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Curriculum Vitae David J. Grdina

CURRICULUM VITAE

NAME: DAVID J. GRDINA



EDUCATION:
University of Houston M.B.A.

Houston, Texas (Finance) 1980


University of Kansas Ph.D.

Lawrence, Kansas (Radiation Biophysics) 1971


University of Kansas M.S.

Lawrence, Kansas (Radiation Biophysics) 1969


St. Mary's College B.A.

Winona, Minnesota (Biology) 1966


Section of Experimental Biology Postdoctoral Fellow March 1971 -

The University of Texas System in Biology May 1972

Cancer Center, M.D. Anderson

Hospital and Tumor Institute,

Houston, Texas
PROFESSIONAL EXPERIENCE:
Department of Radiation and Cellular Professor of Radiation July 1987-

Oncology, The University of Chicago and Cellular Oncology Present

Chicago, Illinois

Associate Professor of Jan. 1985 -

Radiation and Cellular June 1987

Oncology


University of Chicago Co-Program Leader Oct. 1994 -

Cancer Research Center Chemoprevention July 2000

Center for Mechanistic Biology Head, Section of Nov. 1991 -

and Biotechnology Radiation Biology Sept. 1996

(formerly, Biological and Medical

Research Division) Senior Scientist, June 1987 -

Argonne National Laboratory, Group Leader, Sept. 1996

Argonne, Illinois Radiation Carcinogenesis

(Joint Appt. U. of C.)

Scientist, Group Leader, Sept. 1983 -

Radiation Carcinogenesis June 1987
Department of Therapeutic Radiology, Adjunct Associate April 1984 -

Rush Medical College, Rush- Professor March 1985

Presbyterian-St. Luke's Medical Center,

Chicago, Illinois


Department of Experimental Associate Biologist and Sept. 1978 -

Radiotherapy, The University Associate Professor of Sept. 1983

of Texas System Cancer Center, Radiotherapy (Biology)

M.D. Anderson Hospital and

Tumor Institute, Houston, Texas Assistant Biologist and Sept. 1975 -

Assistant Professor of Aug. 1978

Radiotherapy (Biology)
Research Associate June 1972 -

Aug. 1975


Baylor College of Medicine and Visiting Lecturer June-Aug. 1976

St. Luke's Episcopal Hospital Biological Effects Sept. 1983

Houston, Texas, in conjunction of Nuclear Medicine

with University of Houston

School of Nuclear Medicine

Technology


PROFESSIONAL CONSULTANTSHIPS:
National Institutes of Health Consultant

Bethesda, MD Radiation Study Section 1990-1994

Reviewers Reserve 1994-present
National Cancer Institute NCI Discovery and 2007-present

Development P01


HollisEden Consultant 2004-2007
Pinnacle Biologics Consultant 2009-present
Congressional Pharmaceuticals Founding Scientist 2001-2004

Corporation


PrevOnc (Prevention of Oncogenesis) Founding Scientist 1999-2001
Radiation Oncology Modifiers Founding Scientist 1997-1998

Corporation (ROMCOR)


Odyssey Therapeutics Member: Scientific 1993-1996

3461 Route 22 East and Medical Advisory

Somerville, NJ 08876 Board

U.S. Bioscience Member: Basic 1993-1994

One Tower Bridge Science Advisory

100 Front Street, P.O. Box 851 Board

West Conshohocken, PA 19428 Consultant 1999-2000
Microfocus Imaging Consultant 1992-1995

225 Larkin Drive Product Development

Wheeling, IL 60090
Schering-Plough International Speaker 1996-2001

Ethyol Speaker Bureau


ALZA Pharmaceuticals Ethyol

Speakers Bureau Speaker 1996-2001


MedImmune Speakers Bureau Speaker 2001-2004

NIH STUDY SECTIONS:
NIH Special Study Section Member 1989
NIH Radiation Study Section Ad Hoc Member 1990
NIH Radiation Study Section Member 1990 - 1994
NIH Reviewers Reserve Member 1994 - present
NCI Initial Review Group Member 1996 - 2000

Committee-Subcommittee C -

Basic and Preclinical Sciences
NCI Initial Review Group Ad Hoc Member 1998 -

Committee-Subcommittees A,

D, and E
NCI Special Emphasis Panel Ad Hoc Member 2007-present
GRANT REVIEWER:
Department of Energy Ad Hoc Member 1983 - 1995
Veterans Administration Ad Hoc Member 1987 - present

American Cancer Society Member 1991 - 1992

(Illinois Division, Inc.)
Koningin Wilhelmina Fonds Ad Hoc Member 1985 - present

Netherlands Cancer Foundation



MEMBERSHIP ON COMMITTEES:
National
NASA Space Radiation Standing Review Member 2009-present

Panel, Human Research Program


AERAS Global TB Vaccine Foundation

Institutional BioSafety Committee Member 2006-present


NIH/NCI Radiation Carcinogenesis Chairperson and 2006

Workshop Organizer


Blue Ribbon Panel for NIH Strategic Member 2004

Plan and Research Agenda for Medical

Countermeasures Against Radiological

And Nuclear Threats.


Radiation Research Society Member 1997 - 1998

Fundraising Committee


Radiation Research Society Member 1993-1996

Policies and Procedures Committee


Radiation Research Society Member 1993 - 1994

Program Committee

42nd Annual Meeting
BEVALAC Biomedical Program Member 1991 - 1992

Advisory Committee,

Lawrence Berkeley Laboratory
Radiation Research Society Member 1989 - 1993

Executive Committee


Radiation Research Society Chairman 1982 - 1985

Finance Committee


Radiation Research Society Member 1985 - 1987

Management Support Contract

Committee
Radiation Research Society Member 1982 - 1987

Ad Hoc Subcommittee on

Society Journal


The Cell Kinetics Society Member 1982 - 1984

Finance Committee


Local
Nuclear Incident and Radiation Member 2003-2006

Dispersal Device Committee; Subcommittee

Of the ITTF Science and Technology Committee

For The State of Illinois

University of Chicago Cancer Research Member 1994 - 2004

Center Executive Committee

University of Chicago Committee on Member 2000 – 2004 Appointments and Promotions (COAP) 2009-present
University of Chicago Committee on Member 2000 - 2006

