References

46 (6), 630-633

Takagi, M. (1982), Serum Uric-Acid As A Risk Factor for Stroke in A Fishing Village of Rural Southern Japan. Japanese Circulation Journal-English Edition, 46 (2), 131-136

Yamori, Y., Kihara, M., Fujikawa, J., Soh, Y., Nara, Y., Ohtaka, M., Horie, R., Tsunematsu, T., Note, S. and Fukase, M. (1982), Dietary Risk-Factors of Stroke and Hypertension in Japan .2. Validity of Urinalysis for Dietary Salt and Protein Intakes Under A Field Condition. Japanese Circulation Journal-English Edition, 46 (9), 939-943

Malik, A. (1982), Prevention, Diagnosis, Treatment of Stroke and Prospects for Stroke Control in Bangladesh. Japanese Circulation Journal-English Edition, 46 (6), 619-621

Isomura, K. (1982), Hypertension and Stroke Control in A Japanese Rural Area. Japanese Circulation Journal-English Edition, 46 (6), 637-638

Tseng, W.P. (1982), A Survey on Deaths of Patients with Stroke. Japanese Circulation Journal-English Edition, 46 (6), 638-640

Yamori, Y., Kihara, M., Fujikawa, J., Soh, Y., Nara, Y., Ohtaka, M., Horie, R., Tsunematsu, T., Note, S. and Fukase, M. (1982), Dietary Risk-Factors of Stroke and Hypertension in Japan .3. Comparative-Study on Risk-Factors Between Farming and Fishing Villages in Japan. Japanese Circulation Journal-English Edition, 46 (9), 944-947

Haas, L.F. and Bonita, R. (1982), Some Aspects of Stroke in New-Zealand. Japanese Circulation Journal-English Edition, 46 (6), 626-628

Endo, S. (1982), The World Strategy of Who in the Control of Stroke. Japanese Circulation Journal-English Edition, 46 (6), 634-635

Hatano, S. (1982), Current Status of the Stroke Problem in Japan. Japanese Circulation Journal-English Edition, 46 (6), 597-601

Viriyavejakul, A. (1982), Present Status of Stroke Problems in Thailand. Japanese Circulation Journal-English Edition, 46 (6), 614-618

Yamori, Y., Kihara, M., Fujikawa, J., Soh, Y., Nara, Y., Ohtaka, M., Horie, R., Tsunematsu, T., Note, S. and Fukase, M. (1982), Dietary Risk-Factors of Stroke and Hypertension in Japan .1. Methodological Assessment of Urinalysis for Dietary Salt and Protein Intakes. Japanese Circulation Journal-English Edition, 46 (9), 933-938

Yamori, Y., Horie, R., Akiguchi, I., Kihara, M., Nara, Y. and Lovenberg, W. (1982), Symptomatological Classification in the Development of Stroke in Stroke-Prone Spontaneously Hypertensive Rats. Japanese Circulation Journal-English Edition, 46 (3), 274-283

Ooneda, G. (1986), Pathology of Stroke. Japanese Circulation Journal-English Edition, 50 (12), 1224-1234

Matsuno, Y., Morioka, S., Murakami, Y., Kobayashi, S., Shimada, T. and Moriyama, K. (1990), Regulation of External Work of Concentric Hypertrophied Left- Ventricles in Unanesthetized Hypertensive Dogs. Japanese Circulation Journal-English Edition, 54 (11), 1390-1397.

