Ştefan S. Nicolau” raport anual 2015 Şos. Mihai Bravu nr

CI3. Programul Organizaţiei Mondiale a Sănătăţii de evaluarea calităţii pentru determinarea virusului gripal tip A prin metode moleculare (WHO External Quality Assessment Programme for the Detection of Influenza Virus Type A by PCR)

Raport anual.

Anexa B
Lucrări elaborate în cursul anului 2015 în cadrul altor teme de cercetare
1. Popescu CP, Ceausu E, Florescu SA, Chirita D, Ruta S. Complications of Varicella in Unvaccinated Children from Romania, 2002-2013 - A Retrospective Study. Pediatr Infect Dis J. 2015 Nov 5. [Epub ahead of print] PubMed PMID: 26544989, revista ISI, FI=2.72.

2. Antipa C , Popa M, Măruțescu L, Bleotu C, Lazar V, Bertesteanu L, Grigore R, Bezirtzoglou E, Ruta SM. Virulence Profiles of Bacterial Strains Isolated From Periodontal Lesions. Rom Biotechnol Lett, 2015, 20(4), 10662-10669, revista ISI Romania, FI=0.404.

3. Antipa C, Flipescu AG, Anton G, Ruță S, The implication of herpesviruses in periodontal diseases- clinical report , Medicine in evolution, 2015; 21(2): 278-283 “revista B+ Romania”.

4. Comanescu C, Bleotu, C, Huica I, Radulescu M, Grancea C, Anton G. Non-invasive method for the evaluation of IL-6 and IL-10 levels in patients with chronic hepatitis C. Rom Biotechnol Lett, 2015, 20 (6)- revista ISI Romania, FI=0.404.

5. Tiliscan C, Arama V, Mihailescu R, Munteanu D, Streinu-Cercel A, Ruta S, Popescu C, Catana R, Lobodan A, Arama SS – Serum resistin is associated with inflammation in HIV-infected patients undergoing antiretroviral therapy Revista Română de Medicină Internă, 2015, 5. ISSN: 1220-5818, revistă indexată PubMed Central. “revista B+ Romania”.

6. Dita C, Colita A, Asan M, Gheorghe A, Arion, C “Modern Diagnostic Approach of Acute Lymphoblastic Leukemia in Children and Adolescents – Experience of a Single Pediatric Hematology-Oncology Center,” Mod. Med., vol. 22, no. 4, pp. 300–308, 2015.

7. Dita C, Colita A, Asan M, Gheorghe A, Jardan C, Dragomir M, Arion C. Outcome in pediatric acute lymphoblastic leukemia in children and adolescents using Oncology Center. Pract. MED, vol. 10, no. 4(41), pp.340–351, 2015.

8. Botezatu A, Puiu M, Cucu N, Diaconu CC, Badiu C, Arsene C, Iancu IV, Pleşa A, Anton G. Comparative molecular approaches in Prader-Willi syndrome diagnosis, Gene. 2016;575(2 Pt 1):353-8. doi: 10.1016/j.gene.2015.08.058. ISI, IF 2,138 (2014).

9. Comanescu C, Bleotu C, Huica I, Radulescu M, Grancea C, Anton G, Non-invasive method for the evaluation of Il-6 and Il-10 levels with chronic hepatitis C, Romanian Biotechnological Letters.2015; Vol.20 (6):10921- 10927, ISI, IF= 0,351.

10. Iancu I.V., Pleşa A, Botezatu A, Huică I., Stanescu A. D., Socolov D, Anton G. E5HPV16 mRNA expression pattern analysis in patients with cervical lesions in viral status context. Roum Arch Microbiol Immunol. 2015; Vol 74 (Nr 1-2), pg.33-39 (PubMed).

11. Huică I., Iancu I.V., Botezatu A., Banu O., Lupeanu E., Anton M. Circulating miR-21 and TGF-β1 expression levels in patients with cardiovascular diseases. J.Transl.Med.Res 2015; 20(3):132-137 (BDI).