Radioactive Use


University of Chicago Committee on Member 1994 - Present

Cancer Biology

Argonne National Laboratory Member 1984 - 1991

BIM Division, Library Committee


Argonne National Laboratory Member 1985 - 1987

BIM Division, Animal Use Committee


Argonne National Laboratory Member 1988 - 1995

BIM Division, Human Use Committee


Argonne National Laboratory Member 1989 - 1992

BIM Division, Promotions Committee


Argonne National Laboratory Chairman 1989 - 1996

BIM Division, Enrico Fermi

Fellowship Committee
Argonne National Laboratory Chairman 1990 - 1991

BIM Division, Seminar Committee


Argonne National Laboratory Member 1992 - 1994

EEST Personnel Oversight Committee

on Hiring and Promotions
Argonne National Laboratory Member 1993 - 1996

Performance Appraisal Task Force,

Scientific/Engineering

Performance Appraisal Task Force

Argonne National Laboratory Member 1993 - 1995

Working Group to Explore Scientific

Relationship between The University

of Chicago and Argonne National

Laboratory in Medical Sciences.
The University of Texas Graduate Member of committees 1975 - 1983

School of Biomedical Sciences, for six students

Houston, Texas,

Advisory, Supervisory, and/or

Candidacy Examining Committees
The University of Texas Member Jan. 1977 - 1980

System Cancer Center

Academic Standards Committee
M.D. Anderson Hospital and Member 1981 - 1982

Tumor Institute,



Ad Hoc Task Force on Extramural

Impact in FY 82 Academic Plan


The University of Texas Member at Large 1981 - 1983

M.D. Anderson Hospital,

Research Committee
EDITORIAL BOARD:
Associate Editor representing Biology; 1986 – 1990

Radiation Research Journal

Advisory Board Member; CRC Critical 1988 - 1989

Reviews in Sulfhydryl Biochemistry

Advisory Board Member; Libri Oncologici 1992 - present

(Cancer Journal published in English and Croatian)


Member of the Overseas Editorial Board, Journal 2000-2005

of Radiation Research (Japanese Journal)






MEMBERSHIP IN SCIENTIFIC SOCIETIES:
Radiation Research Society

American Association for Cancer Research

University of Texas M. D. Anderson Associates (founding member)
ELECTED OFFICE:
Secretary/Treasurer, 1989 - 1993

Radiation Research Society



VISITING SCIENTISTS/POSTDOCTORALS TRAINED:

Dr. Curt Sigdestad University of Louisville


Dr. Biba Nagy Science Advisor to the President

of the Republic of Croatia

Zagreb, Croatia
Dr. Paul Meechan Northern Illinois University

Dr. Ivan Basic University of Zagreb

Zagreb, Croatia
Dr. Andrew Vaughan University of Birmingham

Birmingham, England


Dr. Yasushi Kataoka National Institute of Radiological Sciences

Chiba, Japan


Dr. Naoyuki Shigematsu Keio University

Tokyo, Japan


Dr. Barton Bergquist University of Northern Iowa
Dr. Coral Quiet University of Chicago
Dr. Jeff Murley Northern Illinois University
Dr. Shie-Chau Liu Illinois Institute of Technology
Dr. William Epperly Argonne National Laboratory


HONORS:

Atomic Energy Commission Special Health Physics Fellowship,

University of Kansas, Sept. 1966 - Aug. 1967.
United States Public Health Service Traineeship in Health Physics,

University of Kansas, Sept. 1968 - Feb. 1971.



AWARDS:
6th International Congress for Radiation Research (ICRR) Travel Award,

1979; 7th ICRR Travel Award, 1983; 8th ICRR Travel Award, 1987; 10th ICRR Travel

Award, 1995
Japanese Government Research Award for Foreign Specialists, 1988.
John Yuhas Award for Excellence in Research,

University of Pennsylvania, 1993.


PROFESSIONAL LISTINGS:
Marquis Who's Who in Cancer Professionals and Facilities, 1st Ed., 1985.
American Men and Women of Science, Physical and Biological Sciences,

16th Ed., 1986.


Marquis Who's Who in the Midwest, 23rd Ed., 1991.


PATENTS
U.S. Patents: “Method for Protection Against Genotoxic Mutagenesis,” 5,488,042, issued January 30, 1996.U.S. Patent 5,567,686, issued October 22, 1996. U.S. Patent 5,869,338, issued February 9, 1999. U.S. Patent 5,891,856, issued April 6, 1999.

“Method for Protection Against Tumor Metastasis Formation. U.S. Patent 6,984,619, 2006.



