Tttttgttttttccttcttacagaaggcactaccctggacgccgcttgcaaacgcctgaagagaaggcagggtgttcccactttttcagaatgggaccaggccctacggccccaatagcagaagcttctctaacccaggactgctcccctcaattcctcccaatatgctgaccgacagctcgacctcacctgggggcggttccgccaggggatggcttaggaaaacctcaggaagagcagcccagcgagtgacg



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ttagc atatt tgagc attac ctcgt taatt cggtc aacac ttatt gatct cctgc tacgt gcaga cattt tgcta

aatcg tataa actcg taatg gagca attaa gccag ttgtg aataa ctaga ggacg atgca cgtct gtaaa acgat


gctat tgtaa ataca aataa taaag tctgc atttc ctgtc ttctt taagc cttca ttgcc tatta aatca ttaca

cgata acatt tatgt ttatt atttc agacg taaag gacag aagaa attcg gaagt aacgg ataat ttagt aatgt


tttta gatta gatat tatat tttga tcatt tgagg aacca aatta aaaat atgga ataag tatgg cattg aatta

aaaat ctaat ctata atata aaact agtaa actcc ttggt ttaat tttta tacct tattc atacc gtaac ttaat


4813 4830 4845

tacat gccta ttgct aatat attca tattt tatag GAT TTA ATG AAA CAG TCT CCC ACT CCA GTT CCT ACC

atgta cggat aacga ttata taagt ataaa atatc CTA AAT TAC TTT GTC AGA GGG TGA GGT CAA GGA TGG

Asp Leu Met Lys Gln Ser Pro Thr Pro Val Pro Thr

D L M K Q S P T P V P T

1605 1610 1615


4860 4875 4890 4905

AAC AAG CAT TTT ATT CGT CTG GCT GAG ATG GAA CAG ACA GTA GCA GAA CAA GAT GAC TCT CTT TCC

TTG TTC GTA AAA TAA GCA GAC CGA CTC TAC CTT GTC TGT CAT CGT CTT GTT CTA CTG AGA GAA AGG

Asn Lys His Phe Ile Arg Leu Ala Glu Met Glu Gln Thr Val Ala Glu Gln Asp Asp Ser Leu Ser

N K H F I R L A E M E Q T V A E Q D D S L S

1620 1625 1630 1635


T=ter (1)

4920 4935 4950 4965 | 4980

TCA CTC TTG GTC AAA CTA AAG AAA GTA TCA CAA GAT TTG GAG AGA CAA AGA GAA ATC ACT GAA TTA

AGT GAG AAC CAG TTT GAT TTC TTT CAT AGT GTT CTA AAC CTC TCT GTT TCT CTT TAG TGA CTT AAT

Ser Leu Leu Val Lys Leu Lys Lys Val Ser Gln Asp Leu Glu Arg Gln Arg Glu Ile Thr Glu Leu

S L L V K L K K V S Q D L E R Q R E I T E L

1640 1645 1650 1655 1660
4995 4512

AAA GTA AAA GAA TTT GAA AAT ATC AAA TTA CA gtaag tcttc gaaat gtatt gtaaa aatag gcaaa

TTT CAT TTT CTT AAA CTT TTA TAG TTT AAT GT cattc agaag cttta cataa cattt ttatc cgttt

Lys Val Lys Glu Phe Glu Asn Ile Lys Leu Gln

K V K E F E N I K L Q

1665 1670 1671


tgata agtga tataa tgaag ataaa cataa gtgtt tgcta tgcca ggcac tgttc taaga ctttt aagta tattg

actat tcact atatt acttc tattt gtatt cacaa acgat acggt ccgtg acaag attct gaaaa ttcat ataac


tctca ttttt atcct cagga ctgct ggtta catat gttat cattt tcccc atttt aaaga gagga tatgg cctca

agagt aaaaa tagga gtcct gacga ccaat gtata caata gtaaa agggg taaaa tttct ctcct atacc ggagt


ggaat gctta atagc atgtc tgggg gtaga tggga aagcc ataat ttgaa actag tcagt ctgac tcaaa agcca

cctta cgaat tatcg tacag acccc catct accct ttcgg tatta aactt tgatc agtca gactg agttt tcggt


