Course Organizers (2008-2009)
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| 8 - CANCER
5 -16 January 2009 IPATIMUP (GABBA Program) Organizer: Raquel Seruca, IPATIMUP The aims: The Oncobiology module will approach the biological/molecular mechanisms of cancer development and progression. All sessions will be based on the discussion of clinical cases followed by open discussions with the students about the underlying aetiological factors (environmental and epigenetic) and the biological pathways underlying pathological lesions. The structure:
Second week - morning lectures followed by lab-contact in the afternoon. All sessions will have a common structure that should follow the following scheme. 1- Presentation of clinical case/s (sporadic or hereditary) 2- Pathological aspects of the tumours 3- Aetiology and molecular basis of the disease 4- Cellular effects mediated by the cancer associated factors 5- Signalling pathways involved Faculty: Senior Researchers and Professors at IPATIMUP. Post-Doc students. Robert Hofstra, University Medical center Groningen, Holland Marc Mareel, Ghent University Hospital, Ghent, Belgium 9 - IMMUNE DISORDERS 19-23 January 2009 Organizer: Luis Graça, FML/IMM Aims: To introduce cutting-edge immunology research and concepts. A few representative topics related to current immunology were selected. These topics include: innate immunity, cytokines, and immune regulation. Proposed daily routine: 9.00 Introduction to the day (the basics for non-immunologists) 10.00 The broad context of the research topic (guest speaker or post-doc from group) 12.00 Research seminar 13.00 lunch break 14.30 Journal club and discussion (presentation of selected papers by students, discussion with guests). Faculty
Topics J-L Casanova, Paris. Pattern recognition receptors and immune deficiency, clinical studies Crystal L. Mackall, NIH, Bethesda. IL-7 influence on lymphocyte reconstitution, clinical studies. Herman Waldmann, Oxford. Immune regulation with monoclonal antibodies in transplantation tolerance. Luciano Adorini, BioXell, Milan. Immunomodulation of dendritic cells.
It is the aim of the module in Clinical Microbiology to discuss the state of the art in the microbiologic diagnosis of infections; the ecology, epidemiology and population biology of microbial pathogens; the current and future strategies for the prophylaxis of infections and the molecular aspects of pathogenesis. To achieve these aims a bacterium, a parasite and a virus were chosen as models. The section dedicated to infections caused by Streptococcus pneumoniae will have a strong focus on the recent paradigm shifts in the management of these infections. The promises and pitfalls of novel diagnostic tools and the problem of antibiotic resistance will be addressed. Emphasis will be provided on molecular epidemiology and the novel understanding it is affording on the recent evolution and population biology of this bacterium and their implications for our understanding of the infections it causes. Dr. Keith Klugman (Division of Infectious Diseases, Emory University School of Medicine, Atlanta, USA) will be our invited speaker. Dr. Klugman has a longstanding interest in the pneumococcus and has been involved in the study of many aspects of its ecology and evolution from a medical standpoint. Simple lab demonstrations are planned to reinforce concepts discussed in the lectures. The overall aim of the malaria´s days will be to give a general picture of the main areas of research in the malaria field. We will focus on the areas studying basic biological phenomena during the many Plasmodium life cycle stages. In particular, we will give special emphasis to the pre-erythrocytic stages and to the more recent genomic approaches. Dr. Mike Blackman (National Institute for Medical Research, Mill Hill, London, UK) will be our special invited speaker. His lab has been studying for many years the process of parasite invasion of red blood cells, focusing on parasite proteases. Recently, his lab has described in a CELL paper a new parasite secretory organelle that contains some of these proteases that control parasite invasion. His experience studying basic biology of a so important step of Plasmodium life cycle will be a beautiful example for the students. Influenza virus was chosen as the viral model system to illustrate basic concepts of virus replication, pathogenesis, epidemiology and ecology. Particular relevance will be put into why novel influenza viruses that circulate naturally in avian reservoirs emerge, either through genetic reassortment or through direct transmission, in the human population to cause pandemics. To this end, we intend to invite Dr Albert Ostrehaus (Erasmus MC at the University of Rotterdam), who is particularly interested in viruses that cross species barriers, are highly pathogenic and which cause disease globally. His research is focused with working on a vaccine against avian flu, as well as studying the pathogenesis and the host range, why the virus crosses the species barrier and under what conditions. Dr. Osterhaus is also investigating the stability of the virus and the possibility for genetic recombination and reassortment between different strains, which could give rise to more dangerous infections. Dr. Osterhaus is an excellent communicator thus inspiring for the students. Faculty
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