Curriculum vitae name: david j. Grdina
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- MEMBERSHIP IN SCIENTIFIC SOCIETIES
- I. PEER REVIEWED JOURNAL ARTICLES 1 Grdina, D.J.
- D.J. Grdina
- D. Grdina
- Grdina, D.J.
- D. J. Grdina
| Curriculum Vitae David J. Grdina CURRICULUM VITAE NAME: DAVID J. GRDINA EDUCATION: University of Houston M.B.A. Houston, Texas (Finance) 1980 University of Kansas Ph.D. Lawrence, Kansas (Radiation Biophysics) 1971 University of Kansas M.S. Lawrence, Kansas (Radiation Biophysics) 1969 St. Mary's College B.A. Winona, Minnesota (Biology) 1966 Section of Experimental Biology Postdoctoral Fellow March 1971 - The University of Texas System in Biology May 1972 Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas
Oncology, The University of Chicago and Cellular Oncology Present Chicago, Illinois Associate Professor of Jan. 1985 - Radiation and Cellular June 1987 Oncology
University of Chicago Co-Program Leader Oct. 1994 - Cancer Research Center Chemoprevention July 2000 Center for Mechanistic Biology Head, Section of Nov. 1991 - and Biotechnology Radiation Biology Sept. 1996 (formerly, Biological and Medical Research Division) Senior Scientist, June 1987 - Argonne National Laboratory, Group Leader, Sept. 1996 Argonne, Illinois Radiation Carcinogenesis (Joint Appt. U. of C.) Scientist, Group Leader, Sept. 1983 - Radiation Carcinogenesis June 1987
Rush Medical College, Rush- Professor March 1985 Presbyterian-St. Luke's Medical Center, Chicago, Illinois Department of Experimental Associate Biologist and Sept. 1978 - Radiotherapy, The University Associate Professor of Sept. 1983 of Texas System Cancer Center, Radiotherapy (Biology) M.D. Anderson Hospital and Tumor Institute, Houston, Texas Assistant Biologist and Sept. 1975 - Assistant Professor of Aug. 1978 Radiotherapy (Biology)
Aug. 1975 Baylor College of Medicine and Visiting Lecturer June-Aug. 1976 St. Luke's Episcopal Hospital Biological Effects Sept. 1983 Houston, Texas, in conjunction of Nuclear Medicine with University of Houston School of Nuclear Medicine Technology PROFESSIONAL CONSULTANTSHIPS: National Institutes of Health Consultant Bethesda, MD Radiation Study Section 1990-1994 Reviewers Reserve 1994-present
Development P01 HollisEden Consultant 2004-2007 Pinnacle Biologics Consultant 2009-present Congressional Pharmaceuticals Founding Scientist 2001-2004 Corporation PrevOnc (Prevention of Oncogenesis) Founding Scientist 1999-2001 Radiation Oncology Modifiers Founding Scientist 1997-1998 Corporation (ROMCOR) Odyssey Therapeutics Member: Scientific 1993-1996 3461 Route 22 East and Medical Advisory Somerville, NJ 08876 Board U.S. Bioscience Member: Basic 1993-1994 One Tower Bridge Science Advisory 100 Front Street, P.O. Box 851 Board West Conshohocken, PA 19428 Consultant 1999-2000
225 Larkin Drive Product Development Wheeling, IL 60090
Ethyol Speaker Bureau ALZA Pharmaceuticals Ethyol Speakers Bureau Speaker 1996-2001 MedImmune Speakers Bureau Speaker 2001-2004 NIH STUDY SECTIONS: NIH Special Study Section Member 1989 NIH Radiation Study Section Ad Hoc Member 1990 NIH Radiation Study Section Member 1990 - 1994 NIH Reviewers Reserve Member 1994 - present NCI Initial Review Group Member 1996 - 2000 Committee-Subcommittee C - Basic and Preclinical Sciences
Committee-Subcommittees A, D, and E
American Cancer Society Member 1991 - 1992 (Illinois Division, Inc.)
