| Effects of mixed exposures
46. The ways in which the constituent substances of a mixed exposure interact, vary considerably. Some mixed exposures involve substances that act on different body tissues or organs, or by different toxilogical mechanisms, these various effects being independent of each other. Other mixtures will include substances that act on the same organs, or by similar mechanisms, so that the effects reinforce each other and the substances are additive in their effect. In some cases the overall effect is considerably greater than the sum of the individual effects and the system is synergistic. This may arise from mutual enhancement of the effects of the constituents or because one substance potentiates another, causing it to act in a way which it would not do alone.
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