Electronic Posters: Cardiovascular

Tuesday 13:30-15:30 Computer 38

13:30 3716. Estimation of LV Function from Navigator Triggered, Real-Time Cardiac Cine Steady-State Free Precession (SSFP) Imaging

Amol Pednekar¹, Benjamin Cheong², Raja Muthupillai², Claudio Arena<sup>2

1</sup>Philips Healthcare, Cleveland, OH, United States; ²Diagnostic and Interventional Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States

We propose an integrated real-time data acquisition and retrospective post-processing strategy to estimate parameters characterizing global function of the left ventricle. Our initial evaluation of feasibility of this approach in normal subjects shows that slice-by-slice LV volumes estimated using the real-time cine imaging approach are comparable to the LV volumes obtained using conventional, breathhold cardiac cine SSFP techniques. The combination of respiratory navigator triggering, real-time unsegmented SSFP cine imaging, and integrated retrospective automated processing may make this approach particularly useful in patients with severe arrhythmias, and/or severely compromised respiratory function.

14:00 3717. ShMOLLI: Shortened Modified Look Locker Inversion Recovery for Cardiac T1 Mapping – from Theory to Normal Human Myocardium

Stefan K. Piechnik¹, Vanessa M. Ferreira², Erica Dall'Armellina², Lowri E. Cochlin³, Stefan Neubauer², Matthew D. Robson<sup>2

1</sup>Cardiovascular Medicine, OCMR, Oxford University , Oxford, Oxfordshire, United States; ²Cardiovascular Medicine, OCMR, Oxford University, Oxford, Oxfordshire, United States; ³Dept of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, United States

We propose a cardiac T1-mapping method based on sequential Look-Locker measurements with conditional reconstruction of incomplete recovery periods. This new method assures that robust T1 mapping can be achieved in a 9 heartbeat breath-hold with accuracy comparable to existing methods.

14:30 3718. Preferential Patterns of Myocardial Iron Deposition by Multislice Multiecho T2* CMR in Thalassemia Major Patients.

Antonella Meloni¹, Vincenzo Positano¹, Alessia Pepe¹, Pasquale Pepe¹, Maria Chiara Dell'Amico¹, Cristina Salvatori¹, Petra Keilberg¹, Gianluca Valeri², Eliana Cracolici³, Pier Paolo Bitti⁴, Angelo Zuccarelli⁵, Maria Filomena Santarelli¹, Massimo Lombardi<sup>1

1</sup>MRI Lab, “G. Monasterio Foundation” and Institute of Clinical Physiology, CNR, Pisa, Italy; ²Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy; ³Policlinico "Paolo Giaccone" , Palermo, Italy; ⁴Dipartimento dei Servizi - P. O. San Francesco, Nuoro, Italy; ⁵Centro trasfusionale e di microcitemia - Ospedale civile, Olbia, Italy

Multislice multiecho T2* MRI allows quantification of iron overload in the whole myocardium. A preferential pattern of iron store in anterior and inferior regions appears to be present in thalassemia major patients with severe and mild-moderate iron overload. The preserved pattern between the groups prevents attributing this datum to additive susceptibility artefacts, which are negligible in heavily iron-loaded patients. A segmental T2* CMR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting.

15:00 3719. RV Function from Cine MRI Using Contour Propagation

Wei Feng¹, Himanshu Gupta², Steven Lloyd², Louis Dell'Italia², Thomas S. Denney Jr<sup>3

1</sup>Biomedical Engineering, MRI Institute, Detroit, MI, United States; ²Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States; ³Electrical Engineering, Auburn University, Auburn, AL, United States

This abstract presents a method for computing right-ventricular volume-versus-time curves and peak ejection and filling rates from standard cardiac cine MRI. The method uses RV contours drawn semi-automatically near end-diastole and end-systole and propagates them to the remaining time frames via a non-rigid registration technique. The propagated contours are validated by comparing them to contours manually drawn by a cardiologist with Level 3 training. In addition, peak ejection and filling rates computed from both manually-drawn and propagated contours are compared.