Mitochondrial dysfunction results from oxidative stress in skeletal muscle of diet-induced insulin resistant mice

Nonstandard abbreviations used: COX: cytochrome c oxidase, CS: citrate synthase, ERRestrogen related receptor, HFHSD: high fat and high sucrose diet, HPRT : hypoxanthine guanine phosphoribosyl transferase, IRS1: insulin receptor substrate 1, Mfn2: mitofusin 2, mtDNA: mitochondrial DNA, mtTFA: mitochondrial transcription factor, NAC : N-acetylcysteine, NBT: nitroblue tetrazolium, NRF: nuclear respiratory factor, PGC1PPAR gamma coactivator 1, POLG: polymerase gamma, ROS: reactive oxygen species, SD: standard diet, SSBP1: single strand binding protein, STZ: streptozotocin.