Welcome to Warwick 2016 the 4th in our series of international polymer chemistry meetings and the largest so far with almost 600 delegates We hope you make many new friends and meet fellow polymer chemists from around the world. The program is designed for you all to spend social time as well as scientific time and for you all to get out of the meeting what you want. Please ask us or any of the Warwick people for any help you require and we will do our best to make your stay pleasant and successful. Most of all enjoy yourselves and make the most of our Campus and surrounding areas. Dave
MACRO GROUP UK
We would like to thank the following for sponsoring or supporting the conference; Gold Sponsors Agilent
The University of Warwick, Materials GRP Silver and Bronze Sponsors and Exhibitors
RSC “Polymer Chemistry”
Shimadzhu Social Program All Free of charge (except Admission Charges) Monday Evening
Welcome Buffet Dinner and “International Quiz Night” Prizes, Prizes, Prizes! Teams of 10/12 required don’t worry we will fix you up in a team – Rootes Social Building Tuesday_Evening___1._7.30-_8.00_PM_Coaches_to_Royal_Leamington_Spa'>Tuesday Evening
1. 7.30- 8.00 PM Coaches to Royal Leamington Spa “English pub night” Experience the delights of English pubs with your student guides,
Coaches return at 10.30 and 11.15 pm to the University. Please sign up but all are invited 2. INVITED GUESTS ONLY. 7.30 PM Coaches to Kenilworth, Walk around Kenilworth Castle with guide and “English Pimms and Beer Evening” at The Queen and Castle pub opposite Kenilworth Castle (walk around the castle weather permitting), Coaches return to the University at 10.30-11.30 PM
Coaches to Stratford upon Avon, home of William Shakespeare
Coaches to Warwick Castle – Entrance tickets available price approx. £15
Coaches to Leamington Spa (Shopping) and Kenilworth Castle Please sign up for preferred trip on the web page, see next page The 4th Polymer 5 a side World Cup on the Sports Field – sign up as teams or individuals
Banquet – with dancing until the early hours. (Bar shuts at 12.30)
Guest appearance – Steve Howdle’s Polymer Rock Band (if you wish to Jam see desk) Sign up for tables at the conference desk and on the web page Kenilworth Castle - Grandeur, Glory, Royalty & Romance!
'This lordly place, where princes feasted and heroes fought' Sir Walter Scott
England’s finest and most extensive castle ruin.
Kenilworth Castle Millennium Trail - a 1.5 mile walk revealing a glorious and beautiful landscape for you to enjoy.
Royal Leamington Spa: perfect mix of Georgian & Victorian architecture, tree-lined avenues, terraces & squares. Visit the Royal Pump Rooms Art Gallery, Museum & Gardens (sample the Spa water!) or sample the excellent number and range of small and large shops.
Warwick a delightful town steeped in history best known for its magnificent castle - the finest mediaeval castle in England.
Stratford-Upon -Avon - beautifully situated on the River Avon, rich in culture and history but most famous for its literary connections relating to the life & works of William Shakespeare.
Poster presenters need to be at their posters at poster sessions.
Posters 1-150 from Monday morning to Tuesday Lunchtime
Posters 151 – 304 from Tuesday Lunchtime to Wednesday Lunchtime
There will be 10 CASH poster prizes which will be presented at the banquet. 4 runners up and 1 first Prize for a) 1-150 and 2) 151-305
Tuesday in the Conference Room (Woods-Scarwen) Industry Session
Tuesday in S0.21 Nanomedicine
Macro Group UK award lectures
Theatre Monday 2.00 pm Dave Adams
Theatre Monday 2.00 pm Paul Topham
Theatre Tuesday 12.00 pm Mike Shaver
Theatre Tuesday 12.30 pm Athina Anastasaki
RSC Polymer Chemistry Award Lectures
Theatre Monday 12.00 pm Richard Hoogenboom
Cinema Monday 2.30 pm Feihe Huang
Directing Macromolecular Chemistry with Light
Professor Christopher Barner-Kowollik
Karlsruhe Institute of Technology
Installing chemical functionality at precise locations within complex macromolecules as well as onto three dimensional direct laser written constructs in the mildest possible fashion (visible light) and without any catalyst becomes possible with powerful light driven, quantitative ligation protocols. Advanced light induced processes enable the parallel encoding of multiple molecules onto predefined locations on surfaces as well as the wavelength dependent addressing of specific parts of a macromolecule for its highly orthogonal functionalization (lambda-orthogonal photochemistry). In addition to exploring the above technologies, the lecture will highlight how polymer functionalization can be directed in its selectivity with light by exploiting light controlled reaction manifolds as well as explore if diffraction unlimited laser lithography is possible based on photo-click chemistry concepts.
