#The most dangerous complication of ace inhibitor therapy

#The most dangerous complication of ACE inhibitor therapy:
-cough
-gipokaliemiya
+angioedema
-hypotension
-violation renal function

# A week later, receiving clonidine with good effect, blood pressure rose again. The mechanism of resistance

+ sodium and water retention
- addictive
- paradoxical reaction
- accelerating metabolism
- the acceleration of excretion

# Mechanism ulcerogenic NSAIDS:

- overproduction of gastrin
+inhibition of prostaglandin synthesis
- stimulation of the formation of thromboxane
- increased production 3.5 - c-AMP
- increased synthesis of prostaglandins

# When changing from parenteral administration GCS hormones on their oral dose should be:

-increasein 2-5 times
+reduced by 2-5 fold
-reduce 1.5-2 times
-increase1.5-2 times
-still unchanged

# ACE inhibitors are contraindicated in:

+double-sided renal artery stenosis
-vasorenal hypertension
-hypertonic lung disease course
-hypertonic disease moderate flow
-hypertonic disease and coronary heart disease

# Which antihypertensive drug is contraindicated for pregnant women?

-gidralazin
-metoprolol
-nifedipin
+captopril
-prazozin

# Specify the drug of choice in the treatment of hypertension in patients with concomitant coronary artery disease:

-apressin
-reserpine
+metoprolol
-klofelin
-nifedipin

# Specify the drug of choice for hypertension combined with obstructive syndrome:

+verapamil
-anaprilin
-reserpine
-sotalol
-raunatin

# Specify the drugs of choice in the treatment of hypertension and diabetes mellitus:

-tiazidovye diuretics
-beta blockers
calcium antagonists
+ACE-inhibitors
alpha-blockers

# What is a side effect commonly observed in the appointment of verapamil?

-swellinglegs and feet
+bradycardia
-hypotension
-prilivy
-reflector tachycardia

# Contraindication for beta-blockers:

- hypertension
+hypothyroidism
- stable angina
- beats
-tachycardia

# What types of adrenergic receptors stimulates norepinephrine (noradrenaline) ?:

+ alpha, beta1
- alpha, beta 2
- beta2
- alpha1, beta1, beta2
- alpha2, beta1, beta2

# Adrenoceptors stimulated by epinephrine (adrenaline) ?:

-only alpha
-only alpha, beta 2
- only beta
- only alpha1, beta1
+ alfa1,2, beta1,2

# Which drug is an ACE inhibitor ?:

-atenolol
-verapamil
+enalapril
-rilminidin
-indapamid

# Which drug is a beta-blocker ?:

+bisoprolol
-ramipril
-benzogeksony
-reserpine
-gidralazin

# Specify the drug, an angiotensin-2 receptor blocker? :

- perindopril
+ valsartan
- indapamide
- moxonidine
-nifedipin

# Preparations of calcium antagonists is:

-raunatin
-klofelin
+amlodipine
-kaptopril
-lozartan

# What is the route of administration of drugs for hypertensive crisis most rational:

+ sublingual
- inside
- rectal
- intramuscular
- intravenous

# Alpha-blockers include:

-amlodipine
-klofelin
+doxazosin
-kaptopril
-lozartan

# Thiazide diuretic used in the treatment of essential hypertension:

-gipotiazid
+indapamide
-furosemid
-diakarb
-spironolakton

# What types of dopamine receptors stimulate?

-only alpha
-only dopamine
- only Beta
- only alpha1, beta1
+ alpha, beta, dopamine

# Most of the daily dose of prednisolone should be administered:

+morning
-day
-in the evening
-for the night
-at night

# Side effects of glucocorticoids:

-hypotension
-bronhospazm
-drowsiness
+diabetes
-hyperkaliemia

# Prednisolone pulse therapy is used to treat:

- pneumonia
- rheumatism
- rheumatoid arthritis
+ systemic lupus erythematosus
-dermatomiozita

# In the treatment of anaphylactic shock are used:

+ epinephrine, prednisone
- atropine, vikasol
- dibazolum, pentamin
- corvalol, nitroglycerin
-nifedipin, clonidine

# The most pronounced anti-inflammatory action has:

-metamizol (analgin)
-piroksikam
+indomethacin
-ibuprofen
-paracetamol

# Aspirin in comparison with indomethacin has a more pronounced:

-analgetic
+ antiplatelet
-hypothermic
-antiinflammatory
-desensibilisation effect

# Side effects of NSAIDs are due to:

-blockage phospholipase A-2
+ blockade of cyclooxygenase-1
-blockade cyclooxygenase-2
-a direct toxic effect on tissues
-blockade lypoxygenase

# What are the clinical effects of NSAIDs appear before other?

+ antipyretic
- anti-inflammatory
-desensitizing
- antiplatelet
- immunosuppression

# Contraindications to the basic anti-inflammatory drugs is:

- rheumatoid arthritis
- vasculitis
- psoriasis
+pregnancy
- carditis

# For what purpose are used allopurinol ?:

- how antipyretic
- as an analgesic
+ to treat gout
- for the prevention of influenza
- for the treatment of rheumatoid arthritis

# Specify the drug inhibits the biosynthesis of uric acid:

-colchicine
-benzbromaron
-indometatsin
+allopurinol
-aspirin

# The use of corticosteroids is dangerous to the fetus ?:

- prednisolone
+ fluorinated corticosteroids
- hydrocortisone
- SCS with metil
- dexamethasone

# Specify the nonselective beta-blockers:

- metoprolol
+ propranolol
- atenolol
-nebivolol
-bisoprolol

# What is the antihypertensive agent is contraindicated in patients suffering from hypertension and asthma ?:

-nifedipin
+bisoprolol
-indapamid
-verapamil
-valsartan

# Specify the typical side effects of nifedipine:

-the development of AV-blockade
-bradycardy
-bronchospasm
+reflex tachycardia
- dry cough

# Specify the immunostimulatory drugs:

-prednisolon
+ interferon
-dimedrol
-ibuprofen
-delagil

# Specify a drug used for the relief of hypertensive crisis:

+ nifedipine
-enalopril
-bisoprolol
-indapamid
-amlodipine

# Specify the irrational drug combinations in the treatment of hypertension:

+ beta-blockers + verapamil, diltiazem
-diuretik + beta-blocker
-calcium antagonist + ACE-inhibitors
-diuretik + ACE-inhibitors
-digidropiridinovy ​​calcium antagonist + beta-blocker

