Electronic Posters: Cardiovascular

Myocardial Viability: Human Models

Hall B Monday 14:00-16:00 Computer 34

14:00 3648. Incremental Benefit of Cardiovascular MRI in the Evaluation of Patients with Systemic Embolism

Monvadi B. Srichai¹, Amelia M. Wnorowski¹, Itzhak Kronzon¹, Leon Axel¹, Ambika Nayar¹, Gila Perk¹, Allison G. Hays², Mark Fisch¹, Vivian S. Lee<sup>1

1</sup>NYU School of Medicine, New York, NY, United States; ²Johns Hopkins, Baltimore, MD, United States

Echocardiography is often the sole imaging technique used for evaluation cardiac sources of embolism. However, studies have demonstrated that up to 40% of patients with ischemic strokes often have no identifiable etiology. Contrast enhanced MRI with MRA identified a cardiovascular source of embolism in an additional 20% of patient in this cohort that was undetected by echocardiography, and hence provides a valuable adjunctive diagnostic imaging method for evaluation of patients with a potential cardiovascular source of embolism, particularly in patients with a negative echocardiography study or who are unable to undergo transesophageal echocardiography.

14:30 3649. Rapid Quantification of Systolic and Diastolic Transverse T1ρ Relaxation Times in the Human Left Ventricle

Gerald A. Zsido II¹, Julio Chirinos², Larry Dougherty³, Kevin Koomalsingh⁴, James J. Pilla^2,4, Walter RT Witschey^1,4, Hee Kwon Song², Joseph H. Gorman III⁴, Robert C. Gorman⁴, Ravinder Reddy<sup>1

1</sup>Radiology, University of Pennsylvania, Center for Magnetic Resonance and Optical Imaging, Philadelphia, PA, United States; ²University of Pennsylvania, Division of Cardiovascular Medicine, Philadelphia, PA, United States; ³Radiology, University of Pennsylvania, Philadelphia, PA, United States; ⁴Surgery, University of Pennsylvania, Philadelphia, PA, United States

A technique for rapid quantification of 1H relaxation times in the human myocardium during systole and diastole was developed. The technique makes use of a T1ρ spin locking pulse cluster, followed by a short, multiecho, radial acquisition, from which k-space-weighted image contrast reconstruction is performed. An 8-fold acceleration of data acquisition was obtained in vivo, compared to a similar set of fully sampled data. In 3 subjects, each scanned 4 times; a significant difference between left ventricular systolic and diastolic relaxation times was measured.

15:00 3650. Three Dimensional Black Blood MRI with Extensive Cardiothoracic Coverage: A Feasibility Study in Healthy Volunteers

Thanh D. Nguyen¹, Keigo Kawaji², Pascal Spincemaille¹, Beatriu Reig¹, Matthew D. Cham¹, Martin R. Prince¹, Yi Wang<sup>1

1</sup>Radiology, Weill Cornell Medical College, New York, NY, United States; ²Biomedical Engineering, Cornell University, Ithaca, NY, United States

Black blood (BB) MRI is useful for morphologic assessment in cardiovascular diseases. While a 3D BB imaging sequence of the whole heart and chest similar to the whole-heart coronary artery imaging approach is highly desirable, commonly used BB preparation techniques rely on blood washout and do not work well in large imaging volumes. The purpose of this study is to develop a free-breathing balanced SSFP sequence for BB imaging of the whole chest using flow-independent T2prep inversion recovery preparation. This sequence was found to provide excellent blood suppression and good BB image quality within a large cardiothoracic volume.

15:30 3651. Detecting Cardiac Involvement in Systemic Sarcoidosis Using a Multi-Contrast Late-Enhancement MRI Technique: Preliminary Results

Yuesong Yang¹, Kim Connelly¹, Jay Detsky¹, Sumaya Al-helali¹, Gideon Paul¹, Rhonda Walcarius¹, Graham A. Wright¹, Alexander J. Dick<sup>1

1</sup>Imaging Research and Cardiology, Sunnybrook Health Sciences Centre, University Of Toronto, Toronto, Ontario, Canada

Sarcoidosis is a systemic disease with a predilection for pulmonary involvement. Although clinical cardiac involvement occurs only in 5-7% of patients with systemic sarcoidosis, the incidence of autopsy-proven disease ranges from 20% to 47%. The presence of cardiac involvement is important to recognize, as it can lead to conduction disturbance and ventricular arrhythmias. Early detection of cardiac involvement with suitable treatment plays a critical role in the prevention of sudden death in these patients. A newly developed multi-contrast late-enhancement (MCLE) MRI has shown the potential to identify subtle myocardial damages in myocardial infarction. In this study we investigated this MCLE technique in the determination of cardiac involvement in systemic sarcoidosis and compared it with conventional IR-FGRE imaging.