From: "Paul Heelis" Subject: New chemistry jobs vacancy site To

points to the

following compounds found in Primula veris:

- primulaverin

- primverin

- primulaverosid

- primverosid

What do you think of that?

Best regards,

Eva Horn Moeller

__________________

Date: Wed, 17 May 2000 12:20:04 -0200 (FST)

From: Jorge E de A Oliveira

Subject: ORGLIST: OrgChem
Dear Orglist members,
I'd like to find a good source of information about OrgChem ,

OrganometChem and Organical Syntesis.

Because i am produced a cientifical resource.

Thanks in advance.

__________________________________

Jorge Eduardo de Araujo Oliveira

[e-mail]

Jesus Christ loves you !!!

__________________
Date: Wed, 17 May 2000 16:33:54 -0400

From: "Sesay, Muctarr"

Subject: ORGLIST: Penicillin hydrolysis
Hello all,
I am planning to utilize penicillin as a stabilizer for my research

work. Does anyone know what products (including structures and

mechanisms if possible) are formed when penicillin G (sodium salt)

undergoes acid hydolysis?

I would appreciate it if you could provide references of reviewed

articles or papers published in journals.

Thanks in advance for your help.
MAS

e-mail: [e-mail]

__________________
Date: Thu, 18 May 2000 14:51:01 -0700

From: Phil Stevens


Subject: ORGLIST: . . . WebMolecules News - May 2000
The May update of the award-winning site:
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Molecule________________ Category_______________________

Formula_________________ Wt(g/mol)______________________

Haloperidol 21.4 Pharmaceuticals-Prescription

C21H23ClFNO2 375.870(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?haloprdl.m3d

Clenbuterol 21.4 Pharmaceuticals-Prescription

C12H18Cl2N2O 277.193(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?clenbtrl.m3d
Hydronium ion 1.0 Acids & Bases

H3O+ 19.0232(3)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?h3o.m3d
Gingerol 10.0 Flavors & Smells

C17H26O4 294.391(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?gingerol.m3d
Vinpocetine 21.4 Pharmaceuticals-Prescription

C22H26N2O2 350.461(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?vinpoctn.m3d
1,1,1,2-Tetrafluoroethane 12.2 Halocarbons - Other

C2H2F4 102.031(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?1112f4et.m3d
Cumene hydroperoxide 19.18 Organics-Peroxides

C9H12O2 152.193(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?cumeneoo.m3d
d-Ephedrine 19.14 Organics-Mixed Functionality

C10H15NO 165.235(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?dephedrn.m3d
l-Ephedrine 19.14 Organics-Mixed Functionality

C10H15NO 165.235(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?lephedrn.m3d
d-Pseudoephedrine 19.14 Organics-Mixed Functionality

C10H15NO 165.235(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?dpephdrn.m3d
l-Pseudoephedrine 19.14 Organics-Mixed Functionality

C10H15NO 165.235(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?lpephdrn.m3d
Barium sulfide 15.0 Inorganics

BaSO4 233.391(7)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?baso4.m3d
FAD 3.0 Biomolecules

C27H33N9O15P2 785.558(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?fad.m3d
Levalbuterol 21.4 Pharmaceuticals-Prescription

C13H21NO3 239.315(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?levlbtrl.m3d
Butene 13.0 Hydrocarbons

C4H8 56.108(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?butene.m3d
Violaxanthin 3.0 Biomolecules

C40H56O4 600.882(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?vilxnthn.m3d
Jasmonic acid 1.0 Acids & Bases

C12H18O3 210.273(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?jasmncac.m3d
Harmine 19.14 Organics-Mixed Functionality

C13H12N2O 212.251(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?harmine.m3d
Gliotoxin 26.0 Toxins

C13H14N2O4S2 326.397(6)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?gliotoxn.m3d
NMP 24.0 Solvents

C5H9NO 99.133(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?nmp.m3d
Nitrogen triiodide 9.0 Energetics/Explosives

I3N 394.72015(7)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?ni3.m3d
2C-B 21.1 Pharmaceuticals-Controlled Subs

C10H14BrNO2 260.131(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?2cb.m3d
Hypericin 19.14 Organics-Mixed Functionality

C30H16O8 504.452(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?hypericn.m3d
Hyperforin 21.3 Pharmaceuticals - OTC

C35H52O4 536.795(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?hyperfrn.m3d
Phencyclidine (PCP) 21.1 Pharmaceuticals-Controlled Subs

C17H25N 243.392(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?pcpangel.m3d
Decachlorobiphenyl 12.2 Halocarbons - Other