# Which drug has a minimum ulcerogenic activity?

+ ibuprofen
-indometatsin
-aspirin
-butadion
-diklofenac

# Which diuretic effective in the glomerular filtration rate of less than 10 ml / min:

-diakarb
-indapamid
+torasemide
-amilorid
-gipotiazid

# Which drug reduces effects of furosemide:

-atropine
-ventolin
-reserpine
-verapamil
+voltaren

# If a clinical situation diuretics are not effective:

-hypercalciemy
+hyponatremia
-giperalbuminemiya
-arterial hypertension
-liver insuffiency

# Which drug potentiates the delay in the appointment of potassium when prescribing amiloride:

-nebivolol
+ captopril
-furosemid.
-nitrosorbid
-gipotiazid
# Specify the dosing regimen of furosemide:
-10-50 Mg / s
-600 Mg / sec
+ 40-600 mg / s
-not menee500 mg / s
-only 100 mg / s

# Choose the correct statement:

-furosemide causes hyperkalemia
-diakarb - a powerful diuretic
+torasemide-strong diuretic
- mannitol causes acidosis
- pananginum indicated in hyperkalemia

# Specify the dosing regimen indapamide:

-40 Mg / day
-100 Mg / day
+1.5-5 mg \ day
-25-50 Mg \ day
0.5 mg \ day

# For security diuretic therapy control everything, except:

refractive acid-base balance
-kreatinin
-electrolit
+fundus
-central hemodynamics

# Which drug is short-acting diuretic:

-indapamid
+ mannitol
-diakarb
-gipotiazid
-veroshpiron

# What diuretic, causing the loss of potassium 1: 1:

-furosemid
-diakarb
-mannitol
+hydrochlorothiazide
-amilorid

# Why NSAIDs cause resistance to loop diuretics.

-sweling bowel wall
-at the expense of hyperuricemia
-acceleration elimination
+blockade of prostaglandin
-konkurentsiya for communication with protein

# Loop diuretics in all states is a means of selecting, except:

-swelling syndrome in circulatory failure
+ hyponatremia
-hypercalciemy different genesis
-hyperkaliemy
-nephrotic syndrome

# Diacarb effective in all states, except:

-metabolic alkalosis
-glaucoma
-epilepsy
- craniocerebral hypertension
+pulmonary heart

# Side effects furosemid include everything except:

-hypokaliemia
+decrease in glomerular filtration rate
-hyperurecimia
-ototoxicity
-hypovolemia

#Assignment thiazides shown at:

-heavy liver failure
-terminal renal failure
+diabetes insipidus
-podagra, acute phase
-circulation insufficiency 3 degrees

# Diuretic effect "thiazide and notiasid" drugs will stop when the largest glomerular filtration rate of less than ml / min:

+30
-80
-60
-70
-65

#Patients with coronary heart disease and postinfarction cardiosclerosis developed pulmonary edema. Diuretic choice:

-mannitol in / veno
+ furosemide / intravenous
-gipotiazid inside
-veroshpiron inside
-diakarb inside

# To correct resistance to diuretics in the nephrotic syndrome should be appointed:

+albumin infusion
-furasemid infusion
-infusion saline
-polarised mixture
-reosorbilakt intravenously

# Resistance to diuretics in congestive heart failure caused by:

-blockaga prostaglandins
-decrease in existing nephrons
-urine protein-bond
+ incomplete and delayed absorption
-quick elimination

# For all antacids are typical side effects, except:

-vismut oxide encephalopathy
- magniy oxide- diarrhea
+ accomodation
-aluminium hydrooxide- constipation
-carbonate, calcium alginate - nephrolithiasis

# Specify the method for preventing the development of tolerance to nitrates:

-replacement nitrate warfarin
-decreasing dose
-increasethe number of intakes
+ designation "correctors" (ACE)
-admitting Riboxin

# Specify the preferred group of anti-anginal drug in vasospastic angina variant:

-beta blockers
+ calcium antagonists
-direct anticoagulants
-inhibitory ACE
-diuretics

# Specify the use of lipid-lowering drugs for primary and secondary prevention of coronary heart disease:

-tsiprofibrat
-enduratsin
-omego-3 PUFAs
+ atorvastatin
-holesteramin

# Name the drug, approved for use during pregnancy:

+maalox
-famotidin
-omeprazole
-de-nol
-pantoprazol

# Specify the main pharmacodynamic effects M-anticholinergics, except:

+ weakening of peristalsis
-extension of the pupil
-paralich accommodation
-increaseintraocular pressure
-tachycardia

# Highlight nitrate prolonged duration of action:

-nitroglycerin tablets
+isosorbide-5-mononitrate
-aerosol nitroglycerin
-izosorbid dinitrate
-plastyr nitroglycerin

#Specify the interaction loop diuretics with other drugs:

-reduces digoxin toxicity
+increasethe ototoxicity of aminoglycosides
-weakening hypotensive effect
-reduces nephrotoxicity of cephalosporins
-reduces effects of anticoagulants

# Name the condition requiring the appointment of fibrates:

-drug choice for hypercholesterolemia
- diabetesinsipidus
-low level of triglycerides
+hypertriglyceridemia
-hypertriglitseridemia homozygous
# Name Pharmacokinetics of isosorbide mononitrate:
-low bioavailability
-availability presystem elimination
-effect first passage
+high bioavailability
-time action 10-30 minutes

# Specify the mechanism of action of statins:

-decreasing cholesterol synthesis
+HMG-CoA reductase
-changing with chloride ions
-improves the activity of lipoprotein lipase
-reduces prostaglandin synthesis

# -Specify One of the most important areas of the treatment of coronary artery disease:

-hypoglicemic therapy
-antisecretor treatment
-antiinflammatory treatment
-eradicative treatment
+antianginal therapy

# What are the enzyme preparation:

-omeprazole
+pankreatin
-maaloks
-almagel
-metoklopramid

# What are the primary pharmacodynamic effect of spironolactone:

+ competitively inhibits aldosterone
-increasing renal blood flow
-effecs speed filtering
-increasing osmotic pressure
-increaseof uric acid

# Specify the indications acetazolamide:

-arterial hypertension
-diabetes
-nephrotic syndrome
-cirrhosis liver, ascites
+ intracranial hypertension

# Specify the side effect of diuretics:

-extrasistoly, bradycardia
-bronchospasm, diathesis
+ hypokalemia, hyponatriemia
-arterial hypertension
-metabolic acidosis

# Specify the antiemetic drug:

-omeprazole
-tsimetidin
+ondansetron
-papaverine
-atropine

# Specify the indication for histamine H2-blockers:

-chronic active hepatitis
+peptic ulcer
-nonspecific ulcerative colitis
-acute hepatitis
-athresia bile ducts