Netherlands Cancer Foundation MEMBERSHIP ON COMMITTEES: National NASA Space Radiation Standing Review Member 2009-present Panel, Human Research Program AERAS Global TB Vaccine Foundation Institutional BioSafety Committee Member 2006-present NIH/NCI Radiation Carcinogenesis Chairperson and 2006 Workshop Organizer Blue Ribbon Panel for NIH Strategic Member 2004 Plan and Research Agenda for Medical Countermeasures Against Radiological And Nuclear Threats. Radiation Research Society Member 1997 - 1998 Fundraising Committee Radiation Research Society Member 1993-1996 Policies and Procedures Committee Radiation Research Society Member 1993 - 1994 Program Committee 42nd Annual Meeting
Advisory Committee, Lawrence Berkeley Laboratory
Executive Committee Radiation Research Society Chairman 1982 - 1985 Finance Committee Radiation Research Society Member 1985 - 1987 Management Support Contract Committee
Society Journal The Cell Kinetics Society Member 1982 - 1984 Finance Committee Local Nuclear Incident and Radiation Member 2003-2006 Dispersal Device Committee; Subcommittee Of the ITTF Science and Technology Committee For The State of Illinois University of Chicago Cancer Research Member 1994 - 2004 Center Executive Committee University of Chicago Committee on Member 2000 – 2004 Appointments and Promotions (COAP) 2009-present
Radioactive Use University of Chicago Committee on Member 1994 - Present Cancer Biology Argonne National Laboratory Member 1984 - 1991 BIM Division, Library Committee Argonne National Laboratory Member 1985 - 1987 BIM Division, Animal Use Committee Argonne National Laboratory Member 1988 - 1995 BIM Division, Human Use Committee Argonne National Laboratory Member 1989 - 1992 BIM Division, Promotions Committee Argonne National Laboratory Chairman 1989 - 1996 BIM Division, Enrico Fermi Fellowship Committee
BIM Division, Seminar Committee Argonne National Laboratory Member 1992 - 1994 EEST Personnel Oversight Committee on Hiring and Promotions
Performance Appraisal Task Force, Scientific/Engineering Performance Appraisal Task Force Argonne National Laboratory Member 1993 - 1995 Working Group to Explore Scientific Relationship between The University of Chicago and Argonne National Laboratory in Medical Sciences.
School of Biomedical Sciences, for six students Houston, Texas, Advisory, Supervisory, and/or Candidacy Examining Committees
System Cancer Center Academic Standards Committee
Tumor Institute, Ad Hoc Task Force on Extramural Impact in FY 82 Academic Plan The University of Texas Member at Large 1981 - 1983 M.D. Anderson Hospital, Research Committee
Radiation Research Journal Advisory Board Member; CRC Critical 1988 - 1989 Reviews in Sulfhydryl Biochemistry Advisory Board Member; Libri Oncologici 1992 - present (Cancer Journal published in English and Croatian) Member of the Overseas Editorial Board, Journal 2000-2005 of Radiation Research (Japanese Journal) MEMBERSHIP IN SCIENTIFIC SOCIETIES: Radiation Research Society American Association for Cancer Research University of Texas M. D. Anderson Associates (founding member)
Radiation Research Society VISITING SCIENTISTS/POSTDOCTORALS TRAINED: Dr. Curt Sigdestad University of Louisville Dr. Biba Nagy Science Advisor to the President of the Republic of Croatia Zagreb, Croatia
Dr. Ivan Basic University of Zagreb Zagreb, Croatia
Birmingham, England Dr. Yasushi Kataoka National Institute of Radiological Sciences Chiba, Japan Dr. Naoyuki Shigematsu Keio University Tokyo, Japan Dr. Barton Bergquist University of Northern Iowa Dr. Coral Quiet University of Chicago Dr. Jeff Murley Northern Illinois University Dr. Shie-Chau Liu Illinois Institute of Technology Dr. William Epperly Argonne National Laboratory HONORS: Atomic Energy Commission Special Health Physics Fellowship, University of Kansas, Sept. 1966 - Aug. 1967.
University of Kansas, Sept. 1968 - Feb. 1971. AWARDS: 6th International Congress for Radiation Research (ICRR) Travel Award, 1979; 7th ICRR Travel Award, 1983; 8th ICRR Travel Award, 1987; 10th ICRR Travel Award, 1995
