References

21 (9), 1289-1292

Keywords: HEART/SEP/STROKE

Bishop, D.S. and Evans, R.L. (1990), Family Functioning Assessment Techniques in Stroke. Stroke, 21 (9), 50-51

Keywords: HEART/STROKE

Hewer, R.L. (1990), Outcome Measures in Stroke - A British View. Stroke, 21 (9), 52-55

Keywords: HEART/STROKE

Lindsberg, P.J., Yue, T.L., Frerichs, K.U., Hallenbeck, J.M. and Feuerstein, G. (1990), Evidence for Platelet-Activating Factor As A Novel Mediator in Experimental Stroke in Rabbits. Stroke, 21 (10), 1452-1457

Keywords: HEART/STROKE

Limburg, M., Vanroyen, E.A., Hijdra, A., Debruine, J.F. and Verbeeten, B.W.J. (1990), Single-Photon Emission Computed-Tomography and Early Death in Acute Ischemic Stroke. Stroke, 21 (8), 1150-1155

Keywords: HEART/STROKE

Loewen, S.C. and Anderson, B.A. (1990), Predictors of Stroke Outcome Using Objective Measurement Scales. Stroke, 21 (1), 78-81

Keywords: HEART/STROKE

Bielenberg, G.W. and Burkhardt, M. (1990), 5-Hydroxytryptamine1A Agonists - A New Therapeutic Principle for Stroke Treatment. Stroke, 21 (12), 161-163.

Abstract: We conducted the present study to investigate the effects of 5- hydroxytryptamine agonists on brain morphology after the induction of focal cerebral ischemia by permanent occlusion of the left middle cerebral artery in rats and mice. Forty-eight hours after vessel occlusion, the damage was quantified in rats by planimetry and subsequent integration on cresyl violet- stained serial sections and in mice by planimetric analysis of the damaged cortical surface after counterstaining with carbon black. All 5-HT(1A) agonists investigated substantially decreased cortical infarct size in the rat focal ischemia model (p < 0.05). Drugs were applied 30 minutes before the induction of ischemia, and efficacy was demonstrated for 8-OH-DPAT (1 mg/kg s.c.), buspirone (10 mg/kg i.p.), gepirone (10 mg/kg i.p.), ipsapiron (10 or 30 mg/kg i.p.), and Bay R 1531 (1 mg/kg i.p.). The most pronounced effects were seen with the higher dose of ipsapirone and Bay R 1531, both compounds reducing cortical infarct size by more than 60%. Except for 8-OH-DPAT, the 5-HT(1A) agonists also caused a reduction in total infarct volumes. In a separate series, ipsapiron (30 mg/kg i.p.), applied 1 hour after vessel occlusion, led to a reduction in cortical and total infarct volumes by about 50% compared with corresponding controls (p < 0.05). In neither series was striatal damage influenced. We tested the compounds in the mouse ischemia model over a broad dose range. Treatment with 8-OH-DPAT (1, 3, or 10 mg/kg s.c.), buspirone (30 mg/kg i.p.), gepirone (10 mg/kg i.p.), or ipsapirone (10 or 30 mg/kg i.p.) 15 minutes before occlusion significantly (p < 0.05) reduced the area of cortical tissue damage. Our results provide evidence for neuroprotectant properties of 5-HT(1A) agonists in two rodent stroke models. As exemplified for ipsapirone, preischemic and postischemic drug application attenuates infarct development after middle cerebral artery occlusion. These data add 5-HT(1A) agonists to current approaches to stroke therapy

Keywords: CEREBRAL INFARCTION/CEREBRAL-ISCHEMIA/HEART/MODULATION/NEOCORTICAL NEURONS/NEUROPROTECTION/RAT/SEROTONIN/STROKE

Hershey, L.A. (1990), Dementia Associated with Stroke. Stroke, 21 (9), 9-11

Keywords: HEART/STROKE

Bevan, H., Sharma, K. and Bradley, W. (1990), Stroke in Young-Adults. Stroke, 21 (3), 382-386

