Curriculum vitae; 4th January 2016 Full name

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CURRICULUM VITAE; 4th January 2016

1. Full name: Koistinen Heikki Allan (male)

2. Date and place of birth, nationality, residence, contact information: 28.8.1968 Joensuu, Finland;

Finnish citizen. Helsinki, Finland. Email: heikki.koistinen@helsinki.fi

3. Education and training:

Medical Specialist in Endocrinology, University of Helsinki, Finland, 22.11.2012 (University of Helsinki, Medical Faculty, PO BOX 20, 00014 University of Helsinki, Finland, tel:+358 2 941 911)

Medical Specialist in Internal Medicine 12.2.2008, University of Helsinki, Finland

Title of Docent in Experimental Internal Medicine 13.12.2002 University of Helsinki, Finland; on 5.11.2013 this was changed to Title of Docent in Clinical Internal Medicine, University of Helsinki, Finland

Doctor of Medical Sciences 23.2.1999 University of Helsinki, Finland

Title of the thesis: Through thick and thin - studies on leptin. (Topic: Leptin physiology in man)

MD 5.4.1994 University of Helsinki, Finland

Graduated from college 31.5.1987, Joensuu, Finland

5. Language skills

Finnish – native speaker

English, Swedish, German, French

6. Current Position:



Independent Researcher and Research Group Leader, Helsinki University Central Hospital, 1.8.2002 onwards

Clinical teacher (internal medicine), Faculty of Medicine, University of Helsinki, 1.1.2015 onwards

Medical Specialist in Endocrinology, Helsinki University Central Hospital, 1.1.2013 onwards (part-time)

Medical advisor (part-time), National Institute for Health and Wellfare, Diabetes Prevention Unit, 1.1.2012 onwards (the formal coordinating person in the Finnish part of the Finland-United States Investigation of NIDDM Genetics); FUSION study Principal Investigator July 2013 onwards

7. Main previous professional appointments:

Resident in internal medicine, the district hospital of Pieksämäki, Finland 23.6.-31.7.1994

General practioner, the health center of Eno, Finland 8.8.-16.9.1994, the health center of Kuusankoski, Finland 26.9.1994 - 13.1.1995, the health center of Kontiolahti, Finland 23.1.-28.2.1995, the health center of Tikkurila, Finland 3.7.-31.7.1995

Research physician Helsinki University Central Hospital, Finland, 1.4.-23.5.1994

Research physician at Orion-Farmos Pharmaceuticals, Espoo, Finland 24.5.-22.6.1994 and 1.3.-30.6.1995.

Resident in neurology, Kymenlaakso central hospital, Kotka, Finland 1.7 -31.7.1996.

Researcher, Unit for Diabetes Research, group of Adjunct Professor Veikko Koivisto, Department of Medicine, Helsinki University Central Hospital, Finland, 1.8.1995-30.9.1999

Resident in Internal Medicine, Helsinki University Central Hospital, Finland, 1.3.1999-31.5.1999, 1.7-31.8.1999.



Post-doctoral studies abroad:

post-doctoral fellow, INSERM U449, Dr Hubert Vidal´s group Lyon, France 4.10.1999 - 18.10.2000

post-doctoral fellow, Karolinska Institutet, Integrativ fysiologi, professor Juleen R Zierath´s and professor Harriet Wallberg-Henriksson´s group, Stockholm, Sweden, 1.11.2000-31.7.2002

Resident in Internal Medicine, Helsinki University Central Hospital, Finland, 1.8.2002-14.1.2007 and 1.7-31.8.2007

Medical specialist in Internal Medicine, Helsinki University Central Hospital, 15.1-30.6.2007 and 1.9.2007-30.4.2010, 1.1-30.4.2012

Clinical teacher of Internal Medicine, Department of Medicine, Helsinki University, 15.1-30.6.2007 and 1.9.2007-30.6.2009

Medical Director, Medical Specialists, Lääkärikeskusyhtymä, 1.4.2010-31.12.2011 (part-time).