Abstract: This study aimed to evaluate the change in external work and its control mechanism in the concentric hypertrophied heart induced by systemic hypertension. The calculated stroke work, myocardial contractility, afterload, and preload were examined in the baseline period (Control Stage, CS) and in the eighth week after the induction of perinephritic hypertension (Hypertensive Stage, HS) in unanesthetized dogs. These variables were examined with echocardiograms and high-fidelity left ventricular (LV) and ascending aortic pressures. Mean aortic pressure was significantly (p < 0.05) elevated from 95 +/- 10 to 134 +/- 27 mmHg in HS. The ratio of end-diastolic wall thickness to radius significantly (p < 0.05) increased in the HS. The calculated stroke work of the LV chamber was significantly (p < 0.05) increased from 7022 +/- 1203 to 8860 +/- 1548 x 10(3) erg in HS while the stroke work normalized for wall thickness by calculating the wall stress was not altered (3069 +/- 1086 v.s. 2989 +/- 866 erg; CS v.s. HS) with no significant change in heart rate in HS. In the HS, the end- systolic wall stress (afterload) and the slope of end-systolic wall stress-dimension relationship (myocardial contractility) were unchanged while the end-diastolic wall stress (preload) slightly reduced. These results suggest that, in the concentric hypertrophied left ventricle induced by systemic hypertension, the LV myocardial external work is normal, whereas the LV chamber external work increases. Furthermore, the major role for allowing the LV myocardial external work to remain normal seems to be not the compensatory changes in preload, myocardial contractility, or heart rate, but rather myocardial hypertrophy; an adaptation to preserve normal ejecting wall stress to chronic pressure overload

Keywords: CANINE LEFT-VENTRICLE/CARDIAC FUNCTION/CARDIAC HYPERTROPHY/CARDIAC-HYPERTROPHY/CIRCULATION/EXTERNAL WORK/HEART-DISEASE/INDEX/JAPAN/PERFORMANCE/RATIO/RENAL- HYPERTENSION/SYSTEMIC HYPERTENSION/UNANESTHETIZED DOGS/WALL STRESS

Sawamura, I., Hazama, F. and Kinoshita, M. (1990), Histological and Histometrical Study of Myocardial Fibrosis in Spontaneously Hypertensive Rats of the Stroke-Prone Strain. Japanese Circulation Journal-English Edition, 54 (10), 1274-1282.

Abstract: In order to obtain fundamental information about the developmental mechanisms of myocardial fibrosis in chronic hypertension, the hearts of male spontaneously hypertensive rats of the stroke-prone strain (SHRSP) and Wistar rats of the Kyoto strain (WKY) were histologically and histometrically examined. Fibrosis was a prominent histological feature of the hearts in SHRSP. It consisted of focal, interstitial, and perivascular fibrosis. For histometrical analysis the percentage areas of interstitial and perivascular fibrosis were calculated by using a color image processor. The percentage area of myocardial fibrosis increased with advancing age in both SHRSP and WKY. However, it was significantly higher in SHRSP than in WKY at 18 and 30 weeks of age. In SHRSP perivascular fibrosis of small arteries had already appeared at 8 weeks of age, while perivascular fibrosis of arterioles and interstitial fibrosis developed later. It is supposed that perivascular as well as interstitial fibrosis is induced by the exudation of some growth factors due to an increased vascular permeability. On the other hand, the focal fibrosis observed in old SHRSP is suspected to occur as a result of injury in myocardium due to stenosis or occlusion of vessels

Keywords: CIRCULATION/COLOR IMAGE PROCESSOR/DISEASE/FIBROSIS/GROWTH-FACTOR/HEART/HYPERTENSION/HYPERTROPHIC CARDIOMYOPATHY/JAPAN/LESIONS/SHRSP/SPONTANEOUSLY HYPERTENSIVE RAT/WKY

Shibukawa, T., Horie, R., Kitao, M. and Yamori, Y. (1990), Stroke-Prone Spontaneously Hypertensive Rats As A Model for Toxemia of Pregnancy and Aggravating and Preventive Effects of Maternal Modifications During Pregnancy on Offsprings Growth. Japanese Circulation Journal-English Edition, 54 (6), 644-652

Keywords: CIRCULATION/JAPAN

Ueda, H., Miyazaki, T., Suganuma, Y., Saito, N. and Kato, Y. (1981), Cardiac Death and Myocardial Lesions in Non-Stroke Shrsp Under Specific Pathogen-Free System. Japanese Heart Journal, 22 (3), 387-393