# Specify the drug used in the failure of exocrine function of the stomach:

+ hydrochloric acid
-ascorbic acid
-famotidin
-almagel
-dyuspatalin

# Which of these cardiac glycosides refers to polar:

-digitoksin
-atsetildigitoksin
+strophanthin
-digoxin
-celanid

# Which of these cardiac glycosides almost significantly associated with plasma proteins:

-celanid
-corglikon
+digitoksin
-strofantin
-atsetilstrofantin

# cardiac glycosides is contraindicated in:

+ ventral paroxysmal tachycardia
-paroxism atrial fibrillation
-tachysystolic atrial fibrillation
-congestive heart failure
-prophilaction AV reciprocating tachycardia

# Contraindications to the appointment of cardiac glycosides everything except:

-syndrome sinus
-syndrome WPW
-appearing sinus bradycardia
-AV Blockade degree I-II
+atrial fibrillation

# Which of these side effects not characteristic of digitalis intoxication:

-increasing heart rate
-ventral arrythmia
+reduction in blood pressure
-dyspeptic disorders
-AV blockade

# When concomitant administration of anticoagulants and antibiotics broad-spectrum effect of anticoagulants:

-decreases
-not changes
+ increases
-not studied
-neutralise

# Based on the index of coagulation is compensated dose anticoagulants?

-content of antithrombin III
-time blood clotting
-etanolovy test
+ prothrombin index, international normalized ratio
-the concentration of fibrinogen

# What are anticoagulants used in atrial fibrillation?

-streptocinaza
-heparin
+ warfarin
-fraksiparin
-hirudin

# With some blood factors related pharmacodynamic activity of heparin:

-Hageman factor
-proatserilin
+antithrombin III
-factor II
-factor VII

# Which drug can cause "rebound" of thrombosis?

+ heparin
-tiklid
-gordoks
-reopoliglyukin
-dipiridamol

# What are the methods of control of antiplatelet therapy?

+ platelet counts
-time coagulation
-the concentration of fibrinogen
-product fibrinogen degradation
-protrombinovoe time

# Labaratory method of monitoring heparin therapy?

- prothrombin time
-trombotest
-ethanol test
+time of blood coagulation
-concentration of fibrinogen

# Specify the method of emergency treatment of an overdose of heparin?

-konakion
-fresh frozen plasma
+protamine sulfate
-vikasol
-ditsinon

# What is the drug used in overdose coumarin derivatives:

-fibrinogen
-ditsinon
-protamina sulfate
-new freezed plasma
+ vikasol

# In case of overdose antiagregants your tactics:

+etamsylate sodium 250-1000 mg / in
-konakion 10-20 mg
-protamina sulfate 50-100 mg / in
-aminocapron acid
-vikasol

# Which of the following is used for thrombolytic overdose:

+ aminocaproic acid
- protamina sulfate
-ditsinon
-konakion
-fresh frozen plasma

# How should change the clotting time in the appointment of heparin?

-elongating 4 times of the original
-does not change
+ extension 2-2.5 times
-changes are dose dependent
-truncation 2-3 times

# What are the main method of monitoring the effectiveness and safety of thrombolytic therapy:

-clotting time
+ concentration of fibrinogen
-protrombin​​index
-protrombin time
-etanol test

# If a clinical situation cardiac glycosides are used:

- ventricular fibrillation
- AV block II Art
-infarction
-arterial hypertension
+ atrial fibrillation

# Choose a rational combination of drugs used in the treatment of CHF pathogenesis:

- furosemide + amidaron+ nitrosobid
- nitrosorbid + reserpine +aspirin
+enalopril + bisoprlol +veroshpiron
-digoksin+ metopralol + indapamide
-klofellin + ramipril + nebivalol

# Vitamin C in high doses may cause:

-hypotension
+formation of kidney stones
-tachycardia
-obostrenie peptic ulcer
-bronhospasm

# Name therapeutic doses of ascorbic acid:

- 15-50 mg / day
-1,5-2 Mg / day
+ 200-500 mg / day
-10-20 Mg / day
-50-150 Mg / day

# Specify the indications of spironolactone:

-hyperkalemia
-swelling leg and foot
+CHF II-IV NYHA functional class
-ginekomastiya
-increasethe level of creatinine

# Name indication for alteplase:

-unstable angina
-treatment venous thrombosis
-stable angina
+ acute myocardial infarction
-prophylactic venous thrombosis

# For low molecular weight heparin include:

- hirudin
-alteplaza
+ enoxaparin
-tiklopidin
-varfarin

# Thrombolytic therapy in myocardial infarction is aimed at:

-pain relief
-normalization AD
-increaseblood pressure
+ limit the area of ​​necrosis
-profilaktika arrhythmias

# Disaggregation mechanism of action of aspirin is associated with:

+ inhibition of production of thromboxane A2
-increasethe synthesis of prostacyclin
-blokada vWF
-violation synthesis of ADP
-blokada phosphodiesterase

# Side effects of heparin include everything except:

- allergic reactions
-alopecia
-arterialnaya hypotension
-bleeding
+ pulmonary fibrosis

# What kind of a structure of a microorganism cephalosporins have an effect:

+ cell wall
-ribosome
-core
-mitochondry
-vakuol

# What side effects characteristic of aminoglycosides:

+ nephrotoxicity
-kardiotoxicity
-gastropathy
-blurred vision
- movement disorder

# Which group of antibiotics often causes allergic reactions:

+ penicillins
-aminoglikozids
-makrolids
- sulfonamides
-linkozamins

# Name antibiotic for exposure to sensitive strains of Streptococcus Pneumoniae in the treatment of pneumonia:

-ciprofloxacin
- gentamicin
+cefotaxime
-doksitsiklin
-tetratsiklin

# Which antibiotics creates high concentrations in the prostate gland:

+ciprofloxacin
-linkomitsin
-ampitsillin
-erythromycin
-vankomitsin

# Which antibiotics should be prescribed for exposure to micro-organisms that produce beta - lactamase:

-penicillin
-ampitsillin
-tsefazolin
+ amoksicillin+clavulanic acid
-amoksicillin