I. PEER REVIEWED JOURNAL ARTICLES
1 Grdina, D.J., P. Lohman, and R.R. Hewitt. A Fluorometric Method for the Detection of Endodeoxyribonuclease on DNA-Polyacrylamide Gels. Analytical Biochemistry, 51:255-264, #1, January, 1973.
2 Grdina, D.J., L. Milas, R.R. Hewitt, and H.R. Withers. Buoyant Density Separation of Human Blood Cells in Renografin Gradients. Experimental Cell Research, 81:250-254, 1973.
3 Grdina, D.J., L. Milas, K. Mason, and H.R. Withers. Separation of Cells from a Fibrosarcoma in Renografin Gradients. Journal of the National Cancer Institute, 52:253-257, #1, January, 1974.
4 Grdina, D.J., M. Meistrich, and H.R. Withers. Separation of Clonogenic Cells from Stationary Phase Cultures by Density Gradient Centrifugation. Experimental Cell Research, 85:15-22, 1974.
5 Basic, I., L. Milas, D. Grdina, and H.R. Withers. Destruction of Hamster Ovarian Cell Cultures by Peritoneal Macrophages from Mice Treated with Corynebacterium granulosum. Journal of the National Cancer Institute, 52:1839-1842, June, 1974.
6 Milas, L., N. Hunter, I. Basic, K. Mason, D.J. Grdina, and H.R. Withers. Nonspecific Immunotherapy of Murine Solid Tumors with C. granulosum. Journal of the National Cancer Institute, 54:895-902, 1975.
7 Basic, I., L. Milas, D.J. Grdina, and H.R. Withers. In vitro Destruction of Tumor Cells by Macrophages from Mice Treated with C. granulosum. Journal of the National Cancer Institute, 55:589-596, 1975.
8 Grdina, D.J., I. Basic, K. Mason, and H.R. Withers. Radiation Response of Clonogenic Cell Populations Separated from a Fibrosarcoma. Radiation Research, 63:483-493, 1975.
9 Grdina, D.J., I. Basic, S. Guzzino, and K.A. Mason. Radiation Response of Cell Populations Irradiated in situ and Separated from a Fibrosarcoma. Radiation Research, 66:634-643, 1976.
10 Grdina, D.J., W.H. Hittleman, A. White, and M.L. Meistrich. The Formation of Lung Colonies. An Analysis Based on Cellular Parameters of Density, Size, and DNA Content. British Journal of Cancer, 36:659-669, 1977.
11 Suzuki, N., M. Frapart, D.J. Grdina, M.L. Meistrich, and H.R. Withers. Cell Cycle Dependency of Metastatic Lung Colony Formation. Cancer Research, 37:3690-3693, October, 1977.
12 Meistrich, M.L., D.J. Grdina, R.E. Meyn, and B. Barlogie. Separation of Cells from Mouse Solid Tumors by Centrifugal Elutriation. Cancer Research, 37:4291-4296, December, 1977.
13 Grdina, D.J., S. Linde, and K. Mason. Response of Selected Tumor Populations Separated from a Fibrosarcoma Following Irradiation in situ with Fast Neutrons. British Journal of Radiology, 51:291- 301, March, 1978.
14 Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. I. Relationship Between Cell Size and Age as Modified by Growth in vivo or in vitro. Journal of the National Cancer Institute, 61:209-214, July, 1978.
15 Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. II. Differential Effects of Cell Size and Age on Lung Retention and Colony Formation in Normal and Pre-Conditioned Mice. Journal of the National Cancer Institute, 61:215- 220, July 1978.
16 Grdina, D.J., C.P. Sigdestad, and L.J. Peters. Phase Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Cells Synchronized by Centrifugal Elutriation. British Journal of Cancer, 39:152-159, February, 1979.
17 Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. Cytotoxic Effect of Adriamycin in vivo on Synchronized Murine Fibrosarcoma Cells. International Journal of Radiation Oncology, Biology, Physics, 5:1305-1308, 1979.
18 Sigdestad, C.P., D.J. Grdina, and K. Ando. Density Gradient Centrifugation of Cells Separated from Multicellular Tumor Spheroids. Experentia, 35/6:815-817, 1979.
19 Hunter, N., L.J. Peters, D.J. Grdina, R.A. White, and A. Bartel. Radiation Sensitivity of Murine Fibrosarcoma Cells Separated by Centrifugal Elutriation. Radiation Research, 80:389-397, 1979.
20 Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. The Effect of Misonidazole in situ on the Radiation Response of Selected Tumor Cell Subpopulations. Clinical Cancer Trials, 3:149-154, 1980.
21 Sigdestad, C.P., and D.J. Grdina. Velocity Sedimentation of Tumor Cells: A Comparison of Methods. Experentia, 37:501-502, 1981.
22 Sigdestad, C.P., and D.J. Grdina. In vivo Cell Cycle Phase Preferential Killing of Murine Fibrosarcoma Cells by Cis-Dichlorodiammine Platinum II. Cancer Treatment Reports, 65:845-851, 1981.
23 Sigdestad, C.P., and D.J. Grdina. Density Centrifugation of Murine Fibrosarcoma Cells Following in situ Labeling with Tritiated Thymidine. Cell Tissue Kinetics, 14:589-600, 1981.
24 Grdina, D.J. Phase-Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Pulmonary Nodules. British Journal of Cancer, 45:438-446, 1982.
25 Grdina, D.J., and N. Hunter. Cyclic-Radiation Response of Murine Fibrosarcoma Cells Grown as Pulmonary Nodules. International Journal of Radiation Oncology, Biology, Physics, 8:1727-1734, 1982.
26 Brock, W.A., D.E. Swartzendruber, and D.J. Grdina. Studies of the Kinetic Heterogeneity in Density Separated Tumor Subpopulations. Cancer Research, 42:4999-5003, 1982.
27 Mian, T.A., J.C. Theiss, and D.J. Grdina. Lung Tumorigenic Response of Strain A Mice Exposed to Hypoxic Cell Sensitizers Alone and in Combination with Gamma Radiation. Cancer Research, 43:146-149, 1983.
28 Thames, H.D., D.J. Grdina, and L. Milas. Response of a Fibrosarcoma Cell Population to Small Doses of Radiation Delivered in situ. International Journal of Radiation Oncology, Biology, Physics, 9:217-220, 1983.
29 Grdina, D.J., and R.A. White. Treatment of Artificially-Induced Pulmonary Metastases with Fractionated Doses of Vincristine and/or Radiation Therapy. Clinical and Experimental Metastasis, 1:71-81, 1983.
30 Grdina, D.J., R.A. White, and J.J. Stragand. Cytotoxic Effects of Vincristine on Tumor Subpopulations Separated from Pulmonary Nodules. British Journal of Cancer, 48:279-287, 1983.
31 Grdina, D.J., and G. Zin. Density Gradient Centrifugation of Tumor Cells from Needle Biopsies and Their Respective Source Tumors: A Comparison of Density Distributions. Experentia, 39:916-917, 1983.
32 Grdina, D.J., M.L. Meistrich, R.E. Meyn, T.S. Johnson, and R.A. White. Cell Synchrony Techniques. I. A Comparison of Methods. Cell and Tissue Kinetics, 17:223-236, 1984.
33 White, R.A., D.J. Grdina, M.L. Meistrich, R.E. Meyn, and T.S. Johnson. Comparison of Cell Synchrony Techniques. II. Cell Progression Data. Cell and Tissue Kinetics, 17:237-245, 1984.
34 Grdina, D.J., H.D. Thames, and L. Milas. Tumor Sensitizing Effect by Misonidazole in a Clinically Relevant Radiation Dose Range. International Journal of Radiation Oncology Biology, Physics, 10:379-383, 1984.
35 Grdina, D.J., S. Jones, and N. Hunter. Effectiveness of AMSA Alone or in Combination with Radiation on Murine Fibrosarcoma Pulmonary Nodules. Clinical and Experimental Metastasis, 2:223-233, 1984.
36 Grdina, D.J., B. Nagy, C.K. Hill, R.L. Wells, and C. Peraino. The Radioprotector WR1065 Reduces Radiation-Induced Mutations at the HGPRT Locus in V79 Cells. Carcinogenesis, 6:929-931, 1985.
