Morbidity
Theron et al. (2014) reported comparative morbidity outcomes after NAAT compared with AFB microscopy. In this study AFB microscopy and NAAT (Xpert) were done at point-of-care to assist same-day clinical decision-making and to improve patient retention and clinical outcomes. Thus, both the NAAT results in the intervention group and the AFB microscopy results in the comparator group were available on the same day as specimen collection. Additionally, only about half the patients who initiated treatment did so on the basis of a positive Xpert result. TB-related morbidity was graded using the TBscore (range 0–13) (Wejse et al. 2008) and the Karnofsky performance score (KPS). The KPS subjectively rates the patient’s performance according to their ability to perform normal daily activities, ability to work, assistance needs, and disease-related symptoms on a scale from 0% to 100% (Rudolf et al. 2013). Morbidity was measured at baseline and at 2 and 6 months. The results are shown in Table .
Table TB-related morbidity at recruitment, 2 months and 6 months, according to baseline culture status in patients given anti-TB treatment, per group
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