# Select the antibacterial agent for the treatment of pneumonia caused by Mycoplasma pneumoniae:

-linkozamids
-penitsillins
-tsefalosporins
+ macrolides
-aminoglikozids

# Which is bactericidal antibiotics:

-tetratsiklin
-linkomitsin
-chloramphenicol
+ amikacin
- erythromycin

# The dosage regimen of antibiotic should be changed with symptoms of renal failure:

-tseftriakson
+ gentamicin
-doksicyclin
- erythromycin
-tsefoperazon

# Which produces high concentrations of antibiotic in the bone:

-gentamicyn
-nalidiks acid
+linkomysin
- erythromycin
-cefatoksim

# What is the side effect is not specific to ampicillin:

-rash
-allergic reaction
-diarrhea
- vaginal candidiasis
+nefrotoxity

# Choose the safest antibiotic for the treatment of pregnant women:

+ampitsillin
-gentamitsin
-ciprofloksacyn
- chloramphenicol
-biseptol

# Select the drug for the treatment of sepsis caused by MRSA:

-ampitsillin
-tsefazolin
-thien
-azitromitsin
+ linezolid

# Selekt the most effective anti-pseudomonal drug:

-amoksitsillin
-sefotaksim
-sefozolin
+ meropenem
-gentamitsin

# Note the anti-pseudomonal cephalosporin:

-tsefazolin
-tsefotaksim
-tseftripakson
+cefepime
-tsefaklor

# What preparation is referred to as "respiratory" fluoroquinolones:

-siprofloksatsin
-ofloksatsin
-norfloksatsin
+ levofloxacin
-lomefloksatsin

# What is an antimicrobial drug is contraindicated in children:

-penicillin
-tseftriakson
-azitromitsin
+ciprofloxacin
-eritromitsin

# Select antiherpetic drug:

-remantadin
-zanamivir
+ acyclovir
-oseltamivir
-arbidol

# Select a fluoroquinolone anti-anaerobic activity:

+ moxifloxacin
-levofloksatsin
-tsiprofloksatsin
-sparfloksatsin
-norfloksatsin

# Select the drug for the treatment of pseudomembranous colitis:

-penicillin
-tsefotaksim
-thien
+ vancomycin
-klaritromitsin

# Select an antifungal medication for the treatment of vaginal candidiasis:

-vorikonazol
-teratsiklin
+ fluconazole
-terbinafin
-amfoteritsin

# Mark derivative of 8-hydroxyquinoline:

+ nitrksolin
-etazol
-acids nalidixic
-tsiprloksatsin
-metronidazol

# Nucleoside derivatives for the treatment of HIV infection:

-atsiklovir
+ zidovudine
-guanidine
-gantsiklovir
-zanimivir

# Specify a drug belonging to the macrolide antibiotics:

-neomitsin
-doksitsiklin
+ clarithromycin
-tsefaloridin
-linkomitsin

# Which refers to a group of antibiotics monobactams:

-ampitsillin
-bitsillin 5
+ aztreonam
-imipenem
-levofloksatsin

# Which is not an aminoglycoside drugs:

-gentamitsin
-streptomycin
+ clindamycin
-neomitsin
-amikatsin

# Which is not a fluoroquinolone drugs:

-ofloksatsin
-ciprfloksatsin
+ ceftazidime
-levofloksatsin
-norfloksatsin

# Which is not penicillin drugs:

-ampitsillin
-amoksatsillin
-tikartsillin
+ vancomycin
-piperatsillin

# Do not recommended for the treatment of pyelonephritis:

-tsiprofloksatsin
-tsefotaksim
+ chloramphenicol
-amikatsin
-amoksitsillin / clavulanate

# Which group of antibiotics is ticarcillin:

+ penicillins
-makrolidy
-tsefalosporiny
-ftorhinolony
-monobaktamy

# Which group of antibiotics cefepime is:

-penitsilliny
-makrolidy
+ cephalosporins
-ftorhinolony
-monobaktamy

# Which group is antibiotics piperacillin:

+ penicillins
-makrolidy
-tsefalosporiny
-ftorhinolony
-monobaktamy

# Which group of antibiotics include ciprofloxacin:

-penitsilliny
-makrolidy
-tsefalosporiny
+ fluoroquinolones
-monobaktamy

# Etiotropic therapy for pneumococcal pneumonia:

+ cefazolin
-eritromitsin
-chloramphenicol
-linkomitsin
-azithromycin

# The use of ipratropium bromide as a bronchodilator in asthma everything except:

- "physical force"
+ viscous mucus
- nocturnal attacks
-with abundant mucus secretion
-with concomitant glaucoma

# Sick "avid" smoker gets theophylline. How does smoking on the half-life of theophylline:

-udlinitsya
+ shortened
-essential not change
-significantly be extended
-anonymous

# The most dangerous side effect of sympathomimetic overdose in patients with asthma is:

-tremor jitter
- mental excitement
-tachycardia
+ symptom of "locking"
-nausea, vomiting

# With the simultaneous use of theophylline and beta-2-agonists include the following changes in effect:

+ potentiation
-leveling
-antagonism
-weakening action
-side effects

# Of selective beta2-agonist is:

-izoprenalin
-ortsiprenalin
-adrenalin
-bekotid
+ terbutaline

# Side effects of beta 2-agonists does not concern:

-tahifilaksiya - resistant chronic administration
-syndrome "ricochet"
-syndrome "blocking light"
+ bradycardia
-tremor, dyspepsia

# H1-histamine blockers are most effective when:

-profilaktike nonallergic inflammation
-Treatment allergic reactions
+ prevention of allergic reactions
- The treatment of non-allergic inflammation
- Exacerbation of peptic ulcer disease

# Lack of antihistamines I generation all except:

-tahifilaksiya
- CNS depression
-tachycardia
-atoniya intestine
+ Cough

# For I generation antihistamines do not include:

- Diphenhydramine
- Suprastin
-fenkarol
+ cetirizine
-tavegil

# A typical side effect of antihistamines II generation:

- CNS depression
+ cardiotoxicity
-atoniya intestine
-atoniya bladder
- tachyphylaxis

# Specify the type 4 phosphodiesterase inhibitor, which is used in severe COPD:

-eufilong
-teopek
+roflumilast
-teodart
-retafil

# The clinical effect of inhaled corticosteroids develops after:

-1-2 Hours
-20-24 Hours
+ 2-4 days
-1 week
-2-3 weeks

# Fexofenadine Duration:

-2 hours
-6 hours
-12 hours
-24 hours
-48 Hours

# Indications antihistamine drugs:

-stomach ulcer
-glomerulonefrit
+ hay fever
-cirrhosis of the liver
-tuberculosis

# Preparations for pathogenetic therapy of chronic specific inflammation in COPD:

+ roflumilast, salmeterol, beclomethasone
-klaritin, fenoterol, nizartidin
-montelukast, libeksin, Inderal
-salbutamol, fluticasone, lazartan
-ambroksol, Atrovent, fluconazole

# By selective beta2-agonists does not concern:

+ isoproterenol
-salbutamol
-salmeterole
-terbutalin
-formoterol

# Intalum when combined with beta 2-agonists effect of the latter:

-reduces
-not changes
-significantly reduced
+ enhanced
-side effects

# The main indication for nasal cromoglycates the:

-bronchial asthma
+ allergic rhinitis
-recidiv urticaria
-food allergies
-purulent sinusitis