C12Cl10 498.659(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?dchlbpnl.m3d
Sodium isopropylxanthate 26.0 Toxins

C4H7NaOS2 158.221(6)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?sprlxnth.m3d
2-Methylhexanoic acid 10.0 Flavors & Smells

C7H14O2 130.187(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?2mhxncac.m3d
3,3,5-Trichloro-4-nonene 12.2 Halocarbons - Other

C9H15Cl3 229.576(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?335tcl4n.m3d
Glutathione, oxidized 3.0 Biomolecules

C20H32N6O12S2 612.639(6)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?oglutthn.m3d
1,2-Dichloroethane 12.2 Halocarbons - Other

C2H4Cl2 98.959(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?12dcethn.m3d
Dextromethorphan 21.4 Pharmaceuticals-Prescription

C18H25NO 271.403(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?dxtrtrpn.m3d
Dodecylsulfate anion 1.0 Acids & Bases

C12H25O4S 265.394(6)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?ddclslft.m3d
Thiosulfate 15.0 Inorganics

HO3S2 113.138(6)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?thioslft.m3d
Podophyllotoxin 21.4 Pharmaceuticals-Prescription

C22H22O8 414.412(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?pdphltxn.m3d
Salsolinol 19.14 Organics-Mixed Functionality

C10H13NO2 179.219(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?salsolnl.m3d
Sodium bicarbonate 1.0 Acids & Bases

CHNaO3 84.007(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?nahco3.m3d
Methylal 19.10 Organics - Ethers

C3H8O2 76.095(1)

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?methylal.m3d
Trimethyl aluminum 20.0 Organometallics

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?tma.m3d

C3H9Al 72.086(1)
s-SMCC 3.0 Biomolecules

http://www.webmolecules.com/cgi-bin/webmolpage.cgi?s_smcc.m3d

C16H17N2NaO9S 436.375(6)

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__________________
Date: Tue, 23 May 2000 14:54:31 +0200

From: Eva Horn Moeller

Subject: ORGLIST: Hydrogen peroxide
Dear all,

do you know of any instances where hydrogen peroxide has been employed

for the oxidation of an alcohol to a ketone? We=B4ve had a discussion of

that in the lab recently, and none of us have come up with something

yet.

Best regards,

Eva Horn Moeller

(M.Sc., Ph.D.)

__________________
Date: Tue, 23 May 2000 09:21:11 -0700

From: "Chapman, Robert D"

Subject: RE: ORGLIST: Hydrogen peroxide
If you accept sodium perborate as hydrogen peroxide in the presence of

borate ions (i.e., the way it is formed), a few examples are reviewed =

by:

McKillop, A.; Sanderson, W.R. Tetrahedron 1995, 51, 6145.

Robert D. Chapman, Ph.D.

Chemistry & Materials Division (Code 4T4200D)

Naval Air Warfare Center

China Lake, CA 93555 USA

__________________
Date: Thu, 25 May 2000 01:47:31 +0800

From: "Jeffry Soon"

Subject: ORGLIST: dilute ammonia gas
Dear all
I was looking the simple process about 1000 L per day of dilution =

ammonia gas into ammonium hydroxide (22-25)%. please advise=20

__________________
Date: Tue, 23 May 2000 12:47:25 -0500

From: David

Subject: Re: ORGLIST: Hydrogen peroxide
I think you need a Mo or W catalyst in addition to the H2O2. I beli=

eve this

method is selective for secondary alcohols over primary. See Tet. Let=

t. 1984,

vol. 25, 173.

and JACS 1992, vol 114, 7375, for W see JOC 1988, vol 53, 3587.

hope this helps,
David O'Dell

Univ of Okla.

__________________
Date: Tue, 23 May 2000 19:42:41 +0200

From:

Subject: Sv: ORGLIST: Hydrogen peroxide
The oxidation of anthrecene-9,10-diol or its ethers, by =

hydrogenperoxide, I believe, will give you anthraquinone, a ketone (a =

diketone), though I do not remember the details or any references.
Also, you might find examples of oxidations with hydrogen peroxide as =

the stoichiometric oxidant in the presence of f.i. acetone (via =

dioxiranes)

__________________

Date: Wed, 24 May 2000 09:28:25 +0200

From: Luis Fernando Garcia Alles

Subject: ORGLIST: Phosphofluoridate
Dear People,

Here I am again with some questions. The problem I have is the following.

