Yallow and Berson found high serum insulin in type diabetes, thus insulin resistance : common underlying biochemical abnormality

Oxidative damage should leave clue in mtDNA

What the hell is mitochondria and its DNA?

mtDNA density decrease precede the development of diabetes in Yochon cohort, 1998

• mtDNA density decrease precede the development of diabetes in Yochon cohort, 1998

• Medical student cohort (KU Lee et al)

• Birth weight and mtDNA density (YY Lee, YA Sung): thrifty phenotype hypothesis

• mtDNA variations and insulin resistance (Asians)

• 16189 T>C,

• haplogroups N9a (resistant)

• haplogroups B and F (sensitive)

• (In collaboration with M Tanaka et al, K Nanjo et al)