# What are the optimal route of administration of bronchodilators for chronic obstructive pulmonary disease:

-intramuscular
-under skin
+ inhalation
-peroral
-intravenous

# To reduce the pulmonary hypertension in patients with chronic obstructive pulmonary disease, can apply everything except:

+ propranolol
-kaptopril
-nitrong
-eufillin
-nifedipin

# In some cases, antibiotic treatment is shown an exacerbation of chronic bronchitis:

-in all cases
-with obstructive syndrome
+ purulent sputum
-bolnye over 55 years
-the presence of pulmonary emphysema

# Maintenance dose aminophylline on exit from the patient's asthmatic status:

+3 mg / kg every 6 hours
-6 Mg / kg every 8 hours
-3 Mg / kg every 12 hours
-6 Mg / kg every 12 hours
-3 Mg / kg once a day

# The main goal in the treatment of COPD:

+ reduction in the progression of the process
-complete cure the patient
-oblegchenie symptoms
-is the inverse development of emphysema
-preparation for surgical treatment.

# The concentration of theophylline in serum, causing bronchodilation:

-5 To 10 ug / ml
+10 -20 mkg / ml
-15-25 Mg / mL
-up 20 ug / ml
-20-30 Mg / mL

# The patient was admitted in asthmatic status. What is the "loading dose of aminophylline":

+5.6 mg / kg
- 3 mg / kg
- 8 mg / kg
- 2.8 mg / kg
- 10 mg / kg

# The concentration of theophylline in serum, causing toxicities

-5 To 10 ug / ml
-10 -20 mkg / ml
-15-25 Mg / mL
+ above 20 mkg / ml
-20-30 Mg / mL

# When you cough with purulent sputum is contraindicated in:

-bromgeksin
+ codeine
-mukaltin
-ambroxol
-atsetiltsistein

# Emergency aid for attack of asthma:

+ salbutamol
-codeine
-libeksin
-teofil
-montelukast

# For acute asthma is not appointed:

+ sodium cromoglycate (Intal) - inhalation
-prednizalon intravenously
-fenoterol - inhalation
-eufillin intravenously
-salbutamol - inhalation

# For Inhaled steroids include:

-gidrokortizon
-triamtsinalon
-prednizalon
-deksametazon
+ beclomethasone

# The effect of drugs on the body of the sick person is studying

-pharmacy
-eksperimental pharmacotherapy
-farmakoterapiya
+clinical pharmacology
-farmakogenetiks

# The half-life (T1 /2 -is indicator of:

-volume of drug distribution
-intensity biotranstransformation
+ the time for which the drug concentration in blood plasma decreases in 2 times
-elimination of constants
-volume distribution

# Almost a significant percentage of the binding of drugs to plasma proteins:

-40-60
+ 80-100
-20-40
-60-80
-15-20

# Which of these types of interaction refers to the pharmacodynamic:

+ competition for the receptor
-concuration for absorption
-concuration for binding to the protein
-concuration for the metabolism
-concuration for elimination

# The main objective of Clinical Pharmacology:

+ increasing the efficiency and safety of pharmacotherapy
-create new drugs
-improved drug supply
-improving production technology of drugs
-regulate drug products

# Drug absorption through the skin in newborns compared with adults:

-in 2-3 times less
-in 4-6 times higher
+ 2-3 times more
-in 4-6 times less
-is not different

# Adolescents (13-14 years) is recommended to prescribe drugs in doses, forming part of the adult:

+ 1/2
-1/12
-14
-3/4 the adult dose
-1-3

# Pharmacodynamics of drugs are:

+ pharmacological effects of drugs in the body
-pathway drug in the body
-effect which does not affect the therapeutic target
-changing effect under the influence of other drugs
-movement drugs in the body

# Amiodarone is indicated for:

+ WPW syndrome
-sinusovaya bradycardia
-ATP-ventricular block II Art.
-atrial fibrillation bradisistolic form
-blokada beam Hiss

# What drugs are used to normalize heart rate in atrial fibrillation?

+ propranolol, verapamil, digoxin
-lidokain, digoxin, propranolol
-adenosine, magnesium sulfate, potassium supplements
-difenin, lidocaine, potassium supplements
-hinidin, lidocaine, potassium supplements

# Which of the following drugs is used for ventricular arrhythmias caused by digitalis intoxication?

-verapamil
-amiodaron
+ lidocaine
-propafenon
-hinidin

# What antiaritmikpredochtitelnee for the treatment of sinus tachycardia in the background of angina?

-nifedipin
+ propranolol
-novokainamid
-hydrochloric potassium
-allapinin

# In patients with thyrotoxicosis paroxysmal atrial fibrillation. What medication can not be used?

-dizopiramid
-sotalol
-propranolol
+ amiodarone
-etatsizin

# In a patient with obstructive bronchitis AV tachycardia . Which is drug is contraindicated?

-diltiazem
-digoxin
+ propranolol
-amiodaron
-lidokain

# What is a side effect commonly observed in the appointment of verapamil?

-oteki legs and feet
+ bradycardia
-prilivy
-reflektornaya tachycardia
-blockade

# Which drug is the drug of choice for atrial arrhythmia in the background neurocirculatory dystonia?

-amiodaron
-verapamil
-etatsizin
+ propranolol
-hinidin

# Assignment verapamil with beta-blockers can cause:

+ reduction in myocardial contractility, bradycardia
-increasing myocardial contractility, bradycardia
-decrease in myocardial contractility, tachycardia
-increasing myocardium, tachycardia
-increasing myocardial contractility, arrhythmia

# Questions absorption, distribution, biotransformation and excretion of drugs studies

-farmakodinamika
+ pharmacokinetics
-chronofarmacology
-pharmakopeya
-pharmakogenetiks

# What determines the frequency of taking drugs?

-type drug
-path administration
+ half-life
a character of the action
-bond with proteins

# What is the drug used in the bradycardia?

-lidokain
-diltiazem
-novokainamid
+ atropine
-sotalol

#What is a drug’s half-life?

-time of maximum drug’s concentration in plasma
-time when drug reaches the systemic circulation
-timewhendrug isdistributed in the body
+time when th eplasma drug concentrationis reduced by 50%
-time when halfof the administered dosereaches thetarget organ

#The breadthof therapeutic action- is:

-therapeutic dose ofmedication
-the ratio ofthe drug concentrationin the organ ortissue toconcentration inplasma
+range between the minimum therapeuticand minimumtoxic concentrationin plasma
-percentage ofnon-protein drugs
-the range between theminimum and maximum concentrations of the rapeutic drugs

#The receptor drugs of competitive action include:

-NSAIDs (non-steroidal anti-inflammatory drugs)
+β-adrenoblockers
-loop diuretics
- nitrates
-fluoroquinolones

#The selectivity of the drug’s action depends on:

-the half-life
-route of administration
-due to the protein
-the volume of distribution
+dose

#What drugs are more easily pass through the blood-brain barrier?