Keywords: HEART/STROKE

Koller, M., Haenny, P., Hess, K., Weniger, D. and Zangger, P. (1990), Adjusted Hypervolemic Hemodilution in Acute Ischemic Stroke. Stroke, 21 (10), 1429-1434

Keywords: HEART/STROKE

Kushner, M.J. (1990), Prospective-Study of Anticardiolipin Antibodies in Stroke. Stroke, 21 (2), 295-298

Keywords: HEART/STROKE

Bednar, M.M., Mcauliffe, T., Raymond, S. and Gross, C.E. (1990), Tissue Plasminogen-Activator Reduces Brain Injury in A Rabbit Model of Thromboembolic Stroke. Stroke, 21 (12), 1705-1709.

Abstract: Tissue plasminogen activator is an endogenous fibrin-specific serine protease with potent thrombolytic activity. We investigated the efficacy of tissue plasminogen activator in reducing cerebral infarct size after thromboembolic stroke in a rabbit model. Seventeen rabbits were randomized to receive either tissue plasminogen activator (2.5 mg/kg, n = 6) or vehicle control (n = 11). We controlled mean arterial pressure, hematocrit, and arterial blood gases before and after the intracarotid embolization of an autologous clot. Cerebral blood flow (cm3/100 g/min) (mean+/-SEM) was immediately reduced from 55.2+/-7.7 to 8.5+/-2.5 in the control group and from 61.8+/-14.8 to 10.0+/-3.5 in the treated group after embolization. Cerebral blood flow recovered significantly within 60 minutes of thrombolytic therapy and attained a value of 59.6+/-10.0 cm3/100 g/min 4 hours after embolization, whereas cerebral blood flow in control animals demonstrated only a minimal recovery to 15.3+/-8.9 cm3/100 g/min. Cerebral infarct size (percent of hemisphere) was reduced from 34.4+/- 5.6% in control animals to 8.8+/-5.6% in treated animals (mean+/-SEM,p < 0.01). These results suggest that tissue plasminogen activator may be efficacious in restoring cerebral blood flow and thus limiting infarct size in acute thromboembolic stroke

Keywords: CEREBRAL BLOOD FLOW/CEREBRAL BLOOD-FLOW/CLEARANCE/EDEMA/EMBOLIC STROKE/HEART/HEMORRHAGIC INFARCTION/ISCHEMIA/MYOCARDIAL- INFARCTION/PLASMINOGEN ACTIVATOR/QUANTIFICATION/RABBITS/STROKE/THERAPY/THROMBOLYSIS/TISSUE-TYPE

Tatemichi, T.K., Foulkes, M.A., Mohr, J.P., Hewitt, J.R., Hier, D.B., Price, T.R. and Wolf, P.A. (1990), Dementia in Stroke Survivors in the Stroke-Data-Bank Cohort - Prevalence, Incidence, Risk-Factors, and Computed Tomographic Findings. Stroke, 21 (6), 858-866

Keywords: HEART/STROKE

Blizard, D.A., Challa, V.R., Iskandar, S.S., Eltamawy, M.S. and Adams, N. (1990), Modification of Stroke Susceptibility by Genotype-Dependent Maternal Influences. Stroke, 21 (11), 134-137

Keywords: HEART/STROKE

Hijdra, A., Verbeeten, B. and Verhulst, J.A.P.M. (1990), Relation of Leukoaraiosis to Lesion Type in Stroke Patients. Stroke , 21 (6), 890-894

Keywords: HEART/STROKE

Lowenthal, A. (1990), European Stroke Prevention Study. Stroke, 21 (8), 1122-1130

Keywords: HEART/STROKE

Keith, R.A. (1990), Status of Measurement in Stroke Rehabilitation Outcomes. Stroke, 21 (9), 30-31