IVS 37 (+ 2150 bp)
ccatc tctac taaaa ataca aaaat tagct gggcc tgatg gtgca cgccc gtagt cccag ctact cagga agttg

ggtag agatg atttt tatgt tttta atcga cccgg actac cacgt gcggg catca gggtc gatga gtcct tcaac


aggca aaaaa atcac ttgaa tctgg gaggc agagg ttgca gtcag ccgag attgc gctgc tgcac tccag cctgg

tccgt ttttt tagtg aactt agacc ctccg tctcc aacgt cagtc ggctc taacg cgacg acgtg aggtc ggacc


gtgac agagt gagac tgggt ctcaa aaaaa ttaaa aatta aaaaa cacac acaca catat gttta tttac atcag

cactg tctca ctctg accca gagtt ttttt aattt ttaat ttttt gtgtg tgtgt gtata caaat aaatg tagtc


5013 5025 5040 5055 5070

G CTT CAA GAA AAC CAT GAA GAT GAA GTG AAA AAA GTA AAA GCG GAA GTA GAG GAT TTA AAG TAT CTT

C GAA GTT CTT TTG GTA CTT CTA CTT CAC TTT TTT CAT TTT CGC CTT CAT CTC CTA AAT TTC ATA GAA

Gln Leu Gln Glu Asn His Glu Asp Glu Val Lys Lys Val Lys Ala Glu Val Glu Asp Leu Lys Tyr Leu

Q L Q E N H E D E V K K V K A E V E D L K Y L

1671 1675 1680 1685 1690


5085 5100 5115 5130 5145

CTG GAC CAG TCA CAA AAG GAG TCA CAG TGT TTA AAA TCT GAA CTT CAG GCT CAA AAA GAA GCA AAT

GAC CTG GTC AGT GTT TTC CTC AGT GTC ACA AAT TTT AGA CTT GAA GTC CGA GTT TTT CTT CGT TTA

Leu Asp Gln Ser Gln Lys Glu Ser Gln Cys Leu Lys Ser Glu Leu Gln Ala Gln Lys Glu Ala Asn

L D Q S Q K E S Q C L K S E L Q A Q K E A N

1695 1700 1705 1710 1715


5160 5175 5190 5205

TCA AGA GCT CCA ACA ACT ACA ATG AGA AAT CTA GTA GAA CGG CTA AAG AGC CAA TTA GCC TTG AAG

AGT TCT CGA GGT TGT TGA TGT TAC TCT TTA GAT CAT CTT GCC GAT TTC TCG GTT AAT CGG AAC TTC

Ser Arg Ala Pro Thr Thr Thr Met Arg Asn Leu Val Glu Arg Leu Lys Ser Gln Leu Ala Leu Lys

S R A P T T T M R N L V E R L K S Q L A L K

1720 1725 1730 1735


5220 5226

GAG AAA CAA CAG AAA gtaag taaca acaga aaatt atcaa cattt aggaa aaata tgtgg tagat tgctt

CTC TTT GTT GTC TTT cattc attgt tgtct tttaa tagtt gtaaa tcctt tttat acacc atcta acgaa

Glu Lys Gln Gln Lys

E K Q Q K

1740 1742


ttaga gaaga tttgt aaatt tataa aagat ggtag tataa atctc cgtgt tgtaa taaaa agtat gagct ttatc

aatct cttct aaaca tttaa atatt ttcta ccatc atatt tagag gcaca acatt atttt tcata ctcga aatag


ttatg ctgtt aaaca aggta tttta gacaa tgctg ttttt gtggg cagat atagt ccaat ttatc ttttt atgtt

aatac gacaa tttgt tccat aaaat ctgtt acgac aaaaa caccc gtcta tatca ggtta aatag aaaaa tacaa


ttcgt caatc tgatt tgtga attat ctata tgaag ttagg aaaaa tctta atgta catta caaaa atata atata

aagca gttag actaa acact taata gatat acttc aatcc ttttt agaat tacat gtaat gtttt tatat tatat


IVS 38 (+ 447 bp)
aagat tttga acttt cacat tcaat gtgga aagaa ttgag tgtaa ttaca aaaga tttat ttgaa aaagt tgagt

ttcta aaact tgaaa gtgta agtta cacct ttctt aactc acatt aatgt tttct aaata aactt tttca actca


tgtta atttg tgaaa tatgt tccat taaac tcata atatt ttaga aaaat agtag gaagt aataa agctt gttta

acaat taaac acttt ataca aggta atttg agtat tataa aatct tttta tcatc cttca ttatt tcgaa caaat


ttttt tatat catat attca tataa aatgt cagtt ttcct ttaaa aatta cattt ttttt ttggt taatt tttag

aaaaa atata gtata taagt atatt ttaca gtcaa aagga aattt ttaat gtaaa aaaaa aacca attaa aaatc


