Supplemental data Table e Number of included mr measurements per quantitative method

Supplemental data
Table e-1. Number of included MR measurements per quantitative method

	Patients (N=28)	Controls (N=61)	Mean age (±sd)^5 (patients/controls)	Age range^5 (patients/controls)
DTI	25	44	12.5(10.7)/7.8(9.2)	0.5-47/0.5-44
Not performed	0	11
Discarded^1	3	6
Included with fewer volumes^2	1	7
MTI	28	53	11.4 (9.9)/6.9(8.6)	0.5-47/0.3-44
Not performed	0	5
Discarded^3	0	3
Not in splenium^4	4	0
T2	28	54	11.4(9.9)/7.0(8.5)	0.5-47/0.3-44
Not performed	0	7
Not in splenium^4	8	0
CSI	27	61	10.7(10.2)/7.9(9.4)	0.5-47/0.3-44
Not performed	1	0

DTI, diffusion tensor imaging; MTI, magnetisation transfer imaging; CSI, chemical shift imaging

¹ because of serious movement artefacts beyond repair

² included after removal of 1-5 (mean 2.7) diffusion-weighted volumes affected by motion artefacts

³ because of serious movement artifacts

⁴ because the splenium was very thin, hampering positioning of a ROI

⁵ in years

MR parametermeasure	WM area	a	b	tau
FA	Splenium	0.792	-0.688	0.573
	Corticospinal tracts	0.399	-0.125	4.604
	Parietal WM	0.306	-0.105	2.272
MD	Splenium	83.7	293.7	0.355
	Corticospinal tracts	76.4	28.4	1.893
	Parietal WM	87.8	27.9	1.935
AD	Splenium	182.7	372.3	0.293
	Corticospinal tracts	111.4	36.3	0.906
	Parietal WM	116.4	24.4	1.914
RD	Splenium	34.3	290.9	0.368
	Corticospinal tracts	58.4	27.7	2.736
	Parietal WM	73.5	29.6	1.944
T2	Splenium	91.0	375.2	0.312
	Corticospinal tracts	103.9	94.6	0.351
	Parietal WM	100.7	111.1	0.551
MTR	Splenium	0.356	-0.514	0.349
	Corticospinal tracts	0.349	-0.109	0.844
	Parietal WM	0.337	-0.162	0.920
Cr	Parietal WM	3.883	1.420	0.887
NAA	Parietal WM	8.065	-1.986	10.390
Cho	Parietal WM	1.397	0.395	3.290
Ins	Parietal WM	3.264	5.487	0.212
NAA/Cr	Parietal WM	1.960	-0.719	3.088

Table e-2. Coefficients of the mono-exponential function fitted per MR parameter measure and WM area

MR, magnetic resonance; WM, white matter; FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; MTR, magnetic transfer ratio; Cr, creatine; NAA, N-acetyl aspartate; Cho, choline; Ins, myo-inositol. Coefficients a and b are given in 10^-5 mm²/s for MD, AD and RD, in ms for T₂, and in mM for metabolite concentrations. Coefficient tau is given in years.

Figure e-1

Quantitative MR parameters measures versus age per white matter area. MD, AD and RD are given in 10^-5mm²/s, in ms for T₂ in ms and metabolite concentrations in mM.