37 Grdina, D.J., C. Peraino, B.A. Carnes, and C.K. Hill. Protective Effect of [S 2 (3 aminopropylamino) ethyl phosphorothioic acid] Against Induction of Altered Hepatocyte Foci in Rats Treated Once with Gamma Radiation Within One Day After Birth. Cancer Research, 45:5379-5381, 1985.
38 Thames, H.D., D.J. Grdina, and L. Milas. On the / Ratio and OER for Clonogenic Tumors Cells. International Journal of Radiation Oncology, Biology, Physics, Correspondence, 11:1572-1573, 1985.
39 Nagy, B., P.J. Dale, and D.J. Grdina. Protection Against Cis-Diammine-dichloroplatinum (II) Cytotoxicity and Mutagenicity in V79 Cells by Free Radical Scavenger 2-[(aminopropyl)amino] ethanethiol. Cancer Research, 46:1132-1135, 1986.
40 Peraino, C., D.J. Grdina, and B.A. Carnes. Synergistic Induction of Altered Hepatocyte Foci by Combined Gamma Radiation and Diethylnitrosamine Administration to Neonatal Rats. Carcinogenesis, 7:445-448, 1986.
41 Sigdestad, C.P., D.J. Grdina, W.R. Hanson, and A.M. Connor. Comparative Radioprotection from Three Neutron Sources with WR2721 and WR151327, Radiation Research, 106:224-233, 1986.
42 Hill, C.K., B. Nagy, C. Peraino, and D.J. Grdina. 2-[(Aminopropyl)amino]ethanethiol (WR1065) is Anti-neoplastic and Anti-mutagenic When Given During 60Co  ray Irradiation, Carcinogenesis, 7:665-668, 1986.
43 Nagy, B., and D.J. Grdina. Protective Effects of 2-[(Aminopropyl) Amino] Ethanethiol Against Bleomycin, Nitrogen Mustard, Cis-Diamminedichloroplatinum, and Radiation Induced Mutagenicity in V-79 Cells. International Journal of Radiation Oncology, Biology, Physics, 12:1475-1478, 1986.
44 Grdina, D.J., and B. Nagy. The Effect of 2-[(aminopropyl)amino] Ethanethiol (WR1065) on Radiation-Induced DNA Damage and Repair and Cell Progression in V79 Cells. British Journal of Cancer, 54:933-941, 1986.
45 Peraino, C., D.J. Grdina, E.F. Staffeldt, J.J. Russell, A. Prapuolenis, and B.A. Carnes. Effects of Separate and Combined Treatments with Gamma Radiation and Diethylnitrosamine in Neonatal Rats on the Induction of Altered Hepatocyte Foci and Hepatic Tumors. Carcinogenesis, 8:599-600, 1987.
46 Sigdestad, C.P., S.H. Treacy, L.A. Knapp, and D.J. Grdina. Effects of 2 [(Aminopropyl)amino] Ethanethiol (WR-1065) on Radiation-Induced DNA Double-Strand Damage and Repair in V79 Cells. British Journal of Cancer, 55:477-482, 1987.
47 Hanson, W.R., and D.J. Grdina. Radiation-Induced DNA Single-Strand Breaks in the Intestinal Mucosal Cells of Mice Treated with the Radioprotectors: WR-2721 or 16-16 Dimethyl Prostaglandin E2. International Journal of Radiation Biology, 52:67-76, 1987.
48 Zhang, J., C.P. Sigdestad, M.A. Gemmell, and D.J. Grdina. Modification of Radiation Response in the Mouse Using Fractionated Extracts of Panax ginseng. Radiation Research, 112:156-163, 1987.
49 Schwartz, J.L., S.M. Giovanazzi, T. Karrison, C. Jones, and D.J. Grdina. 2 [(Aminopropyl)amino] Ethanethiol (WR1065)-Mediated Reductions in 60Co Gamma Ray and Fission-Spectrum Neutron-Induced Chromosome Damage in V79 Cells. Radiation Research, 113:145-154, 1988.
50 Grdina, D.J., B. Nagy, and C.P. Sigdestad. Radioprotectors in Treatment Therapy to Reduce Risk in Secondary Tumor Induction. Pharmacology and Therapeutics, 39:21-25, 1988.
51 Grdina, D.J., W.H. Guilford, C.P. Sigdestad, and C.S. Giometti. Effects of Radioprotectors on DNA Damage and Repair, Proteins, and Cell-Cycle Progression. Pharmacology and Therapeutics, 39:133- 137, 1988.
52 Sigdestad, C.P., K.W. Doak, and D.J. Grdina. In Vitro Modification of Radiation Induced DNA Single-Strand Breaks and Cell Survival by Solcoseryl. Experentia, 44:707-708, 1988.
53 Sigdestad, C.P., W. Guilford, J. Perrin, and D.J. Grdina. Cell Cycle Redistribution of Cultured Cells after Treatment with Chemical Radiation Protectors. Cell and Tissue Kinetics, 21:193-200, 1988.
54 Grdina, D.J., C.P. Sigdestad, P.J. Dale, and J.M. Perrin. The Effect of 2 [(Aminopropyl)amino] Ethanethiol on Fission-Neutron-Induced DNA Damage and Repair. British Journal of Cancer, 59:17- 21, 1989.
55 Grdina, D.J., B. Nagy, C.K. Hill, and C.P. Sigdestad. Protection Against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol Under Conditions of Acute Hypoxia. Radiation Research, 117:251-258, 1989.
56 Grdina, D.J., C.P. Sigdestad, and B.A. Carnes. Protection by WR1065 and WR151326 Against Fission-Neutron-Induced Mutations at the HGPRT Locus in V79 Cells. Radiation Research, 117:500- 510, 1989.
57 Nagy, B. and D.J. Grdina. Plasminogen Activator Activity in Clonogenic Cell Populations Separated from a Murine Fibrosarcoma. Clinical and Experimental Metastasis, 7:243-250, 1989.
58 Rotmensch, J., R.W. Atcher, R. Schlenker, J. Hines, D. Grdina, B.S. Block, M.F. Press, A.L. Herbst, and R.R. Weichselbaum. The Effect of the Alpha-Emitting Radionuclide Lead-212 on Human Ovarian Carcinoma: A Potential New Form of Therapy. Gynecologic Oncology, 32:236-239, 1989.
59 Atcher, R., J. Mitchell, J. Hines, J. Rotmensch, D.J. Grdina. Halogenated Pyrimidines as Radiosensitizers for High-LET Radiation. Radiation Research, 117:351-355, 1989.
60 Ando, K., H. Ohara, S. Matsushita, S. Koike, S. Furukawa, and D.J. Grdina. Radioprotection from Fast Neutron Irradiation by WR151327. Inst. Phys. Chem. Res., 83:40-41, 1989.
61 Rotmensch, J., R.W. Atcher, J. Hines, D.J. Grdina, J.L. Schwartz, M. Toohill and A.L. Herbst. The development of Alpha-Emitting Radionuclide Lead-212 for the Potential Treatment of Ovarian Carcinoma. American Journal of Obstetrics and Gynecology, 160:789-797, 1989.
62 Vaughan, A.T.M., D.J. Grdina, P.J. Meechan, A.E. Milner and D.J. Gordon. Conformational Changes in Chromatin Structure Induced by the Radioprotective Aminothiol, WR1065. British Journal of Cancer, 60:893-896, 1989.
63 Rotmensch, J., J.L. Schwartz, R.W. Atcher, D.J. Grdina, M. Toohill and R.R. Weichselbaum. The Inherent Radiosensitivity of Epithelial Ovarian Carcinoma. Gynecology Oncology, 35:282-285, 1989.
64 Rotmensch, J., J.L. Schwartz, M.A. Beckett, D.J. Grdina, M.F.P. Toohill, and R.R. Weichselbaum. Characterization of a Human Ovarian Carcinoma. Analytical and Quantitative Cytology and Histology, 11:324-330, 1989
65 Van Beek, M.E.A.B., R.L. Doak, C.P. Sigdestad, and D.J. Grdina. Pathological Effects of the Radiation Protector WR151327 in Mice. Radiation Research, 124:79-84, 1990.
66 Gordon, D.J., A.E. Milner, R.P. Beaney, D.J. Grdina, and A.T.M. Vaughan. The Increase in Radioresistance of Chinese Hamster Cells Cultured as Spheroids is Correlated to Changes in Nuclear Morphology. Radiation Research, 121:175-179, 1990.
67 Gordon, D.J., A.E. Milner, R.P. Beaney, D.J. Grdina, and A.T.M. Vaughan. Cellular Radiosensitivity in V79 Cells is Linked to Alterations in Chromatin Structure. International Journal of Radiation Oncology, Biology, Physics, 19:1199-1201, 1990.
68 Meechan, P.J., A. Vaughan, D.J. Grdina. WR1065 Association With CHO AA8 Cells, Nuclei, and