12. Comanescu C, Arama V, Grancea C, Bleotu C, Radulescu M, Tiliscan C, Botezatu A, Anton G, The performance of a rapid test for anti-HCV screening in oral fluids, Roum Arch Microbiol Immunol. 2015; Vol 74 (Nr 1-2), pg.50-55 (PubMed).

13. Antipa C, Popa M, Marutescu L, Bleotu C, Veronica L, Bertesteanu S, Grigore R, Bezirtzoglou E, Ruta SM: Virulence Profiles of Bacterial Strains Isolated From Periodontal Lesions. Romanian Biotechnological Letters 20:10662-10669, 2015. (ISSN 1224-5984) IF: 0.404.

14. Beuran M, Negoi I, Paun S, Ion AD, Bleotu C, Negoi RI, Hostiuc S: The epithelial to mesenchymal transition in pancreatic cancer: A systematic review. Pancreatology 15:217-225, 2015. (ISSN 1424-3903) IF: 2.837.

15. Bleotu C, Chifiriuc MC, Lazar V, Dragusel R, Matei L, Aldea IM, Dragu LD, Ionescu B, Diaconu CC, Cernescu C, Mogoanta CA, Popescu CR, Popescu B, Grigore R, Bertesteanu. SVG: Influence of Staphylococcus aureus attachment to the herpes simplex virus infected cells. Romanian Journal of Morphology and Embryology 56:433-437, 2015. (ISSN (print) 1220-0522 / ISSN (on-line) 2066-8279) IF: 0.659.

16. Bolocan A, Mihaiescu DE, Andronescu E, Voicu G, Grumezescu AM, Ficai A, Vasile BS, Bleotu C, Chifiriuc MC, Pop CS: Biocompatible hydrodispersible magnetite nanoparticles used as antibiotic drug carriers. Romanian Journal of Morphology and Embryology 56:365-370, 2015. (ISSN 1220-0522) IF: 0.659.

17. Calu L, Badea M, Chifiriuc MC, Bleotu C, David G-I, Ionita G, Marutescu L, Lazar V, Stanica N, Soponaru I, Marinescu D, Olar R: Synthesis, spectral, thermal, magnetic and biological characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes with a Schiff base bearing a 1,2,4-triazole pharmacophore. Journal of Thermal Analysis and Calorimetry 120:375-386, 2015. (ISSN 1388-6150) IF: 2.042.

18. Ciulu-Costinescu F, Chifiriuc MC, Popa M, Bleotu C, Neamtu J, Averis LME, Bubulica MV, Simionescu A, Aldea IM, Belu I: Screening of Polyphenol Content and In vitro Studies of Antioxidant, Antibacterial and Cytotoxic Activities of Capsicum Annuum Extracts. Revista De Chimie 66:1261-1266, 2015. (ISSN 0034-7752) IF: 0.81.

19. Chivu-Economescu M., Rubach M. Hematopoietic stem cells therapies. Current Stem Cell Research and Therapy. 2015 Oct 26. Vol 10 [Epub ahead of print]. ISSN: 2212-3946 (Online) ISSN: 1574-888X (Print), IF: 2.212.

20. Dragu DL, Necula LG, Bleotu C, Diaconu CC, Chivu-Economescu M: Therapies targeting cancer stem cells: Current trends and future challenges. World J Stem Cells 7:1185-1201, 2015, ISSN1948-0210.

21. Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C: Antitumoral materials with regenerative function obtained using a layer-by-layer technique. Drug Design Development and Therapy 9:1269-1279, 2015. (ISSN 1177-8881) IF: 3.028.

22. Matei L, Bleotu C, Baciu I, Diaconu CC, Hanganu A, Banu O, Ionita P, Paun A, Tatibouet A, Zarafu I: Synthesis and biological activities of some new isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo 7.3.1.0(2.7) tridec-13-ylidene)-hydr azides. Bioorganic & Medicinal Chemistry 23:401-410, 2015. ISSN: 0968-0896, IF: 2.793.

