Wilhelm bernhard workshop on the cell nucleus


NUCLEAR TRANSLATION. AN OLD STORY



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NUCLEAR TRANSLATION. AN OLD STORY


Iborra F.J. and Cook P.R.

Sir William Dunn School of Pathology, Oxford University, UK

It is widely believed that translation occurs only in the cytoplasm of eukaryotes, but our recent results suggest some takes place in nuclei coupled to transcription. The nonsense-mediated decay (NMD) pathway provides circumstantial evidence for this heterodoxy; it probably uses ribosomes to proofread messenger RNAs. We find components of the machineries involved in transcription, translation, and NMD colocalize, interact, and copurify, and that interactions between them are probably mediated by the C-terminal domain of the catalytic subunit of RNA polymerase II. These results can be explained if the NMD machinery uses nuclear ribosomes to translate – and so proofread – newly-made transcripts; then, faulty transcripts and any truncated peptides produced by nuclear translation would be degraded.





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