This first draft is not complete as there is an overwhelming amount of information regarding CFS (which is complicated by every case different), also there is not a single cause but instead the condition is a syndrome of connected issues leading to each other for effect. This report is an amalgamation of different books and articles, each presented in the order the author deemed best for the recovery process. In the available time to draft this report I did my best to present it in the same steps (and categories) of the original authors, though I apologize there is much overlap and repetion between the categories and the presentation is not always entirely linear. Formating problems have jumbled the order of some of the text, and certain charts are to be included. Further drafts will correct these problems.
Note, when come across words in italic like this: Mitochondrial Function Profile, they denote names of the various articles that can be downloaded and tests Dr Myhill discusses and recommends which can be ordered from her website.
The systrems that are addressed in this report (with the analogy of the body as a car)
Engine is Mitochondria
Fuel is Diet/Nutrition
Oxygen is Lungs
Accelerator pedal is Thyroid
Gearbox is Adrenals
Service and repairs is Sleep
Cleaning oil is Antioxidants
Cooling system is Detoxification
Driver is The brain
First I must recommend working with individual naturopaths or clinics. I have made incredible strides in wellness thanks in no small part to two amazing Naturopaths: Merina Bellocchio (https://www.facebook.com/cosmicalchemy (503) 567-5612), and Lawrence Hoppis (https://www.facebook.com/lhoppis (707) 245-0783), as well as the Holtorf Medical Group www.holtorfmed.com
Second I neglected to add such items as how to source rice to avoid arsenic (Thailand best source, US worst). Why wash rice before cooking (removes 30% of the arsenic). How important it is to cook only with coconut oil, and to eat it as as a spread every day. I will add links as to why vegetable oil is harmful to cook with. Up to 80% of all supermarket olive oils in the US are not olive oil and and contain foreign chemicals, solvents, and other potentially harmful ingredients (link to which oils are safe and where to find them). Importance of avoiding modified food starch. Also, many vinegars contain lead and must be avoided. Not running dishwasher with plastics.
Also I have found a lots of great further research including this article it begins in a rather confusing eay but makes more sense further along.
Holtorf med takes a multi stage approach. Aftrer an initial battery of tests it was discovered I was deficient in certain items to which I was given supplements. I will now do a second volley of different tests. I will add here exactly what the tests and supplements are.
(Note, about to add the details of this presentation 'If you're a potato or coffee lover like me, then I'm afraid I've got some bad news for you...unless you're religiously buying organic, that is.
You see, as a root vegetable potatoes absorb all of the compounds in the soil they're grown in. For conventionally grown potatoes, this means they're soaking up loads of herbicides, pesticides, and fungicides on a daily basis.
According to the USDA, 37 different pesticides have been found on conventionally grown potatoes. Seven of these are possible cancer causing agents, 9 are brain and central nervous system toxins, and 12 are possible hormone disrupters. Even worse, 6 have been shown to potentially cause developmental and reproductive harm!
But it doesn't stop with potatoes. In fact, did you know that there's an ingredient in your daily coffee that could be KILLING your brain? Truth is, this ingredient is so toxic that the United Nations is considering a worldwide BAN, but the food industry is keeping it under wraps in hopes that you don't hear about it.' http://braindrainsolution.com/brain-boost/?sid=bt0709&nmo=1&utm_source=nl&utm_medium=email )
First, what makes the most sense to me for my case is that my head injury affected glands that regulate hormone balancing (in CFS there is a general suppression of the hypothalamic-pituitary-adrenal axis), so improper digestion then resulted, which in turn, led to a lowered immunity and also autoimmunity inflammation response. I used Xifam to correct my biome however biofilm protected some of the invasive bacteria colonies and I have found enzymes that will eradicate the biofilm to expose the colonies as well as the proper pre and probiotics to then employ. Until assessment and ensuing prescription for the hormonal system imbalance properly mitigated, long term benefits of healing individual symptoms is likened to a game of plugging holes in a leaking wall. At the first clinic visit imbalances in hormone levels were already noted, it seems the expertise and technology available to the clinic is the most decisive way to address this communicative cascade (I have attached a diagram of the syndrome). Tending that healing modalities used in treating CFS's differing symptoms are oppositional in practice, the causeprinciple addressed by the clinic proves logical.