23. Nitulescu GM, Draghici C, Olaru OT, Matei L, Ioana A, Dragu LD, Bleotu C: Synthesis and apoptotic activity of new pyrazole derivatives in cancer cell lines. Bioorganic & Medicinal Chemistry 23:5799-5808, 2015, ISSN: 0968-0896, IF: 2.793.

24. Tanase C, Albulescu R, Codrici E, Calenic B, Popescu ID, Mihai S, Necula L, Cruceru ML, Hinescu ME: Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma. Onco Targets Ther 8:81-90, 2015, ISSN: 1178-6930, IF: 2,31.

25. Tanase C, Albulescu R, Codrici E, Popescu ID, Mihai S, Enciu AM, Cruceru ML, Popa AC, Neagu AI, Necula LG, Mambet C, Neagu M: Circulating biomarker panels for targeted therapy in brain tumors. Future Oncology 11:511-524, 2015, ISSN 1479-6694, IF: 2,48.

26. Ionescu B, Ionescu D, Gheorghe I, Mihaescu G, Bleotu C, Sakizlian M, Banu O: Staphylococcus aureus virulence phenotypes among Romanian population. Biointerface Research in Applied Chemistry 5:945-948, 2015. (ISSN 2069-5837).

27. Olteanu AA, Arama C-C, Bleotu C, Lupuleasa D, Monciu CM: Investigation of cyclodextrin based nanosponges complexes with angiotensin i converting enzyme inhibitors (enalapril, captopril, cilazapril). Farmacia 63:492-503, 2015. (ISSN 0014-8237) IF: 1.005.

28. Stoica P, Chifiriuc MC, Rapa M, Bleotu C, Lungu L, Vlad G, Grigore R, Bertesteanu S, Stavropoulou E, Lazar V: Fabrication, characterization and bioevaluation of novel antimicrobial composites based on polycaprolactone, chitosan and essential oils. Romanian Biotechnological Letters 20:10521-10535, 2015. (ISSN 1224-5984) IF: 0.404.

29. Ionescu B, Ionescu D, Gheorghe I, Curutiu C, Banu O, Bleotu C, Mihaescu G, Lazar V, Grigore R, Bezirtzoglou E, Bertesteanu S: Virulence patterns of Staphylococcus aureus hospital strains isolated in Bucharest, Romania. Romanian Biotechnological Letters 20:10536-10546, 2015. (ISSN 1224-5984) IF: 0.404.

30. Ionescu D, Chifiriuc MC, Ionescu B, Cristea VC, Sacagiu B, Duta M, Neacsu G, Gilca R, Bleotu C, Bezirtzoglu E, Lazar V: Frequency and phenotypic virulence features of Streptococcus pyogenes strains isolated from throat carriage in Romanian population. Romanian Biotechnological Letters 20:10470-10477, 2015. (ISSN 1224-5984) IF: 0.404.

31. Janković A, Eraković S, Ristoscu C, Mihailescu Serban N, Duta L, Visan A, Stan GE, Popa AC, Husanu MA, Luculescu CR, Srdić VV, Janaćković Dj, Mišković-Stanković V, Bleotu C, Chifiriuc MC, Mihailescu IN. Structural and biological evaluation of lignin addition to simple and silver-doped hydroxyapatite thin films synthesized by matrix-assisted pulsed laser evaporation. J Mater Sci Mater Med. 26(1):5333, 2015. IF 2.587.

32. Gionea A, Andronescu E, Voicu G, Bleotu C, Surdu VA, Influence of hot isostatic pressing on ZrO2–CaO dental ceramics properties, Int J Pharm. In Press, Corrected Proof 2015 Oct 23. pii: S0378-5173(15)30312-4. doi: 10.1016/j.ijpharm.2015.10.044. IF 3.650.

33. Metoni A, Balanescu P, Dima A, Balanescu E, Badea C, Diaconu C C, Ionescu R A, Baicus C, Matei D, interleukin-17-association to silent lupus nephritis and disease activity. Journal of Translational and Research, 20 (2), 71-75, 2015. (ISSN 2392-7232).

