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Concluzii şi direcţii viitoare de cercetare



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4. Concluzii şi direcţii viitoare de cercetare
O mare eroare a cercetătorilor geneticieni este aceea de a crede că orice articol publicat de ei reprezintă adevărul de necontestat şi sfârşitul poveştii. El este doar un raport de progres.” (Stuart Firestein, former chair of the Department of Biological Sciences at Columbia University, in a Los Angeles Times op-ed about science’s reproducibility crisis - February 14, 2016)

În ceea ce priveşte eventuala mea contribuţie la dezvoltarea ingineriei genetice prin introducerea ingineriei radio-electronice, nu există în acest moment o certificare concretă din partea vreunei instituţii sau a vreunui cercetător a teoriilor emise de mine, editate şi publicate on-line.

Deoarece “natural kinds are the very stuff of science” (114.2016, Trout), va trebui să redactăm cu răbdare rapoarte de progres prin care să descoperim pas cu pas factorii determinanţi ai vieţii şi morţii, adică sfârşitul poveştii, WONDROUS TRUTHS (114.2016, Trout).

În managementul cunoaşterii şi calităţii totale a vieţii nicio informaţie nu trebuie neglijată, chiar dacă pare iraţională la prima vedere. Ea trebuie catalogată şi păstrată cu grijă, ca în cazul probelor extrase de la locul crimelor neelucidate, până când ştiinţa va atinge nivelul necesar şi suficient descifrării corecte a acelei informaţii. Din acest motiv, şi nu numai, certificarea singulară a faptului că mitocondriile pot fi controlate prin informaţiile transmise prin intermediul undelor electromagnetice (74.2014, Alvarez), ar trebui completată cu certificarea moştenirii mitocondriilor paternale rezultată numai şi numai în urma unei fertilizări naturale.

Acest fapt se va produce numai dacă cercetătorii români, care vor dori să participe la acest proiect de analiză a prezenţei şi a localizării precise a mitocondriilor paternale în organismul uman, vor înţelege rolul şi importanţa mitocondriilor paternale în fertilizarea naturală, în bolile cardiace, în imunitate şi în bolile neurovegetative.

Referitor la direcţia de mers a cercetării vieţii, datorită necunoaşterii încă a implicaţiilor viitoare în natură produse de organismele modificate genetic, inclusiv oamenii modificaţi genetic, pe lângă prudenţă (91.2015, Ishii şi 93.2015, Mandell), cred că cea mai bună concluzie poate fi aceea propusă de Congresul SUA în 2015: colaborarea pentru a descoperi ce este viaţa şi care este scopul ei. (104.2015, US Congres).

Am să închid concluziile cu un citat extras din articolul profesorului de biologie moleculară Umberto Galderisi de la Universitatea din Neapole (53.2012, Galderisi): A treia oportunitate a fost refuzul unui student absolvent de a fi inclus în programul meu de doctorate. Replica lui a fost aceasta: “vă mulţumesc pentru ofertă; sunt mândru de ea, dar eu trebuie să găsesc cea mai bună cale de a câştiga bani. Prestigiul nu-l poţi utiliza la plata facturilor.”

În cazul meu concret, cum în prezent sunt pensionar şi nu cred că mai pot găsi o altă cale de a câştiga bani, la oferta venită în 2015 din partea doamnei prof. dr. ing Monica Borda, nu am avut altceva de ales în afara... prestigiului, chiar dacă nu voi putea plăti facturile cu el.


Din aceste motive, şi nu numai, voi direcţiona cercetarea viitoare către descoperirea locului unde se poziţionează mitocondriile paternale în organismul mamiferelor, femele şi masculi, deoarece “există în continuare posibilitatea ca mtDNA paternal să fie detectat numai în anumite ţesuturi” (86.2015, Carreli)

5. Recunoaşteri şi mulţumiri
Recunosc pe această cale că singura instituţie de cercetare şi învăţământ din lume care mi-a deschis porţile pentru a-mi expune raţional ideile şi concluziile la care am ajuns în domeniul cercetării informaţionale a vieţii este Universitatea Tehnică Cluj Napoca.
Mulţumesc doamnei prof. dr. ing. BORDA MONICA şi celorlalţi colegi ai domniei sale pentru deschiderea de care au dat dovadă în acceptarea unei teme din ştiinţa multidisciplinară şi pentru efortul depus de a citi lucrările mele, pentru a le analiza cu responsabilitate şi a le supune atenţiei şi criticii unei recunoscute instituţii de învăţământ din România.
Mulţumesc foştilor mei colegi de facultate şi prietenilor mei care au citit cu răbdare lucrările mele şi care au făcut observaţii pertinente, din care menţionez pe dr. ing. Radu Şerban Ionescu şi prof. dr. ing. Adrian Podoleanu.