Aizawa, Y., Hosokawa, O., Hayashi, S. and Shibata, A. (1981), Stroke Volume Estimated at Aortic Root in M-Mode Echocardiography. Japanese Heart Journal, 22 (2), 185-190

Maemura, S., Niwa, M. and Ozaki, M. (1982), Characteristic Alterations in Adrenal Catecholamine Contents in Shr, Shrsp, and Wky During Development of Hypertension and Stroke. Japanese Heart Journal, 23 (4), 593-602

Okamoto, K., Ito, H., Morita, N., Yamamoto, K. and Ohta, Y. (1983), Further Observations Upon Blood-Pressure, Incidence of Stroke Lesions and Other Characteristics of M-Shrsp and M-Shrsp Crossbred Offspring. Japanese Heart Journal, 24 (5), 782-784

Seitz, W.S. and Spiel, M.S. (1983), Echocardiographic Formula for Computation of Left-Ventricular Volume and Stroke Volume - Comparison with Cardiac- Catheterization and the Teichholz Formula. Japanese Heart Journal, 24 (6), 863-869

Ohtsu, E., Abe, K., Akimori, N., Itoh, H., Matsuzawa, T., Yashiro, K. and Sakanoue, M. (1983), Specific Elevation of Thromboxane Synthetase-Activity and Leukotriene-C Formation in Malignant Hypertension in the Hypothalamus of Stroke-Prone Spontaneously Hypertensive Rats (Shrsp). Japanese Heart Journal, 24 (5), 779-781

Wessale, J.L., Bourland, J.D., Babbs, C.F., Milewski, R.C., Rockenhauser, M.E. and Geddes, L.A. (1985), Correlation of the Cardiogenic Air-Flow in the Respiratory Airway (Ie the Pneumocardiogram) with Left-Ventricular Stroke Volume in Dogs. Japanese Heart Journal, 26 (5), 777-785

Nakada, T. (1981), Plasma-Renin Activity in Stroke-Prone and Resistant Spontaneously Hypertensive Rats - Relationship to Some Antihypertensive Drugs. Japanese Journal of Urology, 72 (2), 159-165

Okada, T. (1981), Depressive Effects of Active Shortening on Stroke Volume of Left-Ventricle and Shortening Amount of Isolated Ventricular Muscle. Japanese Journal of Physiology, 31 (2), 199-215

Nagaoka, A. and Kakihana, M. (1982), Effects of Renal Sympathectomy on Sodium and Water-Excretion in Stroke-Prone Spontaneously Hypertensive Rats. Japanese Journal of Pharmacology, 32 (4), 591-597

Watanabe, T.X., Kawashima, K. and Sokabe, H. (1985), Chronic Effects of Enalapril on Blood-Pressure, Stroke, Plasma- Renin, Urinary Electrolytes and Pge2 Excretion in Stroke-Prone Spontaneously Hypertensive Rats. Japanese Journal of Pharmacology, 38 (4), 419-427

Shimoji, A., Katsuragi, S., Miyakawa, T., Hira, R., Watanabe, K., Miyakawa, K., Ishitsu, T. and Miike, T. (1987), Familial Mitochondrial Encephalomyopathy with Stroke-Like Episodes and Episodic Disturbances of Consciousness - A Study of Pedigree Including 3 Generations with Multisystemic Abnormalities. Japanese Journal of Psychiatry and Neurology, 41 (1), 47-55

Yoshida, F., Sadoshima, S., Fujii, K., Iino, K. and Fujishima, M. (1988), Regional Cerebral Blood-Flow in Chronic Stroke Patients with Dementia. Japanese Journal of Medicine, 27 (2), 172-176