The cause of Chronic Fatigue Syndrome (CFS) is not yet clear. It is a complex disorder which does not have one absolute cause behind it. Rather, there are multiple underlying causes that feed off of each other and together manifest as Chronic Fatigue. Further, the group of factors that may cause one person's illness may be different from another's with similar symptoms.
From Dr. Myhill: "CFS is simply a description of a group of symptoms with several causes, of which more than one may be present in any individual. Most patients present with CFS following a viral infection and therefore it has been assumed that viral infections cause CFS. I don't believe this is entirely right. I think people are predisposed to getting CFS, partly through genetic factors and partly by the way they live their lives. A viral infection just happens to be a powerful stress or trigger, i.e. “the last straw”, which tips them into CFS. I am increasingly seeing patients with CFS following exposure to toxic chemicals such as organophosphates, other pesticides, carbon monoxide, silicone breast implants and other such toxic chemicals which can also act as a powerful trigger. It is no coincidence that the increasing incidence of CFS parallels rising environmental pollution. I suspect that toxic chemicals damage the immune system so that it is unable to deal adequately with viral infections eventually leading to a CFS. I treat CFS by working out the underlying nutritional, biochemical, immunological, toxic, hormonal, and lifestyle mechanisms that cause the symptoms and signs."
Others believe Chronic-Fatigue-Syndrome is due to a damaged immune system (with low natural 'killer cell' activity). This sets the stage for infections with candida, viruses, bacteria, and parasites. Perhaps the low 'killer cell' activity might be due to toxic metals, pesticides, a vitamin D deficiency, as well as other causes? (see http://www.flcv.com/cfsfm.html)
The following health imbalances have all been identified as possible factors that can lead to Chronic Fatigue Syndrome.
a) The Epstein Barr Virus (EBV), which causes mononucleosis (also called glandular fever), has been continually linked with Chronic Fatigue and Fibromyalgia (FM). Many people with these conditions initially had EBV and never recovered. Recent studies continue to associate the two together. Other viruses are also commonly found in the blood of many people with CFS and FM.
People with these conditions, regularly test positive for elevated levels of RNase L, which is an enzyme found in the cells of the body. It is activated when the body is under attack from viruses. However it appears that the RNase L system of those with CFS is compromised, and is therefore unable to effectively fight the viruses.
b) Mycoplasma Bacteria Tied To Chronic Illness
Slow growing infections may cause or promote a host of chronic illnesses, including Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Syndrome. Symptoms such as fatigue, headaches, soreness, joint pain and others overlap across many chronic illnesses. And patients with these ailments have few treatment options because of limited understanding about the cause of their signs and symptoms.
In one study on 203 Chronic Fatigue Syndrome patients, around 70 percent had mycoplasma DNA in their bloodstream, indicating the presence of mycoplasmas. In contrast, only nine percent of 70 healthy individuals compared carried such signs. Another trial compared 200 Gulf War Syndrome patients to 62 healthy military subjects. People with the illness were more than seven times more likely to have mycoplasmal infections.
Mycoplasmas lack many of the features of more aggressive infectious bacteria, such as cell walls, than enable antibiotics like penicillins to target invading germs. Because of their simple structure, mycoplasmas reproduce slowly, using the machinery of invaded cells to produce their energy and many of their synthetic molecules. Individuals with immune systems compromised by viruses, radiation or pollutants appear to be at risk from mycoplasmal infections.
The breakthrough is using new genetic tools to find and measure the bacteria. Dr. Garth Nicolson, the study’s author, has adapted the DNA analysis used by crime investigators to detect germ genes in each patient's bloodstream. Once mycoplasmas are identified, Dr. Nicolson provides antibiotic treatment suggestions to physicians who then treat their patients.
