Electronic Posters: Cardiovascular

Thursday 13:30-15:30 Computer 32

13:30 3628. High Resolution 3D Cardiac Perfusion Imaging Using Compartment-Based k-T PCA

Viton Vitanis¹, Robert Manka, ^1,2, Henrik Pedersen³, Peter Boesiger¹, Sebastian Kozerke<sup>1

1</sup>Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland; ²German Heart Institute Berlin, Berlin, Germany; ³Functional Imaging Unit, Glostrup Hospital, Glostrup, Denmark

k-t PCA is an extension of k-t SENSE aiming at improving reconstruction of non-periodic dynamic images. It is based on a decomposition of the training and undersampled data into a temporally and a spatially invariant term using principal component analysis. In this abstract, a compartment based k-t PCA reconstruction approach is presented, which aims at improving highly undersampled, high-resolution 3D myocardial perfusion imaging by constraining the temporal content of different compartments in the image series based on the bolus arrival times and prior knowledge about the perfusion curves.

14:00 3629. Highly Accelerated 3D SSFP First-Pass Myocardial Perfusion at 3T Using a 32-Channel Coil

Matteo Milanesi¹, Thomas K. Foo², Luca Marinelli², Christopher J. Hardy², Dan W. Rettmann³, Wei Sun⁴, Stephen Garnier⁴, Ersin Bayram⁴, Piergiorgio Masci¹, Vincenzo Positano¹, Luigi Landini⁵, Massimo Lombardi<sup>1

1</sup>"G. Monasterio" Foundation, Pisa, Italy; ²Global Research Center, General Electric, Niskayuna, NY, United States; ³Applied Science Laboratory, GE Healthcare, Rochester, MN, United States; ⁴GE Healthcare, Milwaukee, WI, United States; ⁵Department of Information Engineering, University of Pisa, Italy

This study presents a new highly accelerated 3d saturation recovery first-pass perfusion using balanced steady state free precession (Fiesta) pulse sequence. Saturation was carried out through a 8ms adiabatic BIR4 radio frequency pulse. Acquisition was carried out at 3Tesla using a 32 channel cardiac coil, which allow 4-fold acceleration factor. Good image quality and CNR was obtained in three subjects anticipating a clinical validation of this pulse sequence

14:30 3630. Myocardial T1 During Multiple Bolus Injections

Christian Stehning¹, Timothy Lockie², Eike Nagel³, Masaki Ishida³, Sven Plein<sup>3

1</sup>Philips Research Europe, Hamburg, Germany; ²Cardiovascular Division, King's College, London, United Kingdom; ³Division of Imaging Sciences, King's College, London, United Kingdom

MR first pass perfusion imaging via the dynamic enhancement after intravenous contrast injection has become a valuable clinical tool for the assessment of myocardial perfusion. The aim of the present study was to investigate whether such a saturation effect of myocardial T1 has to be taken into account in MR-based perfusion studies involving multiple injections of Gd-DTPA.

15:00 3631. Magnetic Resonance Quantification of Myocardial Perfusion with a Minimally Constrained Deconvolution Model

Omar El-Sherif^1,2, Robert Z. Stodilka^1,2, Nathan A. Pack^3,4, Edward VR Dibella^3,4, James A. White⁵, Robert Terry Thompson^1,2, Frank S. Prato<sup>1,2

1</sup>Imaging, Lawson Health Research Institute, London, Ontario, Canada; ²Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ³Department of Bioengineering, University of Utah, Salt Lake City, UT, United States; ⁴Radiology, Utah Center for Advanced Imaging Research, Salt Lake City, UT, United States; ⁵Cardiology, London Health Sciences Centre, London, Ontario, Canada

We introduce a novel minimally constrained myocardial perfusion analysis technique. The technique has been implemented on dynamic contrast enhanced magnetic resonance images, obtained from 10 patients with hypertrophic cardiomyopathy. Regional myocardial perfusion estimates were directly compared to both the Fermi perfusion model and a 2 compartment perfusion model. The results indicate that there is discrepancy between Fermi and 2 compartment models during stress exams. However our technique correlates well with the Fermi model during both stress and rest exams.