I would like to syntesize some analogues of a phosphoester [R-O-PO3(2-)]. I

have thought of replacing one of the OH groups in the phosphate for a

fluorine, to get the phosphofluoridate analogue: R-O-P(F)O2(-). I do not

have too much experience with phosphofluoridates (I only know that they are

very toxic) and consequently I have too many doubts. In the literature

there seems to be very few examples of this kind of compounds, all of them

mainly in the field of nucleotide chemistry. Let me show you some of the

ideas I had to get to this compound:

=09

1) an arbusov reaction between an alpha-bromoketone and the

fluorophosphite F-P(OR')2, to get the protected fluorophosphate

(R-O-P=3DO(F)OR'). Here I have several doubts:

How to get to the fluorophosphite??, Do you think that I can use ClP(OR')2

or R2N-P(OR')2 to synthesize the F-P(OR')2??

Is the fluoro-phosphite so reactive as the usual phosphites employed in

this kind of reaction??.

Is it the fluorophosphate stable enough as to allow deprotection

(R-O-P=3DO(F)OR' --> R-O-P=3DO(F)OH ) in the last step, for instance with Pd

black in HCOOH/MeOH if R' is a benzyl group??

2) Using the reaction between the alcohol ROH and the Chlorophosphate

ClP=3DO(F)OR'. More doubts:
Do you think that I can easily replace and purify the ChloroFluorophosphate

in a reaction like Cl2P=3DO(OR') --> ClP=3DO(F)OR'?? Or even starting from

O=3DPCl3 introduce first a fluorine and then benzyl alcohol??
Well I have much more doubts, but I do not want to bore you with more

things. I think that the main problem I have is a lack of experience in

phosphate chemistry, and that is why I am wondering about everything before

doing anything.

Well, I hope somebody out there can send me some light, regarding

stability of this kind of compounds, and this kind of things...=20

=09
In any case, thank you very much to everybody just for reading the

message, and have a very good time.

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

Luis Fernando Garc=EDa Alles, Ph.D.

Departement f=FCr Chemie und Biochemie

Universit=E4t Bern

Freiestrasse 3

CH-3012 Bern, Schweiz

Tel. ++41 (0)31/631 37 92

Fax ++41 (0)31/631 33 83=09

E-mail :[e-mail]

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=

=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D

__________________
Date: Wed, 24 May 2000 16:07:07 +0200

From: "Yantao Chen"

Subject: ORGLIST: replace HMPA
Dear All Members:
Maybe everyone knows that HMPA (hexamethylphosphoramide) is a good =

solvent during the alkylation of carbonyl compounds, especially used =

when the carbon anion was formed using LDA in THF. But due to its high =

toxicity, I am just wondering: is there anybody running the similar =

reaction with other kind of solvents?
Thanks in advance.
Yantao Chen

[e-mail]

__________________
Date: Wed, 24 May 2000 16:30:17 +0200

From: Fredrik Thorstensson

Subject: Re: ORGLIST: replace HMPA
DMPU is a HMPA mimic.

N,N'-Dimethylpropyleneurea.

/FT
--

************************

Fredrik Thorstensson

LKPG University

Sweden

[e-mail]

************************

__________________

Date: Wed, 24 May 2000 16:33:19 +0200

From: "Hanssen, R.W.J.M."

Subject: ORGLIST: SciFinder Scholar ?
Hi Everyone,
In the netherlands there is currently a debate about netherland-wide

introduction of SciFinder Scholar. Can anyone tell me something about the

database, especially in comparison to the more established Science Citation

Index and Beilstein Xfire etc.?

Are you positive about SciF.S. or are the other programs better (in any

way)?
Greetings,

Rob Hanssen
---

Rob Hanssen

Schuit Institute of Catalysis

PO Box 513

5600MB Eindhoven

FAX: [phone]

WWW: http://www.ska.chem.tue.nl

__________________

Date: Wed, 24 May 2000 08:45:48 -0700

From: "Jack Kellum"

Subject: Re: ORGLIST: SciFinder Scholar ?
Can anyone tell me something about the

> database, especially in comparison to the more established Science

Citation

> Index and Beilstein Xfire etc.?

>

> Are you positive about SciF.S. or are the other programs better (in any

> way)?
Rob,
My first experience was with Beilstein. Our university now has SciFinder as

well. I still prefer Beilstein for structure searching because I feel it

allows for more generality or specificity as determined by the user.

SciFinder is excellent though for more general keyword literature searches

as it indexes abstracts for each citation. I've never used the Science

Citation Index you mention, but I'm sure it's very similar to SciFinder in

this respect.
The bottom line is: I like them both and wouldn't have to rely on only one

or the other. But if this is the choice you had to make, I suppose I would

choose SciFinder as it's more versatile and user-friendly.
Jack

__________________

Date: Wed, 24 May 2000 16:58:27 +0100

From: "Rzepa, Henry"