Tez özetleri Astronomi ve Uzay Bilimleri Anabilim Dalı 2

Investıgatıon Of Two Stage Anaerobıc Treatabılıty Of Pharmaceutıcal Industry Wastewater

In this study, two staged anaerobic treatability of etodolac chemical synthesis wastewater from pharmaceutical industry and removal of etodolac pharmaceutical active substance and metabolites are aimed. In this context, ASBR (Anaerobic Sequencing Batch Reactor) and AnMBR (Anaerobic Membrane Bioreactor) systems were selected as a two stage treatment. The systems were independently operated because of the insufficient acidification in the ASBR. The reactors were inoculated with granule sludge of an up-flow anaerobic sludge blanket reactor treating the beer industry wastewater.

Firstly, the full characterization of the wastewater and BMP (Biochemical Methane Potential) tests were carried. Acclimation study was started with the organic loading rates that were estimated from BMP tests.
In the first section of this study, an ASBR was designed as pre–acidification reactor. Operating parameters were pH: 5, temperature: 35^oC, hydraulic retention time (ϴ_h): 1.53 days and 4 L of reactor volume. The rector was operated with the exchange ratio of 62.5 % for 413 days. ASBR was operated with 24 h cycles. Every cycle comprise of (1) filling: 30 min (2) reaction: 20 h–100 rpm (3) settling: 3 h (4) emptying 30 min. Pedaled stirrer and nitrogen gas were used for mixing. COD was increased gradually to 4000 mg/L (OLR: ≈2.6 kgKOİ/m³.d) and 6000 mg/L (OLR: ≈3.9 kgKOİ/m³.d).
Sulphate, sulphite, etodolac and COD removals were reached to 39%, 98%, 60% and 90%, respectively. VFA (volatile fatty acids) and alkalinity concentrations were reached to 1350 mg/L and 600 mg/L CaCO₃, respectively. Increasing the COD to 6000 mg/L was caused to sulphite inhibition and deterioration. Glucose was added to reactor to improve the acidification after the acclimation process. Production of VFA was not observed when the glucose was not added with 6000 mg/L COD loading. ASBR which designed for pre-acidification could not be operated effectively.
In the second section of this study, AnMBR was operated as methanogenic phase. Operating parameters were pH: 7, temperature: 35^oC and 4 L of reactor volume. Pedaled stirrer and nitrogen gas were used for continuous mixing. Nitrogen is used for preventing submerged membrane surface from cake layer occurrence. AnMBR was operated with infinite sludge retention time (theoretically ϴc=∞). COD was increased to 2500 mg/L, 5000 mg/L, 7500 mg/L, 10000 mg/L, and 15000 mg/L, respectively. Hydraulic retention times were (ϴ_h) 12, 15.6, 22.9, 21.4 and 27.6 days respectively. OLR values were 0.21, 0.32, 0.47 and 0.54 kg KOİ/m³.d, respectively. Fluxes were 2.1, 1.6, 1.1, 1.18 and 0.9 L/m².h for the membrane surface area of 66 cm².
Sulphate, sulphite, etodolac, COD removals were reached to 76%, 99%, 60% and 95% respectively. System performance was deteriorated with increasing COD to 15000 mg/L. COD removal rate was decreased to 60%. Sulphite inhibition was likely the reason of the system deterioration.
In conclusion, efficient operation conditions could not be achieved for ASBR. However, if the sulfite inhibition problem can be solved, one stage AnMBR could be applied for treatment of pharmaceutical industry process wastewater. Activeted carbon adsorption is suggested as post treatment for the effective removal of etodolac.
YALÇIN Gözde

Danışman : Prof. Dr. Hüseyin SELÇUK

Anabilim Dalı : Çevre Mühendisliği

Programı : -

Mezuniyet Yılı : 2013

Tez Savunma Jürisi : Prof. Dr. Hüseyin SELÇUK

Prof. Dr. Nilgün BALKAYA

Prof. Dr. Yaşar NUHOĞLU

Doç. Dr. Semih NEMLİOĞLU

Doç. Dr. Yaşar AVŞAR