Nucleoids. Radiation Research, 125: 152-157, 1991.


69 Quiet, C.A., R.R. Weichselbaum, and D.J. Grdina. Variation in Radiation Sensitivity During the Cell Cycle of Two Human Squamous Cell Carcinomas. International Journal of Radiation Oncology, Biology, Physics, 20:733-738, 1991.
70 Sigdestad, C.P., B. Bergquist, and D.J. Grdina. The Effect of Chemical Protectors on Cell Cycle Progression After Gamma or Neutron Irradiation. Cell Proliferation, 24:271-280, 1991.
71 Grdina, D.J., B.J. Wright, and B.A. Carnes. Protection by WR-151327 Against Late Effects Damage Induced by Fission-Spectrum Neutrons. Radiation Research, 128(S):124-127, 1991.
72 Hanson, W.R., and D.J. Grdina. Radiation Protection of Mice From Neutron Injury by Misoprostol, a PGE1 Analog, Protects Mice from Fission-Neutron Injury. Radiation Research, 128(S):12-17, 1991.
73 Schwartz, J.L., R. Mustafi, M.A. Beckett, E.A. Czyzewski, E. Farhangi, D.J. Grdina, J. Rotmensch, and R.R. Weichselbaum. Radiation-Induced DNA Double-Strand Frequencies in Human Squamous Cell Carcinoma Cell Lines of Different Radiation Sensitivities. International Journal of Radiation Biology, 59:1341-1352, 1991.

74 Murley, J.S., D.J. Grdina, and P.J. Meechan. Accumulation of CHO Cells in G2 Phase Following Exposure to WR-1065. Radiation Research, 126:223-228, 1991.