5227 5235 5250 5265 5280

GCA CTT AGT CGG GCA CTT TTA GAA CTC CGG GCA GAA ATG ACA GCA GCT GCT GAA GAA CGT ATT ATT

CGT GAA TCA GCC CGT GAA AAT CTT GAG GCC CGT CTT TAC TGT CGT CGA CGA CTT CTT GCA TAA TAA

Ala Leu Ser Arg Ala Leu Leu Glu Leu Arg Ala Glu Met Thr Ala Ala Ala Glu Glu Arg Ile Ile

A L S R A L L E L R A E M T A A A E E R I I

1743 1745 1750 1755 1760


5295 5310 5325 5340 5355

TCT GCA ACT TCT CAA AAA GAG GCC CAT CTC AAT GTT CAA CAA ATC GTT GAT CGA CAT ACT AGA GAG

AGA CGT TGA AGA GTT TTT CTC CGG GTA GAG TTA CAA GTT GTT TAG CAA CTA GCT GTA TGA TCT CTC

Ser Ala Thr Ser Gln Lys Glu Ala His Leu Asn Val Gln Gln Ile Val Asp Arg His Thr Arg Glu

S A T S Q K E A H L N V Q Q I V D R H T R E

1765 1770 1775 1780 1785


5364

CTA AAG gtgaa catca acacg tgtta atgta acaaa atttc tgata attcc tattg gaaga gaatt cacta

GAT TTC cactt gtagt tgtgc acaat tacat tgttt taaag actat taagg ataac cttct cttaa gtgat

Leu Lys


L K

1788
tgata tatag taatt ttgtt gatga atagg gaatt tataa tgcac tgttg gtggc tagac ataga cacac acatg

actat atatc attaa aacaa ctact tatcc cttaa atatt acgtg acaac caccg atctg tatct gtgtg tgtac
cattt ttcaa caata agtct cttta tgata ctcat ttact gatta tcatc ttggg gatta ggaaa ggata ggcca

gtaaa aagtt gttat tcaga gaaat actat gagta aatga ctaat agtag aaccc ctaat ccttt cctat ccggt


ttatg aacta ctgtt tctaa tgaaa ttaaa tttaa gaaat atttt actta ggatt ttttt taaga cttta ttatt

aatac ttgat gacaa agatt acttt aattt aaatt cttta taaaa tgaat cctaa aaaaa attct gaaat aataa


IVS 39 (+ 658 bp)
tacac tagtt ttttt ttttt ttctc aaagt cgact ttttt cctca aggta gactt gacat gaata tggaa aaata

atgtg atcaa aaaaa aaaaa aagag tttca gctga aaaaa ggagt tccat ctgaa ctgta cttat acctt tttat


tatgt agttt gtggt tattt ttttt ctctt gtgta cttaa aaatt cagac tgaat ttttc ttata atggt atatt

ataca tcaaa cacca ataaa aaaaa gagaa cacat gaatt tttaa gtctg actta aaaag aatat tacca tataa


ttctg tttta tgttc ctttt atcat tgata cttct tgaag agtca tgaat aatac ctttc ttttt ctctt attag

aagac aaaat acaag gaaaa tagta actat gaaga acttc tcagt actta ttatg gaaag aaaaa gagaa taatc


5365 5370 5385 5400 5415 5430

ACA CAA GTT GAA GAT TTA AAT GAA AAT CTT TTA AAA TTG AAA GAA GCA CTT AAA ACA AGT AAA AAC

TGT GTT CAA CTT CTA AAT TTA CTT TTA GAA AAT TTT AAC TTT CTT CGT GAA TTT TGT TCA TTT TTG

Thr Gln Val Glu Asp Leu Asn Glu Asn Leu Leu Lys Leu Lys Glu Ala Leu Lys Thr Ser Lys Asn

T Q V E D L N E N L L K L K E A L K T S K N

1789 1790 1795 1800 1805 1810


5445 5460 5475 5490

AGA GAA AAC TCA CTA ACT GAT AAT TTG AAT GAC TTA AAT AAT GAA CTG CAA AAG AAA CAA AAA GCC

TCT CTT TTG AGT GAT TGA CTA TTA AAC TTA CTG AAT TTA TTA CTT GAC GTT TTC TTT GTT TTT CGG

Arg Glu Asn Ser Leu Thr Asp Asn Leu Asn Asp Leu Asn Asn Glu Leu Gln Lys Lys Gln Lys Ala