6. Anexe
1. Memoriul transmis în 2011 Academiei Române
2. Mitochondrial Adam DNA data transmissions theory - ISBN 978-606-92107-1-0
3. Răspunsul primit în 2012 de la Guvernul României
4. Răspunsul primit în 2012 de la Camera Deputaţilor

academie%2030

adam mtdna

informare guvern

raspuns parlament

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27. 2008 - Julia Kay Christensen Eichman, Elizabeth A. Cowles, and Carolyn Schofield Bronston – Cell to cell communication. Cell signaling © 2008 The College Board.

28. 2008 - Kitzmiller v. Dover – Inteligent design –



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32. 2008 – Yukiko Yamashita – Stem cell centrosome misorientation and cell cycle arrest reduce spermatogenesis with age – EMBO Conference on centrosome and spindle pole bodies EMBL Heidelberg, September, 2008

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36. 2009 - Reiner Hedrich - String Theory. Nomological Unification and the Epicycles of the Quantum Field Theory Paradigm - Institut für Philosophie und Politikwissenschaft Technische Universitat Dortmund

37. 2009 – Brian Helfer, Cherie Kogan - Characterization and design of organic field-effect transistor circuits for sensing bioelectromagnetism - NSF Summer Undergraduate Fellowship in Sensor Technologies, University of Connecticut

38. 2009 – Cristofol Vives-Bauza, Chun Zhou, Yong Huang, Mei Cui, Rosa L.A. de Vries, Jiho Kim, Jessica May, Maja Aleksandra Tocilescu, Wencheng Liu, Han Seok Ko, Jordi Magrane, Darren J. Moore, Valina L. Dawson, Regis Grailhe, Ted M. Dawson, Chenjian Li, Kim Tieu, Serge Przedborski – PINK1-dependent recruitment of Parkin to mitochondria in mitophagy - Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1): 378–383. Published online 2009 Dec 29. doi: 10.1073/pnas.0911187107 PMCID: PMC2806779

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44. 2010 – Brian O’Rourke - From bioblasts to mitochondria: Ever expanding roles of mitochondria in cell physiology - doi: 10.3389/fphys.2010.00007 PMCID: PMC3059936

45. 2010 - Eugene Rosenberg - The hologenome theory of evolution -



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49. 2011 – Yuriy Kirichok - Sperm motility secrets revealed -

http://keck.ucsf.edu/physio/people/kirichoky.html

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51. 2012 - Shelley Adamo – Animal Mind Control -

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52. 2012 - Sylvie Dinant and Paula Suarez-Lopez - Multitude of Long-Distance Signal Molecules Acting Via Phloem - Institut National de la Recherche Agronomique, Versailles, France, e-mail: sylvie.dinant@versailles.inra.fr

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54. 2012 - National Institutes of Health (NIH) Common Fund supported Human Microbiome Project (HMP) - http://www.hmpdacc.org/ and http://www.human-microbiome.org/

55. 2012 – Cristina Luiggi – Indiana Senate backs Creationism bill -

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56. 2012 – Genomic Science Meeting – Bethesda, Maryland – 26-29 February, 2012

57. 2012 - Biolectromagnetism in Neuroscience - WESTFALISCHE WILHELMS-UNIVERSITAT, MUNSTER

58. 2012 – NICE, France - The 4th EMBO meeting advancing the life sciences, 22-25 Sept.

59. 2012 – K. Nishida and P.A. Silver - Induction of Biogenic Magnetization and Redox Control by a Component of the Target of Rapamycin Complex 1 Signaling Pathway - PLoS Biology, doi:10.1371/journal.pbio.1001269, 2012.

60. 2012 – Edward N. Trifonov – Opinion: What is life? Designing the simplest possible living organism artificially may lend clues as to what life is -



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61. 2012 – Bob Grant – Are the kids alright? –



http://the-scientist.com/2012/03/01/are-the-kids-alright/

62. 2012 - Gunther Witzany – Biocommunication in soil microorganisms soil biology - http://simplymb.com/pdf/biocommunication-in-soil-microorganisms-soi...

