaac tctta cttca aaaaa aatat atcgt ttgta ctatt ggaga ctacc ttaat acaaa gtact ttgtc


tttag gaaat cctgt tttaa tattt catac aaaga agaga tagat gctga aaacg aatgg ctttt tgaaa aaggg

aaatc cttta ggaca aaatt ataaa gtatg tttct tctct atcta cgact tttgc ttacc gaaaa acttt ttccc


tctag aaatt ttgaa ttttg gcatt tactt agaaa gtgta cttaa ttgtt cctga aatac cttat cattt cctag

agatc tttaa aactt aaaac cgtaa atgaa tcttt cacat gaatt aacaa ggact ttatg gaata gtaaa ggatc


3462 3465 3480 3495 3510 3525

A CTG AGA GAG ATT TCT GAT ATT GCC AGA AGA CAA GTT GAA ATT TTG AAT GCA CAA CAA CAA TCT AGG

T GAC TCT CTC TAA AGA CTA TAA CGG TCT TCT GTT CAA CTT TAA AAC TTA CGT GTT GTT GTT AGA TCC

Lys Leu Arg Glu Ile Ser Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn Ala Gln Gln Gln Ser Arg

K L R E I S D I A R R Q V E I L N A Q Q Q S R

1154 1155 1160 1165 1170 1175


3540 3555 3570 3573

GAC AAG GAA GTA GAG TCC CTC AGA ATG CAA CTG CTA GAC TAT CAG gtatg tgcag tattg gctct tctac

CTG TTC CTT CAT CTC AGG GAG TCT TAC GTT GAC GAT CTG ATA GTC catac acgtc ataac cgaga agatg

Asp Lys Glu Val Glu Ser Leu Arg Met Gln Leu Leu Asp Tyr Gln

D K E V E S L R M Q L L D Y Q

1180 1185 1190 1191


ataga atcca ctttt ttccc taaat ttaca ttaga tgttg ggagt gggat atgtt atact ttttg tttgt ttcga

tatct taggt gaaaa aaggg attta aatgt aatct acaac cctca cccta tacaa tatga aaaac aaaca aagct


gatag ggtct cattc tgttg cccag ggtgg agtgc agtgg tacat tcaag gctca ttgca gcctt cacca cctgg

ctatc ccaga gtaag acaac gggtc ccacc tcacg tcacc atgta agttc cgagt aacgt cggaa gtggt ggacc


gttca ggtga tcctc ccacc tcagc ctctt agaca gctgg gacta caggc acgtg ccacc acacc taatt ttttt

caagt ccact aggag ggtgg agtcg gagaa tctgt cgacc ctgat gtccg tgcac ggtgg tgtgg attaa aaaaa


IVS 30 (+ 765 bp)
ccact gttat tcagt tacat ttgga tttta agttt gtttg attct aggtt ttttc tttta cagtt ctttg gtaat

ggtga caata agtca atgta aacct aaaat tcaaa caaac taaga tccaa aaaag aaaat gtcaa gaaac catta


tattt gtatt aaagc aaagt tacat ttttg tagat ctcat gtgcc actgt gttaa aactt tgctt agtaa attgt

ataaa cataa tttcg tttca atgta aaaac atcta gagta cacgg tgaca caatt ttgaa acgaa tcatt taaca


gaatt ttaaa tctgt gataa ctttc actgg aaaaa tttga aactt actac aaata tatat ttttt ttaat atcag

cttaa aattt agaca ctatt gaaag tgacc ttttt aaact ttgaa tgatg tttat atata aaaaa aatta tagtc


3574 3585 3600 3615 3630

GCA CAG TCT GAT GAA AAG TCG CTC ATT GCC AAG TTG CAC CAA CAT AAT GTC TCT CTT CAA CTG AGT

CGT GTC AGA CTA CTT TTC AGC GAG TAA CGG TTC AAC GTG GTT GTA TTA CAG AGA GAA GTT GAC TCA

Ala Gln Ser Asp Glu Lys Ser Leu Ile Ala Lys Leu His Gln His Asn Val Ser Leu Gln Leu Ser

