Dr lalji singh



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CURRICULUM VITAE
OF
DR LALJI SINGH
DIRECTOR, CCMB, HYDERABAD





Centre for Cellular & Molecular Biology

Hyderabad 500007

INDIA


FAX Telephones


International 91-40-27160252 or 27160591 Off: 040-27160789

India 040-27160252 or 27160591 Res: 040-27160555 or 27160556

CCMB Website: http://www.ccmb.res.in



E-mail: lalji@ccmb.res.in

Updated 21st April 2008




Name : LALJI SINGH
Father’s Name : Sri Surya Narain Singh
Date of Birth : 5th July 1947
Place of Birth : Jaunpur, Uttar Pradesh, India
Current Position & : DIRECTOR, CCMB, Hyderabad

Address

Present : Centre for Cellular and Molecular Biology

Hyderabad 500 007 (A.P.)

India

Permanent : Village: Kalwari, Post Office: Sikrara,

District: Jaunpur, Uttar Pradesh, India


Educational Qualifications :
B.Sc. with Zoology, Botany and Chemistry, (1964),

M.Sc. in Zoology with thesis in Cytogenetics (1966)

Ph.D in Cytogenetics, 1971, Banaras Hindu University

(Thesis: Evolution of Karyotypes in Snakes)



Research Interests:

1. Molecular Basis of Sex-determination

2. DNA Fingerprinting

3. Wildlife Conservation



  1. Human Genome Analysis

5. Human Genetic Diversity
Publications:
Dr Lalji Singh has more than 150 research papers published in internationally reputed journals.
Please see Annexure ‘D’ for complete list of Publications


Social Impact of some of the research work carried out by

Dr Lalji Singh



1. Development of a universal probe for DNA Fingerprinting:
Dr Lalji Singh and his colleagues at the Centre for Cellular & Molecular Biology (CCMB) developed a probe called Bkm-derived probe for DNA fingerprinting as a fallout of their earlier internationally well-known work on the mechanisms of the determination of sex. Their probe is being extensively used for forensic investigation, paternity determination and seed stock verification. DNA fingerprinting evidence was presented in the court and for the first time in the annals of the history of Indian Judiciary DNA fingerprinting was accepted as an infallible evidence in the court of law; this verdict was upheld by the Kerala High Court. Since then, they have used this indigenous technique in 500 cases such as paternity disputes, identification of missing children identification of mutilated bodies, exchange of babies in maternity wards and cases of rape and murder, etc. These include sensational cases of assassination of the late Prime Minister Shri Rajiv Gandhi, assassination of Punjab Chief Minister and the famous tandoor case of Naina Sahni.
DNA Fingerprinting technology has reached to common man all over India and is providing them a justice which otherwise would not have been possible for them to obtain.
Based on Dr Singh’s above findings a separate autonomous “Centre for DNA Fingerprinting and Diagnostics” has been set up by the Department of Biotechnology, Government of India.

2. Conservation of wildlife
Although our country is endowed with a tremendous wealth of megadiversity in plant and animal wildlife, their very existence is at stake owing to destruction of forests following industrialization, agricultural activities as well as poaching of wildlife for reasons of sports and money. There was therefore an urgent need to arrest this phenomena and work out strategies to tackle these problems by using innovative techniques. CCMB is, therefore, setting up a laboratory for the Conservation of Endangered Species (LaCONES) at Attapur village near Nehru Zoological Park. The potential utility of molecular techniques in the study of evolutionary relationships of plants and animals is already established. Dr Lalji Singh is presently using this technique for wild life preservation and better management of endangered species in our zoos and also for identification and isolation of genes for useful characters in silkworm races.

3. Species identification for forensic applications
Crimes related to the killing of animals are a serious threat in India. In such a case, we need to establish whether a drop of blood, or tiny piece of meat, bunch of hair or some other mutilated biological sample confiscated by the wildlife curators and/or investigating agencies belongs to human or animal, and if animal, to which species of animal. Such investigations have become very important in recent past with our increased awareness towards threats of extinction of many animal species due to human intervention. The law enforcement requires strong evidences in such matters which could be provided by establishing exact identity of confiscated animal(s) or parts and products thereof. The team of researchers headed by Dr Lalji Singh from the CCMB has recently developed, for the first time anywhere in the world, a novel DNA based approach which, without knowing the history of a forensic sample, is able to establish whether a drop of blood or tiny piece of meat belongs to human or animal, and if animal, to which species of the animal. CCMB has already using this approach in providing the service to the society and has resolved more than 50 cases forwarded by various wildlife curators and crime investigation agencies.