R E N S L T D N L N D L N N E L Q K K Q K A

1815 1820 1825 1830


|---| del (2)

5505 | | 5535 5550

TAT AAT AAA ATA CTT AGA GAG AAA GAG GAA ATT GAT CAA GAG AAT GAT GAA CTG AAA AGG CAA ATT

ATA TTA TTT TAT GAA TCT CTC TTT CTC CTT TAA CTA GTT CTC TTA CTA CTT GAC TTT TCC GTT TAA

Tyr Asn Lys Ile Leu Arg Glu Lys Glu Glu Ile Asp Gln Glu Asn Asp Glu Leu Lys Arg Gln Ile

Y N K I L R E K E E I D Q E N D E L K R Q I

1835 1840 1845 1850
5565 5580 5586

AAA AGA CTA ACC AGT GGA TTA CAG gtaat tttat attta actct gataa tgtct gattt acaat ataga

TTT TCT GAT TGG TCA CCT AAT GTC catta aaata taaat tgaga ctatt acaga ctaaa tgtta tatct

Lys Arg Leu Thr Ser Gly Leu Gln

K R L T S G L Q

1855 1860 1862


ggtag tagtt tattt ctact ttatc atttt atcta tggta tttgt taaaa ctgac tttca aatca ctttg attaa

ccatc atcaa ataaa gatga aatag taaaa tagat accat aaaca atttt gactg aaagt ttagt gaaac taatt


tgtaa ttaat ttctt ttgtg acttc tattg tgttt atagt tctag agtag catat tagta tgttg tatta aaatg

acatt aatta aagaa aacac tgaag ataac acaaa tatca agatc tcatc gtata atcat acaac ataat tttac


IVS 40
ca gaagc agcta ccaga ttatc ttatg tatta agtgt cattt agaaa gtatg gtcag tgata gcttc agaaa

gt cttcg tcgat ggtct aatag aatac ataat tcaca gtaaa tcttt catac cagtc actat cgaag tcttt


gttgc tatta tataa ttgaa atatt tactg tctat tttgt tttac attta tttgt aaaaa tataa agtta cattt

caacg ataat atatt aactt tataa atgac agata aaaca aaatg taaat aaaca ttttt atatt tcaat gtaaa


5578 5595 5610 5625 5640

tattt tttag GGC AAA CCC CTG ACA GAT AAT AAA CAA AGT CTA ATT GAA GAA CTC CAA AGG AAA GTT

ataaa aaatc CCG TTT GGG GAC TGT CTA TTA TTT GTT TCA GAT TAA CTT CTT GAG GTT TCC TTT CAA

Gly Lys Pro Leu Thr Asp Asn Lys Gln Ser Leu Ile Glu Glu Leu Gln Arg Lys Val

G K P L T D N K Q S L I E E L Q R K V

1863 1865 1870 1875 1880


del (2) T=ter (2,3)

| 5655 | 5685 5700 5709

AAA AAA CTA GAG AAC CAA TTA GAG GGA AAG GTG GAG GAA GTA GAC CTA AAA CCT ATG AAA GAA AAG

TTT TTT GAT CTC TTG GTT AAT CTC CCT TTC CAC CTC CTT CAT CTG GAT TTT GGA TAC TTT CTT TTC

Lys Lys Leu Glu Asn Gln Leu Glu Gly Lys Val Glu Glu Val Asp Leu Lys Pro Met Lys Glu Lys

K K L E N Q L E G K V E E V D L K P M K E K

1885 1890 1895 1900 1903
gtatg tgaag aaaca tactg actta tatgc ttaag gtagt gacag agtaa gttaa ataca tagct gatta acagt

catac acttc tttgt atgac tgaat atacg aattc catca ctgtc tcatt caatt tatgt atcga ctaat tgtca


taata tactg cctta atttg atgac ctggc tgtat taatt ctgta ttaat tttga ggact ataag cagta ttgaa

attat atgac ggaat taaac tactg gaccg acata attaa gacat aatta aaact cctga tattc gtcat aactt


taacg tagaa aagtc taagt ttctg ttctg tagga attta gagtc tactt gagga gatac ctata atgta actct

attgc atctt ttcag attca aagac aagac atcct taaat ctcag atgaa ctcct ctatg gatat tacat tgaga