Keywords: HEART/STROKE

Struck, L.K., Rodnitzky, R.L. and Dobson, J.K. (1990), Stroke and Its Modification in Parkinsons-Disease. Stroke, 21 (10), 1395-1399

Keywords: HEART/STROKE

Biller, J., Love, B.B., Marsh, E.E., Jones, M.P., Knepper, L.E., Jiang, D., Adams, H.P. and Gordon, D.L. (1990), Spontaneous Improvement After Acute Ischemic Stroke - A Pilot- Study. Stroke, 21 (7), 1008-1012

Keywords: HEART/STROKE

Mcbride, R. (1990), Design of A Multicenter Randomized Trial for the Stroke Prevention in Atrial-Fibrillation Study. Stroke, 21 (4), 538-545

Keywords: HEART/STROKE

Harmsen, P., Rosengren, A., Tsipogianni, A. and Wilhelmsen, L. (1990), Risk-Factors for Stroke in Middle-Aged Men in Goteborg, Sweden. Stroke, 21 (2), 223-229

Keywords: HEART/STROKE

Jongbloed, L. (1990), Problems of Methodological Heterogeneity in Studies Predicting Disability After Stroke. Stroke, 21 (9), 32-34

Keywords: BRITISH/HEART/STROKE

Yasaka, M., Yamaguchi, T., Miyashita, T. and Tsuchiya, T. (1990), Regression of Intracardiac Thrombus After Embolic Stroke. Stroke, 21 (11), 1540-1544

Keywords: HEART/STROKE

Hart, R.G., Foster, J.W., Luther, M.F. and Kanter, M.C. (1990), Stroke in Infective Endocarditis. Stroke, 21 (5), 695-700

Keywords: HEART/STROKE

Lenz, P., Luckhaus, G., Stasch, J.P. and Kazda, S. (1990), Therapy of Diseased Stroke-Prone Spontaneously Hypertensive Rats with Nimodipine. Stroke, 21 (12), 111-112.

Abstract: We investigated the therapeutic effect of nimodipine or parathyroidectomy in old, diseased stroke-prone spontaneously hypertensive rats by observing 98 male 1-year-old rats over 5 months. After stroke had occurred, the rats were divided into three groups: 1) parathyoidectomy, 2) nimodipine, and 3) controls. In the nimodipine group, the rats survived longer than those in the other groups. Blood pressure of the controls did not differ from the nimodipine-treated and parathyroidectomy animals. The increase in calcium content of brain and kidney tissues and of plasma renin activity, urea, and creatinine was attenuated by nimodipine or parathyroidectomy. The histology of the kidneys revealed widespread fibrinoid necrosis of arteries in all rats. In the nimodipine-treated or parathyroidectomy groups, healing of the lesions was detectable. Cerebral lesions were mainly characterized by fibrinoid necrosis. Nimodipine-treated as well as parathyroidectomied animals showed significantly fewer hypertensive cerebral lesions. In old, diseased stroke-prone spontaneously hypertensive rats, therapy with nimodipine or parathyroidectomy increased their survival rate. The cerebrovascular and renovascular lesions of treated animals were attenuated, and morphologic signs of healing were observed. Reduction of calcium overload by nimodipine or parathyroidectomy, even in an advanced stage of disease, had a therapeutic effect

Keywords: HEART/HYPERTENSION/NIMODIPINE/STROKE

Kitagawa, Y., Gotoh, F., Koto, A. and Okayasu, H. (1990), Stroke in Systemic Lupus-Erythematosus. Stroke, 21 (11), 1533-1539

Keywords: HEART/STROKE

Kellyhayes, M. (1990), Time Intervals, Survival, and Destination - 3 Crucial Variables in Stroke Outcome Research. Stroke, 21 (9), 24-26

Keywords: HEART/STROKE

Kohler, J., Kasper, J., Witt, I. and Vonreutern, G.M. (1990), Ischemic Stroke Due to Protein-C Deficiency. Stroke, 21 (7), 1077-1080

Keywords: HEART/STROKE

Yao, H., Sadoshima, S., Kuwabara, Y., Ichiya, Y. and Fujishima, M. (1990), Cerebral Blood-Flow and Oxygen-Metabolism in Patients with Vascular Dementia of the Binswanger Type. Stroke, 21 (12), 1694-1699.