Two federal efforts based on Dr. Nicolson's results are now underway to seek to determine whether antibiotics can cure chronic illness. One, conducted at Walter Reed Army Medical Center, looks at the blood of Gulf War veterans for signs of mycoplasmas. The other, conducted at Veterans Affairs Medical Centers nationwide, involves giving some mycoplasma-positive Gulf War Syndrome patients antibiotics and others dummy pills under rigorous experimental conditions designed to ferret out the true effectiveness of the therapy. Medical Sentinel Vol. 4, no. 5, 172-75 September/October 1999
You could get tested for it and see where you are. Focus Diagnostics is a good lab for testing. http://www.focusdx.com/
Dr. Joel Baseman's http://www.uthscsa.edu/micro/faculty/jbb/jbb.asp assistant explains that if you have antibody titers in the 200-300 range then there might be a possibility that mycoplasma is causing a problem. A helpful reference is the site: http://chronicfatigue.stanford.edu/
Mycoplasma may not be the cause of ME/CFS, but it has some interesting possibilities as a co-factor with a retrovirus.
From US Patent #5242820 for mycoplasma fermentans incognitus (1993):
Coinfection with Mycoplasma fermentans (incognitus strain) enhances the ability of human immunodeficiency virus type-1 (HIV-1) to induce cytopathic effects on human T lymphocytes in vitro. Syncytium formation of HIV-infected T cells was essentially eliminated in the presence of M. fermentans (incognitus strain), despite prominent cell death. However, replication and production of HIV-1 particles continued during the coinfection. Furthermore, the supernatant from cultures coinfected with HIV-1 and mycoplasma may be involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Abstract from Science 251, 1074 (1991). Since the presence of M. fermentans incognitus is most often associated with AIDS and other acute fulminant disease states and more profoundly affects the course of its disease, it can be used to determine the prognosis of these diseases, which information can be utilized for designing therapy regimes. Without being bound by any proposed mechanism, it is believed that antibodies against ORF-1 ... may react against CD4.sup.+ lymphocytes resulting in an auto-antibody response against CD4 on T cells thus enhancing the cytopathic effects of HIV-1 on T cells.
Other Disease States in Which M. fermentans incognitus Has Been Implicated
In addition to AIDS, M. fermentans incognitus has been implicated in a number of other Disease states including Chronic Fatigue Syndrome, Wegener's Disease, Sarcoidosis, respiratory distress syndrome, Kikuchi's disease, autoimmune diseases such as Collagen Vascular Disease and Lupus, and chronic debilitating diseases such as Alzheimer's Disease. M. fermentans incognitus may be either a causative agent of these diseases or a key co-factor in these diseases.
The invention still further relates to a variety of different forms of vaccine against mycoplasma infection
Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes, from Endresen GK1.
Chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) are characterised by a lack of consistent laboratory and clinical abnormalities. Although they are distinguishable as separate syndromes based on established criteria, a great number of patients are diagnosed with both. In studies using polymerase chain reaction methods, mycoplasma blood infection has been detected in about 50% of patients with CFS and/or FMS, including patients with Gulf War illnesses and symptoms that overlap with one or both syndromes. Such infection is detected in only about 10% of healthy individuals, significantly less than in patients. Most patients with CFS/FMS who have mycoplasma infection appear to recover and reach their pre-illness state after long-term antibiotic therapy with doxycycline, and the infection can not be detected after recovery. By means of causation and therapy, mycoplasma blood infection may permit a further subclassification of CFS and FMS. It is not clear whether mycoplasmas are associated with CFS/FMS as causal agents, cofactors, or opportunistic infections in patients with immune disturbances. Whether mycoplasma infection can be detected in about 50% of all patient populations with CFS and/or FMS is yet to be determined.
High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients., from Nijs J1, Nicolson GL, De Becker P, Coomans D, De Meirleir K.