Okamura, T., Motomura, N., Asaba, H., Sakai, T., Fukai, M., Mori, E. and Yamadori, A. (1989), Hypergraphia in Temporal-Lobe Epilepsy - Compared with Stroke of the Right Cerebral Hemisphere. Japanese Journal of Psychiatry and Neurology, 43 (3), 524-525

Hashimoto, T., Kimori, M., Nakamura, Y. and Kuriyama, K. (1989), Effect of Nc-1100 [1-(3,4-Dimethoxyphenyl)-2- (4- Diphenylmethylpiperazinyl) Ethanol Dihydrochloride] on Gamma- Aminobutyric Acid (Gaba) Metabolism in Rat-Brain - Analysis Using Stroke-Prone Spontaneously Hypertensive Rat. Japanese Journal of Pharmacology, 50 (2), 131-139

Morimoto, S., Ohyama, T., Hisaki, K. and Matsumura, Y. (1989), Effects of Cv-4093, A New Dihydropyridine Calcium-Channel Blocker, on Renal Hemodynamics and Function in Stroke-Prone Spontaneously Hypertensive Rats (Shrsp). Japanese Journal of Pharmacology, 51 (2), 257-265

Kitagawa, H., Sasaki, Y., Ishihara, K. and Hirano, Y. (1990), Contribution of Live Heartworms Harboring in Pulmonary-Arteries to Pulmonary-Hypertension in Dogs with Dirofilariasis. Japanese Journal of Veterinary Science, 52 (6), 1211-1217.

Abstract: To investigate whether adult heartworms harboring in the pulmonary arteries contribute to pulmonary hypertension, we determined the cardio-pulmonary values immediately before and after removal of heartworms from the pulmonary arteries and before and after insertion of live worms in their place. In 10 heartworm-infected dogs, 8 to 46 worms were removed. The mean pulmonary arterial pressure fell significantly from 24.5+/-7.9 mmHg to 16.3+/-4.9 mmHg (p < 0.01) immediately after removal. The right cardiac output decreased in 7 of the 10 cases. The total pulmonary resistance and right ventricular stroke work index also decreased. At 24 hours after removal, live heartworms were put back into the pulmonary arteries of their host dog. The mean pulmonary arterial pressure elevated significantly (p < 0.01) immediately after insertion. The right cardiac output further decreased in 7 of the 10 dogs, and the total pulmonary resistance and right ventricular stroke work index increased. Seperate from this, 12 to 42 heartworms were transplanted into the pulmonary arteries of 5 heartworm- free dogs. Immediately after transplantation, the pulmonary arterial pressure did not show any significant change. However, the stroke volume decreased, and the total pulmonary resistance increased. These facts suggest a contribution of live heartworms to the pulmonary hypertension, although there is a complicated interaction among the presence of heartworms, the pulmonary lesions and the pulmonary hypertension

Keywords: DIROFILARIASIS/FLEXIBLE ALLIGATOR FORCEPS/HEARTWORM/IMMITIS/JAPAN/PULMONARY HYPERTENSION/REMOVAL

Kitayama, I., Yamazaki, K., Shibahara, K. and Nomura, J. (1990), Pure Word Deafness with Possible Transfer of Language Dominance. Japanese Journal of Psychiatry and Neurology, 44 (3), 577-584.

Abstract: A 55-year-old, right-handed male patient with a past history of a stroke followed by a difficulty of speech and hearing fell and manifested a left hemiplegia. He could neither comprehend spoken language and melody nor repeat them, though he spoke with paraphasia and understood written language and nonverbal sound. An electroencephalogram, pneumoencephalogram and cerebral angiogram suggested the existence of old infarcts in the left temporal lobe and a probable new one in the right cerebrum. A diagnosis of this case was made as pure word deafness which might be caused by a reimpairment of the language function possibly transferred to to the nondominant, right hemisphere following the early stroke