IVS 41 (+ 4845 bp)
gcaaa tattc caaaa atatt tttta aaaaa atcca aattc taaaa cacgg ctggt tccaa gcgtt tcgta aggga

cgttt ataag gtttt tataa aaaat ttttt taggt ttaag atttt gtgcc gacca aggtt cgcaa agcat tccct


tactc aacct gtata gcaaa atgaa catat ttaca tattc tctag gaaat attag tttac aattt ttcta ggcaa

atgag ttgga catat cgttt tactt gtata aatgt ataag agatc cttta taatc aaatg ttaaa aagat ccgtt


attat aattg ataaa tcata aagaa aattt aaaat aacac tggta atttt cctac ctcct tcgtt attgt tacag

taata ttaac tattt agtat ttctt ttaaa tttta ttgtg accat taaaa ggatg gagga agcaa taaca atgtc


5710 5715 5730 5745 5760 5775

AAT GCT AAA GAA GAA TTA ATT AGG TGG GAA GAA GGT AAA AAG TGG CAA GCC AAA ATA GAA GGA ATT

TTA CGA TTT CTT CTT AAT TAA TCC ACC CTT CTT CCA TTT TTC ACC GTT CGG TTT TAT CTT CCT TAA

Asn Ala Lys Glu Glu Leu Ile Arg Trp Glu Glu Gly Lys Lys Trp Gln Ala Lys Ile Glu Gly Ile

N A K E E L I R W E E G K K W Q A K I E G I

1904 1905 1910 1915 1920 1925


|del-| (1) T=ter (3)

5790 5805 | |5820 | 5835

CGA AAC AAG TTA AAA GAG AAA GAG GGG GAA GTC TTT ACT TTA ACA AAG CAG TTG AAT ACT TTG AAG

GCT TTG TTC AAT TTT CTC TTT CTC CCC CTT CAG AAA TGA AAT TGT TTC GTC AAC TTA TGA AAC TTC

Arg Asn Lys Leu Lys Glu Lys Glu Gly Glu Val Phe Thr Leu Thr Lys Gln Leu Asn Thr Leu Lys

R N K L K E K E G E V F T L T K Q L N T L K

1930 1935 1940 1945
5860 5865

GAT CTT TTT GCC AA gtgag tttaa atatc attat aaaac taatt atgtg taaaa tcctt tagtg acctg

CTA GAA AAA CGG TT cactc aaatt tatag taata ttttg attaa tacac atttt aggaa atcac tggac

Asp Leu Phe Ala Lys

D L F A K

1950 1952


gaaat tatat agctt tatca tagtt gataa tatga gaaat ggtct agttt aaatg atcat ttatt atcta tgatt

cttta atata tcgaa atagt atcaa ctatt atact cttta ccaga tcaaa tttac tagta aataa tagat actaa


IVS 42
t actta ctttt tattt tcttt aaaat ctgtt ttaaa tatat tgtaa caatt ataga tggat tttcc tgtga

a tgaat gaaaa ataaa agaaa tttta gacaa aattt atata acatt gttaa tatct accta aaagg acact


tctcg ttgta aatta gctta tgaca aatat agggt gttac aatta ttgta atttg gtttg gtaat gagta tgcaa

agagc aacat ttaat cgaat actgt ttata tccca caatg ttaat aacat taaac caaac catta ctcat acgtt

5866 5875 |

ttgaa aagcc aaaca ctgaa tggta tattt catga ttcta tatta aattc cacag A GCC GAT AAA GAG AAA

aactt ttcgg tttgt gactt accat ataaa gtact aagat ataat ttaag gtgtc T CGG CTA TTT CTC TTT

Lys Ala Asp Lys Glu Lys

K A D K E K

1952 1955


5880 5895 5910 5925

CTT ACT TTG CAG AGG AAA CTA AAA ACA ACT GGC ATG ACT GTT GAT CAG GTT TTG GGA ATA CGA GCT

GAA TGA AAC GTC TCC TTT GAT TTT TGT TGA CCG TAC TGA CAA CTA GTC CAA AAC CCT TAT GCT CGA

Leu Thr Leu Gln Arg Lys Leu Lys Thr Thr Gly Met Thr Val Asp Gln Val Leu Gly Ile Arg Ala

L T L Q R K L K T T G M T V D Q V L G I R A

1960 1965 1970 1975


5940 5955 5970 5985 6000

TTG GAG TCA GAA AAA GAA TTG GAA GAA TTA AAA AAG AGA AAT CTT GAC TTA GAA AAT GAT ATA TTG

AAC CTC AGT CTT TTT CTT AAC CTT CTT AAT TTT TTC TCT TTA GAA CTG AAT CTT TTA CTA TAT AAC

Leu Glu Ser Glu Lys Glu Leu Glu Glu Leu Lys Lys Arg Asn Leu Asp Leu Glu Asn Asp Ile Leu