34. Holban AM, Bleotu C, Chifriuc MC, Lazar V. Phenotypic and genetic evaluation of the influence of Pseudomonas aeruginosa culture fractions on the human mesenchymal stem cells viability, apoptotic pathways and cytokine profile. Curr Stem Cell Res Ther. 2015, vol 10, DOI: 10.2174/ 1574888X10666151026114817 IF=2.212.

35. Botezatu A, Bleotu C, Nastase A, Anton G, Bacalbasa N, Duda D, Dima SO, Popescu I. Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma. Cancer Genomics Proteomics. 2015;12(1):21-30. IF=2.7.

36. Potențiale ținte moleculare pentru terapia cancerului gastric. Laura G. Necula, Mihaela Chivu-Economescu, Denisa Dragu, Coralia Bleotu, Gabriel Constantinescu, Simona O. Dima, Irinel Popescu, Carmen C. Diaconu. Simpozionul „Academician Nicolae Cajal”. 1 – 4 aprilie 2015. Hotel Novotel City Center, București. Comunicare orală. Lucrarea prezentată în cadrul Simpozionului „Academician Nicolae Cajal” a primit Premiul Herbert Berler – Barbu (Premiul pentru tineri cercetători).

37. Studiul preliminar al citotoxicității și activității antivirale a unor compuși bioactivi naturali (Preliminary research on cytotoxicity and antiviral activity of some natural bioactive compounds), Ioana M. Aldea, Daniela Ionescu, Coralia Bleotu, Mihaela Chivu Economescu, Lilia Matei, Iuliana Crisan, Stefan Stangaciu, Daniela A. Ion, Carmen C. Diaconu, Simpozion Academician Nicolae Cajal, editia a X-a; 01 – 04 aprilie 2015, Hotel Novotel City Center, București, Comunicare orală.

38. New Isoniazid Derived Hydrazones with Anti-Tubercular Activity. Matei L, Aldea IM, Bleotu C, Zarafu I, Mambet C, Neagu AI, Baciu I, Hanganu A, Banu O, Ionita P, Paun A, Tatibouët A, Diaconu CC. Simpozionul "Academician Nicolae Cajal" Editia a X-a, 1-4 Aprilie, 2015. Hotel Novotel City Center, București, Comunicare orală.

39. Synthesis and evaluation of anti-tumoral activity of some new hydrazides and hydrazones. Matei L, Bleotu C, Baciu I, Aldea IM, Paun A, Ionita P, Nemes R, Limban C, Zarafu I. 19th Romanian International Conference of Chemistry and Chemical Engineering, 2-5 Septembrie, 2015. Sibiu, Comunicare orală.

40. Papilomul Inversat Rino-Sinusal- o Continuă Provocare Virusologică și Chirurgicală, Al II-lea Congres National Interdisciplinar de Human Papilomavirus, 18-20 Iunie 2015 București, Vlad Budu, Ionut Bucescu, Alina Năstăsie.

41. Plasma cytokines in distinct phenotypes of JAK2V617F-mutated essential thrombocythemia. Cristina Mambet, Coralia Bleotu, Laura G. Necula, Ioana M. Aldea, Ana I. Neagu, Lilia Matei, Denisa Dragu, Mihaela Chivu Economescu, Carmen C. Diaconu. Congresul Universităţii de Medicină şi Farmacie “Carol Davila” Bucureşti, Ediția a III-a, 28-30 mai 2015, Palatul Parlamentului – București. Poster.

42. Lectura unui hematolog despre indicii trombocitari și relația  lor cu patologia vasculară și bolile maligne - Prof. Dr. Delia Mut-Popescu, Spit. Clinic Colțea, Dr. Silvana Angelescu, UMF Carol Davila, Spit. Clinic Colțea, Dr. Cristina Mambet. A 4-a Conferință Națională a Societății Române de Hemostază și Tromboză, 5-7 noiembrie 2015, Hotel Novotel București. Comunicare orală.