4. DNA based molecular Diagnostics
There are several genetic disorders prevalent in our country. The problem has become much more serious because there are no adequate facilities for diagnosing these disorders. Dr Lalji Singh and his group have set up diagnostic services for many genetic disorders such as sickle cell anemia, Alzheimer’s disease, BCD, male infertility, pancreatitis, Robert’s syndrome, etc. Research by Dr Lalji Singh and his colleagues further helped in better understanding of the role played by genetic factors in these diseases and the possibility of developing better diagnostic tools for the detection and the management of such diseases. These services will be of tremendous help to common man in reducing their agonies whenever therapeutic intervention is possible.

5. Genetic affinities of Andaman Islanders
Dr Lalji Singh and his group have undertaken the study on genetic diversity in primitive tribes of India including the tribal populations of Andaman and Nicobar Islands using Y-chromosomal markers and mtDNA sequences. Data indicates that the Andamanese have closer affinities to Asian than to African population and suggests that they are the descendants of the early Paleolithic colonizers of Southeast Asia – the hunter gatherers and the first migrants moved out of Africa about 60,000-100,000 years ago. These findings have revolutionized the ways of thinking about the origin of man in terms of their evolution and migration from place to place.

6. Genome Foundation and its activities


Human disease and suffering are as old as humanity and genetic disorders are most distressing since there is no cure available for them and the diseases get transmitted across the generations. The problem of genetic disorders in India is enormous. Indians are also genetically susceptible to common diseases, such as, diabetes and heart diseases. Thus, prevention of disability is the only option for these disorders. However, the diagnostic services for them are mostly focused to cater the urban India.
A group of intellectuals with high professional integrity have come together to establish this Foundation under Dr Lalji Singh as its Managing Director, which will provide such diagnostic services to both rural and urban populations of the country. The Foundation will function with people’s participation and utilize the voluntary services of retired scientists and professionals. The Foundation will establish various centres across the length and breadth of India to take these services to the masses through networking with various NGOs and socially committed organizations. The Foundation is already registered under Section 25 of the Companies Act, 1956. A Foundation stone was laid recently by Dr Lalji Singh for a building complex for “Establishing a Rural Centre of Genome Foundation in Northern India” in Jaunpur, UP, India.

Annexures: A. Honours, Awards and Endowment Lectures

  1. Academic and Service Affiliations

  2. Research Interests

  3. List of Publications

  4. List of Patents and Popular Articles

  5. Information on and Relevance of Research Contributions

G. Teaching Experience

H. Organisation of Courses

I. Administrative Experience

J. Sponsored Research/Collaborations

K. International meetings attended

L. Membership of Professional Societies

M. Fellowship of Indian/Foreign Academies

N. Membership of Editorial Boards

O. Membership of Professional Committees

  1. HONOURS, AWARDS AND ENDOWMENT LECTURES

2008

2nd University Foundation Oration


KLE University, Belgaum

2008

18th Convocation of Kakatiya University


Kakatiya University, Warangal (A.P.)

2008

8th Dharma Vira Oration


Sir Gangaram Hospital, New Delhi

2007

Rajbhasha Shri Samman by Bharatiya Rajbhasha Vikas Sansthan


Dehradun

2007

Rashtriya Ekta Samman 2007


National Unity Conference, New Delhi

2007

Sir Edward Mellanby Memorial Lecture


Central Drug Research Institute, Lucknow

2007

Honorary D.Sc. degree


Deendayal Upadhyay Gorakhpur University, Gorakhpur

2006

Dr L D Sanghvi Oration Award


Indian Society of Human Genetics

2006

Father of DNA Fingerprinting Award


Jaunpur Journalists Assocation

2006

J C Bose National Fellowship


Department of Science & Technology

2006

Honorary D.Sc. degree


Uttar Pradesh Rajarshi Tandon Open University, Allahabad

2006

Honorary Professor

Sri Venkateswara University, Tirupati

2005

ISWA Honorary Fellowship (2005)

Indian Science Writers’ Association (ISWA)

2005

Honorary Fellow, Biotech Research Society of India

Biotech Research Society of India

2005

Swami Sukhdevanand Rishi Samman in the field of Genetics

Mumukshu Ashram Siksha Sankul, Shahjahanpur

2004

Intellectuals’ Honour – The Great Son of the Soil

All India Conference of Intellectuals, Meerut

2004

Honorary D.Sc. degree


Banaras Hindu University, Varanasi

2004

Awarded Padma Shri by the President

Government of India

2004

FICCI Award 2002-03 for R&D in Life Sciences

Federation of Indian Chambers of Commerce and Industry, New Delhi.

