Electronic Posters: Cardiovascular

Tuesday 13:30-15:30 Computer 30

13:30 3588. γ-Sarcoglycan Deficiency Reduces Cardiac Function and T2 in Old Mice

Sean Charles Forbes¹, Sean Germain², Nathan Bryant³, Glenn A. Walter<sup>3

1</sup>Department of Physical Therapy, University of Florida, Gainesville, FL, United States; ²Department of Pediatrics, University of Florida, United States; ³Department of Physiology and Functional Genomics, University of Florida, United States

Limb Girdle muscular dystrophy Type 2C is characterized by a deficiency in γ-sarcoglycan, a protein associated with the dystrophin-glycoprotein complex on the cell membrane. In this study, the effects of a lack of γ-sarcoglycan (Sgsg-/-) and dystrophin (mdx) on cardiac function and myocardium T2 in old mice were examined. The findings indicate that Sgsg-/- and mdx have a reduced left ventricular ejection fraction compared to age-matched controls, with no differences in Sgsg-/- and mdx. Also, a shorter T2 was observed in the myocardium of Sgsg-/- compared to controls, suggesting an increased prevalence of fibrosis in Sgsg-/-.

14:00 3589. Development and Validation of 3 Tesla Functional Cardiac Magnetic Resonance Imaging in Preterm and Term Newborns

Alan Groves¹, Gaia Chiesa², Giuliana Durighel², Stephen Goldring², Julie Fitzpatrick², Sergio Uribe³, Reza Razavi⁴, Jo Hajnal², A David Edwards<sup>2

1</sup>Institute of Clinical Sciences, Imperial College , London, United Kingdom; ²Institute of Clinical Sciences, Imperial College, London, United Kingdom; ³Division of Imaging Sciences, King's College , London, United Kingdom; ⁴Division of Imaging Sciences, King's College, London, United Kingdom

The ability to reliably monitor and support the circulation in preterm and term newborns may have a key role in optimising outcome in this population. Cardiac magnetic resonance (CMR) imaging has the potential to significantly advance understanding of cardiac function in sick preterm and term infants. In this work we describe optimisation of cine and phase contrast CMR imaging in newborn infants; assess repeatability of CMR methods and compare this to existing echocardiographic methods; and describe preliminary normative values for cardiac output and systemic flow volume in stable preterm and term infants.

14:30 3590. The Effect of K-Space Trajectory on Strain-Encoded Cardiac MRI

Elsayed H. Ibrahim¹, Wolfgang Rehwald², Sven Zuehlsdorff², Richard D. White<sup>1

1</sup>University of Florida, College of Medicine, Jacksonville, FL, United States; ²Siemens AG Healthcare Sector, Cardiovscular MR R&D, Chicago, IL, United States

Strain encoding (SENC) is a newly-developed MRI technique for measuring myocardial strain in the through-plane direction. It requires simple post-processing and gives resolution on the pixel level. With conventional SENC sequence, two separate scans are required to obtain the strain images. Such approach increases scan time and could result in image misregistration in post-processing. Non-Cartesian k-space trajectories are becoming more popular because they allow for large undersampling with acceptable image quality. In this work, SENC was combined with radial k-space acquisition using interleaved SENC tunings and radial undersampling. Scan time was reduced to one breath-hold with comparable image quality.

15:00 3591. High Resolution, Functional Real-Time Cardiac MR Imaging Using a Combination of Compressed Sensing and Parallel Imaging

Tobias Wech¹, Marcel Gutberlet¹, Daniel Stäb¹, Dietbert Hahn¹, Herbert Köstler<sup>1

1</sup>Institute of Radiology, University of Wuerzburg, Wuerzburg, Bavaria, Germany

To achieve a sufficient temporal and spatial resolution in functional cardiac MRI, real time acquisition has to be accelerated by a factor of 8 – 10 compared to Fourier MRI. In this work, a combination of compressed sensing and parallel imaging has been implemented, tested in a simulation using undersampled data of a segmented cine acquisition and finally applied to in-vivo data sampled in real time. The reconstructions for the real time acquisition and for the simulated data result in high resolution images with an excellent SNR and do not show any visible artefacts.