A Q S D E K S L I A K L H Q H N V S L Q L S

1192 1195 1200 1205 1210


3645 3660 3675 3690 3705

GAG GCT ACT GCT CTT GGT AAG TTG GAG TCA ATT ACA TCT AAA CTG CAG AAG ATG GAG GCC TAC AAC

CTC CGA TGA CGA GAA CCA TTC AAC CTC AGT TAA TGT AGA TTT GAC GTC TTC TAC CTC CGG ATG TTG

Glu Ala Thr Ala Leu Gly Lys Leu Glu Ser Ile Thr Ser Lys Leu Gln Lys Met Glu Ala Tyr Asn

E A T A L G K L E S I T S K L Q K M E A Y N

1215 1220 1225 1230 1235


3720 3735 3750 3765

TTG CGC TTA GAG CAG AAA CTT GAT GAA AAA GAA CAG GCT CTC TAT TAT GCT CGT TTG GAG GGA AGA

AAC GCG AAT CTC GTC TTT GAA CTA CTT TTT CTT GTC CGA GAG ATA ATA CGA GCA AAC CTC CCT TCT

Leu Arg Leu Glu Gln Lys Leu Asp Glu Lys Glu Gln Ala Leu Tyr Tyr Ala Arg Leu Glu Gly Arg

L R L E Q K L D E K E Q A L Y Y A R L E G R

1240 1245 1250 1255


T=ter (1)

3780 3795 3810 | 3825

AAC AGA GCA AAA CAT CTG CGC CAA ACA ATT CAG TCT CTA CGA CGA CAG TTT AGT GGA GCT TTA CCC

TTG TCT CGT TTT GTA GAC GCG GTT TGT TAA GTC AGA GAT GCT GCT GTC AAA TCA CCT CGA AAT GGG

Asn Arg Ala Lys His Leu Arg Gln Thr Ile Gln Ser Leu Arg Arg Gln Phe Ser Gly Ala Leu Pro

N R A K H L R Q T I Q S L R R Q F S G A L P

1260 1265 1270 1275
3840 3855 3870 3885 3900

TTG GCA CAA CAG GAA AAG TTC TCC AAA ACA ATG ATT CAA CTA CAA AAT GAC AAA CTT AAG ATA ATG

AAC CGT GTT GTC CTT TTC AAG AGG TTT TGT TAC TAA GTT GAT GTT TTA CTG TTT GAA TTC TAT TAC

Leu Ala Gln Gln Glu Lys Phe Ser Lys Thr Met Ile Gln Leu Gln Asn Asp Lys Leu Lys Ile Met

L A Q Q E K F S K T M I Q L Q N D K L K I M

1280 1285 1290 1295 1300


3915 3930 3945 3960

CAA GAA ATG AAA AAT TCT CAA CAA GAA CAT AGA AAT ATG GAG AAC AAA ACA TTG GAG ATG GAA TTA

GTT CTT TAC TTT TTA AGA GTT GTT CTT GTA TCT TTA TAC CTC TTG TTT TGT AAC CTC TAC CTT AAT

Gln Glu Met Lys Asn Ser Gln Gln Glu His Arg Asn Met Glu Asn Lys Thr Leu Glu Met Glu Leu

Q E M K N S Q Q E H R N M E N K T L E M E L

1305 1310 1315 1320


3975 3990 4005 4020 4029

AAA TTA AAG GGC CTG GAA GAG TTA ATA AGC ACT TTA AAG GAT ACC AAA GGA GCC CAA AAG gtaaa

TTT AAT TTC CCG GAC CTT CTC AAT TAT TCG TGA AAT TTC CTA TGG TTT CCT CGG GTT TTC cattt

Lys Leu Lys Gly Leu Glu Glu Leu Ile Ser Thr Leu Lys Asp Thr Lys Gly Ala Gln Lys

K L K G L E E L I S T L K D T K G A Q K

1325 1330 1335 1340 1343


cattt aaact tgatt ttttt tttta agaga cagta tcttg atctg tttcc caggc tggag ttcag tggtg caaac

gtaaa tttga actaa aaaaa aaaat tctct gtcat agaac tagac aaagg gtccg acctc aagtc accac gtttg


atagc tggaa ctcct gggct caagg gactc tctag cctca gcctc ctgag tagtt gtagc tggca gtaca ggtgc

tatcg acctt gagga cccga gttcc ctgag agatc ggagt cggag gactc atcaa catcg accgt catgt ccacg


acacc accat accta cctaa ttttt taaaa ttttt aaatt ttttt gtaga gacaa ggtct cactt tgtca cccag

tgtgg tggta tggat ggatt aaaaa atttt aaaaa tttaa aaaaa catct ctgtt ccaga gtgaa acagt gggtc