Prevalence of Mycoplasma species infections in chronic fatigue syndrome (CFS) has been extensively reported in the scientific literature. However, all previous reports highlighted the presence of Mycoplasmas in American patients. In this prospective study, the presence of Mycoplasma fermentans, M. penetrans, M. pneumoniae and M. hominis in the blood of 261 European CFS patients and 36 healthy volunteers was examined using forensic polymerase chain reaction. One hundred and seventy-nine (68.6%) patients were infected by at least one species of Mycoplasma, compared to two out of 36 (5.6%) in the control sample (P<0.001). Among Mycoplasma-infected patients, M. hominis was the most frequently observed infection (n=96; 36.8% of the overall sample), followed by M. pneumoniae and M. fermentans infections (equal frequencies; n=67; 25.7%). M. penetrans infections were not found. Multiple mycoplasmal infections were detected in 45 patients (17.2%). Compared to American CFS patients (M. pneumoniae>M. hominis>M. penetrans), a slightly different pattern of mycoplasmal infections was found in European CFS patients (M. hominis>M. pneumoniae, M. fermentansz.Gt;M. penetrans).
Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome. Nasralla M1, Haier J, Nicolson GL.
The aim of this study was to investigate the presence of different mycoplasmal species in blood samples from patients with chronic fatigue syndrome and/or fibromyalgia syndrome. Previously, more than 60% of patients with chronic fatigue syndrome/fibromyalgia syndrome were found to have mycoplasmal blood infections, such as Mycoplasma fermentans infection. In this study, patients with chronic fatigue syndrome/fibromyalgia syndrome were examined for multiple mycoplasmal infections in their blood. A total of 91 patients diagnosed with chronic fatigue syndrome/fibromyalgia syndrome and with a positive test for any mycoplasmal infection were investigated for the presence of Mycoplasma fermentans, Mycoplasma pneumoniae, Mycoplasma hominis and Mycoplasma penetrans in blood using forensic polymerase chain reaction. Among these mycoplasma-positive patients, infections were detected with Mycoplasma pneumoniae (54/91), Mycoplasma fermentans (44/91), Mycoplasma hominis (28/91) and Mycoplasma penetrans (18/91). Multiple mycoplasmal infections were found in 48 of 91 patients, with double infections being detected in 30.8% and triple infections in 22%, but only when one of the species was Mycoplasma pneumoniae or Mycoplasma fermentans. Patients infected with more than one mycoplasmal species generally had a longer history of illness, suggesting that they may have contracted additional mycoplasmal infections with time.
What is mycoplasma infection?
Mycoplasma infection is respiratory illness caused by Mycoplasma pneumoniae , a microscopic organism related to bacteria.
Mycoplasma infections occur sporadically throughout the year. Widespread community outbreaks may occur at intervals of four to eight years. Mycoplasma infection is most common in late summer and fall.
How is mycoplasma spread?
Mycoplasma is spread through contact with droplets from the nose and throat of infected people especially when they cough and sneeze. Transmission is thought to require prolonged close contact with an infected person. Spread in families, schools and institutions occurs slowly. The contagious period is probably fewer than 10 days and occasionally longer.
What are the symptoms of mycoplasma infection?
Typical symptoms include fever, cough, bronchitis, sore throat, headache and tiredness. A common result of mycoplasma infection is pneumonia (sometimes called "walking pneumonia" because it is usually mild and rarely requires hospitalization). Infections of the middle ear (otitis media) also can result. Symptoms may persist for a few days to more than a month.
How soon after exposure do symptoms appear?
Symptoms generally begin 15 to 25 days after exposure. The symptoms generally develop slowly, over a period of two to four days.
How is mycoplasma infection diagnosed?
Mycoplasma infection is usually diagnosed on the basis of typical symptoms. A nonspecific blood test (cold agglutinins) is helpful in definitive diagnosis, but is not always positive. The use of more specific laboratory tests is often limited to special outbreak investigations.
Does past infection with mycoplasma make a person immune?
Immunity after mycoplasma infection does occur, but is not lifelong. Second infections are known to occur, although they may be milder. The duration of immunity is unknown.
What is the treatment for mycoplasma infection?