Multicellular cancer spheroids as a tool to understand the toxicity of nanoparticles
Professor Martina Stenzel
Micelles and vesicles have long been proposed as carriers for low molecular weight molecules including drugs. Polymer chemist have designed a variety of different micelles and tested their ability to deliver drugs using a tradition assay of cell in 2D. However, the uptake of nanoparticles in vitro does not take the actual structure of tumors into account, which requires the movement of particles into the tissue. Multicellular tumor spheroids (MCTS) can act as a 3D tumor model to investigate the biological responses to polymeric micelles as nanocarriers for therapeutic applications. Therefore, a range of nanoparticles were prepared to study the correlation between nanoparticle type and spheroid penetration. It was found that stable micelles, which were stabilized by crosslinking, penetrated deeper and delivered more drugs into MCTS than the diffusion of the free drug.
The living cationic ring-opening polymerization of 2-oxazolines has been studied in great detail since its discovery in 1966. The versatility of this polymerization method allows copolymerization of a variety of 2-oxazoline monomers to give a range of tunable polymer properties that enable, for example, hydrophilic, hydrophobic, fluorophilic, as well as hard and soft materials. However, this class of polymers was almost forgotten in the 1980s and 1990s because of the long reaction times and limited application possibilities. In the new millennium, a revival of poly(2-oxazoline)s has arisen because of their potential use as biomaterials and thermoresponsive materials, as well as the easy access to defined amphiphilic structures for (hierarchical) self-assembly. Recent developments from our research that illustrate the potential of poly(2-oxazoline)s will be discussed in this lecture, including the preparation of defined high-molar mass polymers as well as functional biomaterials.
Macromolecular Engineering by ATRP
Professor Krzysztof Matyjaszewski
Macromolecular engineering is based on precise design, synthesis, processing and characterization of targeted materials for specific applications. Many advanced nanostructured functional materials were recently designed and prepared by controlled/ living atom transfer radical polymerization (ATRP). ATRP of acrylates, methacrylates, styrenes, acrylamides, acrylonitrile and other vinyl monomers was employed for macromolecular engineering of polymers with precisely controlled molecular weights, low dispersities, designed shape, composition and functionality. Examples of block, graft, star, hyperbranched, gradient and periodic copolymers, molecular brushes and various hybrid materials and bioconjugates prepared with high precision will be presented.
Making molecules with the tiniest machines
Professor Dave Leigh
University of Manchester
Over the past few years some of the first examples of synthetic molecular level machines and motors—all be they primitive by biological standards—have been developed. These molecules respond to light, chemical and electrical stimuli, controlling the motion of the components. Nature achieves the sequence-specific synthesis of information-rich oligomers and polymers through the operation of complex molecular machines that transcribe information from the genetic code (e.g. the ribosome, DNA polymerases etc). We will discuss the first steps towards doing this at a very basic level with artificial molecular machines.
Controllable Supramolecular Polymerization
Professor Xi Zhang
Supramolecular polymers are of great interest because the nature of noncovalent interactions holding them together imparts dynamic, reversible and degradable characteristics to these materials. Although the study of supramolecular polymers has made considerable progress, it remains a big challenge to realize control over supramolecular polymerization. In this presentation, I will introduce two strategies to fabricate supramolecular polymers, leading to advancement of controllable supramolecular polymerization. One is supramolecular polymerization promoted and controlled by molecular self-sorting. The other method involves noncovalent preparation of supramonomers and covalent polymerization of the supramonomers. It is highly anticipated that these studies will enrich the methodology of fabricating supramolecular polymers with molecular weight and structure control.