IVS 31 (+ 632 bp)
ttcca acata atttg aagat tttta ttgta aaatc ccaca tattt gtaga aaagt ctatg gaaat cctaa ataag

aaggt tgtat taaac ttcta aaaat aacat tttag ggtgt ataaa catct tttca gatac cttta ggatt tattc


atttt gtcat gtagt ttgac aaaag ataac attgt gtctt atttt atttt agaat ggcca ttact ttcaa ttaaa

taaaa cagta catca aactg ttttc tattg taaca cagaa taaaa taaaa tctta ccggt aatga aagtt aattt


atcat tatca tcaat ggagg aatgt tattt gttaa tatag cattt atatt tgtgt atata aattg taaat cttag

tagta atagt agtta cctcc ttaca ataaa caatt atatc gtaaa tataa acaca tatat ttaac attta gaatc


4030 4035 4050 4065 4080 4095

GTA ATC AAC TGG CAT ATG AAA ATA GAA GAA CTT CGT CTT CAA GAA CTT AAA CTA AAT CGG GAA TTA

CAT TAG TTG ACC GTA TAC TTT TAT CTT CTT GAA GCA GAA GTT CTT GAA TTT GAT TTA GCC CTT AAT

Val Ile Asn Trp His Met Lys Ile Glu Glu Leu Arg Leu Gln Glu Leu Lys Leu Asn Arg Glu Leu

V I N W H M K I E E L R L Q E L K L N R E L

1344 1345 1350 1355 1360 1365


del (1)

4110 || 4125 4140 4155

GTC AAG GAT AAA GAA GAA ATA AAA TAT TTG AAT AAC ATA ATT TCT GAA TAT GAA CGT ACA ATC AGC

CAG TTC CTA TTT CTT CTT TAT TTT ATA AAC TTA TTG TAT TAA AGA CTT ATA CTT GCA TGT TAG TCG

Val Lys Asp Lys Glu Glu Ile Lys Tyr Leu Asn Asn Ile Ile Ser Glu Tyr Glu Arg Thr Ile Ser

V K D K E E I K Y L N N I I S E Y E R T I S

1370 1375 1380 1395
4170 4185 4194

AGT CTT GAA GAA GAA ATT GTG CAA CAG AAC AAG gtttt atttt atatt tattt cattt ttttc cctaa

TCA GAA CTT CTT CTT TAA CAC GTT GTC TTG TTC caaaa taaaa tataa ataaa gtaaa aaaag ggatt

Ser Leu Glu Glu Glu Ile Val Gln Gln Asn Lys

S L E E E I V Q Q N K

1390 1395 1398


gtttt ttttt ttttt ttttt ttttt gagat ggagt ctcac tctgt cgccc agact ggagt gcagt ggcgt gatct

caaaa aaaaa aaaaa aaaaa aaaaa ctcta cctca gagtg agaca gcggg tctga cctca cgtca ccgca ctaga


cggct cactg caagc tctgc ctccc gggtt catgc cattc tcctg cctca gcctc ccaag tagct gggac tacag

gccga gtgac gttcg agacg gaggg cccaa gtacg gtaag aggac ggagt cggag ggttc atcga ccctg atgtc


gcacc cgcca ccgtg cctgg ctaat ttttt gtatt tttag tagag acggg gtttc accat attag ccagg atggt

cgtgg gcggt ggcac ggacc gatta aaaaa cataa aaatc atctc tgccc caaag tggta taatc ggtcc tacca