-with high solubilityin water
+with high solubilityin fats
-exhibiting properties of weakacids
-exhibiting properties ofweak bases
-loosely coupledplasma proteins

#Define a group of drugs with a narrow therapeutic index:

-β-blockers
-penicillins
+cardiac glycosides
-ACE inhibitors
-powerful diuretics

#Development of asystole is possible in combination of propranolol with:

-phenobarbital
-furosemide
+verapamil
-phenytoin
-ranitidine

#The risk of toxicity is increased in combination of gentamicin with:

+furosemide
-penicillin
-methylxanthines
-macrolides
-glucocorticoids

#To strengthen the anti-anginal effect is a combination of the most secure:

-verapamil + propranolol
-verapamil + atenolol
-verapamil + metoprolol
+verapamil +isosorbide dinitrate
-verapamil +diltiazem

#In angina pectoris the drugs of choice are following classes:

-histamine receptor’s blockers
+β-adrenergic blockers
-α-adrenergic blockers
-imidazoline receptor’s agonists
-angiotensin II receptor’s blockers
#In vasospastic angina the drugs of choice are following classes:
-histamine receptor’s blockers
-β-adrenergic blockers
-α-adrenergic blockers
+calcium channel blockers
-angiotensin II receptor’s blockers

#Adequate monitoring methods of efficacy and safety of antihypertensive therapy are:

-ECG monitoring
+BP monitoring
-one-time blood pressure measurement
-measurement of the ERF
-the dynamics of the QT interval on the electrocardiogram

#Select the unwanted effect that is not characteristic of verapamil:

-bradycardia
-constipation
-the development of AV-blockade
-swelling of legs and feet
+bronchospasm

#In treatment of hypertension the drug of first choice in patients with chronic heart failure is:

+enalapril
-verapamil
-clonidine
-prazosin
-nifedipine

#Choose the antihypertensive drug that increases the activity of sympathoadrenal system:

+nifedipine
-clonidine
-captopril
-metoprolol
-irbesartan

#In patients with hypertension combined with sinus tachycardia preference should be given to:

-calcium channel blockers of the dihydropyridine derivatives
-loop diuretics
+β-adrenergic blockers
-α-adrenergic blockers
-thiazide diuretics

#α₁-adrenergic blockers are the drugs of choice for the treatment of hypertension:

-in patients with liver disease
-in patients with cardiac arrhythmias
+in older men with prostate adenoma and difficult urination
-in patients with angina pectoris
-in patients with myocardial infarction

#For the treatment of hypertension in patients with asthma cannot be used:

-calcium channel blockers
-angiotensin II receptor’s antagonists
-α₁-adrenergic blockers
+β-adrenergic blockers
-diuretics

#Patients with hypertension and myocardial infarction in the first place should be appointed:

+β-adrenergic blockers
-diuretics
-calcium channel blockers
-imidazoline receptor agonists
-α₁-adrenergic blockers

#List the group of drugs that improve the prognosis of patients with chronic heart failure:

-ACE inhibitors
-β-adrenergic blockers
-angiotensin II receptor’s blockers
-spironolactone
+mark all these drugs

#List the drugs, which have a direct positive inotropic effect:

-digoxin
-dopamine
-amrinone
-levosimendan
+mark all these drugs

#Dose titration of ACE inhibitors and β-blockers in patients with CHF includes:

-initiation of therapy with minimal doses of the drug
-increase the dose every 2 weeks
-the achievement of the target dose of the drug
-reducing the number of hospitalizations and increase a lifetimeof patient
+mark all the listed symptoms

#Principles of diuretic therapy in CHF:

-diuretics in heart failure of II-IVFC by NYHA classification
-weight loss of 0.5-1.0 kg per day
-blood pressure control
-monitoring the level of potassium in the blood
+mark all listed

#Drugs lengthening the interval QT:

-clindamycin
-amiodarone
-cotrimoxazole
-quinidine
+all of these drugs

#List the medications prescribed for the prevention of arrhythmia in WPW-syndrome:

-digoxin
-diltiazem
+amiodarone
-procainamide
-all of the products

#Drug of choice for the treatment of paroxysmal ventricular tachycardia:

-lidocaine
-procainamide
-bretylium
-propafenone
+mark all these drugs

#Side effects of amiodarone:

-photosensitivity
-thyroid dysfunction
-dry cough
-transient increase in liver transaminases
+mark all these effects

#From selective β2-agonists is a long-acting:

-fluticasone
+salmeterol
-salbutamol
-fenoterol
-terbutaline

#Long-acting anticholinergic include:

-ipratropium bromide
-kromglikat sodium
+tiotropium bromide
-oxitropium bromide
-triamcinolone acetonide

#A side effect of inhaled corticosteroids is:

-headache
-obesity
+oral candidiasis
-diabetes
-polyuria

#The mucolytics include:

-codeine
-cromolyn sodium
+acetylcysteine
-salmeterol
-theophylline

#Drug of basic treatment in chronic obstructive bronchitis is:

+tiotropium bromide
-nedocromil sodium
-fenoterol
-montelukast
-aminophylline

#Select the group of antibacterial drugs for the treatment of infections caused by intracellular pathogens:

+macrolides
-penicillins
-aminoglycosides
-cephalosporins
-sulfonamides

#Good penetrate the blood-brain barrier following antibiotics:

-lincosamides
-macrolides
-tetracyclines
-aminoglycosides
+III generation of cephalosporins

#A preferred group of antibacterial drugs in the treatment of chronic prostatitis are:

-sulfonamides
-carbapenems
-quinolones
-linkozaminy
+fluoroquinolones

#Select the drug that most inhibits the secretion of hydrochloric acid:

-pirenzepine
-cimetidine
-misoprostol
-antacids
+omeprazole

#The maximum number of side effects among H2-blockers has:

+cimetidine
-roxatidine
-nizatidine
-ranitidine
-famotidine

#Syndrome of return caused by:

-synthetic prostaglandins
-antacids
-blockers of "proton pump"
-M-anticholinergics
+H2-blockers
#The eradication therapy to eliminate H pylori uses following antibiotic:
-carbenicillin
-erythromycin
-ceftazidime
+clarithromycin
-chloramphenicol

#Bactericidal action against H pylori has:

-sucralfate
+bismuth subcitrate
-almagelum
-famotidine
-pirenzepine

# What medications are increasingly exposed to metabolism in the liver:

+ lipophilic
-hydrophilic
- lipophobic
- having an acid reaction
- having alkaline reacting