75 Sigdestad, C.P., A.M. Connor, D.J. Grdina, K.W. Doak. Chemical Radiation Protection from Fission Spectrum Neutrons. Nuclear Science Applications, 4:157 166, 1991.
76 Grdina, D.J., B.A. Carnes, D. Grahn, and C.P. Sigdestad. Protection Against Late Effects of Radiation by S-2-(3-Aminopropylamino)-Ethylphosphorothioic Acid. Cancer Research, 51:4125-4130, 1991.
77 Vaughan, A.T.M., D.J. Gordon, D. Grdina, and A.M. Milner. Analysis of Free Radical Damage Within Single Cells Using Flow Cytometry. Molecular Aspects of Medicine, 12:129-135, 1991.
78 Grdina, D.J., B.A. Carnes, and B. Nagy. Protection by WR2721 and WR151327 Against Late Effects of Gamma Rays and Neutrons. Advances in Space Research, 12:(2)257-(2)263, 1992.
79 Grdina, D.J., P. Dale, and R. Weichselbaum. Protection Against AZT-Induced Mutagenesis at the HGPRT Locus in a Human Cell Line by WR-151326. International Journal of Radiation Oncology, Biology, Physics, 22:813-815, 1992.
80 Kataoka, Y., I. Basic, J. Perrin, and D.J. Grdina. Anti-Mutagenic Effects of Radioprotector WR-2721 Against Fission-Spectrum Neutrons and 60Co -Rays in Mice. International Journal of Radiation Biology, #3, 61:387-392, 1992.
81. Meechan, P.J., D.J. Haraf, A.M. Diamond, and D.J. Grdina. Reversion of Radiosensitivity in Azacytidine-Treated xrs-5 Cells Does Not Result in Full Radioprotection by WR 1065. International Journal of Radiation Oncology, Biology, Physics, 23:999 1002, 1992.
82. Grdina, D.J., and C.P. Sigdestad. Chemical Protection and Cell-Cycle Effects on Radiation-Induced Mutagenesis. Cell Proliferation, 25:23-29, 1992.
83. Rotmensch, J., R. Atcher, J. Schwartz, and D. Grdina. Analysis of Ascites from Patients with Ovarian Carcinoma by Cell Flow Cytometry. Gynecological Oncology, 44:10-12, 1992.
84. Carnes, B.A., and D.J. Grdina. In Vivo Protection by the Aminothiol WR-2721 Against Neutron-Induced Carcinogenesis. International Journal of Radiation Biology, No. 5, 61:567-576, 1992.
85. Grdina, D.J., Y. Kataoka, I. Basic, and J. Perrin. The Radioprotector WR-2721 Reduces Neutron-Induced Mutations at the Hypoxanthine-Guanine Phosphoribosyl Transferase Locus in Mouse Splenocytes When Administered Prior to or Following Irradiation. Carcinogenesis, vol. 13, no. 5, pp. 811-814, 1992.
86. Hallahan, D.E., S. Virudachalam, D. Grdina, and R.R. Weichselbaum. The Isoquinoline Sulfonamide H7 Attenuates Radiation-Mediated Protein Kinase C Activation and Delays the Onset of X Ray Induced G2 Arrest. International Journal of Radiation Oncology, Biology, Physics, Vol 24, 687-692, 1992.
87. Constantinou, A., D. Grdina, K. Kiguchi, and E. Huberman. The Effect of Topoisomerase inhibitors on the Expression of Differentiation Markers and Cell Cycle Progression in Human K-562 Leukemia Cells. Experimental Cell Research, 203: 100-106, 1992.
88. Murley, J.S., D.J. Grdina, and P.J. Meechan. Effects of Growth Media on Cell Cycle Progression in CHO Cells Exposed to the Radioprotector WR-1065. Cell Proliferation, 25: 643-650, 1992.
89. Kataoka, Yasushi, Jane Perrin, and David J. Grdina. Induction of HPRT Mutations in Mice following Exposure to Fission-Spectrum Neutrons or 60Co Rays. Radiation Research, 136:289-292, 1993.
90. Grdina, D.J., A. Constantinou, N. Shigematsu, and J.S. Murley. Inhibition of Topoisomerase II Activity in CHO K1 Cells by 2-[(Aminopropyl)Amino]Ethanethiol (WR 1065). Radiation Research, 138: 44-52, 1994.
91. Grdina, D.J., and B.A. Carnes. Chemoprevention by WR 2721. Libri Oncologici 23:11-16, 1994.

92. Hallahan, D.E., D. Bleakman, S. Virudachalam, D. Lee, D.J. Grdina, D. W. Kufe, and R.R. Weichselbaum. The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation. Radiation Research, 138: 392-400, 1994.


93. Shigematsu, N., J.L. Schwartz, and D.J. Grdina. Protection Against Radiation-Induced Mutations at the hprt locus by spermine and N,N -(dithiodi-2-1-Ethanediyl)bis-1,3-Propanediamine (WR 33278). Mutagenesis 9:355-360, 1994.
94. Matsushita, S., K. Ando, S. Koike, D.J. Grdina, and S. Furukawa. Radioprotection by WR 151327 Against the Late Normal Tissue Damage in Mouse Hind Legs from Gamma Ray Radiation. International Journal of Radiation Oncology, Biology, and Physics, 30: 867-872, 1994.
95. Schwartz, J.L., B.A. Sedita, N. Laffely, and D.J. Grdina. Chromosome Terminal Deletion Formation in Chinese Hamster Ovary Cells. Mutation Research, 311: 125-131, 1994.
96. Meechan, P.J., D.J. Haraf, A.M. Diamond, and D.J. Grdina. Varying Levels of Radioprotection from the Effects of JANUS Neutrons in Repair Deficient XRS-5 Hamster Cells Treated with AZAcytidine. Radiation Research, 140: 437-440, 1994.
97. Thraves, P.J., S. Varghese, M. Jung, D.J. Grdina, J.S. Rhim, and A. Dritschilo. Transformation of Human Epidermal Keratinocytes with Fission Neutrons. Carcinogenesis, 15: 2867-2873, 1994.
98. Halpern, H.J., C. Yu, M. Peric, E. Barth, D.J. Grdina, B.A. Teicher. Oxymetry Deep in Tissues with Low Frequency Electron Paramagnetic Resonance. Proceedings of the National Academy of Sciences, USA, 91: 13047-13051, 1994.
99. Grdina, D.J., N. Shigematsu, P. Dale, G.L. Newton, J.A. Aguilera, and R.C. Fahey. Thiol and Disulfide Metabolites of the Radiation Protector and Potential Chemopreventive Agent WR-2721 are Linked to Both its Anticytotoxic and Antimutagenic Mechanisms of Action, Carcinogenesis, 16: 767-774, 1995.
100. Woloschak, G.E., T. Paunesku, C.R. Libertin, C.M. Chang-Liu, and D.J. Grdina. Expression of Thymidine Kinase RNA and a Related Transcript is Modulated by Radioprotector WR-1065. Cancer Research, 55:4788-4792, 1995.
101. Murley, J.S. and D.J. Grdina. Effects of Cycloheximide and WR-1065 on Repair Processes Related to Cell Survival and Mutagenesis Following Single and Split-doses of Radiation Exposure. Carcinogenesis, 16:2699-2705, 1995.
102. Halpern, H.J., G.V.R. Chandramouli, C. Yu, M. Peric, E.D. Barth, B.A. Teicher, and D.J. Grdina. Pharmacological compartment viscosity and polarity measured with very low frequency EPR in tumors of living animals. Magnetic Resonance in Chemistry, 33:S147-S153, 1995.
103. Sidjanin, D., D.J. Grdina, and G.E. Woloschak. UV-Induced Changes in Cell Cycle and Gene Expression within Rabbit Lens Epithelial Cells. Photochemistry and Photobiology, 63:79-85, 1996.
104. Halpern, H.J., C. Yu, M. Peric, E.D. Barth, G.S. Karczamar, J.N. River, D.J. Grdina, and B.A. Teicher. Measurement of Differences in pO2 Response to Perfluorocarbon/ Carbogen in FSa and NFSa Murine Fibrosarcomas with Low Frequency Electron Paramagnetic Oxymetry. Radiation Research, 145:610-618, 1996.
105. Kataoka, Y., J. Perrin, N. Hunter, L. Milas and D.J. Grdina. WR-2721 Protects Against Cytoxan-Induced HPRT Mutagenesis Without Affecting Therapeutic Effectiveness. Seminars in Oncology, 23: Suppl. 8, 53-57, 1996.