Abstract: We performed clinical and neuroradiologic studies, including positron emission tomography, in five patients with vascular dementia of the Binswanger type. The clinical features of those cases consisted of slowly progressive dementia, together with vascular risk factors such as hypertension and often a history of minor stroke, and characteristic white matter lesions on brain computed tomograms or magnetic resonance images. Digital subtraction angiography of the cervical and intracranial arteries demonstrated no occlusive lesion in any patient. Both cerebral blood flow and the cerebral metabolic rate for oxygen were decreased in the parietal (73% of control), frontal (74-80%), and temporal (74-83%) cortices, where no abnormalities were detected by brain computed tomography or magnetic resonance imaging. We conclude that vascular dementia of the Binswanger type may be caused by disconnection between the cerebral cortex and subcortical structures due to ischemic damage in the white matter

Keywords: BRAIN/CEREBRAL BLOOD FLOW/CORTICAL ARTERIOSCLEROTIC ENCEPHALOPATHY/DEMENTIA/DISEASE/EMISSION COMPUTED- TOMOGRAPHY/HEART/LEUKOENCEPHALOPATHY/METABOLISM/O-15/STROKE

Tagami, M., Nara, Y., Kubota, A., Fujino, H. and Yamori, Y. (1990), Ultrastructural-Changes in Cerebral Pericytes and Astrocytes of Stroke-Prone Spontaneously Hypertensive Rats. Stroke, 21 (7), 1064-1071

Keywords: HEART/STROKE

Hermsmeyer, K., Hatton, D.A., Karanja, N. and Mccarron, D. (1990), Effects of Dietary Calcium on Nimodipine-Sensitive Calcium- Channel Function in Stroke-Prone Spontaneously Hypertensive Rats. Stroke, 21 (12), 98-101.

Abstract: We studied the effects of dietary Ca2+ on blood pressure, survival, and calcium channel function to investigate cardiovascular disease mechanisms in stroke-prone spontaneously hypertensive rats. Beginning at 3 weeks of age, rats were fed high sodium chloride diets (8.0%) in combination with either high (2.0%) or low (0.2%) Ca2+ group diets for 8 weeks. At 12 weeks of age, survival was 90% in the high Ca2+ group and 30% in the low Ca2+ group. The higher blood pressure and lower survival in the low Ca2+ group suggest an intensification of altered vascular muscle cell mechanisms by a dietary Ca2+ deficit. Nimodipine (1-10 nM) effectively blocked L-type Ca2+ currents in isolated vascular muscle cells from both groups. Contraction of isolated cells that were not patch clamped to high potassium solutions were also blocked by 1 nM nimodipine. Disappearance of the L-type Ca2+ channel current was accelerated by holding at depolarizing potentials (positive to -50 mV) and by depolarizing steps to 0 mV. Nimodipine block of the L-type Ca2+ currents in vascular muscle is believed to contribute substantially to antihypertensive properties and stroke prevention, actions that may develop fully only in stroke-prone spontaneously hypertensive rats on a diet of at least normal Ca2+

Keywords: CALCIUM/CALCIUM CHANNELS/HEART/HYPERTENSION/STROKE

Lyden, P.D., Madden, K.P., Clark, W.M., Sasse, K.C. and Zivin, J.A. (1990), Incidence of Cerebral-Hemorrhage After Antifibrinolytic Treatment for Embolic Stroke in Rabbits. Stroke, 21 (11), 1589-1593

Keywords: HEART/STROKE

Kinkel, W.R. (1990), Classification of Stroke by Neuroimaging Technique. Stroke, 21 (9), 7-8