Antibiotics such as erythromycin, clarithromycin or azithromycin are effective treatment. However, because mycoplasma infection usually resolves on its own, antibiotic treatment of mild symptoms is not always necessary.
What can be done to prevent the spread of mycoplasma?
At this time, there are no vaccines for the prevention of mycoplasma infection and there are no reliably effective measures for control. As with any respiratory disease, all people should cover their face when coughing or sneezing.
Mycoplasma is a genus of bacteria that lack a cell wall. Without a cell wall, they are unaffected by many common antibiotics such as penicillin or other beta-lactam antibiotics that target cell wall synthesis. They can be parasitic or saprotrophic. Several species are pathogenic in humans, including M. pneumoniae, which is an important cause of atypical pneumonia and other respiratory disorders, and M. genitalium, which is believed to be involved in pelvic inflammatory diseases.
Molecular Terrorism By Mycoplasm - Genetically Engineered Stealth Microbes May Be The Source Of Your Health Problems
from http://portland.indymedia.org/en/2005/01/309675.shtml by Gary Tunsky / Crusador Newsletter / Portland IndyMedia
You wake up dead tired. You feel like you've been hit by a truck. Sleep becomes sporadic, if at all. When sound sleep occurs, the restoration of energy is minimal causing you to meticulously save your energy like a miser hoards gold. If you force yourself into activities beyond the scope of your normal daily chores, you pay a heavy price. A possible consequence is being bedridden for days. You have trouble concentrating. Short-term memory losses make you feel like you're trapped in a brain fog. You have unexplained muscle aches and joint pains like a never-ending flu. Your spouse and family don't understand this new metamorphic change in you, going from active and bubbly to sick and decrepit in the prime of your life almost overnight. Your social life has disintegrated and once close friends are slowly drifting away because the monotonous explanation that you're too tired to see a movie or go out to dinner has waned thin. Your taking an abundance of sick time and your boss is starting to question your sanity. Nobody understands. Nobody believes. Nobody offers help. Well, almost…Read more
Mycoplasma Variants Linked To Numerous Diseases
1.) M. Fermentans (incognitas strain). The term fermentans reveals fermentation process (i.e.: yeast, molds, fungus, spores, cancer). 2.) M. Penetrans penetrate the cell membrane and invade host cells. 3.) M. Pneumoniae attacks upper respiratory epithelial cells, inflaming them and causing upper respiratory infections and chronic pneumonia. 4.) M. Genitalium (Genitalia) invades urethral tissue and cells in the genital area causing pelvic inflammation and urethritis. 5.) M. Hominus is found in joint tissues in rheumatoid arthritis. 6.) M. Pirum is found in AIDS as a co-factor accelerating AIDS progression. 7.) M. Salivarium is found in salivary glands and joint tissues in rheumatoid arthritis.
Low-level exposure to bodily fluids where concentrations are less will contribute to chronic fatigue syndrome, fibromyalgia, multiple sclerosis and other autoimmune diseases. Specific diseases can be targeted by controlling the Mycoplasma concentrations to bodily fluids.
Mycoplasma Thrives On Cholesterol
For DNA replication, transcription and translation with no organelle or cell wall, They have lost their genes for amino acid and fatty acid synthesis, forcing them to invade and steal proteins, sugars and sterols (cholesterol) from healthy neighboring cells to survive.
These take up residency in the individual's genetically pre-disposed weaknesses, (the weak link in the chain of organs or systems), or the path of least resistance. Since Mycoplasma has absolute dependence upon the uptake of preformed sterols (cholesterol structures), they have an affinity toward cell membranes, nerve cells, sex hormone cell factories, glands and the gray matter in brain tissue, where cholesterol sterols are found. Since cholesterol is a co-factor in glandular hormone production, the endocrine balance is drastically altered with cholesterol being pulled out of the cell cycle. That is why pathogenic changes are seen most often during pregnancy, hormone replacement therapy, steroid therapy, menstrual cycles and xenoestrogens from pesticides, herbicides, meat and dairy.