L E S E K E L E E L K K R N L D L E N D I L

1980 1985 1990 1995 2000


6011

TAT ATG AG gtaag ctatt atgtg gaaat gtgcc accca ttgta atgaa aaact ggttg acccc tagaa attga

ATA TAC TC cattc gataa tacac cttta cacgg tgggt aacat tactt tttga ccaac tgggg atctt taact

Tyr Met Arg

Y M R

2004


aataa taaat gtgtg ttgtc ttaag cttgg gttat gtttt ctttt cccat gtgaa ttgag atatt cctgg ttctt

ttatt attta cacac aacag aattc gaacc caata caaaa gaaaa gggta cactt aactc tataa ggacc aagaa


catat gccac ataat tttgg tgtat ttttg atctt ttgaa tatta tattg tgaga ctctg gttct tgttt aaatt

gtata cggtg tatta aaacc acata aaaac tagaa aactt ataat ataac actct gagac caaga acaaa tttaa


ctatg ggaaa atgta gatac ttttg tttta gcatg caatc ggtct aatta ggttc aggcc acaag ttcca acctc

gatac ccttt tacat ctatg aaaac aaaat cgtac gttag ccaga ttaat ccaag tccgg tgttc aaggt tggag


IVS 43 (+ 2133 bp)
atcat ttaaa ggagg ccttc agtga atgct ctgta gagga ttatt ttata atact aattt tgata tccta attta

tagta aattt cctcc ggaag tcact tacga gacat ctcct aataa aatat tatga ttaaa actat aggat taaat


tttgt tataa agttt agaag gtttg aagaa tttaa aatat agtgt taata aacac actga acttt tcttt tttta

aaaca atatt tcaaa tcttc caaac ttctt aaatt ttata tcaca attat ttgtg tgact tgaaa agaaa aaaat


tcttg tattt ttata tagta caaca gaaaa aagat gaaat gtgaa tagta aagag tctgt gattg ttgtt catag

agaac ataaa aatat atcat gttgt ctttt ttcta cttta cactt atcat ttctc agaca ctaac aacaa gtatc


6012 6015 6030 6045 6060 6075

G GCC CAC CAA GCT CTT CCT CGA GAT TCT GTT GTA GAA GAT TTA CAT TTA CAA AAT AGA TAC CTC CAA

C CGG GTG GTT CGA GAA GGA GCT CTA AGA CAA CAT CTT CTA AAT GTA AAT GTT TTA TCT ATG GAG GTT

Arg Ala His Gln Ala Leu Pro Arg Asp Ser Val Val Glu Asp Leu His Leu Gln Asn Arg Tyr Leu Gln

R A H Q A L P R D S V V E D L H L Q N R Y L Q

2004 2005 2010 2015 2020 2025


6090 6105 6120 6135

GAA AAA CTT CAT GCT TTA GAA AAA CAG TTT TCA AAG GAT ACA TAT TCT AAG CCT TCA gtaag tgtat

CTT TTT GAA GTA CGA AAT CTT TTT GTC AAA AGT TTC CTA TGT ATA AGA TTC GGA AGT cattc acata

Glu Lys Leu His Ala Leu Glu Lys Gln Phe Ser Lys Asp Thr Tyr Ser Lys Pro Ser

E K L H A L E K Q F S K D T Y S K P S

2030 2035 2040 2045


atctt ttatt atttt tttct ttttt ccatg ttaaa atgca tgaaa gtgaa atcaa cttct ttctt aatct ggcca

tagaa aataa taaaa aaaga aaaaa ggtac aattt tacgt acttt cactt tagtt gaaga aagaa ttaga ccggt


aaagc attac atctt tctca ttaat agtaa tacag taaat tcaac tttta ttttt aacag gtagt gatgt gtaat

tttcg taatg tagaa agagt aatta tcatt atgtc attta agttg aaaat aaaaa ttgtc catca ctaca catta


aattt attta atcct tttta acata ataac agtaa actta agatt cttaa gcttt tcata aagct cataa atgat

ttaaa taaat tagga aaaat tgtat tattg tcatt tgaat tctaa gaatt cgaaa agtat ttcga gtatt tacta