University of Pennsylvania, 1993. PROFESSIONAL LISTINGS: Marquis Who's Who in Cancer Professionals and Facilities, 1st Ed., 1985. American Men and Women of Science, Physical and Biological Sciences, 16th Ed., 1986. Marquis Who's Who in the Midwest, 23rd Ed., 1991. PATENTS U.S. Patents: “Method for Protection Against Genotoxic Mutagenesis,” 5,488,042, issued January 30, 1996.U.S. Patent 5,567,686, issued October 22, 1996. U.S. Patent 5,869,338, issued February 9, 1999. U.S. Patent 5,891,856, issued April 6, 1999. “Method for Protection Against Tumor Metastasis Formation. U.S. Patent 6,984,619, 2006. I. PEER REVIEWED JOURNAL ARTICLES 1 Grdina, D.J., P. Lohman, and R.R. Hewitt. A Fluorometric Method for the Detection of Endodeoxyribonuclease on DNA-Polyacrylamide Gels. Analytical Biochemistry, 51:255-264, #1, January, 1973. 2 Grdina, D.J., L. Milas, R.R. Hewitt, and H.R. Withers. Buoyant Density Separation of Human Blood Cells in Renografin Gradients. Experimental Cell Research, 81:250-254, 1973. 3 Grdina, D.J., L. Milas, K. Mason, and H.R. Withers. Separation of Cells from a Fibrosarcoma in Renografin Gradients. Journal of the National Cancer Institute, 52:253-257, #1, January, 1974. 4 Grdina, D.J., M. Meistrich, and H.R. Withers. Separation of Clonogenic Cells from Stationary Phase Cultures by Density Gradient Centrifugation. Experimental Cell Research, 85:15-22, 1974. 5 Basic, I., L. Milas, D. Grdina, and H.R. Withers. Destruction of Hamster Ovarian Cell Cultures by Peritoneal Macrophages from Mice Treated with Corynebacterium granulosum. Journal of the National Cancer Institute, 52:1839-1842, June, 1974. 6 Milas, L., N. Hunter, I. Basic, K. Mason, D.J. Grdina, and H.R. Withers. Nonspecific Immunotherapy of Murine Solid Tumors with C. granulosum. Journal of the National Cancer Institute, 54:895-902, 1975. 7 Basic, I., L. Milas, D.J. Grdina, and H.R. Withers. In vitro Destruction of Tumor Cells by Macrophages from Mice Treated with C. granulosum. Journal of the National Cancer Institute, 55:589-596, 1975. 8 Grdina, D.J., I. Basic, K. Mason, and H.R. Withers. Radiation Response of Clonogenic Cell Populations Separated from a Fibrosarcoma. Radiation Research, 63:483-493, 1975. 9 Grdina, D.J., I. Basic, S. Guzzino, and K.A. Mason. Radiation Response of Cell Populations Irradiated in situ and Separated from a Fibrosarcoma. Radiation Research, 66:634-643, 1976. 10 Grdina, D.J., W.H. Hittleman, A. White, and M.L. Meistrich. The Formation of Lung Colonies. An Analysis Based on Cellular Parameters of Density, Size, and DNA Content. British Journal of Cancer, 36:659-669, 1977. 11 Suzuki, N., M. Frapart, D.J. Grdina, M.L. Meistrich, and H.R. Withers. Cell Cycle Dependency of Metastatic Lung Colony Formation. Cancer Research, 37:3690-3693, October, 1977. 12 Meistrich, M.L., D.J. Grdina, R.E. Meyn, and B. Barlogie. Separation of Cells from Mouse Solid Tumors by Centrifugal Elutriation. Cancer Research, 37:4291-4296, December, 1977. 13 Grdina, D.J., S. Linde, and K. Mason. Response of Selected Tumor Populations Separated from a Fibrosarcoma Following Irradiation in situ with Fast Neutrons. British Journal of Radiology, 51:291- 301, March, 1978. 14 Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. I. Relationship Between Cell Size and Age as Modified by Growth in vivo or in vitro. Journal of the National Cancer Institute, 61:209-214, July, 1978. 15 Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. II. Differential Effects of Cell Size and Age on Lung Retention and Colony Formation in Normal and Pre-Conditioned Mice. Journal of the National Cancer Institute, 61:215- 220, July 1978. 16 Grdina, D.J., C.P. Sigdestad, and L.J. Peters. Phase Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Cells Synchronized by Centrifugal Elutriation. British Journal of Cancer, 39:152-159, February, 1979. 17 Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. Cytotoxic Effect of Adriamycin in vivo on Synchronized Murine Fibrosarcoma Cells. International Journal of Radiation Oncology, Biology, Physics, 5:1305-1308, 1979. 