Keywords: HEART/STROKE

Wooddauphinee, S.L., Williams, P.T.J.I. and Shapiro, S.H. (1990), Examining Outcome Measures in A Clinical-Study of Stroke. Stroke, 21 (5), 731-739

Keywords: HEART/STROKE

Kojima, S., Omura, T., Wakamatsu, W., Kishi, M., Yamazaki, T., Iida, M. and Komachi, Y. (1990), Prognosis and Disability of Stroke Patients After 5 Years in Akita, Japan. Stroke, 21 (1), 72-77

Keywords: HEART/STROKE

May, E.F. and Jabbari, B. (1990), Stroke in Neuroborreliosis. Stroke, 21 (8), 1232-1235

Keywords: HEART/STROKE

Lampl, Y., Paniri, Y., Eshel, Y. and Sarovapinhas, I. (1990), Cerebrospinal-Fluid Lactate-Dehydrogenase Levels in Early Stroke and Transient Ischemic Attacks. Stroke, 21 (6), 854-857

Keywords: HEART/STROKE

Steed, D.L., Peitzman, A.B., Grundy, B.L. and Webster, M.W. (1982), Causes of Stroke in Carotid Endarterectomy. Surgery, 92 (4), 634-641

Schuler, J.J., Flanigan, D.P., Lim, L.T., Keifer, T., Williams, L.R. and Behrend, A.J. (1982), The Effect of Carotid Siphon Stenosis on Stroke Rate, Death, and Relief of Symptoms Following Elective Carotid Endarterectomy. Surgery, 92 (6), 1058-1067

Jernigan, W.R., Fulton, R.L., Hamman, J.L., Miller, F.B. and Mani, S.S. (1984), The Efficacy of Routine Completion Operative Angiography in Reducing the Incidence of Perioperative Stroke Associated with Carotid Endarterectomy. Surgery, 96 (5), 831-838

Knox, J.B., Everson, C.T., Pellom, G.L., Hamm, D.P., Morris, J.J. and Wechsler, A.S. (1984), Right and Left-Ventricular Responses to Isoproterenol and Dopamine Assessed by Stroke Work-End Diastolic Dimension Analysis. Surgical Forum, 35 353-356

Tranmer, B.I., Gross, C.E., Kindt, G.W. and Adey, G.R. (1985), Effect of Pulsatile Vs Nonpulsatile Blood-Flow in the Treatment of Ischemic Stroke. Surgical Forum, 36 483-485

Yonekura, M., Austin, G., Poll, N. and Hayward, W. (1981), Evaluation of Cerebral Blood-Flow in Patients with Transient Ischemic Attacks and Minor Stroke. Surgical Neurology, 15 (1), 58-65

Yonekura, M., Austin, G. and Hayward, W. (1982), Long-Term Evaluation of Cerebral Blood-Flow, Transient Ischemic Attacks, and Stroke After Sta-Mca Anastomosis. Surgical Neurology, 18 (2), 123-130

Hirsh, L.F. (1982), Vasculitis, Thrombotic Thrombocytopenic Purpura, and Stroke After Aneurysm Surgery. Surgical Neurology, 17 (6), 426-428

Chang, C.N. and Defai, H. (1985), Stroke-In-Evolution - An Indication for An Emergency Extracranial Intracranial Bypass. Surgical Neurology, 23 (4), 443-446

Takeshita, M., Kagawa, M., Izawa, M. and Kitamura, K. (1986), Hemorrhagic Stroke in Infancy, Childhood, and Adolescence. Surgical Neurology, 26 (5), 496-500

Kapp, J.P., Smith, R.R., Peeler, D.F., Morrow, S. and Smith, E.S. (1988), Isovolemic Hemodilution in Stroke - A Study in Gerbils. Surgical Neurology, 29 (3), 191-193

Lee, K.S. and Davis, C.H. (1989), Stroke, Myocardial-Infarction, and Survival During Long-Term Follow-Up After Carotid Endarterectomy. Surgical Neurology, 31 (2), 113-119