Keywords: CEREBRAL ANGIOGRAM/ELECTROENCEPHALOGRAM/HEMIPLEGIA/JAPAN/PNEUMOENCEPHALOGRAM/PURE WORD DEAFNESS/SEP/STROKE/TRANSFER OF LANGUAGE DOMINANCE

Chopard, J.L. and Cotte, L. (1989), Ischemic Stroke and Oral-Contraceptives - Possible Medico-Legal Implications. Journal de Medecine Legale Droit Medical, 32 (1), 79-85

Bazard, M.C., Becker, A., Berrod, J.P. and Raspiller, A. (1990), The Chorioretinitis in Congenital Toxoplasmosis. Journal Francais D Ophtalmologie, 13 (8-9), 434-440.

Abstract: The goal of this study was to establish the incidence of chorioretinis in 100 infants whose mothers presented a seroconversion during the pregnancy. It is a retrospective study over 6.5 years. There were 17 cases of latent congenital toxoplasmosis (56.7%) and 13 cases of clinical congenital toxoplasmosis (43.3%). Three infants presented with chorioretinis: one at birth in a context of general stroke, the two others at 2 and 17 months after birth, despite treatment. The risk of retinochorioditis was the same in the case of latent or clinical congenital toxoplasmosis. The fall in the antibody titre was not a good criterion of cure; the percentage of lymphocytes in the cerebrospinal fluid could constitue a better criterion. This study confirmed the efficacy of systemic treatment of congenital toxoplasmosis

Keywords: CHORIORETINITIS/INFANT/TOXOPLASMOSIS

Hamrin, E. (1982), Attitudes of Nursing Staff in General Medical Wards Towards Activation of Stroke Patients. Journal of Advanced Nursing, 7 (1), 33-42

Axelsson, K., Norberg, A. and Asplund, K. (1986), Relearning to Eat Late After A Stroke by Systematic Nursing Intervention - A Case-Report. Journal of Advanced Nursing, 11 (5), 553-559

Carr, E.K. and Hawthorn, P.J. (1988), Lip Function and Eating After A Stroke - A Nursing Perspective. Journal of Advanced Nursing, 13 (4), 447-451

Hamrin, E.K.F. and Lindmark, B. (1990), The Effect of Systematic Care Planning After Acute Stroke in General-Hospital Medical Wards. Journal of Advanced Nursing, 15 (10), 1146-1153

Kaufman, S. (1988), Illness, Biography, and the Interpretation of Self Following A Stroke. Journal of Aging Studies, 2 (3), 217-227

Bleed, P. and Bleed, A. (1987), Energetic Efficiency and Hand Tool Design - A Performance Comparison of Push and Pull Stroke Saws. Journal of Anthropological Archaeology, 6 (2), 189-197

Koop, S. and Martin, G.L. (1983), Evaluation of A Coaching Strategy to Reduce Swimming Stroke Errors with Beginning Age-Group Swimmers. Journal of Applied Behavior Analysis, 16 (4), 447-460

Loeppky, J.A., Greene, E.R., Hoekenga, D.E., Caprihan, A. and Luft, U.C. (1981), Beat-By-Beat Stroke Volume Assessment by Pulsed Doppler in Upright and Supine Exercise. Journal of Applied Physiology, 50 (6), 1173-1182

Quail, A.W., Traugott, F.M., Porges, W.L. and White, S.W. (1981), Thoracic Resistivity for Stroke Volume Calculation in Impedance Cardiography. Journal of Applied Physiology, 50 (1), 191-195

Heckman, J.L., Stewart, G.H., Tremblay, G. and Lynch, P.R. (1982), Relationship Between Stroke Volume and Pneumocardiogram. Journal of Applied Physiology, 52 (6), 1672-1677

Horsfield, K., Gabe, I., Mills, C., Buckman, M. and Cumming, G. (1982), Effect of Heart-Rate and Stroke Volume on Gas Mixing in Dog Lung. Journal of Applied Physiology, 53 (6), 1603-1607

