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Prevalence and molecular characterization of G6PD deficiency in two Plasmodium vivax endemic areas in Venezuela: predominance of the African A-202A/376G variant



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Prevalence and molecular characterization of G6PD deficiency in two Plasmodium vivax endemic areas in Venezuela: predominance of the African A-202A/376G variant


Glucose-6-phosphate dehydrogenase (G6PD) deficiency causes acute haemolytic anaemia triggered by oxidative drugs such as primaquine (PQ), used for Plasmodium vivax malaria radical cure...

Esmeralda Vizzi, Gilberto Bastidas, Mariana Hidalgo, Laura Colman and Hilda A. Pérez

Malaria Journal 2016 15:19

Why do health workers give anti-malarials to patients with negative rapid test results? A qualitative study at rural health facilities in western Uganda


The large-scale introduction of malaria rapid diagnostic tests (RDTs) promises to improve management of fever patients and the rational use of valuable anti-malarials. However, evidence on the impact of RDT in...

Robin Altaras, Anthony Nuwa, Bosco Agaba, Elizabeth Streat, James K. Tibenderana and Clare E. Strachan

Malaria Journal 2016 15:23

Antibody profiles to plasmodium merozoite surface protein-1 in Cambodian adults during an active surveillance cohort with nested treatment study


In addition to evidence for a protective role of antibodies to the malaria blood stage antigen merozoite surface protein 1 (MSP1), MSP1 antibodies are also considered as a marker of past malaria exposure in se...

Michele D. Spring, Sathit Pichyangkul, Chanthap Lon, Panita Gosi, Kosol Yongvanichit, Utaiwan Srichairatanakul, Amporn Limsalakpeth, Chaiyaporn Chaisatit, Soklyda Chann, Sabaithip Sriwichai, Montida Auayapon, Suwanna Chaorattanakawee, Sheetij Dutta, Satharath Prom, Char Meng Chour, Douglas S. Walsh…

Malaria Journal 2016 15:17

Malaria burden and anti-malarial drug efficacy in Owando, northern Congo


In the Republic of Congo, previous epidemiological studies have only been conducted in the south of the country where it is most accessible. Nationally representative data on the efficacy of new anti-malarial ...

Brice P. Singana, Hervé Bogreau, Brunelle D. Matondo, Louis R. Dossou-Yovo, Prisca N. Casimiro, Rigobert Mbouka, Kim Yen Ha Nguyen, Bruno Pradines, Leonardo K. Basco and Mathieu Ndounga

Malaria Journal 2016 15:16

Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo


The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country is ...

Henry M. T. Ntuku, Gianfrancesco Ferrari, Christian Burri, Antoinette K. Tshefu, Didier M. Kalemwa and Christian Lengeler

Malaria Journal 2016 15:18

Alterations of blood coagulation in controlled human malaria infection


Alterations of blood coagulation are thought to be involved in malaria pathogenesis. This study had the aim to investigate changes of blood coagulation under the standardized conditions of controlled human mal...

Julia Riedl, Benjamin Mordmüller, Silvia Koder, Ingrid Pabinger, Peter G. Kremsner, Stephen L. Hoffman, Michael Ramharter and Cihan Ay

Malaria Journal 2016 15:15

Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria


Glucose-6-phosphate dehydrogenase (G6PD) deficiency exhibits considerable allelic heterogeneity which manifests with variable biochemical and clinical penetrance. It has long been thought that G6PD deficiency ...

Shivang S. Shah, Kirk A. Rockett, Muminatou Jallow, Fatou Sisay-Joof, Kalifa A. Bojang, Margaret Pinder, Anna Jeffreys, Rachel Craik, Christina Hubbart, Thomas E. Wellems and Dominic P. Kwiatkowski

Malaria Journal 2016 15:13

The role of gender on malaria preventive behaviour among rural households in Kenya


Malaria remains a major health and development challenge in the sub-Saharan African economies including Kenya, yet it can be prevented. Technologies to prevent malaria are available but are not universally ado...

Gracious M. Diiro, Hippolyte D. Affognon, Beatrice W. Muriithi, Sarah Kingori Wanja, Charles Mbogo and Clifford Mutero

Malaria Journal 2016 15:14

A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria


The factors leading to poor outcomes in malaria infection are incompletely understood. Common genetic variation exists in the human genes for Toll like receptors (TLRs) that alter host responses to pathogen-a...

William O. Hahn, Susanna Harju-Baker, Laura K. Erdman, Srivicha Krudsood, Kevin C. Kain, Mark M. Wurfel and Wayne C. Liles

Malaria Journal 2016 15:12

Targeting indoor residual spraying for malaria using epidemiological data: a case study of the Zambia experience


In Zambia and other sub-Saharan African countries affected by ongoing malaria transmission, indoor residual spraying (IRS) for malaria prevention has typically been implemented over large areas, e.g., district...

Jessie Pinchoff, David A. Larsen, Silvia Renn, Derek Pollard, Christen Fornadel, Mark Maire, Chadwick Sikaala, Chomba Sinyangwe, Benjamin Winters, Daniel J. Bridges and Anna M. Winters

Malaria Journal 2016 15:11

Diagnosis of an imported Plasmodium ovale wallikeri infection in Malaysia


Plasmodium ovale is rare and not exactly known to be autochthonous in Malaysia. There are two distinct forms of the parasite, namely P. ovale curtisi (classic form) and P. ovale wallikeri

Jonathan Wee Kent Liew, Rohela Mahmud, Lian Huat Tan and Yee Ling Lau

Malaria Journal 2016 15:8


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