IVS 32 (+ 796 bp)
gatgg atgga tggat ggata gactg aaatc cttac ttcac atctg ccttt gtgat cttac acaag ttact tcacc

ctacc tacct accta cctat ctgac tttag gaatg aagtg tagac ggaaa cacta gaatg tgttc aatga agtgg


tctct gagtt tgtat ttttt tccat aaaag gaaaa taatt acagt ttctt caatg tgttg tgagg attag ataag

agaga ctcaa acata aaaaa aggta ttttc ctttt attaa tgtca aagaa gttac acaac actcc taatc tattc


aaaat atata taaaa tgcct gttat gtgcc tgatg tcttc gtgta tgtgt ctgac acaaa ttgtc ctttt tttag

tttta tatat atttt acgga caata cacgg actac agaag cacat acaca gactg tgttt aacag gaaaa aaatc


4195 4200 4215 4230 4245 4260

TTT CAT GAA GAA AGA CAA ATG GCC TGG GAT CAA AGA GAA GTT GAC CTG GAA CGC CAA CTA GAC ATT

AAA GTA CTT CTT TCT GTT TAC CGG ACC CTA GTT TCT CTT CAA CTG GAC CTT GCG GTT GAT CTG TAA

Phe His Glu Glu Arg Gln Met Ala Trp Asp Gln Arg Glu Val Asp Leu Glu Arg Gln Leu Asp Ile

F H E E R Q M A W D Q R E V D L E R Q L D I

1399 1400 1405 1410 1415 1420


4275 4290 4302

TTT GAC CGT CAG CAA AAT GAA ATA CTA AAT GCG GCA CAA AAG gtatg aatga ttaat cttgt ttgtt

AAA CTG GCA GTC GTT TTA CTT TAT GAT TTA CGC CGT GTT TTC catac ttact aatta gaaca aacaa

Phe Asp Arg Gln Gln Asn Glu Ile Leu Asn Ala Ala Gln Lys

F D R Q Q N E I L N A A Q K

1425 1430 1434


actct gtagc atagt ctaga gtgtt aactc acaga aatat ttcct gtatc agatg taatt ttaat tgatg ttata

tgaga catcg tatca gatct cacaa ttgag tgtct ttata aagga catag tctac attaa aatta actac aatat


IVS 33
tt gtata tttaa aatat aagag gggtt taatc tatgt tttat catac agctg taaaa attaa tagtt actct

aa catat aaatt ttata ttctc cccaa attag ataca aaata gtatg tcgac atttt taatt atcaa tgaga


4303 4320

caatg ctgca actgc ttttt taaaa aacat actat ttctt aatag TTT GAA GAA GCT ACA GGA TCA ATC CCT

gttac gacgt tgacg aaaaa atttt ttgta tgata aagaa ttatc AAA CTT CTT CGA TGT CCT AGT TAG GGA

Phe Glu Glu Ala Thr Gly Ser Ile Pro

F E E A T G S I P

1435 1440


4335 4350 4365 4380 4395

GAC CCT AGT TTG CCC CTT CCA AAT CAA CTT GAG ATC GCT CTA AGG AAA ATT AAG GAG AAC ATT CGA

CTG GGA TCA AAC GGG GAA GGT TTA GTT GAA CTC TAG CGA GAT TCC TTT TAA TTC CTC TTG TAA GCT

Asp Pro Ser Leu Pro Leu Pro Asn Gln Leu Glu Ile Ala Leu Arg Lys Ile Lys Glu Asn Ile Arg

D P S L P L P N Q L E I A L R K I K E N I R

1445 1450 1455 1460 1465


4410 4425 4437

ATA ATT CTA GAA ACA CGG GCA ACT TGC AAA TCA CTA GAA GAG gtaat tagaa gaatt tgcat tttga

TAT TAA GAT CTT TGT GCC CGT TGA ACG TTT AGT GAT CTT CTC catta atctt cttaa acgta aaact

Ile Ile Leu Glu Thr Arg Ala Thr Cys Lys Ser Leu Glu Glu

I I L E T R A T C K S L E E

1470 1475 1479


ttagt gtatt atttg gtatg tttgg ggggc tttct aaata atatt tcttt atgag ggcaa tgcat agaat gatga

aatca cataa taaac catac aaacc ccccg aaaga tttat tataa agaaa tactc ccgtt acgta tctta ctact


atcta ttgct aattt cacta ttttt ctatt ctcct ataat gtttc taata gccaa taatg aacag cagat atagt

tagat aacga ttaaa gtgat aaaaa gataa gagga tatta caaag attat cggtt attac ttgtc gtcta tatca


taatt tgaat tcact attta attat tagtt ggtac ctttc ggtac actga atatg aaagg aaata aaaag cattt

attaa actta agtga taaat taata atcaa ccatg gaaag ccatg tgact tatac tttcc tttat ttttc gtaaa


