Yallow and Berson found high serum insulin in type diabetes, thus insulin resistance : common underlying biochemical abnormality

1. Yallow and Berson found high serum insulin in type 2 diabetes, thus insulin resistance : common underlying biochemical abnormality

• 1. Yallow and Berson found high serum insulin in type 2 diabetes, thus insulin resistance : common underlying biochemical abnormality

• 2. Molecular approach (insulin receptor and post-receptor mechanisms) was not successful

• 3. Epidemiologic approach by establishing a disease entity (syndrome X) proposed by Reaven (1988)

• 4. WHO experts gave new name; metabolic syndrome (1998)

Genetic cause (thrifty genotype hypothesis. Neel JV, 1962)

• Genetic cause (thrifty genotype hypothesis. Neel JV, 1962)

• Fetal malnutrition (thrifty phenotype hypothesis. Barker DJP and Hales CN, 1992)

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