  1. Diamond, A.M., J.L. Murray, P. Dale, R. Tritz, P.A. Sandstrom, and D.J. Grdina. The effects of

Selenium on Glutathione Peroxidase Activity and Radioprotection in Mammalian Cells. Radiat.

Onco. Investigations, 3: 383-386, 1996.

107. Diamond, A.M., P. Dale, J.L. Murray, and D.J. Grdina. The inhibition of Radiation-Induced Mutagenesis by the Combined Effects of Selenium and the Aminothiol WR-1065. Mutation Research, 356:147-154, 1996.


108. Schwartz, J.L., J. Cowan, D.J. Grdina, and R.R. Weichselbaum. Attenuation of G2 Cell Cycle Checkpoint Control is Associated with Increased Frequencies of Unrejoined Chromosome Breaks in Human Tumor Cell. Radiation Research, 146:139-143,1996.
109. Woloschak, G.E., T. Paunesku, C.R. Libertin, C-M. Chang-Liu, M. Churchill, J. Panozzo, D. J.

Grdina, M.A. Gemmell, and C. Giometti. Regulation of Thymus PCNA Expression is Altered in

Radiation-Sensitive Wasted Mice. Carcinogenesis, 17:2357-2365, 1996.




  1. Liu, S.C., J.S. Murley, G. Woloschak, and D.J. Grdina. Repression of c-myc Gene Expression by

Thiol and Disulfide Forms of the Cytoprotector Amifostine. Carcinogenesis, 18:2457-2459,1997.


  1. Murley, J.S., A. Constantinou, N.S. Kamath, and D.J. Grdina. WR-1065, an Active Metabolite of

the Cytoprotector Amifostine, Affects Phosphorylation of Topoisomerase II Leading to Changes in

Enzyme Activity and Cell cycle progression in CHO AA8 Cells. Cell Proliferation,30:283-294, 1997.





  1. Grdina, D.J., J.S. Murley, and J.C. Roberts. Effect of Thiols on Topoisomerase-II Activity and Cell Cycle Proliferation. Cell. Proliferation, 31: 217-229, 1998.

113. Grdina, D.J., N. Hunter, Y. Kataoka, J. Murley, and L. Milas. Chemopreventive Doses of Amifostine Confer No Cytoprotection to Tumor Nodules Growing in the Lungs of Mice Treated with

Cyclophosphamide. Seminars in Oncology, 26 (#2 Suppl. F): 22-27, 1999.
114. Kataoka, Y., A.M. Diamond, R.R. Weichselbaum, D.J. Grdina, and D.B. Mansur. Modification

of Anti-Oxidant Enzymatic Activity by Low Dose Selenium Supplementation Does Not Affect



Radiosensitivity of Human Malignant Glioma Cells. Libri Oncologici, 27:63-67, 1998.


  1. Cai, Y., M. Wu, S.M. Ludeman, D.J. Grdina, and E. Dolan. Role of O6-Alkylguanine-DNA

Alkyltransferase in Protecting against Cyclophosphamide-induced Toxicity and Mutagenicity

Cancer Res., 59:3059-3063, 1999.


  1. Kataoka, Y., J.S. Murley, R. Patel, and D.J. Grdina. Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. International Journal of Radiation Biology, 76:633-639, 2000.




  1. Grdina, D.J., J.S. Murley, Y. Kataoka, and W. Epperly. Relationships between cytoprotection and mutation prevention by WR-1065. Military Medicine, 167(2 Suppl):51-53, 2002.




  1. Snyder, R.D. and D.J. Grdina, Further evidence that the radioprotective aminothiol WR-1065 catalytically inactivates mammalian topoisomerase II. Cancer Res., 60:1186-1188, 2000.




  1. Mansur, D.B., Y. Kataoka, D.J. Grdina, and A. Diamond. Radiosensitivity of mammalian cell lines engineered to over-express cytosolic glutathione peroxidase. Radiation Res., 155 (No 4):536-542, 2001.




  1. Murley, J.S., Y. Kataoka, D.E. Hallahan, J.C. Roberts, and D.J. Grdina. Activation of NFkB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radical Biology and Medicine, 30(No 12):1426-1439, 2001.




  1. Grdina, D.J., Y. Kataoka, J.S. Murley, N. Hunter, R.R. Weichselbaum, and L. Milas. Inhibition of spontaneous metastases formation by Amifostine. International Journal of Cancer, 97:135-141, 2002.




  1. Grdina, D.J., J.S. Murley, Y. Kataoka, and D.P. Calvin, Differential activation of nuclear transcription factor kB, gene expression, and proteins by Amifostine’s free thiol in human microvascular endothelial and glioma cells. Seminars in Radiation Oncology, 12(No. 1),Suppl. 1:103-111, 2002.




  1. Khodarev, N.N., J. Yu, E. Nodzenski, J.S. Murley, Y. Kataoka, C.K. Brown, D.J. Grdina, R.R. Weichselbaum, Method of RNA purification from endothelial cells for DNA array experiments. BioTechniques, 32:316-320, 2002.




  1. Kataoka, Y., J.S. Murley, N.N. Khodarev, R.R. Weichselbaum, and D.J. Grdina, Activation of the nuclear transcription factor B (NFB) and differential gene expression in U87 glioma cells following exposure to the cytoprotector amifostine. International Journal of Radiation Oncology, Biology, Physics, 53:180-189, 2002.