18 Sigdestad, C.P., D.J. Grdina, and K. Ando. Density Gradient Centrifugation of Cells Separated from Multicellular Tumor Spheroids. Experentia, 35/6:815-817, 1979. 19 Hunter, N., L.J. Peters, D.J. Grdina, R.A. White, and A. Bartel. Radiation Sensitivity of Murine Fibrosarcoma Cells Separated by Centrifugal Elutriation. Radiation Research, 80:389-397, 1979. 20 Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. The Effect of Misonidazole in situ on the Radiation Response of Selected Tumor Cell Subpopulations. Clinical Cancer Trials, 3:149-154, 1980. 21 Sigdestad, C.P., and D.J. Grdina. Velocity Sedimentation of Tumor Cells: A Comparison of Methods. Experentia, 37:501-502, 1981. 22 Sigdestad, C.P., and D.J. Grdina. In vivo Cell Cycle Phase Preferential Killing of Murine Fibrosarcoma Cells by Cis-Dichlorodiammine Platinum II. Cancer Treatment Reports, 65:845-851, 1981. 23 Sigdestad, C.P., and D.J. Grdina. Density Centrifugation of Murine Fibrosarcoma Cells Following in situ Labeling with Tritiated Thymidine. Cell Tissue Kinetics, 14:589-600, 1981. 24 Grdina, D.J. Phase-Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Pulmonary Nodules. British Journal of Cancer, 45:438-446, 1982. 25 Grdina, D.J., and N. Hunter. Cyclic-Radiation Response of Murine Fibrosarcoma Cells Grown as Pulmonary Nodules. International Journal of Radiation Oncology, Biology, Physics, 8:1727-1734, 1982. 26 Brock, W.A., D.E. Swartzendruber, and D.J. Grdina. Studies of the Kinetic Heterogeneity in Density Separated Tumor Subpopulations. Cancer Research, 42:4999-5003, 1982. 27 Mian, T.A., J.C. Theiss, and D.J. Grdina. Lung Tumorigenic Response of Strain A Mice Exposed to Hypoxic Cell Sensitizers Alone and in Combination with Gamma Radiation. Cancer Research, 43:146-149, 1983. 28 Thames, H.D., D.J. Grdina, and L. Milas. Response of a Fibrosarcoma Cell Population to Small Doses of Radiation Delivered in situ. International Journal of Radiation Oncology, Biology, Physics, 9:217-220, 1983. 29 Grdina, D.J., and R.A. White. Treatment of Artificially-Induced Pulmonary Metastases with Fractionated Doses of Vincristine and/or Radiation Therapy. Clinical and Experimental Metastasis, 1:71-81, 1983. 30 Grdina, D.J., R.A. White, and J.J. Stragand. Cytotoxic Effects of Vincristine on Tumor Subpopulations Separated from Pulmonary Nodules. British Journal of Cancer, 48:279-287, 1983. 31 Grdina, D.J., and G. Zin. Density Gradient Centrifugation of Tumor Cells from Needle Biopsies and Their Respective Source Tumors: A Comparison of Density Distributions. Experentia, 39:916-917, 1983. 32 Grdina, D.J., M.L. Meistrich, R.E. Meyn, T.S. Johnson, and R.A. White. Cell Synchrony Techniques. I. A Comparison of Methods. Cell and Tissue Kinetics, 17:223-236, 1984. 33 White, R.A., D.J. Grdina, M.L. Meistrich, R.E. Meyn, and T.S. Johnson. Comparison of Cell Synchrony Techniques. II. Cell Progression Data. Cell and Tissue Kinetics, 17:237-245, 1984. 34 Grdina, D.J., H.D. Thames, and L. Milas. Tumor Sensitizing Effect by Misonidazole in a Clinically Relevant Radiation Dose Range. International Journal of Radiation Oncology Biology, Physics, 10:379-383, 1984. 35 Grdina, D.J., S. Jones, and N. Hunter. Effectiveness of AMSA Alone or in Combination with Radiation on Murine Fibrosarcoma Pulmonary Nodules. Clinical and Experimental Metastasis, 2:223-233, 1984. 36 Grdina, D.J., B. Nagy, C.K. Hill, R.L. Wells, and C. Peraino. The Radioprotector WR1065 Reduces Radiation-Induced Mutations at the HGPRT Locus in V79 Cells. Carcinogenesis, 6:929-931, 1985. 37 Grdina, D.J., C. Peraino, B.A. Carnes, and C.K. Hill. Protective Effect of [S 2 (3 aminopropylamino) ethyl phosphorothioic acid] Against Induction of Altered Hepatocyte Foci in Rats Treated Once with Gamma Radiation Within One Day After Birth. Cancer Research, 45:5379-5381, 1985. 38 Thames, H.D., D.J. Grdina, and L. Milas. On the / Ratio and OER for Clonogenic Tumors Cells. International Journal of Radiation Oncology, Biology, Physics, Correspondence, 11:1572-1573, 1985. 