Professor Virgil Percec
University of Pennsylvania
A Material Genome Approch to Complex Systems
A materials genome approach to complex systems that involves the discovery and the prediction of the structure responsible for function will be discussed. Examples will range from protocells via sequence defined building blocks to Ni-precatalysts for quantitative organic transformations and to helical assemblies that disregard the stereochemical information of their building blocks.
Nanostructure recipes using block polymers as key ingredients
Professor Marc Hillmyer
Block polymers are remarkable hybrid materials that can self-assemble on nanoscopic length scales. By controlling the composition, architecture, chemical nature, end groups, and molar mass, synthetic chemists can precisely tune the morphologies adopted by these materials. The morphology in turn dictates ultimate properties. In this talk, I will discuss the design, synthesis, self-assembly and applications of block polymers for use in nanopatterning at very small length scales and for use in high-performance membrane materials. Emphasis will be placed on modern synthetic techniques for the facile generation of nanostructures in both thin films and the bulk state. In-situ generation of bicontinuous nanostructures will be highlighted as a particularly practical route to advanced nanostructured materials.
Peptide-containing conjugates for triggered assembly and controlled delivery from collagen matrices
Temperature-triggered formation of nanostructures with distinct biological activity offers opportunities in selective modification of matrices and in drug delivery. Toward these ends, motifs from structural proteins, such as collagen and resilin, have been conjugated to polymers including poly(ethylene) glycol, poly(ethyleneimine), or thermally responsive poly(acrylate)-based polymers. Analysis via dynamic light scattering and electron microscopy suggests that the thermally responsive conjugates are able to form a range of nanostructures depending on temperature. Collagen-peptide-modified nanoparticles have enabled the retention and sustained release of cargo from collagen-based materials, offering substantial improvement in cargo activity over that achieved by free nanoparticles. These results suggest the utility of these techniques for designing tunable, collagen-based delivery systems.
First Initiator-Driven Chain-Growth Supramolecular Polymerization
Professor Takuzo Aida
Over the last decade, significant progress in supramolecular polymerization has had a substantial impact on the design of soft materials (1). However, most studies are still based on a preconceived notion that supramolecular polymerization mechanistically follows step-growth polymerization, which does not, in principle, permit the chain-length, sequential, and stereochemical structural control of polymers. Here we report the first noncovalent chain-growth polymerization by designing metastable monomers with an intramolecular hydrogen-bonding network (2). The monomers are disabled for spontaneous polymerization at ambient temperatures, but begin to polymerize with a typical character of living polymerization upon mixing with tailored initiators. The chain growth occurs stereoselectively and therefore enables optical resolution of a racemic monomer: (1) T. Aida, E. W. Meijer, and S. I. Stupp, Science 2012, 335, 813. (2) J. Kang, D. Miyajima et al., Science 2015, 347, 646.
Professor Steve Armes
University of Sheffield
Occlusion of organic nanoparticles within inorganic crystal offers a unique model to examine biomineralization while providing a versatile route to new nanocomposite materials. Herein, a series of poly(ammonium 2-sulfatoethyl methacrylate)-based diblock copolymer nanoparticles are prepared via RAFT-mediated polymerization-induced self-assembly (PISA). Their anionic charge character and size distributions are evaluated by aqueous electrophoresis, dynamic light scattering and transmission electron microscopy. XPS studies confirm that the stabiliser density of these nanoparticles can be tuned by varying the PISA synthesis conditions, e.g. using either aqueous emulsion polymerisation or dispersion polymerisation in ethanol/water mixtures. Some of these anionic nanoparticles can be efficiently incorporated within calcite crystals, with thermogravimetric analysis indicating up to 7.5 wt% (14.8 vol %) occlusion.