  1. Murley J.S., Y. Kataoka, C.J. Weydert, L.W. Oberley, and D.J. Grdina, Delayed cytoprotection following enhancement of MnSOD gene expression in SA-NH mouse sarcoma cells exposed to Amifostine’s active metabolite WR1065. Radiation Research, 158:101-109, 2002.




  1. Grdina, D.J., , J.S. Murley, and Y. Kataoka, Radioprotectants: Current Status and New Directions. Oncology, 63(suppl 2):2-10, 2002.




  1. Grdina, D.J., Y. Kataoka, J.S. Murley, K. Swedberg, J.Y. Lee, N. Hunter, R.R. Weichselbaum, and L. Milas, Anti-metastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Seminars in Oncology, 29, No. 6, (Suppl 18):22-28, 2002.




  1. Elas, M., A. Parasca, D.J. Grdina, H.J. Halpern: Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochemica et Biophysica Acta, 1637:151-155, 2003.




  1. Khodarev, N.N., Y. Kataoka, J.S. Murley, R.R. Weichselbaum, and D.J. Grdina: Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Int. J. Radiat. Oncol., Biol., Phys. 60(2):553-563, 2004.




  1. J.S, Murley, Y. Kataoka, and D.J. Grdina: Delayed radioprotection via NFkB mediated induction of Sod2 (MnSOD) in SA-NH tumor cells following exposure to clinically used thiol containing drugs. Radiat. Res. 162 (5):536-546, 2004.




  1. Stone H.B., J.E. Moulder, C.N. Coleman, K.K. Ang, M.S. Anscher, M.H. Barcellos-Hoff, W.S. Dyan, J.R. Fike, D.J. Grdina, et al., Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Radiat. Res. 162(6):711-728, 2004.




  1. Grdina, D.J., J.S. Murley, Y. Kataoka, D. Zhou, and T.M. Seed: Radioprotectors: Current Status and New Directions, Radiat. Res. 163(6):704-705, 2005.




  1. Murley, J.S., Y. Kataoka, C.J. Weydert, L.W. Oberley, and D.J. Grdina, Delayed radioprotection by nuclear transcription factor kB-mediated induction of Manganese Superoxide Dismutase in Human Microvascular Endothelial Cells after exposure to free radical scavenger WR1065, Free Radical Biol. Med., 40:1004-1016, 2006.




  1. Kataoka, Y., V.P. Bindokas, R.C. Duggan, J.S. Murley, and D.J. Grdina. Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells, J. Radiat. Res. 47(3-4):245-257, 2006.




  1. Murley, J.S., Y. Kataoka, K.L. Baker, A. Diamond, W.F. Morgan, and D.J. Grdina. Manganese Superoxide Dismutase (Sod2) Mediated Delayed Radioprotection Induced by the Free Thiol Form of Amifostine and Tumor Necrosis Factor-α, Radiat. Res. 167:465-474, 2007.




  1. Kataoka, Y., J.S. Murley, K. Baker, and D.J. Grdina. Relationship Between Phosphorylated Histone H2AX Formation and Cell Survival in Human Microvascular Endothelial Cells (HMEC) as a Function of Ionizing Radiation Exposure in the Presence or Absence of Thiol Containing Drugs., Radiat. Res., 168:106-114, 2007.




  1. Murley, J.S., D. Nantajit, K.L. Baker, Y. Kataoka, J.J. Li, and D.J. Grdina. Maintenance of Manganese Superoxide Dismutase (Sod2)-Mediated Delayed Radioprotection Induced by Repeated Administration of the Free Thiol Form of Amifostine. Radiat. Res., 169:495-505, 2008.




  1. Paunesku D., T. Paunesku, A. Wahl, Y. Kataoka, J. Murley, D.J. Grdina, G.E. Woloschak. Incidence of Tissue Toxicities in Gamma Ray and Fission Neutron-Exposed Mice Treated with Amifostine. Int. J. Radiat. Biol., 84(8):623-634, 2008.




  1. Dziegielewski J., J.E. Baulch, W. Goetz, M.C. Coleman, D.R. Spitz, J.S. Murley, D.J. Grdina, W.F. Morgan. WR1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radical Biol. Med., 45(12):1674-1681, 2008.




  1. Grdina D.J., J.S. Murley, Y. Kataoka, K.L. Baker, R. Kunnavakkam, M.C. Coleman, and D.R. Spitz. Amifostine Induces Anti-Oxidant Enzymatic Activities in Normal Tissues and a Transplantable Tumor That Can Affect Radiation Response. Int. J. Rad. Oncol. Biol. Phys.,73(3):886-896, 2009.




  1. Fu P., A.A. Birukova, J. Xing, S. Sammani, J.S. Murley, J.G. Garcia, D.J. Grdina, K.G. Birukov. Amifostine reduces lung vascular permeability via suppression of inflammatory signaling. Eur. Respir. J., 33(3):612-624, 2009.




  1. Ahmed, K.M., D. Nantajit, M. Fan, J.S. Murley, D.J. Grdina, Li, J.J. Co-activation of ATM/ERK/NF-κB in Low Dose Radiation-Induced Adaptive Radioresistance in Human Skin Keratinocytes. Free Radical Biol. Med., 46(11):1543-1550, 2009.




  1. Hooker, A.M., D.J. Grdina, J.S. Murley, B.J. Blyth, R.J. Ormsby, E. Bezak, K.A. Giam, P.M. Sykes. Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose. Int. J. Low Radiat., 6(1):43-56, 2009.




  1. Dziegielewski, J., W. Goetz, J.S. Murley, D.J. Grdina, W.F. Morgan, and J.E. Baulch. Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat. Res.,173:175-183, 2010.




  1. Murley, J.S., Y. Kataoka, R.C. Miller, J.J. Li, G. Woloschak, D.J. Grdina. SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. Radiat. Res. 175: 57-65, 2011.




  1. Fu, P., J.S. Murley, D.J. Grdina, A.A. Birukova, K.G. Birukov. Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit. Care Med. 39(12):2711-2721, 2011.




  1. Murley, J.S., K.L. Baker, R.C. Miller, T.E. Darga, R.R. Weichselbaum, D.J. Grdina. SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radical Biol. Med. 51: 1918-1925, 2011.



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