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Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study



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Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study


Prenatal exposure to Plasmodium falciparum affects development of protective immunity and susceptibility to subsequent natural challenges with similar parasite antigens. However, the nature of these effects has n...

Boniphace Sylvester, Dinah B. Gasarasi, Said Aboud, Donath Tarimo, Siriel Massawe, Rose Mpembeni and Gote Swedberg

Malaria Journal 2016 15:379

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity


In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malari...

Bradley W. Hickey, Joanne M. Lumsden, Sharina Reyes, Martha Sedegah, Michael R. Hollingdale, Daniel A. Freilich, Thomas C. Luke, Yupin Charoenvit, Lucy M. Goh, Mara P. Berzins, Lolita Bebris, John B. Sacci, Patricia De La Vega, Ruobing Wang, Harini Ganeshan, Esteban N. Abot…

Malaria Journal 2016 15:377

Malaria vector research and control in Haiti: a systematic review


Haiti has a set a target of eliminating malaria by 2020. However, information on malaria vector research in Haiti is not well known. This paper presents results from a systematic review of the literature on ma...

Joseph Frederick, Yvan Saint Jean, Jean Frantz Lemoine, Ellen M. Dotson, Kimberly E. Mace, Michelle Chang, Laurence Slutsker, Arnaud Le Menach, John C. Beier, Thomas P. Eisele, Bernard A. Okech, Valery Madsen Beau de Rochars, Keith H. Carter, Joseph Keating and Daniel E. Impoinvil

Malaria Journal 2016 15:376

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin


Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across...

Muturi J. Njokah, Joseph N. Kang’ethe, Johnson Kinyua, Daniel Kariuki and Francis T. Kimani

Malaria Journal 2016 15:381

Development of a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine and artemether-lumefantrine to treat Plasmodium falciparum infections in Swaziland: a pilot study


Countries remain reluctant to adopt the 2012 World Health Organization recommendation for single low-dose (0.25 mg/kg) primaquine (SLD PQ) for Plasmodium falciparum transmission-blocking due to concerns over drug...

Eugenie Poirot, Adam Soble, Nyasatu Ntshalintshali, Asen Mwandemele, Nomcebo Mkhonta, Calisile Malambe, Sibonakaliso Vilakati, Sisi Pan, Sarah Darteh, Gugu Maphalala, Joelle Brown, Jimee Hwang, Cheryl Pace, Andy Stergachis, Eric Vittinghoff, Simon Kunene…

Malaria Journal 2016 15:384

Anti-malarial seroprevalence assessment during an elimination programme in Chabahar District, south-eastern Iran


Iran has achieved a substantial decline in malaria incidence over the past decades. A common feature of malaria-endemic settings is the requirement for more sensitive techniques to describe levels of low trans...

Sedigheh Zakeri, Lotus Leonie van den Hoogen, Akram Abouie Mehrizi, Fatemh Karimi, Ahmad Raeisi and Chris Drakeley

Malaria Journal 2016 15:382

Routine implementation costs of larviciding with Bacillus thuringiensis israelensis against malaria vectors in a district in rural Burkina Faso


The key tools in malaria control are early diagnosis and treatment of cases as well as vector control. Current strategies for malaria vector control in sub-Saharan Africa are largely based on long-lasting inse...

Peter Dambach, Michael Schleicher, Hans-Christian Stahl, Issouf Traoré, Norbert Becker, Achim Kaiser, Ali Sié and Rainer Sauerborn

Malaria Journal 2016 15:380

A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents


Drugs that kill or inhibit Plasmodium gametocytes in the human host could potentially synergize the impact of other chemotherapeutic interventions by blocking transmission. To develop such agents, reliable method...

Noemí Bahamontes-Rosa, María G. Gomez-Lorenzo, Joël Lelièvre, Ane Rodriguez Alejandre, María Jesus Almela, Sonia Lozano, Esperanza Herreros and Francisco-Javier Gamo

Malaria Journal 2016 15:385

An experimental hut evaluation of Olyset Plus, a long-lasting insecticidal net treated with a mixture of permethrin and piperonyl butoxide, against Anopheles fluviatilis in Odisha State, India


Fast development of pyrethroid resistance in malaria vectors prompted the development of new vector control tools including combination of insecticides with different modes of action as part of resistance mana...

Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Rajpal Singh Yadav, Olivier Pigeon and Purushothaman Jambulingam

Malaria Journal 2016 15:375

Chicken volatiles repel host-seeking malaria mosquitoes


Anopheles arabiensis is a dominant vector of malaria in sub-Saharan Africa, which feeds indoors and outdoors on human and other vertebrate hosts, making it a difficult species to contr...

Kassahun T. Jaleta, Sharon Rose Hill, Göran Birgersson, Habte Tekie and Rickard Ignell

Malaria Journal 2016 15:354

Cytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-119 IgG antibody levels in a malaria-endemic area of the Brazilian Amazon


The immune response against Plasmodium vivax immunogenic epitopes is regulated by pro- and anti-inflammatory cytokines that determine antibody levels and class switching. Cytokine gene polymorphisms may be respon...

Adriana A. C. Furini, Marcela P. Capobianco, Luciane M. Storti-Melo, Maristela G. Cunha, Gustavo C. Cassiano and Ricardo Luiz D. Machado

Malaria Journal 2016 15:374


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