43. Probleme în evaluarea numărului de trombocite în laborator – Dr. Cristina Mambet, Dr. Ileana Apostolescu, Dr. Alina Ionelia Ganță, Dr. Carmen Rotaru, Dr. Antoanela Curici. A 4-a Conferință Națională a Societății Române de Hemostază și Tromboză, 5-7 noiembrie 2015, Hotel Novotel București. Comunicare orală.

44. Rolul Interleukinei -17 (IL-17) in afectarea renala si cardiovasculara la pacientii cu lupus eritematos sistemic, Adriana Metoni, Paul Balanescu, Carmen C Diaconu, Dumitru Matei, Cristian Baicus, Simpozionul "Academician Nicolae Cajal" Editia a X-a, 1-4 Aprilie, 2015. Hotel Novotel City Center, București, Comunicare orală.

45. Popescu Elena-Silvia, Nicolae-Daniel Pirici, Carmen Cristina Diaconu, Daniela Adriana Ion, “Rolul AQP-4 in menţinerea echilibrului hidric la nivel cerebral”/ „The role of AQP-4 in maintaining the hydric balance in the brain, Congresul Național cu participare internațională Clasic si modern in fiziopatologie: O abordare integrativa in educaţie si cercetare, 07-10.05.2015 Iasi, Comunicare orală.

46. Evidence-based management of staphylococcal infections. Săndulescu O, Bleotu C, Aldea IM, Streinu-Cercel A, Chifiriuc MC, Rafila A, Tălăpan D, Dorobăț O, Neguț AC, Berciu I, Streinu-Cercel. The 11th Edition of the Scientific Days of the National Institute of Infectious Diseases “Prof.Dr. Matei Balş”, Bucharest, Romania, 14-16 October 2015. Abstract volume ISSN 2457-8525, page 25-26 – lucrare premiata in cadrul conferintei. Comunicare orală.

47. Prevalenta genotipurilor HPV cu risc crescut in probe de citologie cervicovaginala la paciente din Romania. Stroe R, Mambet C, Ivan F, Alexa L, Morjan C, Bleotu C, Lazar V. Sesiunea de comunicari Stiintifice a Studentilor Facultatii de Biologie, 29 mai 2015, Bucuresti, Romania Comunicare orală.

48. Phenotypic profile of Staphylococcus spp. A study on biofilm formation in clinical versus commensal strains. Săndulescu O, Bleotu C, Streinu-Cercel A, Neguț AC, Chifiriuc C, Lazar V, Berciu I, Calistru PI, Ion DA, Streinu-Cercel A. Cel de-al treilea Congres Științific cu participare internațională al Universității de Medicină și Farmacie Carol Davila din București, 28-30 mai 2015, București. Abstract publicat în jurnalul Mædica - a Journal of Clinical Medicine, indexat BDI (PubMed, EBSCO). Comunicare orală.

49. Modificări ale căilor de semnalizare în cancerul gastric – posibile ținte terapeutice. Ioana M. Aldea, Laura G. Necula, Mihaela Chivu Economescu, Lilia Matei, Coralia Bleotu, Denisa Dragu,Gabriel Constantinescu, Simona O. Dima, Irinel Popescu, Carmen C. Diaconu, Manifestarea stiintifica: Sesiunea anuală a institutului “Victor Babes” al 8-lea Simpozion Naţional de Patologie Medicina de precizie – de la modele experimentale la biomarkeri; 19-21.11.2015, INCD Victor Babeș, București, Poster.

50. Phage susceptibility and biofilm-inhibition in clinically relevant methicillin-resistant staphylococci. Alina Cristina Neguț, Oana Săndulescu, Marcela Popa, Anca Streinu-Cercel, Coralia Bleotu, Otilia Banu, Mariana Carmen Chifiriuc, Adrian Streinu-Cercel, Mircea-Ioan Popa. 21st Biennial Evergreen International Phage Meeting, 2-7 august 2015, Olympia, SUA, Poster.

