2011 YÜksek lisans tez özetleri

An investigation of the relationship between diabetes and chromosome damage in human peripheral blood lymphocytes

Birth, growth, maturing, aging and death are the main features of living things. Among them aging is a natural process like the others. In this natural process some metabolic changes are seen and the risk of certain diseases also increases with increasing age. One of these diseases is diabetes mellitus. Diabetes mellitus is the 5^th among the diseases that cause death in many societies take place and the micro- and macro complications of diabetes mellitus in these patients is the most important cause of morbidity and mortality has become a major public health problem.

Diabetes mellitus is usually 2 types. Type 1 diabetes mellitus is often seen in childhood. Type 2 diabetes mellitus is often observed in adult age and it is the most common type of diabetes mellitus.

This thesis work, was done with thirty patients group diagnosed as type 2 diabetes mellitus and thirty healthy individuals at the same age group. In culture that in made with peripheral blood which getting from healthy and patients individuals, chromosome aberrations that were scored by the formation of micronucleus and proliferative indeks of lymphocytes, were investigated by the MN technique.

As a result, the diagnosis of type 2 diabetes mellitus has proved the applicability of the MN technique.

ALBAYRAK Esra

Danışman : Yrd. Doç. Dr. Oya ÖZULUĞ

Anabilim Dalı : Biyoloji

Programı : Zooloji

Mezuniyet Yılı : 2011

Tez Savunma Jürisi : Yrd. Doç. Dr. Oya ÖZULUĞ

Prof. Dr. Mustafa TEMEL

Prof. Dr. Cihan DEMİRCİ TANSEL

Prof. Dr. Melike ERTAN

Doç. Dr. Kadriye AKGÜN DAR