Grubb, B.R. (1982), Cardiac-Output and Stroke Volume in Exercising Ducks and Pigeons. Journal of Applied Physiology, 53 (1), 207-211

Fortney, S.M., Wenger, C.B., Bove, J.R. and Nadel, E.R. (1983), Effect of Blood-Volume on Forearm Venous and Cardiac Stroke Volume During Exercise. Journal of Applied Physiology, 55 (3), 884-890

Tolle, F.A., Judy, W.V., Yu, P.L. and Markand, O.N. (1983), Reduced Stroke Volume Related to Pleural Pressure in Obstructive Sleep-Apnea. Journal of Applied Physiology, 55 (6), 1718-1724

Overton, J.M., Tipton, C.M., Matthes, R.D. and Leininger, J.R. (1986), Voluntary Exercise and Its Effects on Young Shr and Stroke- Prone Hypertensive Rats. Journal of Applied Physiology, 61 (1), 318-324

Hopper, M.K., Coggan, A.R. and Coyle, E.F. (1988), Exercise Stroke Volume Relative to Plasma-Volume Expansion. Journal of Applied Physiology, 64 (1), 404-408

Ray, C.A., Cureton, K.J. and Ouzts, H.G. (1990), Postural Specificity of Cardiovascular Adaptations to Exercise Training. Journal of Applied Physiology, 69 (6), 2202-2208.

Abstract: The purposes of this study were to determine 1) whether posture affects the magnitude of cardiovascular adaptations to training and 2) whether cardiovascular adaptations resulting from exercise training in the supine posture transfer (generalize) to exercise in the upright posture and vice versa. Sixteen sedentary men, aged 18-33 yr, were trained using high-intensity interval and prolonged continuous cycling in the supine (STG; supine training group) or upright (UTG; upright training group) posture 4 days/wk, 40 min/day, for 8 wk, while seven male subjects served as nontraining controls. After training, maximal O2 uptake measured during supine and upright cycling, respectively, increased significantly (P < 0.05) by 22.9 and 16.1% in the STG and by 6.0 and 14.6% in the UTG. No significant cardiovascular adaptations were observed at rest. During submaximal supine cycling at 100 W, significant increases in end-diastolic volume (21%) and stroke volume (22%) (radionuclide ventriculography and CO2 rebreathing) and decreases in heart rate, blood pressure, and systemic vascular resistance occurred in the STG, whereas only a significant decrease in blood pressure occurred in the UTG. During upright cycling at 100 W, a significant decrease in blood pressure occurred in the STG, whereas significant increases in end- diastolic volume (17%) and stroke volume (18%) and decreases in blood pressure and systemic vascular resistance occurred in the UTG. Volume of myocardial contractility, ejection fraction, and systolic blood pressure-to-end-systolic volume ratio did not change significantly after training when measured during supine and upright cycling in either training group. Blood volume increased significantly in the UTG but remained unchanged in the STG. No significant metabolic or cardiovascular changes occurred in the control group. It was concluded that the magnitude of cardiovascular adaptations to training in the supine and upright posture is not different. However, changes are, for the most part, specific to the training posture

Keywords: BLOOD PRESSURE/BLOOD-VOLUME/CO2/END-DIASTOLIC VOLUME/END-SYSTOLIC VOLUME/HEART RATE/MEN/PHYSIOLOGICAL/RADIONUCLIDE VENTRICULOGRAPHY/RESPONSES/STROKE VOLUME/SUPINE/SYSTEMIC VASCULAR RESISTANCE/TRAINING SPECIFICITY/UPRIGHT

Stein, K.L., Kramer, D.J., Killian, A. and Pinsky, M.R. (1990), Hemodynamic-Effects of Synchronous High-Frequency Jet Ventilation in Mitral Regurgitation. Journal of Applied Physiology, 69 (6), 2120-2125.