51. Antitumoural role of mast cells in gastric neoplasia: New evidence. Micu GV, Popp C, Cioplea M, Stoica G, Pop G, Bosa M, Bleotu C, Staniceanu F. Al 27-lea Congres European de Patologie in 5-9 septembrie 2015, Belgrad, PS-08-044, publicat in Virchows Archives, Eur. J Pathol, 467, 1, S129, 2015. Poster.

52. Nanoarchitectonics based on magnetite functionalized with plant-derived compounds alter the adherence, invasion and secretory features in Pseudomonas aeruginosa. Holban AM, Chifiriuc MC, Grumezescu A, Bleotu C, Lazar V, Andronescu E. 25th ECCMID, 25-28. 04.2015, Copenhagen, Denmark. Poster.

53. Antimicrobial effect of magnetite nanoarchitectonics functionalized with plant-derived compounds against methicillin resistant Staphylococcus aureus. Holban AM, Grumezescu V, Chifiriuc MC, Grumezescu AM, Bleotu C, Vasile O, Lazar V, Andronescu E. European Materials Search Society (EMRS 2015), 11-15.05.2015, Lille, Franta. Poster.

54. Prevalence of plasmid mediated beta-lactam genes amongst ESBL and CRE Klebsiella pneumoniae strains isolated from patients with cardiovascular disease. Banu O, Bleotu C, Burtea M, Cobzar I, Gheorghe I, Chifiriuc C. 40th FEBS Congress, 4-9.07.2015, Berlin, Germania. Poster.

55. Calcipressin plasma level difference between atherosclerotic and non-atherosclerotic subjects. Torac E, Magda SL, Vinereanu D, Gaman L, Stoian I, Torac A, Roceanu A, Bleotu C, Atanasiu V. Atherosclerosis Congress 241(1):E148, 2015, IF 3,99, Glasgow, UK. Poster.

56. Determinants of staphylococcal virulence in commensal and clinical strains. Săndulescu O, Bleotu C, Aldea IM, Streinu-Cercel A, Rafila A, Tălăpan D, Dorobăț O, Chifiriuc MC, Neguț AC, Berciu I, Streinu-Cercel A. The 11th Edition of the Scientific Days of the National Institute of Infectious Diseases “Prof.Dr. Matei Balş”, Bucharest, Romania, 14-16 October 2015. Abstract volume ISSN 2457-8525, page 62-3. Poster

57. Cyto-adhesion and internalization patterns of Staphylococcus spp. strains from clinical infection versus asymptomatic nasal carriage. Săndulescu O, Bleotu C, Streinu-Cercel A, Berciu I, Diaconu CC, Aldea IM, Neguț AC, Calistru PI, Ion DA, Streinu-Cercel A. Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) and International Society of Chemotherapy (ISC)’s International Congress of Chemotherapy and Infection (ICC), San Diego, California, USA. 17-21 septembrie 2015. Poster.

Anexa C
Cărţi (capitole de carte) editate în edituri din ţară/străinătate

1. Voicu V (coordonator); colectiv : Stoian M, Sima A, Ruta S, Diaconu CC, Anton G, Constantinescu SN, Capitolul Sanatatea- de la biologia moleculara la medicina personalizata de varf in Romania, aparut in volumul Strategia Academiei Române de dezvoltare a României în următorii 20 de ani / coord.: Valentin-Ionel Vlad. Editura Academiei Române, Vol. 1, 2015, ISBN 978-973-27-2556-6.

2. Botezatu A, Iancu IV, Popa O, Pleşa A, Manda D, Huica I, Vladoiu S, Anton G, Badiu C  Carcinogenesis in Human – (capitolul) The Multifactorial Foundation and Deciphering the Mechanisms-Mechanisms of oncogene activation, Book edited by: Dmitry Bulgin ISBN 978-953-51-4382-6, Publisher: InTech,  ISBN 978-953-51-0858-0
3. Coralia Bleotu, Demetra Socolov, Mariana Anton, Anca Botezatu, Adriana Plesa, Iulia Virginia Iancu, Lorelei Irina Brasoveanu, Gabriela Anton and Carmen Cristina Diaconu, Interplay of Epigenetics with Gynecological Cancer, in Gynecologic Cancers - Basic Sciences, Clinical and Therapeutic Perspectives, Editura Intech, in press.