63. 2012 - Tanya Yatsunenko, Federico E. Rey, Mark J. Manary, Indi Trehan, Maria Gloria Dominguez-Bello, Monica Contreras, Magda Magris, Glida Hidalgo, Robert N. Baldassano, Andrey P. Anokhin, Andrew C. Heath, Barbara Warner, Jens Reeder, Justin Kuczynski, J. Gregory Caporaso, Catherine A. Lozupone, Christian Lauber, Jose Carlos Clemente, Dan Knights, Rob Knight and Jeffrey I. Gordon - Human gut microbiome viewed across age and geography - Nature (2012) doi:10.1038/nature11053

64.2013 - Elizabeth Isaac Aleman, Andrew Mbogholi, Yilan Fung Boix, Justo Gonzalez-Olmedo, Antonio Chalfun-Junior - Effects of EMFs on Some Biological Parameters in Coffee Plants (Coffea arabica L.) Obtained by in vitro Propagation - Pol. J. Environ. Stud. Vol. 23, No. 1 (2014), 95-101

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67. 2013 – Riekelt H. Houtkooper, Laurent Mouchiroud, Dongryeol Ryu, Norman Moullan, Elena Katsyuba, Graham Knott, Robert W. Williams and Johan Auwerx - Mitonuclear protein imbalance as a conserved longevity mechanism –

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68. 2013 - Kyu-Sun Lee, Zhihao Wu, Yan Song, Siddhartha S. Mitra, Abdullah H. Feroze, Samuel H. Cheshier, and Bingwei Lu - Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway - GENES & DEVELOPMENT 27:2642–2647

69. 2013 - David J. Pagliarini and Jared Rutter - Hallmarks of a new era in mitochondrial biochemistry - GENES & DEVELOPMENT 27:2615–2627

70. 2013 – Christoph Schmid, Sibylle Bauer, Benedikt Müller and Maik Bartelheimer - Belowground neighbor perceptionin Arabidopsis thaliana studied by transcriptome analysis: roots of Hieracium pilosella cause biotic stress – Frontiers in PLANT SCIENCE – doi:10.3389/fpls.2013.00296

71. 2013 - Xi Wang, Madhavi Bathina, John Lynch, Brian Koss, Christopher Calabrese, Sharon Frase, John D. Schuetz, Jerold E. Rehg, and Joseph T. Opferman - Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction - GENES & DEVELOPMENT 27:1351–1364 _ 2013

72. 2013 – Esra A. Akbay, Javid Moslehi, Camilla L. Christensen, Supriya Saha, Jeremy H. Tchaicha, Shakti H. Ramkissoon, Kelly M. Stewart, Julian Carretero, Eiki Kikuchi, Haikuo Zhang, Travis J. Cohoon, Stuart Murray, Wei Liu, Kazumasa Uno, Sudeshna Fisch, Kristen Jones, Sushma Gurumurthy, Camelia Gliser, Sung Choe, Marie Keenan, Jaekyoung Son, Illana Stanley, Julie A. Losman, Robert Padera, Roderick T. Bronson, John M. Asara, Omar Abdel-Wahab, Philip C. Amrein,6 Amir T. Fathi, Nika N. Danial, Alec C. Kimmelman, Andrew L. Kung, Keith L. Ligon, Katharine E. Yen, William G. Kaelin Jr., Nabeel Bardeesy, and Kwok-Kin Wong - D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice - GENES & DEVELOPMENT 28:479–490

73. 2014 – Jim Al-Khalili, and Johnjoe McFadden Solving biology's mysteries using quantum mechanics. The new field of quantum biology applies the craziness of quantum physics to biology's most fundamental processes –

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74. 2014 - Nina Bardi de Alvarez - Biophysics and Cancer: The Electromagnetic Fields Produced by the Mitochondria and Its Effect on the Cell’s Metabolic Regulation - Journal of Electromagnetic Analysis and Applications, 2014, 6, 328-334

75. 2014 – Emmanouil Dokianakis and Emmanuel D. Ladoukakis - Different degree of paternal mtDNA leakage between male and female progeny in interspecific Drosophila crosses - 19 June 2014 - DOI: 10.1002/ece3.1069

76. 2014 – Alexander V. Emelyanov, Joshua Rabbani,1 Monika Mehta, Elena Vershilova, Michael C. Keogh, and Dmitry V. Fyodorov - Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization - GENES & DEVELOPMENT 28:2027–2040

77. 2014 – A new agreement in the European Union allows genetically engineered crops to be approved without member-state votes, likely allowing several GMO foods to enter the market - http://www.the-scientist.com//?articles.view/articleNo/41618/title/...

