Traditional Posters: Body Imaging
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| Hepato-Biliary & Liver
Hall B Monday 14:00-16:00 2581. Fat Content Quantification Errors Using Multiple Gradient Echo Imaging: A Phantom and Simulation Study Benjamin Leporq1, Hélène Ratiney1, Sophie Cavassila1, Frank Pilleul2, Olivier Beuf1 1Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Villeurbanne, France; 2Université de Lyon, Creatis-LRMN, CNRS UMR 5220, Inserm U630, INSA-Lyon, Université Lyon 1, Hospices Civils de Lyon, Lyon, France In the past decade, the incidence increase of obesity, diabetes and lipid metabolism disorders involved an epidemic increase of Non-Alcoholic Fatty Liver Diseases (NAFLD) in the occidental population. Because NAFLD can evolve into Non-Alcoholic Steato-Hepatitis (NASH) and may lead to liver fibrosis up to cirrhosis, a clinical follow-up of NAFLD would be very valuable. This work investigated fat content quantification error using different models based on multiple gradient echo imaging and presents some computer simulations, phantom study and examples of in-vivo application. Multiple gradient echo acquisitions with two different flip angles associated with a model correcting for T1 saturation and T2* decay appears to be a simple but effective non-invasive method available on all clinical systems to monitor patients with chronic liver diseases. 2582. Improvements in Hepatic Stiffness Assessment with 3-D/3-Axis MR Elastography Meng Yin1, Kevin J. Glaser1, Jun Chen1, Jayant A. Talwalkar2, Armando Manduca1, Richard L. Ehman1 1Department of Radiology, Mayo Clinic, Rochester, MN, United States; 2Division of Gastroenterology, Mayo Clinic, Rochester, MN, United States One advantage of liver MR elastography (MRE) over biopsy or ultrasound-based transient elastography is its ability to reduce sampling errors by measuring liver stiffness over a large portion of the liver. While existing 2-D or localized approaches yield valid results in a substantial part of the volume, a full 3-D/3-axis wave analysis is required for valid measurements of stiffness throughout the entire liver. This investigation compares a 2-D and a 3-D approach for liver MRE and demonstrates that 3-D MRE analysis improves the homogeneity of hepatic stiffness estimates. 2583. A Software Tool for Volume Registration and Atlas-Based Segmentation of Human Fat-Water MRI Data in Longitudinal Studies Anand Arvind Joshi1, H Harry Hu2, Michael Goran3, Richard Leahy2, Arthur Toga1, Krishna Nayak2 1Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States; 2Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles; 3Keck School of Medicine, University of Southern California, Los Angeles, CA Obesity continues to be a worldwide epidemic. Accurate quantification of subcutaneous and visceral adipose tissue depot volumes and the degree fat infiltration in the liver, the pancreas, skeletal muscle, and the kidneys, are important endpoints in determining the efficacy of therapeutic and interventional measures against obesity. For example, in longitudinal studies, measures are taken at multiple time points in each subject to determine the effects of diet, exercise, lifestyle modifications, and surgery, on fat quantity and distribution. In this work, we present an automated atlas-based tool for performing 3D volume registration and segmentation of abdominal adipose tissue depots and organs. 2584. Orthotopic Liver Transplantation: MRI Based Measurement of Donor Graft Steatosis, Graft Performance and Outcome. David John Lomas1, Richard T. Black1, Andrew J. Patterson1, Kieren G. Hollingsworth1, Susan Davies2, Graeme J. Alexander3, Mike E. Allison3, Neville V. Jamieson4, Alex E. Gimson3, Raaj K. Praseedom4, Chris J. Watson4 1Radiology, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 2Pathology, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 3Hepatology, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 4Surgery, University of Cambridge & Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom The results of rapid MRI based measurement of donor graft steatosis immediately prior to orthotopic liver transplantation in 49 patients were correlated with surgical and histopathology estimates, first week graft performance and 3 and 12 month outcomes. MR measurements correlated significantly with the other steatosis estimates but did not correlate with early serum performance markers. Both MRI and pathology estimates indicated significantly increased graft steatosis in those grafts failing at 3 months but not at 12 months. Such MRI based measurements may be a valuable tool for further investigating the impact of graft steatosis on transplant outcomes. 2585. Effect of Intravenous Gadolinium on Estimation of Liver Stiffness with MR Elastography Yüklə 458,11 Kb. Dostları ilə paylaş:
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