Brenowitz, G. and Yonas, H. (1990), Selective Occlusion of Blood-Supply to the Anterior Perforated Substance of the Dog - A Highly Reproducible Stroke Model. Surgical Neurology, 33 (4), 247-252

Perepech, N.B. and Nedoshivin, A.O. (1986), Change in the Stroke Volume in Ventricular Extrasystoles. Terapevticheskii Arkhiv, 58 (11), 83-86

Oganov, R.G., Zhukovsky, G.S., Fedin, A.I., Varlamova, T.A., Migirov, A.A., Surkov, E.P. and Sidorov, A.M. (1989), Brain Stroke Morbidity and Mortality Among the Population of Moscow. Terapevticheskii Arkhiv, 61 (9), 29-32

Goloshchapov, O.A., Goldabin, V.I., Geller, A.L. and Mashin, A.A. (1990), Hemodynamic-Responses to the Calcium-Antagonists Verapamil and Nifedipine in Patients Suffering from Essential-Hypertension. Terapevticheskii Arkhiv, 62 (10), 149-152.

Abstract: As many as 98 patients suffering from essential hypertension (EH) were examined for the effects of verapamil and nifedipine. The hemodynamics and heart contractility were estimated by means of echocardiography on an "Aloka D-280" outfit (Japan). The following parameters of the cardio- and hemodynamics were computed: the stroke and minute blood volumes, cardiac index, mean velocity of ventricular evacuation, performance of the left heart, energy consumption by the myocardium, arterial pressure (systolic, diastolic and mean), total peripheral vascular resistance, ejection fraction, and the rate of circulatory shortening of myocardial fibers. Analysis of the effects of verapamil and nifedipine on the cardio- and hemodynamics in EH patients has demonstrated that in addition to their unidirectional action manifested by a steady hypotensive effect, the drugs under consideration produced an action of different directions as regards certain essential parameters in a considerable number of the patients

Okies, J.E., Page, U.S., Bigelow, J.C., Krause, A.H., Salomon, N.W. and Laxer, K.L. (1986), The Impact of Electroencephalography, Pressure, and Po2 Monitoring on the Risk of Stroke During Cardiopulmonary Bypass. Texas Heart Institute Journal, 13 (1), 97-104

Hart, R.G. and Sherman, D.G. (1987), Stroke and the Total Artificial-Heart - Neurologic Considerations. Texas Heart Institute Journal, 14 (1), 63-71

Saleem, S. and Saleem, A. (1981), Thromboembolism in Stroke Patients. Texas Medicine, 77 (5), 55-56

Oxford, S., Redford, D.S. and Albin, M.S. (1982), Unsuspected Foreign Object in Hypopharynx Following Stroke. Texas Medicine , 78 (9), 46-47

Vanderlinde, F. (1981), Risk-Factors for Stroke and Implications for Prevention. Therapeutische Umschau, 38 (8), 709-716

Zinn, W.M. (1981), Possibilities and Limitations of Rehabilitation Measures in Stroke Patients - Financial Consequences. Therapeutische Umschau, 38 (8), 776-790

Chappuis, C. (1987), Rehabilitation for Stroke. Therapeutische Umschau, 44 (3), 245-250

Hamann, H. (1988), Carotid Endarterectomy - Prevention of Stroke in Asymptomatic (Stage-I) and Symptomatic (Stage-Ii) Patients. Thoracic and Cardiovascular Surgeon, 36 (5), 272-275

Marx, P. (1989), The Value of Diagnostic Procedures in Treating Ischemic Attacks and Stroke. Thoracic and Cardiovascular Surgeon, 37 (4), 253-258

Mulley, G.P., Heptinstall, S., Taylor, P.M. and Mitchell, J.R.A. (1983), Adp-Induced Platelet-Release Reaction in Acute Stroke. Thrombosis and Haemostasis, 50 (2), 524-526