Medical Director, Diabetes Care Unit, Aava Lääkärikeskus, Lääkärikeskusyhtymä, 1.1.2012-31.12.2015 (part-time)

Academy of Finland Clinical Researcher, Department of Medicine, Division of Cardiology, Helsinki University Central Hospital; and Minerva Foundation Institute for Medical Research, 1.1.2009-31.12.2011

Resident in Endocrinology 1.5.2010-31.10.2010, 1.5.2011-31.10.2011, 1.5.2012-31.10.2012

Academy of Finland Clinical Researcher, Minerva Foundation Institute for Medical Research and Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital 1.9.2012-31.8.2015

8. Major grants, research group leadership, scientific supervision

2008 Academy of Finland, 3-year funding for promotion of Clinical Researcher´s career 1.1.2009-31.12.2011, EUR 207 240, Principal Investigator

2011 Finnish Medical Foundation, 3-year funding for promotion of Clinical Researcher´s career 2012-2014, EUR 200 000, Principal Investigator

2012 Academy of Finland, 3-year funding for promotion of Clinical Researcher´s career 1.9.2012-31.8.2015, EUR 249 081, Principal Investigator

Research group leader, Department of Medicine, Helsinki University Central Hospital, 1.8.2002 onwards



Scientific supervision:

Supervisor of post-doctoral researcher Yen H. Nguyen, PhD, May 2012 onwards

Master´s thesis of Heidi Kuoppamaa ”The effect of adiponectin in human skeletal muscle", University of Helsinki, Department of Biochemistry, 2007 (eximia)

Master´s thesis of Maarit Sihvo ”The effect of angiotensin II on glucose metabolism in human skeletal muscle", University of Helsinki, Department of Biochemistry, 2007 (eximia)

Master´s thesis of Stephanie von Kraemer ”Do MC-acylcarnitines, products of incomplete β-oxidation, affect insulin signalling in L6 muscle cells?”, University of Helsinki, Department of Biosciences, 2010 (magna cum laude approbatur)

Advanced studies of Anna Zitting, MB ”The acute metabolic effects of resveratrol in human skeletal muscle cells” University of Helsinki, Faculty of Medicine, 2012 (eximia)

PhD thesis of Paulina Skrobuk, MSci (biotechnology) ”Glucose and lipid metabolism in human skeletal muscle”. University of Helsinki, Faculty of Medicine, 2012.

Advanced studies of Johannes Kärkkäinen, MB ” Angiotensin 2 and insulin resistance in human skeletal muscle”, University of Helsinki, Faculty of Medicine, 2014 (laudatur)

Supervisor of PhD-studies of Selina Mäkinen, MSci, topic: Mechanisms of insulin resistance in skeletal muscle, University of Helsinki, Faculty of Medicine, 2012 onwards, work-in-progress.

Supervisor of advanced studies of Petro Kyrylenko, Medical student ” The effect of steviol on glucose metabolism in skeletal muscle”, University of Helsinki, Faculty of Medicine, 2015 onwards, work-in-progress

9. Pedagogical training and teaching experience.



a) Pedagogical training:

Introduction into University Pedagogy, 27.4.2007, Research and Development Unit for Medical Education, University of Helsinki 4 h=0,15 Cr

Basic Course on University Pedagogy, 2007-2008, Research and Development Unit for Medical Education, University of Helsinki 10 Cr

Course on University Pedagogy: Supervision at University, 2009, Centre for Research and Development of Higher Education, University of Helsinki, 5 Cr (grade 4/5)

Course on University Pedagogy: Developing the pedagological professionalism of the teacher, 2010, Centre for Research and Development of Higher Education, University of Helsinki, 10 Cr (grade 5/5, excellent)

In total: Basic studies on university pedagogy, 25 Cr, University of Helsinki, 2010 (5/5, excellent)

Special qualification to train medical doctors, Finnish Medical Association, 2010

b) Practical teaching experience:

Full time clinical teacher of Internal Medicine, Department of Medicine, University of Helsinki, basic medical education for medical students 15.1-30.6.2007, 1.9.2007-30.6.2009 and 1.1.2015 onwards

Inluding: Propedeutics (introductory course on clinical medicine), group teaching

Cardiology: ecg sessions in groups, group teaching, problem based learning-sessions

