Extrasenzoriale

7. Conclusions

Coherent electromagnetic fields generated by microtubules in living cells represent a new and outstanding issue in present-day cell biology. Effectiveness of microtubule oscillations depends on mitochondrial function. Besides ATP and GTP production and liberation of nonutilized energy mitochondria form important boundary links between chemical-genetic and physical processes in living cells. They set up conditions for physical mechanisms in living cells. Establishment of a strong static electric field and formation of a layer of ordered water around mitochondria belong to essential conditions for the generation of coherent electrodynamic field by microtubules. The electrodynamic field can provide directional transport in the cell, facilitate organization of structures and organelles, and affect interactions in the cell and between cells, including information transfer.

Inhibition of the pyruvate transfer into mitochondrial matrix causes mitochondrial dysfunction in a large group of cancers. Other defects (for instance, in the citric acid cycle) diminish proton transfer from the matrix space too. Dysfunction of mitochondria results in decreased static electric field, diminished water ordering around them, and lowered energy supply. Consequently, electrodynamic field generated by microtubules is characterized by low power, diminished coherence, and altered frequency spectrum. The space pattern of the field may be disordered too. Biological functions dependent on generated electrodynamic fields are very likely to be disturbed as a result.

However, there is another group of cancers. Mitochondrial dysfunction is not developed in a cancer cell but in the associated fibroblasts. The supply of energy rich metabolites from associated fibroblasts results in a strong aggressiveness of cancer cells. This cancer type deserves special analysis concerning increased electrodynamic activity.

We propose that essential and specific differences between healthy and cancer cells should be exploited for the development of a new generation of cancer therapies. The conventional cancer therapeutic strategy is based on cancer cell killing with associated collateral damage to healthy tissue. The main effort is aimed at finding sufficiently specific property to kill the cancer cells and to limit damage to healthy cells. However, the healthy cells may be damaged too and treatment of recurrent cancers remains unsolved.

Mitochondrial dysfunction may be a specific and essential difference between healthy and cancer tissues. One cause of the dysfunction is known—inhibition of the pyruvate pathway into mitochondrial matrix. Treatment by DCA of cancers with the Warburg effect and by DCA in combination with glycolysis inhibitors of cancers with the reverse Warburg effect can stimulate synthesis of new drugs restoring physiological role of mitochondria and normal function of various cancer cells.

Acknowledgment

This study was supported by Grant no. P102/11/0649 of the Czech Science Foundation GA CR.

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Piatra pe care au lepădat-o zidarii a ajuns să fie pusă în capul unghiului" (Petru).

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