Thomassin-bourrel hélène Date of Birth: 15th November 1959 Current appointment

INSTITUT de BIOLOGIE PARIS-SEINE

Curriculum Vitae
Group Title: Drosophila Genetics and Epigenetics
Name: THOMASSIN-BOURREL Hélène

Date of Birth: 15^th November 1959
Current appointment: Researcher CR 1st class CNRS
Academic qualifications: 1987 Ph.D. in Cellular and Molecular Biology, University Louis Pasteur (Strasbourg 1)

1982 Engineer in Biochemistry, INSA Lyon

Research experience

2012 – Present: Senior scientist, University Paris VI & CNRS UMR7622, Director Catherine Jessus, Paris, France, Group of Christophe Antoniewski.

2004-2011: Senior scientist, Pasteur Institute & CNRS UMR2578, Paris, France. G5 group of Christophe Antoniewski.

1995-2004: Senior Scientist, University Paris VII & Jacques Monod Institute, Paris, France, Group of Thierry Grange.

1991-1995: Senior scientist, CNRS UPR A9078, Meudon, France, Group of Jean-Louis Danan.

1988-1991: Post-doctoral Fellow, Cancer Research Institute of Laval University, Québec, Canada. Supervisor: Dr Luc Bélanger.

1987-1988: Post-doctoral Fellow, Cancer Research Institute of Laval University, Québec, Canada. Supervisor: Prof. Guy Poirier.

1983-1987: Ph.D thesis, University Strasbourg 1 & CNRS Neurochemistry Center, Strasbourg, France. Supervisor: Prof. Paul Mandel.

Talks and seminars in foreign countries

1 invited lecture by foreign Institutes

3 lectures at international conferences
Main national and international scientific and administrative responsibilities

National

Co-Organizer of INSERM Workshop N°169 Phase II, « miRNAs and Genome Regulation in Eukaryotes » in Paris (November 2006)

Member of Jury for the recruitment of CNRS engineer assistants (2003)

Co-Organizer of 2 training courses (February 1994 and 1995), “Methods to Study DNA-Protein Interactions”, INSTN and CNRS, CEA Saclay, France.

International

Co-Organizer of 2 EMBO courses (September 1999 and 2001) on “In vivo DNA-Protein interactions”, Jacques Monod Institute, Paris, France.

Teaching

1996-2001, Lectures in DEA and Doctoral school at the INSTN, the Universities Paris 6 and Paris 7, and the Museum d’Histoire Naturelle.

10 main publications

Kress C., Thomassin H. and Grange T., Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks (2006). Proc. Natl. Acad. Sci. USA 103, 11112-11117. Epub 2006 Jul 13

Thomassin H., Kress C. and Grange T. (2004) MethylQuant : a sensitive method for quantifying methylation of specific cytosines within the genome. Nucleic Acids Res. 32, e168.
Thomassin H., Flavin M., Espinas M.L. and Grange T. (2001). Glucocorticoid-induced DNA demethylation and gene memory during development. EMBO J. 20, 1974-1983.
Thomassin H., Bois-Joyeux B., Delille R., Ikonomova R. and Danan J.L. (1996). Chicken Ovalbumin Upstream Promoter-Transcription Factor, Hepatocyte Nuclear Factor 3, and CCAAT/Enhancer Binding protein controls the far upstream enhancer of the rat -fetoprotein gene. DNA and Cell Biology 15, 1063-1074.
Bernier D., Thomassin H., Allard D., Guertin M., Hamel D., Blaquière M., Beauchemin M., Larue H., Estable-Puig M. and Bélanger L. (1993). Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the ₁-fetoprotein gene promoter and the albumin/₁-fetoprotein intergenic enhancer. Mol. Cell. Biol. 13, 1619-1633.
Thomassin H., Hamel D., Bernier D., Guertin M. and Bélanger L. (1992). Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the ₁-fetoprotein gene. Further analysis of C/EBP and C/EBP. Nucleic Acids Res. 20, 3091-3098.
Thomassin H., Ménard L., Hengartner C., Kirkland J. B., and Poirier G. G. (1992). Poly(ADP-ribosyl)ation of chromatin in an in-vitro poly(ADP-ribosyl)ation turnover system. Biochim. Biophys. Acta 1137, 171-181.
Thomassin H., Jacobson M.K., Guay J., Verreault A., Aboul-Ela N., Ménard L. and Poirier G.G. (1990). An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase. Nucleic Acids Res. 18, 4691-4694.
Thomassin H., Martins de Sa C., Scherrer K., Maniez C. and Mandel P. (1988). Cytoplasmic poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase in AEV transformed chicken erythroblasts. Molec. Biol. Rep. 13, 35-44.
Thomassin H., Niedergang C. and Mandel P. (1985). Poly(ADP-ribose) polymerase associated with free cytoplasmic mRNA-protein particles. Biochem. Biophys. Res. Commun. 133, 654-661.