Traditional Posters: Body Imaging

Andrzej Roman Jedynak¹, Frederick Kelcz¹, Alex Frydrychowicz¹, Scott K. Nagle^1,2, Scott B. Reeder<sup>1,3

1</sup>Radiology, University of Wisconsin, Madison, WI, United States; ²Radiology, Middleton Veterans Affairs (VA) Hospital, Madison, WI, United States; ³Medical Physics, University of Wisconsin, Madison, WI, United States

Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition of extra- and intra-hepatic biliary ducts. In our clinical practice we routinely use the combination of high resolution gadoxetate-enhanced T1-MRC and heavily T2-weighted MRCP for the evaluation of PSC. This work set out to validate the clinical diagnostic utility of adding high-resolution 3D T1-weighted gadoxetate-enhanced hepatobiliary phase MRC to 3D T2 weighted MRCP. Preliminary results indicate that T1-MRC is an excellent adjunct to T2 MRCP that provides not only anatomical visualization of the biliary tree and associated disease but also offers useful functional/physiologic information that can be tremendously helpful in many cases.

2621. Gd-EOB-DTPA as a Correlate for Chronic Liver Disease Through Contrast Uptake, Uptake Rate, and Bile Excretion

Hiroumi Kitajima¹, Puneet Sharma, Christina Lurie, Khalil Salman, Gaye Ray, Bobby Kalb, Diego Martin

¹Emory University, Atlanta, GA, United States

Gd-EOB-DTPA demonstrates liver clearance kinetics that allow for its use as a marker for patients with chronic liver disease. Signal uptake, uptake rate, and common bile duct excretion as imaged by 3D T1-weighted GRE allow for quantitative assessment of liver fibrosis.

2622. MR Cholangiopancreatography: Does Butylscopolamine (Buscopan®) Make a Difference to Ductal Visualization?

Natalie Yang¹, Sarah Jenkins¹, Errol Colak¹, Anish Kirpalani<sup>1

1</sup>Radiology, St Michael's Hospital, Toronto, Ontario, Canada

The effect of butylscopolamine (Buscopan) on image quality for MR cholangiopancreatography (MRCP) examinations is examined in our study. The inferior common bile duct demonstrated improved visualization after the administration of butylscopolamine whilst other ductal segments demonstrated minimal benefit. The use of butylscopolamine in patients with suspected inferior common bile duct disease improves image quality and thus may improve diagnosis.

2623. MRI of Intrabiliary Delivery of Motexafin Gadolinium Into Common Bile Duct Walls: In Vitro and Ex Vivo Evaluations

feng zhang¹, Huidong Gu¹, Yanfeng Meng¹, Bensheng Qiu¹, Xiaoming Yang<sup>1

1</sup>Image-Guided Bio-Molecular Intervention Section, Department of Radiology, University of Washington School of Medicine, Seattle, WA, United States

MR imaging was used to investigate the capability of Motexafin gadolinium(MGd) entering human cholangiocarcinoma cells (Mz-ChA-1) and the feasibility of intrabiliary local delivery of MGd into the common bile duct(CBD) wall. T1 weighted MR imaging of Mz-ChA-1 cells treated with MGd demonstrated a linear increase of signal intensities(SI) from 25 to 75-¦Ìg/mL MGd, and a plateau pattern of SIs from 75 to 150-¦Ìg/mL MGd. Confocal microscopy showed MGd internalized Mz-ChA-1 cells as intracytoplasm pink dots. Ex vivo experiments revealed significant higher contrast-to-noise ratio in the MGd-infused CBD walls than that in the controlled CBD walls with phosphate-buffered saline.

2624. 7T Liver MRI in Humans: Initial Results.

Lale Umutlu¹, Andreas K. Bitz², Stefan Maderwald³, Stephan Orzada³, Sonja Kinner⁴, Oliver Kraff, Irina Brote, Susanne C. Ladd, Gerald Antoch, Mark E. Ladd³, Harald H. Quick³, Thomas C. Lauenstein

¹Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen , Essen, Germany; ²Erwin L.Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; ³2Erwin L.Hahn Institute for Magnetic Resonance Imaging; ⁴1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen

Aim of this study was to investigate the feasibility of 7 Tesla liver MRI, with optimization and implementation of a dedicated examination protocol. 8 healthy subjects were examined at a 7T whole-body MR system utilizing a custom-built 8-channel RF transmit/receive body coil. Delineation of liver vessels, overall image quality and presence of artifacts was assessed. T1w imaging revealed very good delineation of liver vasculature, with best imaging scores for T1w 2D FLASH imaging. T2w TSE imaging remained strongly impaired by artifacts. This pilot study of dedicated hepatic imaging at 7 Tesla demonstrates the feasibility of in vivo ultra-high-field liver imaging.

2625. In Vivo Evaluation of Exocytic Activity in Kupffer Cells Using Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging; an Experimental Study on Gadolinium Chloride-Induced Liver Injury in Rats.

Toshihiro Furuta^1,2, Masayuki Yamaguchi¹, Ryutaro Nakagami^1,3, Akira Hirayama^1,4, Masaaki Akahane², Manabu Minami⁵, Kuni Ohtomo², Hirofumi Fujii<sup>1

1</sup>Functional Imaging Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; ²The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan; ³Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa, Tokyo, Japan; ⁴GE Healthcare Japan, Hino, Tokyo, Japan; ⁵Tsukuba University Hospital, Tsukuba, Ibaraki, Japan

Hepatic signal recovery on MR images after a single dose of superparamagnetic iron oxide (SPIO) would be well correlated with exocytic activity of Kupffer cells (KCs). In this study, we actually showed the delay of hepatic signal recovery after SPIO administration depending on the severity of KCs' injury in an animal model, in which rat KCs were injured by intravenous administration of gadolinium chloride in a dose-dependent manner. We believe that at least two-week follow up MR imaging scans after SPIO administration are useful for the evaluation of not only phagocytic but also exocytic activities of KCs.

2626. Qualitative and Quantitative Evaluation of Time-Resolved Flow Analysis of Portal Venous Hemodynamics of Liver Cirrhosis Patients and Volunteers

Zoran Stankovic¹, Zoltan Csatari¹, Peter Deibert², Wulf Euringer¹, Wolfgang Kreisel², Susanne Eggerking², Philipp Blanke¹, Zahra Abdullah Zadeh¹, Jürgen Hennig¹, Mathias Langer¹, Michael Markl<sup>1

1</sup>Department of Diagnostic Radiology and Medical Physics, University Hospital Freiburg, Freiburg, Baden Württemberg, Germany; ²Gastroenterology, University Hospital Freiburg, Freiburg, Baden Württemberg, Germany

Time-resolved flow-sensitive 4D MRI permits qualitative and quantitative evaluation of portal venous hemodynamics of liver cirrhosis patients compared to volunteers. Our results demonstrate a persistent reduction of the peak velocities in the portal venous system between patients and different age group volunteers. Analysis showed significant correlation for peak and mean velocities between MRI and US measurements (r=0.53, p< 0.001) which served as reference standard. In liver cirrhosis patients 3D MR velocity mapping may be a standardized technique for evaluating flow characteristics modification, therapy monitoring or disease progression.