Anexa D
Articole stiinţifice apărute în reviste de specialitate din străinătate
1. Popescu CP, Ceausu E, Florescu SA, Chirita D, Ruta S. Complications of Varicella in Unvaccinated Children from Romania, 2002-2013 - A Retrospective Study. Pediatr Infect Dis J. 2015 Nov 5. [Epub ahead of print] PubMed PMID: 26544989, revista ISI, FI=2.72.

2. Ozaras R, Corti G, Ruta S, Lacombe K, Mondelli M, Irving W, Puoti M, Khalighi A, Santos ML, Harxhi A, Lazaravic I, Soriano V, Gervain J, Leblebicioglu H, Salmon D, Arends J, on behalf of ESCMID Study Group for Viral Hepatitis, Differences in Availability of Diagnostics and Treatment Modalities for Chronic Hepatitis B Across Europe. Clin Microbiol Infect. 2015, pii: S1198-743X(15)00692-8.doi: 10.1016/j.cmi.2015.07.002. [Epub ahead of print] PMID:26166544., revista ISI, FI=5,768.

3. Ruta S, Cernescu C., Injecting drug use: A vector for the introduction of new hepatitis C virus genotypes. World J Gastroenterol. 2015;21(38):10811-23. doi: 10.3748/wjg.v21.i38.10811. PMID: 26478672, revista ISI, FI=2.36.

4. Ene L, Duiculescu D, Tardei G, Ruta S, Smith D, Mehta S, Letendre S, Achim C, Hepatitis B virus compartmentalization in the cerebrospinal fluid of HIV-infected patients Clin Microbiol Infect. 2015, 21(4): 387.e5-8. doi: 10.1016/j.cmi.2014.11.012..PMID: 25658525; revista ISI, FI=5,768.

5. Ruta S, Sultana C, Oprea C, Vagu C, Ceausu E, Cernescu C. HCV non1b genotypes are becoming prevalent in injecting drug users from Romania, acceptat spre publicare in Journal of Infection in Developing Countries- revista ISI, FI=1.3.

6. Botezatu A, Bleotu C, Nastase A, Anton G, Bacalbasa N, Duda D, Dima SO, Popescu I. Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma, Cancer Genomics Proteomics. 2015, 12(1):21-30. ISI, IF= 2,7 (2014).

7. Botezatu A, Puiu M, Cucu N, Diaconu CC, Badiu C, Arsene C, Iancu IV, Pleşa A, Anton G. Comparative molecular approaches in Prader-Willi syndrome diagnosis, Gene. 2016;575 (2 Pt 1):353-8. doi: 10.1016/j.gene.2015.08.058. ISI, IF 2,138 (2014).

8. Grigoroiu-Serbanescu M, Diaconu CC, Heilmann-Heimbach S, Neagu AI, Becker T: Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients. Psychiatry Res, 2015. ISSN: 0165-1781, IF: 2,467.

9. Beuran M, Negoi I, Paun S, Ion AD, Bleotu C, Negoi RI, Hostiuc S: The epithelial to mesenchymal transition in pancreatic cancer: A systematic review. Pancreatology 15:217-225, 2015. (ISSN 1424-3903) IF: 2.837.

10. Calu L, Badea M, Chifiriuc MC, Bleotu C, David G-I, Ionita G, Marutescu L, Lazar V, Stanica N, Soponaru I, Marinescu D, Olar R: Synthesis, spectral, thermal, magnetic and biological characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes with a Schiff base bearing a 1,2,4-triazole pharmacophore. Journal of Thermal Analysis and Calorimetry 120:375-386, 2015. (ISSN 1388-6150) IF: 2.042.