2003

Biotechnologist of the year 2002

Metro Vision Business & Technology Magazine, Hyderabad

2003

Vigyan Gaurav Award

Council of Science & Technology, Government of Uttar Pradesh

2003

The Honorary D.Sc. degree

Mahatma Gandhi Kashi Vidyapeeth, Varanasi

2003

Purvanchal Ratna

Veer Bahadur Singh Poorvanchal University, Jaunpur

2002

ISHEER AWARD

Indian Society of Health Environment Education and Research (ISHEER), Jodhpur Centre, Jodhpur

2002

TWAS Fellowship

Third World Academy of Sciences Trieste, Italy

2002

Sixth Prof. S. P. Ray-Chaudhuri Memorial Lecture Award

Prof. S. P. Ray-Chaudhuri Foundation, BHU, Varanasi

2002

New Millennium Plaques of Honour - 2001-2002 award for outstanding services in the field of Biological Sciences

By the Prime Minister of India at the 89th Session of the Indian Science Congress-2002

2001

K N Bhal Memorial Gold Medal for 2001

Society of Biosciences, Muzaffarnagar

2001

The D.A.E. – C.V. RAMAN Lecturership-2000

Indian Physics Association, Mumbai

2001

Goyal Prize in Life Sciences-2000

Kurukshetra University, Haryana

2001

CRI Foundation Day Oration Lecture

Cancer Research Foundation, Mumabi

2001

Late Sri Damodaram Sanjivayya Endowment Lecture



Sri Venkateswara University, Tirupati

2001

Dr Y Nayudamma Memorial Extension Lecture on Biotechnology-1999

Dr Y Nayudamma Memorial Turst, Tenali



2001

Kothari Memorial Endowment Lecture

Pondicherry University,

Pondicherry



2000

Visesha Puraskaaram

Dr Ramineni Foundation, USA

2000

The Honorary D.Sc., degree

Purvanchal University, Jaunpur, U.P.

2000

Fellow

Andhra Pradesh Akademi of Sciences, Hyderabad

2000

IMTECH Foundation Day Lecture

Institute of Microbial Technology, Chandigarh

1999

II Mansi Ram Memorial Lecture

University of Delhi, Delhi

1999

Professional Excellence Award in Science & Technology - for Expertise in DNA Fingerprinting

Viswabharathy Academy, Hyderabad

1999

IV Endowment Lecture

The Indian Instrumentation Society, Hyderabad Chapter, Hyderabad


1998

Scroll of Honour: Outstanding Forensic Expert Award - for Indianization of DNA Fingerprinting Technology

The Medico Legal Society, All India Institute of Medical Sciences, New Delhi.

1998

Honorary Professor

School of Animal Sciences, University of Hyderabad, Hyderabad

1998

Indian Academy of Neurology Oration

Indian Academy of Neurology, Bangalore

1998

Dr Yellapragada Subbarow Memorial Oration

The Indian Medical Association, Vijayawada

1997

Joy Govind Law Memorial Medal

The Asiatic Society, Calcutta

1997

Padma Bhushan Dr P S Siva Reddy Endowment Award

Dr P Siva Reddy Founda-tion, Hyderabad

1996

Shri Om Prakash Bhasin Award – in the field of Biotechnology

Shri Om Prakash Bhasin Foundation for Science & Technology, Delhi

1996

Haldane Oration Medal

Society for Bionaturalists, India

1995

The VASVIK Research Award – for Biological Sciences & Technology for the year 1992

Vividhlaxi Audyogik Samshodhan Vikas Kendra, Bombay

1995

Professor Vishwanath Memorial Lecture Award

Indian National Science Academy, New Delhi.

1995

Jagdish Chandra Bose Award – for Research in Life Sciences

Hari Om Ashram Trust, Delhi

1994

Ranbaxy Research Award – in the field of basic medical sciences

Ranbaxy Research Foundation, Ranbaxy, New Delhi

1994

Prof S P Ray-Chaudhuri 75th Birthday Endowment Lecture Award

Banaras Hindu University, Varanasi

1992

CSIR Technology Award – for biological sciences

Council of Scientific & Industrial Research, New Delhi

1974-

76


Commonwealth Scholarship – for Postdoctoral Research in Molecular Biology


Edinburgh University, UK

1974

INSA Medal for Young Scientists

Indian National Science Academy, New Delhi

1973

Dr S P Basu Memorial Medical - for outstanding contribution in the field of Cytogenetics

Zoological Society, Calcutta


1966

Banaras Hindu University Gold Medal – for standing first in order of merit in M.Sc (Zoology)

Banaras Hindu University, Varanasi


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