Haematology: group teaching, problem based learning-sessions

Rheumatology: group teaching, problem based learning-sessions

Gastroenterology and nephrology, group teaching, problem based learning-sessions

Endocrinology, group teaching, problem based learning-sessions

Developing into a medical doctor, group teaching

Oral examination on clinical skills (OSCE)

In total: more than 560 h

c) Production of learning materials

Koistinen HA, Jänne OA: Endokriininen järjestelmä (The Endocrine System). Chapter in book: “Endokrinologia”, (Finnish Textbook of Endocrinology), Duodecim Medical Publications Ltd, 2009, pp. 12-30

Koistinen H: Sisätautisia ongelmatilanteita. (Common Patient Problems in Internal Medicine) Chapter in “Terapiamuistio 2010”, Orion-Pharma Oyj, 2009, pp 77-96

Koistinen H: Hypo- and hypermagnesemia. Therapia Fennica, Kandidaattikustannus Oy, 10th Edition: pp.981-984, 2015

Koistinen H: Hypomagnesemia. Akuuttihoito-opas (Handbook on emergency medicine), Duodecim Medical Publications, Ltd, 18th Edition, pp. 459-460, 2015

d) supervision of theses

1 PhD-thesis, 3 Master´s theses, 2 Advanced medical studies-theses (see 8.)

10. Research awards, honours

2004 Klinisk Forsker Stipend, Novo Nordisk Foundation, Denmark



11. Other academic and professional merits and activities:

Scientific evaluation of other´s work:

Reviewer of the PhD-thesis of Petteri Nieminen, MD, magister of philosophy, “Survival of fattest - leptin, melatonin, thyroxine and the seasonal adaptation of mammals”. Department of Mathematics and Natural Sciences, University of Joensuu, Finland, 2000.

Reviewer of the PhD-thesis of Elena Korsheninnikova, MD “Molecular mechanisms of insulin resistance in human skeletal muscle and lipodystrophic adipose tissue” University of Helsinki, Finland, 2003.

Opponent of the PhD-thesis of Anne-Mari Mustonen, magister of philosophy, ”Seasonality, photoperiod and nutritional status in the control of endocrinological weight-regulation” Department of Mathematics and Natural Sciences, University of Joensuu, Finland, 2003.

Reviewer of the PhD-thesis of Sami Heikkinen, magister of philosophy, “Glucose metabolism in heterozygous hexokinase II knock-out mice, University of Kuopio, Finland, 2004.

Opponent of the PhD-thesis of Olli Laukkanen MB, “Genes regulating insulin secretion and insulin signaling as candidate genes for type 2 diabetes in subjects with impaired glucose tolerance”, University of Kuopio, Finland, 2006

Reviewer of Master´s thesis of Anna Kotronen, MB, “Tissue specificity of insulin resistance in humans”. University of Helsinki, Finland, 2007

Reviewer and member of the thesis committee (rapporteur) in the defence of the PhD-thesis of Sara Fröjdö, Master of Science, ”Functional relationship between insulin signalling pathways, the protein deacetylase SIRT1 and the polyphenol resveratrol: studies in skeletal muscle cells and C. elegans” INSERM U.870/INRA U. 1235/INSA Lyon /Université Lyon1/Hospices Civils, Lyon, France, 13.2.2009

Reviewer of the PhD-thesis of Eija Pirinen, magister of philosophy,. “Involvement of Polyamine Catabolism in the Regulation of Glucose, Energy and Cholesterol Metabolism in Mice.” University of Kuopio, 2009.