IVS 34 (+ 711 bp)
aatga agttt ctagc atatg taata gtctt ataaa taagc atgca aataa ctgct gtcaa ttaga attag tcagt

ttact tcaaa gatcg tatac attat cagaa tattt attcg tacgt ttatt gacga cagtt aatct taatc agtca


ttaac cttat taagt atcaa atggc tattg tacat atgat gtgaa aaata aagtg aattt ttttt ggcta ataac

aattg gaata attca tagtt taccg ataac atgta tacta cactt tttat ttcac ttaaa aaaaa ccgat tattg


taatc taaaa ttcag atgaa gcatt ttaaa gggaa aaaga tactt taatg attta ttata attta atcat tgcag

attag atttt aagtc tactt cgtaa aattt ccctt tttct atgaa attac taaat aatat taaat tagta acgtc


4438 4455 4470 4485 4500

AAA CTA AAA GAG AAA GAA TCT GCT TTA AGG TTA GCA GAA CAA AAT ATA CTG TCA AGA GAC AAA GTA

TTT GAT TTT CTC TTT CTT AGA CGA AAT TCC AAT CGT CTT GTT TTA TAT GAC AGT TCT CTG TTT CAT

Lys Leu Lys Glu Lys Glu Ser Ala Leu Arg Leu Ala Glu Gln Asn Ile Leu Ser Arg Asp Lys Val

K L K E K E S A L R L A E Q N I L S R D K V

1480 1485 1490 1495 1500


4515 4530 4545 4560

ATC AAT GAA CTG AGG CTT CGA TTG CCT GCC ACT GCA GAA AGA GAA AAG CTC ATA GCT GAG CTA GGC

TAG TTA CTT GAC TCC GAA GCT AAC GGA CGG TGA CGT CTT TCT CTT TTC GAG TAT CGA CTC GAT CCG

Ile Asn Glu Leu Arg Leu Arg Leu Pro Ala Thr Ala Glu Arg Glu Lys Leu Ile Ala Glu Leu Gly

I N E L R L R L P A T A E R E K L I A E L G

1505 1510 1515 1520


4575 4590 4605 4620 4635

AGA AAA GAG ATG GAA CCA AAA TCT CAC CAC ACA TTG AAA ATT GCT CAT CAA ACC ATT GCA AAC ATG

TCT TTT CTC TAC CTT GGT TTT AGA GTG GTG TGT AAC TTT TAA CGA GTA GTT TGG TAA CGT TTG TAC

Arg Lys Glu Met Glu Pro Lys Ser His His Thr Leu Lys Ile Ala His Gln Thr Ile Ala Asn Met

R K E M E P K S H H T L K I A H Q T I A N M

1525 1530 1535 1540 1545


del (2)

4650 | 4665 4680 4695

CAA GCA AGG TTA AAT CAA AAA GAA GAA GTA TTA AAG AAG TAT CAA CGT CTT CTA GAA AAA GCC AGA

GTT CGT TCC AAT TTA GTT TTT CTT CTT CAT AAT TTC TTC ATA GTT GCA GAA GAT CTT TTT CGG TCT

Gln Ala Arg Leu Asn Gln Lys Glu Glu Val Leu Lys Lys Tyr Gln Arg Leu Leu Glu Lys Ala Arg

Q A R L N Q K E E V L K K Y Q R L L E K A R

1550 1555 1560 1565
4704

GAG gtatt ttatt atatt atgag ttatg ctgtt atcca ttagt ttttt taagc aaatg ctaaa tatta tttta

CTC cataa aataa tataa tactc aatac gacaa taggt aatca aaaaa attcg tttac gattt ataat aaaat