#Preparations providing unidirectional action called:

-agonists
+synergists
-antagonists
-mimetics
-litics

#What factors affect the half-life:

+hepatic and renal clearance
-bioavailability
-velocity distribution
-communication with protein
-excretion by the kidneys

# Bioavailability - is:

-percentage of substance extracted from the organism
+the percentage of the substance has reached the systemic circulation
- the effective dose, has a therapeutic effect
- the percentage of the drug-related protein
- none of the above

#What determines the bioavailability:

-the absorption and protein link
+presystemic metabolism and absorption
-renal excretion and biotransformation in the liver
-volume of distribution
-the absorption

# The higher drug concentration in plasma when administered sublingually than orally because:

+the drug is not subject to first-pass metabolism
-the drug do not bound to plasma proteins
-the drugs do not bound to tissues
-increases the hydrophilicity of the drug
- increasing the lipophilicity of the drug

#If the effect of the two drugs is greater than the sum of the individual effects, it is called:

-antagonism
-the summary effect
-an additive effect
+potentiation
-sensitization

# What is included the concept of pharmaceutical interaction:

-displacement of the drug from binding with the protein
-inhibition of the metabolism in the liver
+inactivation of drugs in the infusion solution
-inhibition of drugs absorption
-reacting at the level of excretion in the kidney

# Indicate the disease, which reduces the binding of drugs to plasma proteins:

-ischemic heart disease
-acute infection
+liver cirrhosis
-asthma
-pneumonia

#The syndrome of "rebound" - is:

-reduction effect of the drug in its canceled
-increase the effect of the drug in its canceled
-the response of the body to cancel the drug
+development of the reverse effect with continued use of the drug
-absence of drug’s effect

# What factors reduce the absorption of drugs in the gastrointestinal tract:

-constipation
+antacids
-anticholinergics
-a good blood supply to the intestine wall
-B-blokers

# If you are using thiazide diuretics may occur:

- hyperkalemia
-gynecomastia
-Raynaud's syndrome
+gout
-hypoglycaemia

# Prescription of what vitamin during pregnancy can lead to malformations in the child:

+A
-B1
-B2
-C
-PP

# Which drug is not recommended for gout due to its ability to cause hyperuricemia:

-nitroglycerin
-erythromycin
-propranolol
+gipotiazid
-captopril

# What is a diuretic can cause the development of hirsutism and gynecomastia:

-gipotiazid
+spironolactone
-furosemide
-diakarb
-indapamide

# Which of the following drugs does not increase blood plasma atherogenicity:

-furosemide
+nifedipine
-diacarb
-gipotiazid
-propranolol

# Choose the hemodynamic effects of nifedipine:

-negative inotropic effects
-an increase in cardiac output, heart rate reduction
-increase in heart rate, dilation of venules
+an increase in heart rate, dilation of the arterioles
-a decrease in heart rate

# Which of the drugs causes a decrease in plasma renin activity:

- prazosin
-gipotiazid
-enalapril
+metoprolol
-nifedipine

# Point the factors that increase the hypotensive effect of captopril:

-low plasma’s renin activity
+giponatriyemiya
-an increasing of catecholamines
-gipernatriyemiya
-giperkaliyemiya

#The acceptance of the drug sublingual can be cut short episodes of rise in blood pressure:

+captopril
-gipotiazid
-athenolol
-ramipril
-furosemide

# Select a vasodilator, which does not cause tachycardia:

+enalapril
-prazosin
-nifedipine
-propranolol
-sodium nitroprusside

#What explains the rapid effect of furosemide intravenously for hypertensive crisis:

-diuretic effect
-natriuretic effect
+dilation of arteries and veins
-reduction in the level of renin
-activation of the RAAS

#What hypotensive agent is administered in an inactive form:

-clofelin
+enalapril
-nifedipine
-metoprolol
-captopril

# What is a side effect of -blockers which increase by combined with thiazide diuretics:

+atherogenic effect
-gipokaliyemiya
-reduction of renal function
-negative chronotropism
-negative inotropic effect

#What type of cooperation leads to the joint prescription of ramipril and hypothiazide:

-summation of effects
+potentiation
-an additive effect
-sensitization
-antagonism

#Why is the dose of verapamil inside for a sufficient hypotensive effect should be high:

+due to the pronounced first-pass metabolism
-due to the slow onset of effect
-due to the small T 1/2
-due to rapid clearance of the drug
-due to the rapid onset of effect

#The mainly due to the hypotensive effect of nifedipine:

-a decrease in cardiac output
+a decrease in peripheral vascular resistance
-a decrease in circulating blood volume
-reduction in plasma renin activity
- increase of circulating blood volume

#The antihypertensive effect of nifedipine with taking per os developed through:

+10 minutes
-30 minutes
-1 hour
-3 hours
-5 hours

# Specify a side effect that is not characteristic of captopril:

-dry cough
+hyperglycemia
-proteinuria
-neutropenia
-dyspeptic disorders

#The phenomenon of the first dose manifests with receiving of prazosin:

-short-term increase in blood pressure
+orthostatic hypotension
-a decrease in cardiac output
-a sharp increase in heart rate
-the development of arrhythmia

#What is the absolute contraindication for appointment of B-blockers:

-old age
-chronic heart insufficiency
+bronchial asthma
-impotence
-ulcer disease

#Which drug is contraindicated in hypertensive crisis with severe tachycardia:

-clonidine
-captopril
+nifedipine
-P enap
-verapamil

#Which drug should not be administered with reduced kidney function:

-fosinopril
- furosemide
-nifedipine
+gipotiazid
- amlodipine

# Why develops of tachycardia when taking arteriolar vasodilators:

-an increase in renin activity
+increased activity of sympathoadrenal
-sympatholytic effect
-cholinolytic effect
+decrease activity of sympathoadrenal

# What caused the action of losartan:

-blockade 1-receptor
-the activation of the central 2-receptor
-APF inhibition
+angiotensin receptor blockade
-the blockade of the synthesis of renin

#For what drug is not characteristic the development of orthostatic hypotension:

-clonidine
-benzogexonium
-prazosin
+amlodipine
-captopril

#What mechanism is due to additional vasodilator effect of carvedilol:

+blockade 1– receptors
-stimulation 1 - receptors
-stimulation 2-receptor
-the direct myotropic effect
-an increase in the synthesis of NO in blood vessels

#The mechanism of the antihypertensive action of perindopril is due to:

-blockade 1-receptors
-blockade B1- adrenoreceptors
-the blockade of the synthesis of renin
+the blockade of ACE
-angiotensin receptor blockade

