The Preparation And Investigation of Nanoparticle Based Drug Carriers The aim of this work was to prepare stimuli (thermoresponsive) sensitive polymers from monomers of N-isopropylacrylamide (NIPAm), also comonomers of acrylamide and cationic monomer [ (3-acrylamidopropyl) trimethylammonium chloride], in presence of crosslinking agent of N,N’-methylenebisacrylamide, polymerization initatior potassium persulfate and surfactant sodium dodecyl sulfate was used.
The low critical solution temperature (LCST) and zeta potentials of nanoparticles were analyzed that they had been synthesized by joining alone or together with a proportion of monomers (5%, 10% or 15%) with DLS method. Swelling and shrinkage at different temperature and zeta potential of each polymers were determined as comparative.
It was observed with DLS analysis that LCST value of PoliNIPAM increased to higher LCST values with acrylamide addition.
It was observed that cationic monomer (3-acrylamido propyl) trimethyl ammonium chloride added NIPAM did not show distinct LCST value contrary to pure PNIPAM and acrylamide-NIPAM polymer. But it was gradually shrank with increasing temperature. However the LCST of cationic monomer-acrylamide-NIPAM polymer had been nearly same value with PNIPAM, and it showed less shrinkage.
Fluorescein dye was used as model drug to investigate release behaviour of synthesized polymers with dialysis bag method.