39 Nagy, B., P.J. Dale, and D.J. Grdina. Protection Against Cis-Diammine-dichloroplatinum (II) Cytotoxicity and Mutagenicity in V79 Cells by Free Radical Scavenger 2-[(aminopropyl)amino] ethanethiol. Cancer Research, 46:1132-1135, 1986. 40 Peraino, C., D.J. Grdina, and B.A. Carnes. Synergistic Induction of Altered Hepatocyte Foci by Combined Gamma Radiation and Diethylnitrosamine Administration to Neonatal Rats. Carcinogenesis, 7:445-448, 1986. 41 Sigdestad, C.P., D.J. Grdina, W.R. Hanson, and A.M. Connor. Comparative Radioprotection from Three Neutron Sources with WR2721 and WR151327, Radiation Research, 106:224-233, 1986. 42 Hill, C.K., B. Nagy, C. Peraino, and D.J. Grdina. 2-[(Aminopropyl)amino]ethanethiol (WR1065) is Anti-neoplastic and Anti-mutagenic When Given During 60Co ray Irradiation, Carcinogenesis, 7:665-668, 1986. 43 Nagy, B., and D.J. Grdina. Protective Effects of 2-[(Aminopropyl) Amino] Ethanethiol Against Bleomycin, Nitrogen Mustard, Cis-Diamminedichloroplatinum, and Radiation Induced Mutagenicity in V-79 Cells. International Journal of Radiation Oncology, Biology, Physics, 12:1475-1478, 1986. 44 Grdina, D.J., and B. Nagy. The Effect of 2-[(aminopropyl)amino] Ethanethiol (WR1065) on Radiation-Induced DNA Damage and Repair and Cell Progression in V79 Cells. British Journal of Cancer, 54:933-941, 1986. 45 Peraino, C., D.J. Grdina, E.F. Staffeldt, J.J. Russell, A. Prapuolenis, and B.A. Carnes. Effects of Separate and Combined Treatments with Gamma Radiation and Diethylnitrosamine in Neonatal Rats on the Induction of Altered Hepatocyte Foci and Hepatic Tumors. Carcinogenesis, 8:599-600, 1987. 46 Sigdestad, C.P., S.H. Treacy, L.A. Knapp, and D.J. Grdina. Effects of 2 [(Aminopropyl)amino] Ethanethiol (WR-1065) on Radiation-Induced DNA Double-Strand Damage and Repair in V79 Cells. British Journal of Cancer, 55:477-482, 1987. 47 Hanson, W.R., and D.J. Grdina. Radiation-Induced DNA Single-Strand Breaks in the Intestinal Mucosal Cells of Mice Treated with the Radioprotectors: WR-2721 or 16-16 Dimethyl Prostaglandin E2. International Journal of Radiation Biology, 52:67-76, 1987. 48 Zhang, J., C.P. Sigdestad, M.A. Gemmell, and D.J. Grdina. Modification of Radiation Response in the Mouse Using Fractionated Extracts of Panax ginseng. Radiation Research, 112:156-163, 1987. 49 Schwartz, J.L., S.M. Giovanazzi, T. Karrison, C. Jones, and D.J. Grdina. 2 [(Aminopropyl)amino] Ethanethiol (WR1065)-Mediated Reductions in 60Co Gamma Ray and Fission-Spectrum Neutron-Induced Chromosome Damage in V79 Cells. Radiation Research, 113:145-154, 1988. 50 Grdina, D.J., B. Nagy, and C.P. Sigdestad. Radioprotectors in Treatment Therapy to Reduce Risk in Secondary Tumor Induction. Pharmacology and Therapeutics, 39:21-25, 1988. 51 Grdina, D.J., W.H. Guilford, C.P. Sigdestad, and C.S. Giometti. Effects of Radioprotectors on DNA Damage and Repair, Proteins, and Cell-Cycle Progression. Pharmacology and Therapeutics, 39:133- 137, 1988. 52 Sigdestad, C.P., K.W. Doak, and D.J. Grdina. In Vitro Modification of Radiation Induced DNA Single-Strand Breaks and Cell Survival by Solcoseryl. Experentia, 44:707-708, 1988. 53 Sigdestad, C.P., W. Guilford, J. Perrin, and D.J. Grdina. Cell Cycle Redistribution of Cultured Cells after Treatment with Chemical Radiation Protectors. Cell and Tissue Kinetics, 21:193-200, 1988. 54 Grdina, D.J., C.P. Sigdestad, P.J. Dale, and J.M. Perrin. The Effect of 2 [(Aminopropyl)amino] Ethanethiol on Fission-Neutron-Induced DNA Damage and Repair. British Journal of Cancer, 59:17- 21, 1989. 55 Grdina, D.J., B. Nagy, C.K. Hill, and C.P. Sigdestad. Protection Against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol Under Conditions of Acute Hypoxia. Radiation Research, 117:251-258, 1989. 56 Grdina, D.J., C.P. Sigdestad, and B.A. Carnes. Protection by WR1065 and WR151326 Against Fission-Neutron-Induced Mutations at the HGPRT Locus in V79 Cells. Radiation Research, 117:500- 510, 1989. 57 Nagy, B. and D.J. Grdina. Plasminogen Activator Activity in Clonogenic Cell Populations Separated from a Murine Fibrosarcoma. Clinical and Experimental Metastasis, 7:243-250, 1989. 