Abstract: We tested the hypothesis that increases in intrathoracic pressure (ITP), by decreasing the pressure gradient for anterograde left ventricular (LV) ejection, should augment cardiac output in acute mitral regurgitation (MR). In a pentobarbital-anesthetized closed-chest canine model, LV stroke volume (SL(LV)) was measured by integration from an aortic flow probe signal. MR was induced by a regurgitant ring. ITP was elevated over apnea by means of intermittent positive-pressure ventilation (IPPV), asynchronous (asynch) high-frequency jet ventilation (HFJV), and cardiac cycle-specific (synch) HFJV. IPPV resulted in the greatest increase in ITP. MR caused a fall in SV(LV) and a rise in LV filling pressure that were not altered by IPPV. Compared with IPPV or apnea, both asynch and synch HFJV increased SV(LV) and reduced LV filling pressures (P < 0.05). Systolic synch HFJV induced a greater increase in SV(LV) (32%) than diastolic synch HFJV (26%) despite similar ventilatory settings. Our data suggest that when LV contractility is normal but MR impairs forward flow, cardiac cycle-specific increases in ITP will augment forward flow

Keywords: AUGMENTATION/CARDIAC CYCLE-SPECIFIC EFFECTS/CARE/CIRCULATORY ASSISTANCE/CYCLE-SPECIFIC INCREASES/INTRATHORACIC PRESSURE/LEFT VENTRICULAR EJECTION/MR/PHYSIOLOGICAL/POSITIVE PLEURAL PRESSURE/THERAPY

Tipton, C.M., Mcmahon, S., Leininger, J.R., Pauli, E.L. and Lauber, C. (1990), Exercise Training and Incidence of Cerebrovascular Lesions in Stroke-Prone Spontaneously Hypertensive Rats. Journal of Applied Physiology, 68 (3), 1080-1085

Keywords: EXERCISE/PHYSIOLOGICAL

Thompson, S.C., Bundek, N.I. and Sobolewshubin, A. (1990), The Caregivers of Stroke Patients - An Investigation of Factors Associated with Depression. Journal of Applied Social Psychology, 20 (2), 115-129

Vanveldhuisen, D.J., Girbes, A.R.J., Crijns, H.J., Smit, A.J., Degraeff, P.A. and Lie, K.I. (1990), Efficacy and Safety of Ibopamine in Congestive-Heart-Failure. Journal of Autonomic Pharmacology, 10 S115-S121.

Abstract: 1 Ibopamine is a new orally active inodilator, which is developed for the treatment of congestive heart failure (CHF). We treated 13 patients with moderate to severe CHF already on maximal conventional medication with ibopamine and studied its effects on haemodynamic parameters, exercise capacity, plasma norepinephrine (NE) and ventricular arrhythmias on ambulatory EGG monitoring. 2 Both cardiac and stroke volume index increased significantly after ibopamine (33% and 35% resp.). These changes were accompanied by a fall in systemic vascular resistance without changes in heart rate or blood pressure. During cardiopulmonary exercise testing, both maximal oxygen consumption and exercise time increased. Plasma NE levels were not significantly changed after ibopamine. Using the Morganroth criteria for proarrhythmia on ambulatory EGG monitoring, two patients showed proarrhythmia from ibopamine, which was not clinically relevant, but four patients had a decrease in ventricular arrhythmias. 3 This study suggests that ibopamine elicits favourable effects on haemodynamics and exercise tolerance in patients with CHF. During ibopamine treatment, there appears to be no increase in ventricular arrhythmias

Keywords: CHRONIC CARDIAC-FAILURE/DOPAMINE/EXERCISE/ORAL IBOPAMINE/STATE/THERAPY

Akpogomeh, B.A. and Johns, E.J. (1990), The Alpha-Adrenoceptor Mediating the Tubular Actions of the Renal Nerves in Spontaneously Hypertensive and Stroke-Prone Spontaneously Hypertensive Rats. Journal of Autonomic Pharmacology,