IVS 44 (+ 3946 bp)
tactt gcttt gcttc cattg taatt aaaac aaacc atact acctt tgttc tgcaa gtttt gtatt ctaac ttatt

atgaa cgaaa cgaag gtaac attaa ttttg tttgg tatga tggaa acaag acgtt caaaa cataa gattg aataa


tattt ttggc tttca ccaga acact ccgat tttct catat tcctt tgagg aaaaa aagtt acctt ttgac agtat

ataaa aaccg aaagt ggtct tgtga ggcta aaaga gtata aggaa actcc ttttt ttcaa tggaa aactg tcata


tttct tatcc agtat gtctt ttatg gcttt tattt attaa acttt aaaaa tattc ctaat ttcat ttccc tgaag

aaaga atagg tcata cagaa aatac cgaaa ataaa taatt tgaaa ttttt ataag gatta aagta aaggg acttc


6136 6150 6165 6180 6195

ATT TCA GGA ATA GAG TCA GAT GAT CAT TGT CAG AGA GAA CAG GAG CTT CAG AAG GAA AAC TTG AAG

TAA AGT CCT TAT CTC AGT CTA CTA GTA ACA GTC TCT CTT GTC CTC GAA GTC TTC CTT TTG AAC TTC

Ile Ser Gly Ile Glu Ser Asp Asp His Cys Gln Arg Glu Gln Glu Leu Gln Lys Glu Asn Leu Lys

I S G I E S D D H C Q R E Q E L Q K E N L K

2046 2050 2055 2060 2065


6210 6225 6240 6255

TTG TCA TCT GAA AAT ATT GAA CTG AAA TTT CAG CTT GAA CAA GCA AAT AAA GAT TTG CCA AGA TTA

AAC AGT AGA CTT TTA TAA CTT GAC TTT AAA GTC GAA CTT GTT CGT TTA TTT CTA AAC GGT TCT AAT

Leu Ser Ser Glu Asn Ile Glu Leu Lys Phe Gln Leu Glu Gln Ala Asn Lys Asp Leu Pro Arg Leu

L S S E N I E L K F Q L E Q A N K D L P R L

2070 2075 2080 2085


6270

AAG gtgaa tttaa tgttt tttat tagga aatct aatgc ctaaa actcc ttcct tagtt gttat gttta ctttt

TTC cactt aaatt acaaa aaata atcct ttaga ttacg gattt tgagg aagga atcaa caata caaat gaaaa

Lys


K

2090


attag cttat taaga agtca aaaat gcata ttcct aatat atcat ggtga tggta tactt tatac atttg ctctt

taatc gaata attct tcagt tttta cgtat aagga ttata tagta ccact accat atgaa atatg taaac gagaa


tagca tttat ttgtt gaagg cctac tttat attaa acact cctcc agatg ctggg aaaca gcagt caaaa aattc

atcgt aaata aacaa cttcc ggatg aaata taatt tgtga ggagg tctac gaccc tttgt cgtca gtttt ttaag


cttat actca tagga cttac gttct agtgg agaag actga caata aacaa gtcac taaat agtat gtcat ctgat

gaata tgagt atcct gaatg caaga tcacc tcttc tgact gttat ttgtt cagtg attta tcata cagta gacta


IVS 45 (+ 682 bp)
ttgca tcagg caata atgtg ggaaa tacct tgaca tttca tatac acaat attct tgtat taatt taacg tctta

aacgt agtcc gttat tacac ccttt atgga actgt aaagt atatg tgtta taaga acata attaa attgc agaat


gttca aaatc ttcct tgtta atata gagac cctat tattt ggttt ggcaa tacag ttgaa gagat tgatg gttct

caagt tttag aagga acaat tatat ctctg ggata ataaa ccaaa ccgtt atgtc aactt ctcta actac caaga


tatga attgt ttgcc ttttc ttttc aatgg ctgta gctat gttaa attat tacat gtttg cttgt tatct ttcag

atact taaca aacgg aaaag aaaag ttacc gacat cgata caatt taata atgta caaac gaaca ataga aagtc


(2) T=ter

6271 6285 6300 6315 6330 |

AAT CAA GTC AGA GAT TTG AAG GAA ATG TGT GAA TTT CTT AAG AAA GAA AAA GCA GAA GTT CAG CGG

TTA GTT CAG TCT CTA AAC TTC CTT TAC ACA CTT AAA GAA TTC TTT CTT TTT CGT CTT CAA GTC GCC

Asn Gln Val Arg Asp Leu Lys Glu Met Cys Glu Phe Leu Lys Lys Glu Lys Ala Glu Val Gln Arg

N Q V R D L K E M C E F L K K E K A E V Q R

2091 2095 2100 2105 2110
6345 6356

AAA CTT GGC CAT GTT AGA GG ggtat gtgag aattt accat acatt tgttt tggtt tcagc agtga taagc