58 Rotmensch, J., R.W. Atcher, R. Schlenker, J. Hines, D. Grdina, B.S. Block, M.F. Press, A.L. Herbst, and R.R. Weichselbaum. The Effect of the Alpha-Emitting Radionuclide Lead-212 on Human Ovarian Carcinoma: A Potential New Form of Therapy. Gynecologic Oncology, 32:236-239, 1989. 59 Atcher, R., J. Mitchell, J. Hines, J. Rotmensch, D.J. Grdina. Halogenated Pyrimidines as Radiosensitizers for High-LET Radiation. Radiation Research, 117:351-355, 1989. 60 Ando, K., H. Ohara, S. Matsushita, S. Koike, S. Furukawa, and D.J. Grdina. Radioprotection from Fast Neutron Irradiation by WR151327. Inst. Phys. Chem. Res., 83:40-41, 1989. 61 Rotmensch, J., R.W. Atcher, J. Hines, D.J. Grdina, J.L. Schwartz, M. Toohill and A.L. Herbst. The development of Alpha-Emitting Radionuclide Lead-212 for the Potential Treatment of Ovarian Carcinoma. American Journal of Obstetrics and Gynecology, 160:789-797, 1989. 62 Vaughan, A.T.M., D.J. Grdina, P.J. Meechan, A.E. Milner and D.J. Gordon. Conformational Changes in Chromatin Structure Induced by the Radioprotective Aminothiol, WR1065. British Journal of Cancer, 60:893-896, 1989. 63 Rotmensch, J., J.L. Schwartz, R.W. Atcher, D.J. Grdina, M. Toohill and R.R. Weichselbaum. The Inherent Radiosensitivity of Epithelial Ovarian Carcinoma. Gynecology Oncology, 35:282-285, 1989. 64 Rotmensch, J., J.L. Schwartz, M.A. Beckett, D.J. Grdina, M.F.P. Toohill, and R.R. Weichselbaum. Characterization of a Human Ovarian Carcinoma. Analytical and Quantitative Cytology and Histology, 11:324-330, 1989 65 Van Beek, M.E.A.B., R.L. Doak, C.P. Sigdestad, and D.J. Grdina. Pathological Effects of the Radiation Protector WR151327 in Mice. Radiation Research, 124:79-84, 1990. 66 Gordon, D.J., A.E. Milner, R.P. Beaney, D.J. Grdina, and A.T.M. Vaughan. The Increase in Radioresistance of Chinese Hamster Cells Cultured as Spheroids is Correlated to Changes in Nuclear Morphology. Radiation Research, 121:175-179, 1990. 67 Gordon, D.J., A.E. Milner, R.P. Beaney, D.J. Grdina, and A.T.M. Vaughan. Cellular Radiosensitivity in V79 Cells is Linked to Alterations in Chromatin Structure. International Journal of Radiation Oncology, Biology, Physics, 19:1199-1201, 1990. 68 Meechan, P.J., A. Vaughan, D.J. Grdina. WR1065 Association With CHO AA8 Cells, Nuclei, and Nucleoids. Radiation Research, 125: 152-157, 1991. 69 Quiet, C.A., R.R. Weichselbaum, and D.J. Grdina. Variation in Radiation Sensitivity During the Cell Cycle of Two Human Squamous Cell Carcinomas. International Journal of Radiation Oncology, Biology, Physics, 20:733-738, 1991. 70 Sigdestad, C.P., B. Bergquist, and D.J. Grdina. The Effect of Chemical Protectors on Cell Cycle Progression After Gamma or Neutron Irradiation. Cell Proliferation, 24:271-280, 1991. 71 Grdina, D.J., B.J. Wright, and B.A. Carnes. Protection by WR-151327 Against Late Effects Damage Induced by Fission-Spectrum Neutrons. Radiation Research, 128(S):124-127, 1991. 72 Hanson, W.R., and D.J. Grdina. Radiation Protection of Mice From Neutron Injury by Misoprostol, a PGE1 Analog, Protects Mice from Fission-Neutron Injury. Radiation Research, 128(S):12-17, 1991. 73 Schwartz, J.L., R. Mustafi, M.A. Beckett, E.A. Czyzewski, E. Farhangi, D.J. Grdina, J. Rotmensch, and R.R. Weichselbaum. Radiation-Induced DNA Double-Strand Frequencies in Human Squamous Cell Carcinoma Cell Lines of Different Radiation Sensitivities. International Journal of Radiation Biology, 59:1341-1352, 1991. 74 Murley, J.S., D.J. Grdina, and P.J. Meechan. Accumulation of CHO Cells in G2 Phase Following Exposure to WR-1065. Radiation Research, 126:223-228, 1991. 75 Sigdestad, C.P., A.M. Connor, D.J. Grdina, K.W. Doak. Chemical Radiation Protection from Fission Spectrum Neutrons. Nuclear Science Applications, 4:157 166, 1991. 76 Grdina, D.J., B.A. Carnes, D. Grahn, and C.P. Sigdestad. Protection Against Late Effects of Radiation by S-2-(3-Aminopropylamino)-Ethylphosphorothioic Acid. Cancer Research, 51:4125-4130, 1991. 