11. Chivu-Economescu M., Rubach M. Hematopoietic stem cells therapies. Current Stem Cell Research and Therapy. 2015 Oct 26. [Epub ahead of print]. ISSN: 2212-3946 (Online)
ISSN: 1574-888X (Print), IF: 2.212.

12.Dragu DL, Necula LG, Bleotu C, Diaconu CC, Chivu-Economescu M: Therapies targeting cancer stem cells: Current trends and future challenges. World J Stem Cells 7:1185-1201, 2015, ISSN1948-0210.

13. Ficai D, Sonmez M, Albu MG, Mihaiescu DE, Ficai A, Bleotu C: Antitumoral materials with regenerative function obtained using a layer-by-layer technique. Drug Design Development and Therapy 9:1269-1279, 2015. (ISSN 1177-8881) IF: 3.028.

14. Matei L, Bleotu C, Baciu I, Diaconu CC, Hanganu A, Banu O, Ionita P, Paun A, Tatibouet A, Zarafu I: Synthesis and biological activities of some new isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo 7.3.1.0(2.7) tridec-13-ylidene)-hydr azides. Bioorganic & Medicinal Chemistry 23:401-410, 2015. ISSN: 0968-0896, IF: 2.793.

15. Necula LG, Mambet C, Albulescu R, Diaconu CC: Epigenetics in gastric carcinogenesis: TET genes as important players. J Immunoassay Immunochem 36:445-455, 2015, ISSN: 1532-4230, IF: 0,73.

16. Nitulescu GM, Draghici C, Olaru OT, Matei L, Ioana A, Dragu LD, Bleotu C: Synthesis and apoptotic activity of new pyrazole derivatives in cancer cell lines. Bioorganic & Medicinal Chemistry 23:5799-5808, 2015, ISSN: 0968-0896, IF: 2.793.

17. Tanase C, Albulescu R, Codrici E, Calenic B, Popescu ID, Mihai S, Necula L, Cruceru ML, Hinescu ME: Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma. Onco Targets Ther 8:81-90, 2015, ISSN: 1178-6930, IF: 2,31.

18. Tanase C, Albulescu R, Codrici E, Popescu ID, Mihai S, Enciu AM, Cruceru ML, Popa AC, Neagu AI, Necula LG, Mambet C, Neagu M: Circulating biomarker panels for targeted therapy in brain tumors. Future Oncology 11:511-524, 2015, ISSN 1479-6694, IF: 2,48.

19. Janković A, Eraković S, Ristoscu C, Mihailescu Serban N, Duta L, Visan A, Stan GE, Popa AC, Husanu MA, Luculescu CR, Srdić VV, Janaćković Dj, Mišković-Stanković V, Bleotu C, Chifiriuc MC, Mihailescu IN. Structural and biological evaluation of lignin addition to simple and silver-doped hydroxyapatite thin films synthesized by matrix-assisted pulsed laser evaporation. J Mater Sci Mater Med. 26(1):5333, 2015. IF 2.587.

20. Gionea A, Andronescu E, Voicu G, Bleotu C, Surdu VA, Influence of hot isostatic pressing on ZrO2–CaO dental ceramics properties, Int J Pharm. In Press, Corrected Proof 2015 Oct 23. pii: S0378-5173(15)30312-4. doi: 10.1016/j.ijpharm.2015.10.044. IF 3.650.

21. Holban AM, Bleotu C, Chifriuc MC, Lazar V. Phenotypic and genetic evaluation of the influence of Pseudomonas aeruginosa culture fractions on the human mesenchymal stem cells viability, apoptotic pathways and cytokine profile. Curr Stem Cell Res Ther. 2015, vol 10, DOI: 10.2174/1574888X10666151026114817 IF=2.212.

22. Popescu D., Ichim L., Fratila R., Gornea D., Robotic system sed for navigation and tracking, in real time, with the obstacle avoidance, Advanced Materials Research, vol. 1077, pp. 221–226, 2015, ISSN: 1662-8985.