#What is expressed in the phenomenon of "first dose" for captopril:

-violation of the peripheral circulation
-increase in heart rate
-a temporary increase in blood pressure
+hypotension
-fibrillation

#​​What is advisable to combine with diuretics enalapril in hypertension:

-veroshpiron
+hydrochlorothiazide
-mannitol
-triamteren
-diakarb

#The joint appointment B-blockers and oral hypoglycemic may cause:

+potentiation of the hypoglycemic action
-reduction of hypoglycemic effect
-the lack of interaction
-increase in blood pressure
-the development of arrhythmia

#Select a diuretic for stoping of hypertensive crisis:

-gipotiazid
+furosemide
-spironolactone
-triamterene
-mannitol

#Select the sublingual drug for reception in uncomplicated hypertensive crisis:

+captopril
-ramipril
-bisoprolol
-furosemide
-losartan

#Select a diuretic for long-term control of blood pressure:

-furosemide
-diakarb
+indapamide
-triamterene
-veroshpiron

#Select the rational combination of antihypertensive:

-nifedipine + B-blockers
-B-blockers + verapamil
+APF inhibitors + amlodipine
-APF inhibitor + blockers of angiotensin II receptor
- B-blockers+alfa-blokers

#Point the calcium antagonist with the longest hypotensive effect:

+amlodipine
-felodipine
-nifedipine
-diltiazem
-nifedipine-retard SR

#Specify a drug belonging to the group of direct anticoagulants:

-alteplase
-varfarin
-clopidogrel
+fraxiparine
-aspirin

#Specify a drug belonging to the group of antiplatelet agents:

-fraxiparin
+acetylsalicylic acid
-urokinase
-hirudin
-varfarin

#Specify a drug belonging to the group of thrombolytics:

-acetylsalicylic acid
+tenecteplase
-varfarin
-heparin
-fraxiparin

#What is the mechanism of action of aspirin antiplatelet:

-invertible inhibition of cyclooxygenase
-suppression of thromboxane
-blockage of glycoprotein complex IIb / IIIa
+irreversible inhibition of cyclooxygenase activity
-fibrinolysis

#Which class of drugs is fraxiparine:

-trombolitics
-antiplatelet agents
-vitamin K antagonists
+low molecular weight heparins
-statins

#Specify the mechanism of action of clopidogrel:

-blockage of COX
-blockage of receptor IIb/IIIa
+ADP receptor blockade
-blockage synthesis of clotting factors in the liver
-increase the synthesis of plasmin

#What dose aspirin should be taken in cases of suspected myocardial infarction:

-125 Mg
-250 mg
+500 Mg
-1g
-3 G

#To dissolve the fibrin clot is used:

-heparin
-aspirin
-clopidogrel
+alteplase
-clexane

#Check the effects of cardiac glycosides:

-negative chronotropic
-negative dromotropic
-negative bathmotropic
-vasodilation
+all of the above

#Specify the length of the diuretic action of hydrochlorothiazide:

-3 hours
-6 hours
+12 hours
-18 hours
-24 hours

#Why do not cause cardiac glycosides increase in myocardial oxygen consumption:

-increase the force of contraction
+the lower heart rate
-slowing of AV-conductance
-cause an increase in urine output
-improve diastolic relaxation

#What is the maximum potassium saliuretics effect?

-uregei
-furosemide
+gipotiazid
-veroshpiron
-triamterene

#What is the drug can cause hyper potassium in urea with a joint appointment with enalapril:

-digoxin
-gipotiazid
-furosemide
-prazosin
+veroshpiron

#Which of the diuretic is a competitive aldosterone antagonist?

-indapamide
-gipotiazid
-furosemide
+spironolactone
-mannitol

#Which of the cardiac glycosides has the highest bond with the protein?

-strophanthin
+digitoxin
-digoxin
-celanid
-corglicon

#Which of diuretics acting in the ascending portion of the loop of Henle?

-hypotiazid
-veroshpiron
+furosemide
-triamterene
-indapamide

#What is a diuretic can be used at a low glomerular filtration rate?

-hypotiazid
-triamterene
-spironolactone
+furosemide
- indapamide

#Specify a diuretic, which is not used in the treatment of chronic heart failure:

+mannitol
-furosemide
-gipotiazid
-spironolactone
-torasemide

#The use of what antimicrobial drugs is safe during pregnancy?

-aminoglycosides
-cotrimoxazole
-nitrofurans
+penicillins
-fluoroquinolones

#Specify the antibiotic which is the drug of choice for treatment of infections caused by methicillin-resistant staphylococcus:

-linkomycin
-erythromycin
+vancomycin
-penicillin
-oxacillin
#Is active against atypical pathogens (mycoplasma, chlamydia, legionella):
-gentamicin
+erythromycin
-ampioks
-chloramphenicol
-clindamycin

#What is the mechanism of action of bets- 2 adrenergic agonists?

-inhibition of phosphodiesterase
-inhibition of mast cell degranulation
-blockade of histamine receptors
-inhibition of the action of leukotrienes in the airways
+activation of adenylate cyclase, increased cAMP formation

# Beta-2-adrenoagonists long-acting are:

-salbutamol
-terbutaline
-fenoterol
-ortsiprenaline sulfate
+formoterol

#Specify the drug with the most potent inhibitory effect on gastric acid secretion:

+omeprazole
-cimetidine
-famotidine
-sucralfate
-pirentsipin

#The bioavailability of nifedipine is low due to:

+presistemna elimination in the liver
-low absorption
-plasma protein binding
-inactivation in the gastrointestinal tract
-accumulation in lipids

#Captopril is contraindicated in patients:

-with cirrhosis
+with chronic renal failure
-with pulmonary heart
-diabetes
-a stomach ulcer

#Specify the mechanism of action of nitroglycerin:

-adrenoceptor blockade
+antispasmodic, myotropic effect on the smooth muscle of the vascular wall
-blockage of small calcium channels of the cell membrane
-increased activity -retseptorovsosudistoy walls of the coronary arteries
-it increases the slow stream of calcium into the cell

#What are the contraindications to the use of nitrates?

-acute myocardial infarction
-arterial hypertension
+hypotension
-bradycardia
-atrioventricular block

#The antianginal effect caused by adrenoblocators?

-expansion of the coronary vessels
-decline after cardiac preload
+decrease of the heart action
-a central mechanism of action
-an increase in myocardial oxygen demand

#Specify the contraindications to nifedipine:

-hypertension
-heart failure
-bronchial asthma
+hypotension
-AV block of 2nd degree

#Specify a drug belonging to the group 1 antiarrhythmic drugs (membrane stabilizing action):

-lidocaine
-izoptine
-cordarone
+novokainamide
-difinine