Opponent of the PhD-thesis of Markku Vänttinen MD, “Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor genes and insulin sensitivity”, University of Eastern Finland, Finland, 2012

Reviewer of the PhD-thesis of Dr Feng Wang ”Bioactivation and physiological role of steroid fatty acyl esters in adipose tissue” , University of Helsinki, 2013

Opponent of the PhD-thesis of Mikko Lehtovirta MD, “Heritability of type 2 diabetes and related traits”, University of Helsinki, Finland, 2014

Opponent of the PhD-thesis of Yuvaraj Mahendran, MSci ”Identification of biomarkers for type 2 diabetes”, University of Eastern Finland, 2014

Opponent of the PhD-thesis of Janne Orava MD, “Characterisation of functional brown adipose tissue in adult humans”, University of Turku, Finland, 2014

Reviewer and member of the thesis committee (opponent) of the PhD-thesis of Andreas J.T. Pedersen MB, “Studies of insulin resistance in Type 2 diabetes: effects of insulin, exercise and post-exercise insulin stimulation on signalling to glucose uptake and glycogen synthesis in skeletal muscle”, Department of Endocrinology and Metabolism, Odense University Hospital, 2014

Reviewer of the PhD-thesis of Pirkka-Pekka Laurila, MD, “The molecular link between lipid metabolism and energy homeostasis”, University of Helsinki, Finland, 2015

Opponent of the PhD-thesis of Dorota Kaminska, MSci, “ Regulation of alternative splicing in obesity and weight loss”, University of Eastern Finland, Kuopio, Finland, 2015

Reviewer of grant application for Austrian Science Fund 2007.

Reviewer of grant application for Diabetes UK in 2012 and in 2013.

Referee for scientific journals Diabetes, Diabetologia, American Journal of Physiology, Plos One, Journal of International Obesity, Journal of Clinical Endocrinology and Metabolism, Journal of Endocrinology, Molecular and Cellular Endocrinology

Memberships in scientific and professional societies

American Diabetes Association, European Association for the Study of Diabetes, Endocrine Society,

Duodecim, Finska Läkaresällskapet, Finnish Diabetes Research Society, Finnish Medical Association

Member of the steering committee of Programme for Translational Medicine, Faculty of Medicine, University of Helsinki, Finland, 2011-2013
Member of the scientific committee of the Finnish Diabetes Research Foundation 2012-14
Chairperson of the scientific committee of the Finnish Diabetes Research Foundation 2013-14

Title of Docent in Experimental Internal Medicine 13.12.2002 University of Helsinki, Finland; on 5.11.2013 this was changed to Title of Docent in Clinical Internal Medicine, University of Helsinki, Finland

Competence for assistant professorship, University of Helsinki, 2014

Competence for professorship, University of Helsinki, 2015

12. Impact of scientific activity (Web of Science, accessed 4.1.2016)

44 original scientific publications in international peer-reviewed series, 69 publications in total

Hirsch index 25, Sum of Times Cited without self-citations 1841
13. Five relevant original publications

1. Ivaska KK, Heliövaara MK, Ebeling P, Bucci M, Huovinen V, Väänänen HK, Nuutila P, Koistinen HA: The effects of acute hyperinsulinemia on bone metabolism. Endocr Connect. 2015 Sep;4(3):155-62. doi: 10.1530/EC-15-0022.

2. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, on behalf of T2D-GENES; Boehnke M, on behalf of GoT2D; Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, on behalf of SIGMA T2D; Ebert BL: Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes. N Engl J Med 371:2488-98, 2014

3. Skrobuk P, von Kraemer S, Semenova MM, Zitting A, Koistinen HA: Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells. Diabetologia 55:3051-60, 2012. DOI 10.1007/s00125-012-2691-1.

4. Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR : siRNA based gene silencing reveals specialized roles of IRS1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metabolism 4 :89-96, 2006

5. Karlsson HKR, Ahlsén M, Zierath JR, Wallberg-Henriksson H, Koistinen HA: Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes 55 :1283-1288, 2006



14. Other:

1987 Little-Finlandia Prize (Competition on Essay on Literature, College graduates=abiturients)

1995 Little-Niilo Prize (Competition of Finnish Medical Society Duodecim on essay on medicine)

Elected member of the international Galileo - Innovators in Diabetes and Metabolic Syndrome network for young scientists 2004-2006

2011 Elected participant in a Workshop for Clinical Investigators on Genetics of Complex Diseases, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3-5.4.2011

Member of the collegium of medical doctors, Lääkärikeskusyhtymä, 2009-2011

2013 Elected participant in Genomics in Metabolism-meeting, Copenhagen Bioscience Conferences, 3-6.11.2013 Denmark

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