77 Vaughan, A.T.M., D.J. Gordon, D. Grdina, and A.M. Milner. Analysis of Free Radical Damage Within Single Cells Using Flow Cytometry. Molecular Aspects of Medicine, 12:129-135, 1991. 78 Grdina, D.J., B.A. Carnes, and B. Nagy. Protection by WR2721 and WR151327 Against Late Effects of Gamma Rays and Neutrons. Advances in Space Research, 12:(2)257-(2)263, 1992. 79 Grdina, D.J., P. Dale, and R. Weichselbaum. Protection Against AZT-Induced Mutagenesis at the HGPRT Locus in a Human Cell Line by WR-151326. International Journal of Radiation Oncology, Biology, Physics, 22:813-815, 1992. 80 Kataoka, Y., I. Basic, J. Perrin, and D.J. Grdina. Anti-Mutagenic Effects of Radioprotector WR-2721 Against Fission-Spectrum Neutrons and 60Co -Rays in Mice. International Journal of Radiation Biology, #3, 61:387-392, 1992. 81. Meechan, P.J., D.J. Haraf, A.M. Diamond, and D.J. Grdina. Reversion of Radiosensitivity in Azacytidine-Treated xrs-5 Cells Does Not Result in Full Radioprotection by WR 1065. International Journal of Radiation Oncology, Biology, Physics, 23:999 1002, 1992. 82. Grdina, D.J., and C.P. Sigdestad. Chemical Protection and Cell-Cycle Effects on Radiation-Induced Mutagenesis. Cell Proliferation, 25:23-29, 1992. 83. Rotmensch, J., R. Atcher, J. Schwartz, and D. Grdina. Analysis of Ascites from Patients with Ovarian Carcinoma by Cell Flow Cytometry. Gynecological Oncology, 44:10-12, 1992. 84. Carnes, B.A., and D.J. Grdina. In Vivo Protection by the Aminothiol WR-2721 Against Neutron-Induced Carcinogenesis. International Journal of Radiation Biology, No. 5, 61:567-576, 1992. 85. Grdina, D.J., Y. Kataoka, I. Basic, and J. Perrin. The Radioprotector WR-2721 Reduces Neutron-Induced Mutations at the Hypoxanthine-Guanine Phosphoribosyl Transferase Locus in Mouse Splenocytes When Administered Prior to or Following Irradiation. Carcinogenesis, vol. 13, no. 5, pp. 811-814, 1992. 86. Hallahan, D.E., S. Virudachalam, D. Grdina, and R.R. Weichselbaum. The Isoquinoline Sulfonamide H7 Attenuates Radiation-Mediated Protein Kinase C Activation and Delays the Onset of X Ray Induced G2 Arrest. International Journal of Radiation Oncology, Biology, Physics, Vol 24, 687-692, 1992. 87. Constantinou, A., D. Grdina, K. Kiguchi, and E. Huberman. The Effect of Topoisomerase inhibitors on the Expression of Differentiation Markers and Cell Cycle Progression in Human K-562 Leukemia Cells. Experimental Cell Research, 203: 100-106, 1992. 88. Murley, J.S., D.J. Grdina, and P.J. Meechan. Effects of Growth Media on Cell Cycle Progression in CHO Cells Exposed to the Radioprotector WR-1065. Cell Proliferation, 25: 643-650, 1992. 89. Kataoka, Yasushi, Jane Perrin, and David J. Grdina. Induction of HPRT Mutations in Mice following Exposure to Fission-Spectrum Neutrons or 60Co Rays. Radiation Research, 136:289-292, 1993. 90. Grdina, D.J., A. Constantinou, N. Shigematsu, and J.S. Murley. Inhibition of Topoisomerase II Activity in CHO K1 Cells by 2-[(Aminopropyl)Amino]Ethanethiol (WR 1065). Radiation Research, 138: 44-52, 1994. 91. Grdina, D.J., and B.A. Carnes. Chemoprevention by WR 2721. Libri Oncologici 23:11-16, 1994. 92. Hallahan, D.E., D. Bleakman, S. Virudachalam, D. Lee, D.J. Grdina, D. W. Kufe, and R.R. Weichselbaum. The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation. Radiation Research, 138: 392-400, 1994. 93. Shigematsu, N., J.L. Schwartz, and D.J. Grdina. Protection Against Radiation-Induced Mutations at the hprt locus by spermine and N,N -(dithiodi-2-1-Ethanediyl)bis-1,3-Propanediamine (WR 33278). Mutagenesis 9:355-360, 1994. 94. Matsushita, S., K. Ando, S. Koike, D.J. Grdina, and S. Furukawa. Radioprotection by WR 151327 Against the Late Normal Tissue Damage in Mouse Hind Legs from Gamma Ray Radiation. International Journal of Radiation Oncology, Biology, and Physics, 30: 867-872, 1994. 95. Schwartz, J.L., B.A. Sedita, N. Laffely, and D.J. Grdina. Chromosome Terminal Deletion Formation in Chinese Hamster Ovary Cells. Mutation Research, 311: 125-131, 1994. 