Precision Functional Polymers by Precision Polymerizations
Professor Mitsuo Sawamoto
Taking metal-catalyzed living radical and living cationic polymerizations that the author's group have been developing as examples, the lecture will overview the current status of catalyst developments and precision synthesis of functional polymers and oligomers. Special attention will be focused on the principles for reaction control, polymer topology, and sequence-control, among others.
Organocatalytic Polymerization of Ylides: A powerful tool towards well-defined polyethylene-based polymers
Professor Nikos Hadjichistidis
Access to well-defined (high degree of structural, molecular weight and compositional homogeneity) polyethylenes (PEs) and PE-based copolymers is necessary in order to elucidate the structure-properties relationships and evaluate potential applications. Polyhomologation, first discovered by Shea, is a borane-initiated living polymerization of ylides leading to well-defined polymethylene (C1 polymerization). Our group is developing both novel borane catalysts/initiators and ylide monomers and combines polyhomologation with other living polymerizations to synthesize model polymethylene (equivalent to polyethylene, PE)-based polymeric materials.
Macro Group UK Award Lecture
Professor Dave Adams, Emily R. Draper, C. Colquhoun, J. Raeburn, L. Chen
Supramolecular polymers can be formed by self-assembly and have many applications , from sensing, cell culturing, and electronics. We have been investigating the formation of gels using small molecule gelators, the assembly of which into long fibrous structures forms the gel matrix. Mixing building blocks can be used to make a range of interesting new materials. Here, we will describe a range of mixed systems. We will show how fibrous structures form in these systems and show how we can control how different types of fibrous networks are built up in multicomponent systems. We describe both self-sorted and co-assembled networks and the effect of these different networks on the gel properties.
Macro Group UK Award Lecture
Dr Paul D Topham,
A strategy to use block copolymer technology to modify surface properties of thin films
A strategy to use block copolymer technology to modify surface properties of thin films is presented. Focus is paid on external physical stimuli, such as temperature, to trigger changes in surface character of polymer films. In contrast to chemical modification, external physical triggers render the processes more amenable to industrially-relevant roll-to-roll printing processes. The specific materials discussed are targeted for use in organic photovoltaics, however, the strategy should be amenable to a variety of surface technologies/applications. The use of x-ray scattering to probe the nanomorphology of the thin films is also explained and discussed in reference to controlling the film properties through manipulation of the molecular composition of the block copolymers.
Professor Daniel Savin, Greg Strange, Ian Smith, Craig Machado, Jacob Ray
This study involves the bottom-up design and tunability of responsive, peptide-based block polymers. The self-assembly of amphiphilic block polymers is dictated primarily by the balance between the hydrophobic core volume and the hydrophilic corona. In these studies, amphiphilic diblock, triblock and star polymers containing poly(lysine) (PK) and poly(glutamic acid) (PE) were synthesized and their solution properties studied using dynamic light scattering, circular dichroism spectroscopy and transmission electron microscopy. This talk will present some recent studies in solution morphology transitions that occur in these materials as a result of the helix-coil transition and associated charge-charge interactions. We exploit the responsiveness of these materials to encapsulate and release therapeutics such as doxorubicin and demonstrate the potential to achieve triggered release as a function of pH due to morphology transitions.
Professor Feihe Huang,
RSC Polymer Chemistry Award Lecture
Supramolecular Polymers Based on Host-Guest Molecular Recognition Motifs
We are interested in the fabrication of supramolecular polymers based on host-guest molecular recognition motifs. Self-sorting organization of two AB–type heteroditopic monomers led to the formation of linear supramolecular alternating copolymers. By utilization of host-guest and metal-ligand noncovalent recognitions motifs, different topologies of supramolecular polymers, such as linear and crosslinked species, can be reversibly interconverted by external stimuli. Based on the dibenzo-24-crown-8/1,2-bis(pyridinium)ethane recognition motif, a hyperbranched mechanically interlocked polymer was prepared by polyesterification of an easily available dynamic trifunctional AB2 pseudorotaxane monomer. By utilization of a crown ether-based host-guest recognitions motif, a supramolecular polymer gel constructed from a low molecular weight A-B monomer shows thermo- and pH-induced reversible gel-sol transitions.