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Scale of the malaria problem

  • 107 endemic countries with 3.2 billion people at risk (40% of world’s population)

  • At least 1 million people die in Africa each year from malaria

  • Over 200 million clinical malaria cases in Africa each year

  • Over 4 million people in SA live in malaria areas (10% of the population)

  • Almost 80 million cases each year in the Southern Africa malaria control area

  • Climate change will increase population at risk in Southern Africa fourfold by 2020



Global distribution of malaria risk



Current situation



Building for the future:



The South African Malaria Initiative



The discovery pipeline in SAMI



From Knowledge to Innovation in SAMI



From Knowledge to Innovation in SAMI



Early successes

  • Drug delivery system able to reverse chloroquine resistance

  • Provisional patent covering anti-malarial activity of a drug registered for other uses

  • Novel RDT ready for field screening by mid-2008

  • Novel in vitro HTS assay validated

  • Drug target accepted for in silico virtual screening (WISDOM)






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