96. Meechan, P.J., D.J. Haraf, A.M. Diamond, and D.J. Grdina. Varying Levels of Radioprotection from the Effects of JANUS Neutrons in Repair Deficient XRS-5 Hamster Cells Treated with AZAcytidine. Radiation Research, 140: 437-440, 1994. 97. Thraves, P.J., S. Varghese, M. Jung, D.J. Grdina, J.S. Rhim, and A. Dritschilo. Transformation of Human Epidermal Keratinocytes with Fission Neutrons. Carcinogenesis, 15: 2867-2873, 1994. 98. Halpern, H.J., C. Yu, M. Peric, E. Barth, D.J. Grdina, B.A. Teicher. Oxymetry Deep in Tissues with Low Frequency Electron Paramagnetic Resonance. Proceedings of the National Academy of Sciences, USA, 91: 13047-13051, 1994. 99. Grdina, D.J., N. Shigematsu, P. Dale, G.L. Newton, J.A. Aguilera, and R.C. Fahey. Thiol and Disulfide Metabolites of the Radiation Protector and Potential Chemopreventive Agent WR-2721 are Linked to Both its Anticytotoxic and Antimutagenic Mechanisms of Action, Carcinogenesis, 16: 767-774, 1995. 100. Woloschak, G.E., T. Paunesku, C.R. Libertin, C.M. Chang-Liu, and D.J. Grdina. Expression of Thymidine Kinase RNA and a Related Transcript is Modulated by Radioprotector WR-1065. Cancer Research, 55:4788-4792, 1995. 101. Murley, J.S. and D.J. Grdina. Effects of Cycloheximide and WR-1065 on Repair Processes Related to Cell Survival and Mutagenesis Following Single and Split-doses of Radiation Exposure. Carcinogenesis, 16:2699-2705, 1995. 102. Halpern, H.J., G.V.R. Chandramouli, C. Yu, M. Peric, E.D. Barth, B.A. Teicher, and D.J. Grdina. Pharmacological compartment viscosity and polarity measured with very low frequency EPR in tumors of living animals. Magnetic Resonance in Chemistry, 33:S147-S153, 1995. 103. Sidjanin, D., D.J. Grdina, and G.E. Woloschak. UV-Induced Changes in Cell Cycle and Gene Expression within Rabbit Lens Epithelial Cells. Photochemistry and Photobiology, 63:79-85, 1996. 104. Halpern, H.J., C. Yu, M. Peric, E.D. Barth, G.S. Karczamar, J.N. River, D.J. Grdina, and B.A. Teicher. Measurement of Differences in pO2 Response to Perfluorocarbon/ Carbogen in FSa and NFSa Murine Fibrosarcomas with Low Frequency Electron Paramagnetic Oxymetry. Radiation Research, 145:610-618, 1996. 105. Kataoka, Y., J. Perrin, N. Hunter, L. Milas and D.J. Grdina. WR-2721 Protects Against Cytoxan-Induced HPRT Mutagenesis Without Affecting Therapeutic Effectiveness. Seminars in Oncology, 23: Suppl. 8, 53-57, 1996.
Selenium on Glutathione Peroxidase Activity and Radioprotection in Mammalian Cells. Radiat. Onco. Investigations, 3: 383-386, 1996. 107. Diamond, A.M., P. Dale, J.L. Murray, and D.J. Grdina. The inhibition of Radiation-Induced Mutagenesis by the Combined Effects of Selenium and the Aminothiol WR-1065. Mutation Research, 356:147-154, 1996. 108. Schwartz, J.L., J. Cowan, D.J. Grdina, and R.R. Weichselbaum. Attenuation of G2 Cell Cycle Checkpoint Control is Associated with Increased Frequencies of Unrejoined Chromosome Breaks in Human Tumor Cell. Radiation Research, 146:139-143,1996. 109. Woloschak, G.E., T. Paunesku, C.R. Libertin, C-M. Chang-Liu, M. Churchill, J. Panozzo, D. J. Grdina, M.A. Gemmell, and C. Giometti. Regulation of Thymus PCNA Expression is Altered in Radiation-Sensitive Wasted Mice. Carcinogenesis, 17:2357-2365, 1996.
Thiol and Disulfide Forms of the Cytoprotector Amifostine. Carcinogenesis, 18:2457-2459,1997.
the Cytoprotector Amifostine, Affects Phosphorylation of Topoisomerase II Leading to Changes in Enzyme Activity and Cell cycle progression in CHO AA8 Cells. Cell Proliferation,30:283-294, 1997.
113. Grdina, D.J., N. Hunter, Y. Kataoka, J. Murley, and L. Milas. Chemopreventive Doses of Amifostine Confer No Cytoprotection to Tumor Nodules Growing in the Lungs of Mice Treated with Cyclophosphamide. Seminars in Oncology, 26 (#2 Suppl. F): 22-27, 1999.
of Anti-Oxidant Enzymatic Activity by Low Dose Selenium Supplementation Does Not Affect Radiosensitivity of Human Malignant Glioma Cells. Libri Oncologici, 27:63-67, 1998.
Alkyltransferase in Protecting against Cyclophosphamide-induced Toxicity and Mutagenicity Cancer Res., 59:3059-3063, 1999.
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