78. 2014 - Aydogan Ozcan - A new microscope attachment can allow smartphone users to take a closer look at fluorescently labeled DNA –



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79. 2014 - Ministerul Agriculturii şi Dezvoltării Rurale - Strategia pentru dezvoltarea sectorului agroalimentar pe termen mediu şi lung. - Orizont 2020-2030

80. 2014 – Konstantina Skourti-Stathaki and Nicholas J. Proudfoot – A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression - GENES & DEVELOPMENT 28:1384–1396

81. 2014 - K. Ye et al. - Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals - PNAS, doi:10.1073/pnas.1403521111, 2014.



82. 2015 – Erin Abner, University of Kentucky – Can the brain be trained? - http://www.the-scientist.com/?articles.view/articleNo/42522/title/O...

83. 2015 - Claire Asher and Seirian Sumner – The Genetics of Society - http://www.the-scientist.com//?articles.view/articleNo/41704/title/...

84. 2015 - N. Moullan et al., Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research - Cell Reports, doi:10.1016/j.celrep.2015.02.034.

85. 2015 - Richard Bankert, Steven Bradfute, and Priti Kumar - Humanized mouse models: applications in Oncology and Infectious Disease –



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86. 2015 – Valerio Carreli - Keeping in shape the dogma of mitochondrial DNA maternal inheritance - May 14, 2015 - DOI: 10.1371/journal.pgen.1005179

87. 2015 – Arnold De Louf – From Darwin’s On the Origin of Species by Means of Natural Selection... to The evolution of Life with Communication - DOI: 10.9784/LEB3(3)DeLoof.01

88. 2015 – N. Dheilly et al. - Who is the puppet master? Replication of a parasitic wasp-associated virus correlates with host behaviour manipulation - doi:10.1098/rspb.2014.2773, 2015.

89. 2015 - Gerald W. Dorn II, Rick B. Vega, and Daniel P. Kelly - Mitochondrial biogenesis and dynamics in the developing and diseased heart - GENES & DEVELOPMENT 29:1981–1991

90. 2015 – Fotografii diverse - Mutace sveta rostlin v okolí elektrarny Fukusima

91. 2015 - Tetsuya Ishii – Opinion: On global GMO regulation - http://www.the-scientist.com//?articles.view/articleNo/42276/title/...

92. 2015 – Melvin Konner – Women after all. Sex evolution, and the end of male supremacy - http://www.the-scientist.com//?articles.view/articleNo/42040/title/...



93. 2015 – D. Mandell et al - Biocontainment of genetically modified organisms by synthetic protein design - Nature, doi: 10.1038/nature14121, 2014.

94. 2015 - Jeffrey Marlow and Jan Amend – The energy of life -



http://www.the-scientist.com//?articles.view/articleNo/41990/title/...

95. 2015 – Roberta B. Ness – The creativity crisis

http://www.the-scientist.com//?articles.view/articleNo/41856/title/...

96. 2015 - Brandon N. Nicolay, Paul S. Danielian, Filippos Kottakis, John D. Lapek Jr, Ioannis Sanidas, Wayne O. Miles, Mantre Dehnad, Katrin Tschop, Jessica J. Gierut, Amity L. Manning, Robert Morris, Kevin Haigis, Nabeel Bardeesy, Jacqueline A. Lees, Wilhelm Haas, and Nicholas J. Dyson - Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation - GENES & DEVELOPMENT 29:1875–1889 Published

97. 2015 – E. Rechavi et al. - Timely and spatially regulated maturation of B and T cell repertoire during human fetal development - doi:10.1126/scitranslmed.aaa0072, 2015.

98. 2015 – Contzen Pereira – The energy of life. Electromagnetic radiation, a living cell and the soul: a collated hypothesis – NeuroQuantology - DOI: 10.14704/nq.2015.13.4.862

99. 2015 - Jiri Pokorny, Jan Pokorny, Alberto Foletti, Jitka Kobilkova, Jan Vrba and Jan Vrba Jr. - Mitochondrial dysfunction and disturbed coherence: Gate to cancer - Pharmaceuticals 2015, 8, 675-695; doi:10.3390/ph8040675

100. 2015 - S. Premi et al. - Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure - Science, doi:10.1126/science.1256022, 2015.

101. 2015 USA – U.S. Approves Genetically Engineered Apples - http://www.the-scientist.com//?articles.view/articleNo/42173/title/...

102. 2015 – Anton Samuelsson – Bioelectromagnetics for improved crop productivity – Swedish University of Agricultural Sciences



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