Traditional Posters: Body Imaging
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| Anna Louise Babin1,2, Catherine Cannet1, Christelle Gerard1, Clive P. Page3, Nicolau Beckmann1
1Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, BS, Switzerland; 2Sackler Institute of Pulmonary Pharmacology, King’s College, London, SE1 1UL, United Kingdom; 3Sackler Institute of Pulmonary Pharmacology, King's College, London, SE1 1UL, United Kingdom Micro-CT has been shown to be useful in characterizing anatomical changes related to lung fibrosis models in rats. However, radiation doses are an issue both in the clinics and in experimental studies, and repetitive measurements are limited. In the present work, we show that proton MRI can be used to follow longitudinally in spontaneously breathing rats the development of structural changes related to lung fibrosis induced by bleomycin administration, and thus MRI represents a non-X ray based imaging alternative to study experimental fibrosis. 2513. Non-Invasive Assessment of Mucociliary Clearance with Micron-Sized Iron Oxide Particles in Rat Lungs Selina Bucher1, Michael Neumaier1, Sascha Koehler2, Birgit Jung3, Detlef Stiller1 1In-Vivo Imaging Unit, Dept. of Drug Discovery Support, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany; 2Method Development, Bruker BioSpin MRI GmbH, Ettlingen, Germany; 3Dept. of Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, BW, Germany Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and mucus production. Because an excess of mucus triggers infections, an efficient mucociliary clearance (MCC) is important. To detect therapy-induced changes in MCC, non-invasive imaging techniques are needed. We used 2D radial MRI and micron-sized iron-oxide particles to evaluate MCC in the rat lung, where four different iron-oxide particles yielded an attenuated MR signal. Clearance of 4.5 µm-sized particles occurred within one day, whereas smaller and larger particles were not cleared. Our results indicate a great potential for MRI with micron-sized iron-oxide particles to visualize and quantify MCC in patients. 2514. Fast and Robust T1 Mapping of the Human Lung at Different Sites Jakob Kreutner1, Ruobing Yang2, Simon Triphan1,3, Martin Blaimer3, Felix Breuer3, Peter Michael Jakob1,3 1Experimental Physics 5, University of Würzburg, Würzburg, Bavaria, Germany; 2University of British Columbia, Vancouver, Canada; 3Research Center Magnetic Resonance Bavaria, Würzburg, Germany Characterization of pathologic lung tissue necessitates a robust method for diagnosis. T1 relaxation times provide information about oxygen transfer in the lung. To demonstrate the robustness of the IR Snapshot FLASH sequence we repeatedly quantified T1 at different sites using a lung phantom made of several Gd-DTPA doped bottles. The results show an excellent reproducibility of the relaxation times. 2515. Mapping the Ventilation–perfusion Ratio in Chronic Obstructive Pulmonary Disease Using Oxygen-Enhanced MRI Penny Louise Hubbard1,2, Geoff J. M. Parker1,2, Dave Singh3, Jørgen Vestbo3, Simon S. Young4, Eva Bondesson5, Lars E. Olsson6, Josephine H. Naish1,2 1Imaging Sciences and Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2The University of Manchester Biomedical Imaging Institute, Manchester, United Kingdom; 3Airway Pharmacology Group, School of Translational Medicine,, University Hospital of South Manchester Foundation Trust, Manchester, United Kingdom; 4AstraZeneca R & D, Charnwood, United Kingdom; 5AstraZeneca R & D, Lund, Sweden; 6AstraZeneca R & D, Mölndal, Sweden We present a regional characterisation of the ventilation-perfusion ratio using a novel two-compartment physiological model analysis of oxygen-enhanced MRI data. A preliminary analysis of subjects with chronic obstructive pulmonary disease and age-matched healthy subjects shows how changes in T1 can be related directly to physiological parameters indicative of lung function. This novel MR method is minimally-invasive and repeatable, and reveals enhanced sensitivity to the early onset of disease than more traditional global lung function measures. 2516. Physiological Modelling of Oxygen-Enhanced MRI in the Lung Yüklə 458,11 Kb. Dostları ilə paylaş:
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