TTT GAA CCG GTA CAA TCT CC ccata cactc ttaaa tggta tgtaa acaaa accaa agtcg tcact attcg

Lys Leu Gly His Val Arg Gly

K L G H V R G

2115 2119

cagaa atgaa aagtt tagat atgtt gtaaa agtac tgata tgcct ctaca agtgc cctgt agttt cagtg tttat

gtctt tactt ttcaa atcta tacaa cattt tcatg actat acgga gatgt tcacg ggaca tcaaa gtcac aaata


tctgc atctg taata taaaa cagta agcat ttcta tgtgt ctcaa agtat tttat catct gttat acctt acata

agacg tagac attat atttt gtcat tcgta aagat acaca gagtt tcata aaata gtaga caata tggaa tgtat


ctttc atctc tcttt ttatt gaata tgcct ccata ccttg aaaac attta acttc cagga atcct tttgt ttatg

gaaag tagag agaaa aataa cttat acgga ggtat ggaac ttttg taaat tgaag gtcct tagga aaaca aatac


IVS 46 (+ 1197 bp)
tgcat gattt tagga atgtc aaatt tccta agtct tggtt ttctt gtatt taaaa tggaa attat aattc ctatc

acgta ctaaa atcct tacag tttaa aggat tcaga accaa aagaa cataa atttt acctt taata ttaag gatag


tcata gaatt gtttt aagga tgaat tgaat taata cagtt ttgac ttcaa atatt aggaa ttatt gagta taata

agtat cttaa caaaa ttcct actta actta attat gtcaa aactg aagtt tataa tcctt aataa ctcat attat


agcct gttgt attgt tggta cttcg tatta tactt actaa aatat ttgat taaag attta acata ttctt tcgta

tcgga caaca taaca accat gaagc ataat atgaa tgatt ttata aacta atttc taaat tgtat aagaa agcat


6357 6360 6375 6390 6405 6420

G TCT GGT AGA AGT GGA AAG ACA ATC CCA GAA CTG GAA AAA ACC ATT GGT TTA ATG AAA AAA GTA GTT

C AGA CCA TCT TCA CCT TTC TGT TAG GGT CTT GAC CTT TTT TGG TAA CCA AAT TAC TTT TTT CAT CAA

Gly Ser Gly Arg Ser Gly Lys Thr Ile Pro Glu Leu Glu Lys Thr Ile Gly Leu Met Lys Lys Val Val

G S G R S G K T I P E L E K T I G L M K K V V

2119 2120 2125 2130 2135 2340


6435 6450 6465 6480

GAA AAA GTC CAG AGA GAA AAT GAA CAG TTG AAA AAA GCA TCA GGA ATA TTG ACT AGT GAA AAA ATG

CTT TTT CAG GTC TCT CTT TTA CTT GTC AAC TTT TTT CGT AGT CCT TAT AAC TGA TCA CTT TTT TAC

Glu Lys Val Gln Arg Glu Asn Glu Gln Leu Lys Lys Ala Ser Gly Ile Leu Thr Ser Glu Lys Met

E K V Q R E N E Q L K K A S G I L T S E K M

2145 2150 2155 2160


6495 6510 6522

GCT AAT ATT GAG CAG GAA AAT GAA AAA TTG AAG gtaat ttttt ttaat gtgat cattt ttagg ggaat

CGA TTA TAA CTC GTC CTT TTA CTT TTT AAC TTC catta aaaaa aatta cacta gtaaa aatcc cctta

Ala Asn Ile Glu Gln Glu Asn Glu Lys Leu Lys

A N I E Q E N E K L K

2165 2170 2174


atttt acgtt ttgtt actat ttagg aaaat ttcaa atatg ctcat tacta tataa aatgg cttta atgaa tacaa

taaaa tgcaa aacaa tgata aatcc tttta aagtt tatac gagta atgat atatt ttacc gaaat tactt atgtt


tacat atttt ataaa tatag aaaaa aactt atgag aggca aggct aaggg ttata gagta ggtct acctg atctt

atgta taaaa tattt atatc ttttt ttgaa tactc tccgt tccga ttccc aatat ctcat ccaga tggac tagaa


tcttg ttatt tcaag accaa tactt ttcac ttttc tctct gacag catag attaa ttacc tgtgt ctctc ttttt

agaac aataa agttc tggtt atgaa aagtg aaaag agaga ctgtc gtatc taatt aatgg acaca gagag aaaaa



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