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An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba, Came



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An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba, Cameroon


The search for a vaccine against malaria caused by Plasmodium falciparum has lasted for more than 100 years, with considerable progress in the identification of a number of vaccine candidates. The post-genomic er...

Raymond B. Nyasa, Helen K. Kimbi, Denis Zofou, Jeremy D. DeBarry, Jessica C. Kissinger and Vincent P. K. Titanji

Malaria Journal 2016 15:281

Challenges for malaria elimination in Brazil


Brazil currently contributes 42 % of all malaria cases reported in the Latin America and the Caribbean, a region where major progress towards malaria elimination has been achieved in recent years. In 2014, mal...

Marcelo U. Ferreira and Marcia C. Castro

Malaria Journal 2016 15:284

PCR detection of malaria parasites and related haemosporidians: the sensitive methodology in determining bird-biting insects


Knowledge about feeding preference of blood-sucking insects is important for the better understanding epidemiology of vector-borne parasitic diseases. Extraction of DNA from blood present in abdomens of engorg...

Rasa Bernotienė and Gediminas Valkiūnas

Malaria Journal 2016 15:283

Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants


The liver-stage anti-malarial activity of primaquine and other 8-aminoquinoline molecules has been linked to bio-activation through CYP 2D6 metabolism. Factors such as CYP 2D6 poor metabolizer status and/or co...

Xiannu Jin, Brittney Potter, Thu-lan Luong, Jennifer Nelson, Chau Vuong, Corttney Potter, Lisa Xie, Jing Zhang, Ping Zhang, Jason Sousa, Qigui Li, Brandon S. Pybus, Mara Kreishman-Deitrick, Mark Hickman, Philip L. Smith, Robert Paris…

Malaria Journal 2016 15:280

Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail


The high incidence and mortality rate of malaria remains a serious burden for many developing countries, and a vaccine that induces durable and highly effective immune responses is, therefore, desirable. An ea...

Alexander Boes, Holger Spiegel, Robin Kastilan, Susanne Bethke, Nadja Voepel, Ivana Chudobová, Judith M. Bolscher, Koen J. Dechering, Rolf Fendel, Johannes F. Buyel, Andreas Reimann, Stefan Schillberg and Rainer Fischer

Malaria Journal 2016 15:279

Malaria prevalence, severity and treatment outcome in relation to day 7 lumefantrine plasma concentration in pregnant women


Day 7 plasma concentrations of lumefantrine (LF) can serve as a marker to predict malaria treatment outcome in different study populations. Two main cut-off points (175 and 280 ng/ml) are used to indicate plas...

Ritah F. Mutagonda, Appolinary A. R. Kamuhabwa, Omary M. S. Minzi, Siriel N. Massawe, Betty A. Maganda and Eleni Aklillu

Malaria Journal 2016 15:278

Microsatellite genotyping and genome-wide single nucleotide polymorphism-based indices of Plasmodium falciparum diversity within clinical infections


In regions where malaria is endemic, individuals are often infected with multiple distinct parasite genotypes, a situation that may impact on evolution of parasite virulence and drug resistance. Most approache...

Lee Murray, Victor A. Mobegi, Craig W. Duffy, Samuel A. Assefa, Dominic P. Kwiatkowski, Eugene Laman, Kovana M. Loua and David J. Conway

Malaria Journal 2016 15:275

Where chloroquine still works: the genetic make-up and susceptibility of Plasmodium vivax to chloroquine plus primaquine in Bhutan


Bhutan has made substantial progress in reducing malaria incidence. The national guidelines recommend chloroquine (CQ) and primaquine (PQ) for radical cure of uncomplicated Plasmodium vivax, but the local efficac...

Sonam Wangchuk, Tobgyel Drukpa, Kinley Penjor, Tashi Peldon, Yeshey Dorjey, Kunzang Dorji, Vishal Chhetri, Hidayat Trimarsanto, Sheren To, Amanda Murphy, Lorenz von Seidlein, Ric N. Price, Kamala Thriemer and Sarah Auburn

Malaria Journal 2016 15:277

Gravid Anopheles gambiae sensu stricto avoid ovipositing in Bermuda grass hay infusion and it’s volatiles in two choice egg-count bioassays


A number of mosquito species in the Culex and Aedes genera prefer to lay eggs in Bermuda grass (Cynodon dactylon) hay infusions compared to water alone. These mosquitoes are attracted to volatile compounds from t...

Lynda K. Eneh, Michael N. Okal, Anna-Karin Borg-Karlson, Ulrike Fillinger and Jenny M. Lindh

Malaria Journal 2016 15:276

Census-derived migration data as a tool for informing malaria elimination policy


Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction throug...

Nick W. Ruktanonchai, Darlene Bhavnani, Alessandro Sorichetta, Linus Bengtsson, Keith H. Carter, Roberto C. Córdoba, Arnaud Le Menach, Xin Lu, Erik Wetter, Elisabeth zu Erbach-Schoenberg and Andrew J. Tatem

Malaria Journal 2016 15:273

Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India


Wells and overhead tanks (OHT) are the major breeding sources of the local malaria vector, Anopheles stephensi in the Indian city of Chennai; they play a significant role in vector breeding, and transmission of u...

Shalu Thomas, Sangamithra Ravishankaran, Johnson A. Justin, Aswin Asokan, Manu T. Mathai, Neena Valecha, Matthew B. Thomas and Alex Eapen

Malaria Journal 2016 15:274


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