Matsuo, T., Shinomiya, K., Okuno, S., Matsuo, C. and Matsuo, O. (1984), Urinary-Excretion Rate of Antithrombin-Iii Related Antigen in Cerebral Stroke. Thrombosis and Haemostasis, 52 (3), 305-307

Umegaki, K., Inoue, Y. and Tomita, T. (1985), The Appearance of Exhausted Platelets at the Time of Stroke in Stroke-Prone Spontaneously Hypertensive Rats. Thrombosis and Haemostasis, 54 (4), 764-767

Tomita, T., Umegaki, K. and Hayashi, E. (1985), The Appearance of Exhausted Platelets Due to A Duration of Hypertension in Stroke-Prone Spontaneously Hypertensive Rats. Thrombosis Research, 37 (1), 195-200

Umegaki, K., Ikeda, M. and Tomita, T. (1986), Defective Calcium-Transport in Platelets from Stroke-Prone Spontaneously Hypertensive Rats. Thrombosis Research, 41 (3), 415-423

Lee, T.K., Chen, Y.C. and Kuo, T.L. (1987), Comparison of the Effect of Acetylsalicylic-Acid on Platelet- Function in Male and Female-Patients with Ischemic Stroke. Thrombosis Research, 47 (3), 295-304

Ikeda, M., Umegaki, K., Takeshita, N., Mitsubori, M., Tomita, T. and Tomita, I. (1989), Congenital Changes of Platelet Functions in Stroke-Prone Shr- Aggregability of Gel-Filtered Platelets, Prp and Whole-Blood, and Effects of Hypotensive Treatment. Thrombosis Research, 56 (3), 441-452

Ho, C.H., Hu, H.H. and Wong, W.J. (1989), The Serial Hemostasis-Related Changes in Patients with Cerebral Infarction - Comparison Between Progressing and Non-Progressing Stroke. Thrombosis Research, 56 (5), 635-647

Takano, K., Yamaguchi, T., Okada, Y., Uchida, K., Kisiel, W. and Kato, H. (1990), Hypercoagulability in Acute Ischemic Stroke - Analysis of the Extrinsic Coagulation Reactions in Plasma by A Highly Sensitive Automated-Method. Thrombosis Research, 58 (5), 481-491

Lowenthal, A. (1990), Secondary Prevention of Myocardial-Infarction in the 1St European Stroke Prevention Study. Thrombosis Research, 59-63.

Abstract: The first European Stroke Prevention Study (ESPS 1) showed that a statistically significant degree of secondary ischemic lesions could be prevented by combined therapy with aspirin (330 mg) and dipyridamole (75 mg) t.i.d. The risk of both central and myocardial secondary ischemic lesions was reduced by more than 30%. Similar results were seen after both transient ischemic attacks and stroke, and in both men and women

Keywords: ASPIRIN/DIPYRIDAMOLE/ESPS-1/MYOCARDIAL INFARCTION/SECONDARY PREVENTION/STROKE

Mojica, J.A.P., Nakamura, R., Kobayashi, T., Handa, T., Morohashi, I. and Watanabe, S. (1988), Effect of Ankle-Foot Orthosis (Afo) on Body Sway and Walking Capacity of Hemiparetic Stroke Patients. Tohoku Journal of Experimental Medicine, 156 (4), 395-401

Nakamura, R., Handa, T., Watanabe, S. and Morohashi, I. (1988), Walking Cycle After Stroke. Tohoku Journal of Experimental Medicine, 154 (3), 241-244

Nakamura, R., Hosokawa, T., Yamada, Y. and Mojica, J.A.P. (1988), Application of Computer-Assisted Gait Training (Cagt) Program for Hemiparetic Stroke Patients - A Preliminary-Report. Tohoku Journal of Experimental Medicine, 156 (2), 101-107

Nakamura, R., Watanabe, S., Handa, T. and Morohashi, I. (1988), The Relationship Between Walking Speed and Muscle Strength for Knee Extension in Hemiparetic Stroke Patients - A Follow-Up- Study. Tohoku Journal of Experimental Medicine,