Glu


E

1568
cccta aagtg gtatt tcttt tcttg ctttc aaatg attct attta agaat tgtta cttgc atgtg attgg attac

gggat ttcac cataa agaaa agaac gaaag tttac taaga taaat tctta acaat gaacg tacac taacc taatg
acctc tgtca gtaaa actgg aagtt tgtgt acatg tatct ttcta ttata cactg actaa accac gagta gctat

tggag acagt cattt tgacc ttcaa acaca tgtac ataga aagat aatat gtgac tgatt tggtg ctcat cgata


catgg tgaaa tcata tgatt ttgaa aaata tttta attga gttta taggt gagga ttgag gcaat agggt ggaat

gtacc acttt agtat actaa aactt tttat aaaat taact caaat atcca ctcct aactc cgtta tccca cctta


IVS 35
g aaata tatca caccg gtaat cagta gaaat cagat ttgtt agaac ttcgt ggggg aaagc taaca tttaa

c tttat atagt gtggc catta gtcat cttta gtcta aacaa tcttg aagca ccccc tttcg attgt aaatt


ttttt tctag aagta agtta aaaga tgata gatac atgtc attct aatgt taaga ataaa ttatg aactg aggct

aaaaa agatc ttcat tcaat tttct actat ctatg tacag taaga ttaca attct tattt aatac ttgac tccga


gggct tgtca acttg aacat tgtct gaggg gacat gcata ccagt ctaga tacat acata tatgg agata ctgtt

cccga acagt tgaac ttgta acaga ctccc ctgta cgtat ggtca gatct atgta tgtat atacc tctat gacaa


tcttc ctcat ctcaa aggaa tttta gaaga ttgaa gagaa aatat ataag gtctt caaaa tgtga atttg tttta

agaag gagta gagtt tcctt aaaat cttct aactt ctctt ttata tattc cagaa gtttt acact taaac aaaat


(3) T=ter

4705 4710 4725 |

atcac aattt aagat atagt ttcga ttttc tgtaa aacag GAG CAA AGA GAA ATT GTG AAG AAA CAT GAG

tagtg ttaaa ttcta tatca aagct aaaag acatt ttgtc CTC GTT TCT CTT TAA CAC TTC TTT GTA CTC

Glu Gln Arg Glu Ile Val Lys Lys His Glu

E Q R E I V K K H E

1569 1570 1575
T=ter (2)

4740 4755 4770 | 4785 4800

GAA GAC CTT CAT ATT CTT CAT CAC AGA TTA GAA CTA CAG GCT GAT AGT TCA CTA AAT AAA TTC AAA

CTT CTG GAA GTA TAA GAA GTA GTG TCT AAT CTT GAT GTC CGA CTA TCA AGT GAT TTA TTT AAG TTT

Glu Asp Leu His Ile Leu His His Arg Leu Glu Leu Gln Ala Asp Ser Ser Leu Asn Lys Phe Lys

E D L H I L H H R L E L Q A D S S L N K F K

1580 1585 1590 1595 1600
4812

CAA ACG GCT TGG gtaag attct aagaa ctttg ttcca ttctt tattg atttt tgtga ccatg taaat taaaa

GTT TGC CGA ACC cattc taaga ttctt gaaac aaggt aagaa ataac taaaa acact ggtac attta atttt

Gln Thr Ala Trp

Q T A W

1604
ttcag ctctc ttctt ttttg gaatg gaagt taccc ttttt gttgc caaaa taatc ttctg aaaac atagc tctga

aagtc gagag aagaa aaaac cttac cttca atggg aaaaa caacg gtttt attag aagac ttttg tatcg agact
tcatt cttcc tcctg tagct caccg ctgtt cacaa aatta tattt ataat tctta gccat gtact caatc tgcta

agtaa gaagg aggac atcga gtggc gacaa gtgtt ttaat ataaa tatta agaat cggta catga gttag acgat


tgaac ctacc tgcct ttctt ttcaa attct actca ctgtg agttt agcta tatct aactt ccaga attca gctca

acttg gatgg acgga aagaa aagtt taaga tgagt gacac tcaaa tcgat ataga ttgaa ggtct taagt cgagt


IVS 36
t atttg cctct tttga ccatt ctgtt ccata tgtat gaaat gacat gtctt tcatc tttta atgtg taacc

a taaac ggaga aaact ggtaa gacaa ggtat acata cttta ctgta cagaa agtag aaaat tacac attgg



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