School of child & adolescent health

Department of Paediatrics & Child Health

UNIVERSITY OF CAPE TOWN

ANNUAL RESEARCH DAYS 2013




ANNUAL RESEARCH DAYS 2015

Programme and Abstract Book

27^th & 28^th October

D3 Lecture Theatre, D Floor

Red Cross War Memorial Children’s Hospital




Courtesy of B. Morrow with permission

CPD Points
Tuesday, 27 October 2015 4 points

Wednesday, 28 October 2015 7 points
Please sign the attendance register on both days to claim your points.
^{PROGRAMME AND CONTENTS PAGE}
Oral Presentations Page No.

Tuesday, 27 October 2015

12H15 – 12H25 Welcome and Opening B Morrow

12H25 – 13H10 Keynote Address: “Research in the health sciences in South
Africa.” C. Stefan

Session 1: Chairperson: D Greenfield
13H15 – 13H30 Field evaluation of point-of-care testing for early infant diagnosis
in Cape Town, South Africa. L. Dunning 6
13H30 – 13H45 HIV exposed very low birth weight (<1500g) infants: are they all
really "high risk"? C. Levin 7

13H45 – 14H00 Vaccination of the preterm infant - is it feasible and safe? B. Louw 8

14H00 – 14H15 Bacteraemia in the neonatal unit at New Somerset Hospital: a
retrospective record review of blood cultures, 2011 - 2014. W. Mabaso 9
14H15 – 14H30 The influence of anaesthetic method on outcomes of preterm
infants delivered by caesarean section in a tertiary hospital in
South Africa: a pilot review. R. Stander 10

14H30 – 15H00 T E A & POSTERS

Session 2: Chairperson: R Ramesar
15H00 – 15H15 Clinical outcome of MLPA testing for intellectual disability at
Red Cross War Memorial Children's Hospital genetic clinic. K. Fieggen 11

15H15 – 15H30 Frequency of selected SNPS associated with kidney disease

amongst sickle cell disease patients in Africa. A. Geard 12
15H30 – 15H45 Identification of genetic features underlying a rare childhood
cancer syndrome: Constitutional Mismatch Repair Deficiency
(CMMR-D) syndrome. L. Lamola 13
15H45 – 16H00 Investigating the prevalence of selected MYO7A mutations
amongst a group of sub-Saharan African patients with non-
syndromic hearing loss. N. Manyisa 14

16H00 – 16H15 Distribution of sickle cell disease-related genetic markers in

malaria-free sub-Saharan African countries. K. Mnika 15

16H15 – 16H30 Hydroxyurea induces γ-Globin expression through micro-RNAs-

mediated actions in primary erythroid and K562 cells. G. Pule 16


Wednesday, 28 October 2015
Session 3: Chairperson: S Naidoo
08H30 – 08H45 A novel approach to ductal spasm during percutaneous device
occlusion of patent ductus arteriosus. R. de Decker 17

08H45 – 09H00 Increasing the efficiency of a paediatric cardiology clinic using

simulation optimisation. C. van Niekerk 18
09H00 – 09H15 Continuous flow peritoneal dialysis (CFPD) use in children with
AKI and inadequate ultrafiltration on convention peritoneal
dialysis (PD). P. Nourse 19

09H15 – 09H30 Pediatric lupus in South Africa: treatment and outcomes. C. Scott 20

09H30 – 09H45 A study of the aetiology and outcome of crescentic
glomerulonephritis in children presenting to the Red Cross
Children's Hospital. C. Mwaba 21
09H45 – 10H00 Treatment of infants with epilepsy: common practice across
the world. R. Burman 22

10H00– 10H15 Resolved lower limb muscle tone abnormalities in children with
HIV encephalopathy receiving standard antiretroviral therapy. T. Mann 23

10H15– 10H30 Review of liver injuries in young children. A.B. van As 24

10H30 – 11H00 T E A & POSTERS

Page No.
Session 4: Chairperson: B Eley
11H00 – 11H15 The effects on proning on regional ventilation in children with
acute respiratory distress syndrome (ARDS) or acute lung injury
(ALI) - a pilot study. B. Morrow 25

11H15 – 11H30 Chest radiographic abnormalities in HIV-infected African children

– a longitudinal study. R. Pitcher 26

11H30 – 11H45 Clinical predictors of culture confirmed pulmonary tuberculosis

(PTB) in a high TB and HIV prevalence area. L. Frigati 27
11H45 – 12H00 Microbiological yield from induced sputum compared to
oropharyngeal swab in young children with cystic fibrosis. M. Zampoli 28

12H00 – 12H15 The effect of body position on regional distribution of ventilation

and muscle activity in mechanically ventilated infants and
children. A. Lupton-Smith 29
12H15 – 12H30 Adenoviral pneumonia at Red Cross War Memorial Children's
Hospital: a retrospective descriptive study reviewing the
presentation, clinical course and outcomes of laboratory-confirmed
adenovirus associated pneumonia at RCWMCH. Z. Mukuddem-
Sablay 30
12H30 – 12H45 Lung function in HIV-infected adolescents on antiretroviral
therapy in Cape Town, South Africa. L. Githinji 31

12H45 – 13H00 Risk factors for Bordetella pertussis disease in hospitalised

children. R. Muloiwa 32


13H00 – 14H00 L U N C H (Venue: Tea Room, Johnson & Johnson Building, RXH)
Session 5: Chairperson: L Cooke
14H00 – 14H15 Every child counts - lessons from the South African child death
review pilot. S. Mathews 33
14H15 – 14H30 Descriptive study evaluating the use of the Road to Health Card
by doctors in a tertiary paediatric hospital setting. J. Wiles 34

14H30 – 14H45 An evaluation of the impact of outreach and support child health

services on level 2 and level 3 facilities. W. Breytenbach 35