Electronic Posters: Cardiovascular

Tuesday 13:30-15:30 Computer 32

13:30 3620. Optimization of Spiral Pulse Sequences for First-Pass Myocardial Perfusion Imaging

Michael Salerno¹, Christopher M. Kramer², Christopher Sica³, Craig H. Meyer<sup>4

1</sup>Department of Medicine, Cardiology, University of Virginia, Charlottesville, VA, United States; ²Department of Radiology, University of Virginia, Charlottesville, VA; ³Biomedical Engineering, Hershey Medical Center, Hershey, PA; ⁴Biomedical Engineering, University of Virginia, Charlottesville, VA

Optimized Spiral Pulse Sequences may have advantages for clinical myocardial perfusion imaging. The goal of this project was to evaluate how variations in the readout duration per interleaf, number of spiral interleaves, and spatial resolution affect the image quality and artifacts for first-pass myocardial perfusion imaging using spiral trajectories in human subjects.

14:00 3621. A Fully Quantitative Pixel Based Approach for Measuring Myocardial Blood Flow in First-Pass Contrast-Enhanced Perfusion MRI: Microspheres Validation in Dogs and Feasibility Study in Humans

Li-Yueh Hsu¹, Daniel W. Groves¹, Anthony H. Aletras¹, Peter Kellman¹, Andrew E. Arai<sup>1

1</sup>National Institutes of Health, Bethesda, MD, United States

We developed a fully quantitative method to estimate myocardial blood flow (MBF) in first-pass contrast-enhanced perfusion MR images at the pixel level. The results were validated in an animal model and show that the MR perfusion estimates correlated with microspheres over a wide range of absolute MBF. To test feasibility in humans, the method was also applied to clinical perfusion MR images to estimate pixel-wise MBF at rest and during stress.

14:30 3622. First-Pass Cardiac Perfusion Imaging of the Infarcted Rat Heart

Daniel James Stuckey¹, Carolyn A. Carr¹, Stephanie Meader¹, Damian J. Tyler¹, Kieran Clarke<sup>1

1</sup>Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxon, United Kingdom

We developed a first-pass cardiac perfusion imaging method which identified regions of perfusion deficit in the infarcted rat heart. Seven days after infarction, cine-MRI was combined with first-pass imaging, which acquired one image per heartbeat during Gd-DTPA bolus. Perfusion deficit at 7 days was larger in rats that went on to develop greater cardiac impairment by 42 days, and provided a more accuracy early indicator of the extent of myocardial infarction than ejection fraction. First-pass MRI will be useful for evaluation of rodent models of human disease and experimental therapies, including cytokine and stem-cell mediated angiogenesis in the infarcted heart.

15:00 3623. Myocardial Perfusion MRI at 3.0T with Sliding-Window Conjugate-Gradient HYPR for the Detection of Coronary Artery Disease

Heng Ma¹, Lan Ge², Dong Xu¹, Qing Tang¹, Han Li¹, Yu Zhang¹, Jiabin Liu¹, Qi Yang¹, Jing An³, Lixin Jin⁴, Renate Jerecic⁴, Xiangying Du¹, Kuncheng Li¹, Debiao Li<sup>2

1</sup>Xuanwu Hospital, Capital Medical University, Beijing, China; ²Radiology, Northwestern University, Chicago, IL, United States; ³Siemens Mindit Magnetic Resonance Ltd, Shenzhen, China; ⁴Siemens Ltd, Healthcare Sector, China

SW-CG-HYPR is a promising method to improve the myocardial perfusion MR imaging with reduced acquisition window, increased spatial coverage, improved spatial resolution and SNR. In this work, 10 patients with suspected CAD were scanned at 3.0T with SW-CG-HYPR. Our initial results show that myocardial perfusion MRI at 3.0T with SW-CG-HYPR is feasible in a clinical population, and has high image quality and diagnostic accuracy in patients with suspected CAD.